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The map label for this gene is cadA [H]

Identifier: 68536524

GI number: 68536524

Start: 1695817

End: 1697709

Strand: Direct

Name: cadA [H]

Synonym: jk1438

Alternate gene names: 68536524

Gene position: 1695817-1697709 (Clockwise)

Preceding gene: 68536523

Following gene: 68536526

Centisome position: 68.87

GC content: 66.4

Gene sequence:

>1893_bases
ATGAGCTCGGCGTGTGGATGCGCACACGAACCCGCCACAGAGATCGAAGAACTCGATCGGCCATGGTGGAAGGACCCCGA
GTTGCTACTGCCGATCTTCTCCGGCGTAGCCCTCGGCATAGGTCTGGCGCTGGACTGGTCCGGGGTAGAGACACCCGCGA
CAGTACTGTTCTGGGTCGGCCTGCTGCTAGGGGCGTATACGTTCGCGCCCGGCGCGATCCGAAACCTTGTCACGAAGCGC
AAGCTCGGCATTGGTTTGCTGATGACGATCAGCGCGGTCGGCGCGGTAATCCTCGGTTACGTCGGAGAGGCCGCGGCGCT
AGCGTTCCTGTACTCGATCGCCGAGGCGCTGGAAGACAAGGCAATGGACCGGGCACAGGGCGGGCTGCGGGCACTGTTGA
AGTTGGTACCGCAGACCGCGACGGTGCTGCGCGACGGCACGTCGGTCAAGGTCGCAGCGAAGGACCTCGTGGCTGGCGAA
CTGATGCTCGTGCGCCCCGGAGAGCGGATCGCCACGGACGGCATCATTCGGTCTGGACGTTCCAGCCTTGACACCTCAGC
GATCACCGGAGAATCCATTCCGGAGGAGGTTGCACCCGGCGACGAGGTGCCCGCGGGTGCGATCAACTCCGCCGGTGTGC
TGGAAGTAGAGACGACCGCAGCTGGAACGGACAACTCGCTGACCACACTCGTCGACCTCGTCGAGCAGGCGCAGGCGGAG
AAGGGTGACCGCGCCCGGATCGCCGACCGAATTGCCCAACCCCTAGTGCCCGGGGTGATGATCCTGGCGGTGCTGGTCGG
CGTGATCGGCTCGCTGCTGGGTGACCCAGAGACTTGGATCACCCGTGCGCTGGTGGTCCTGGTCGCAGCGTCGCCGTGCG
CGCTGGCAATCTCCGTGCCGCTGACGGTCGTGGCCGCCATCGGCGCGGCCAGCCAGTTCGGCGTGGTCATCAAGTCCGGC
GCGGCGTTCGAGCGACTCGGTGGCATCCGTCACCTGGCGGTGGACAAGACCGGAACCCTTACCCGCAACCAGCCCGAGGT
TACCGACGTGGTCCCGGCAGACGGATTCGATCCGGCGCAGGTGCTTGCCTTCGCGGCGGCAGTTGAGCAGCAATCGACGC
ACCCCCTCGCTGCGGCGATCGCGGCAGCGGTGCCCGAAGCGCCCGCCGCCCAGGACATCAGCGAGGAAGCCGGACATGGC
ATCGGCGGCACTGTCGAAGGTCGACGGGTGCTGGTGGGCAGCCCCCGGTGGATCGACGCCGGGCCACTAAAGGCAGACGT
TGAGCGCATGGAGTCCGAGGGCCAGACCTGCGTCCTTGTCACCGTCGATGACGCCCTCTCTGGGGCGATCGGGGTCCGCG
ACGAGCTGCGGCCCGAGGTGCCCGAAGCCGTGCAGACCCTGCACGCCAACGACGTGGAAGTGAGCATGCTCACCGGCGAC
AACACTCGCACCGCCCGGGCGCTGGCTGAAATCGCCGGAATCGACGACGTGCGCGCCGAGCTTCGCCCGGAGGACAAGGC
AAACATTGTCGCCGAACTCTCCTCCAAGACGCCGACGGCGATGATTGGCGACGGCATCAACGACGCTCCTGCGCTGGCGG
GCGCGACGGTGGGCATAGCGATGGGAGCGACCGGCTCCGACGCCGCAATCGAGTCCGCTGACGTCGCCTTCACCGGCCAC
GACCTCCGGTTGATCCCGCAGGCGCTGCAGCACGCCCGTCGAGGCAGCAGGATTATTAACCAGAACATCGTGCTGTCTCT
GGCCATCATCATCGTGTTGATGCCACTGGCGATCAGCGGTGTGCTGGGGCTGGCCGCCGTCGTATTGGTTCACGAGGTCG
CTGAAGTCATTGTCATCTTGAACGGCCTGCGGGCCGCACGAGCGAAGCGCTAA

Upstream 100 bases:

>100_bases
TCAACGCGCTGGTGAACGCGACGTTGGCTGTCGACGAAAACGCCCCGTGCATCGACCCTGAATGCTCGGTGCCCGGCTGC
GGCGAGAAGGGAGCGGACGC

Downstream 100 bases:

>100_bases
GACACACCTTCGCCCAGCGCGCTGGCTCTCCAGCGCGGACCTTGGAAGGATCGAGCTGCTCAGGAACCAAGCGTCGCCTC
AAAACTTTTGCTGCCGAGCT

Product: putative cadmium-transporting ATPase

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 630; Mature: 629

Protein sequence:

>630_residues
MSSACGCAHEPATEIEELDRPWWKDPELLLPIFSGVALGIGLALDWSGVETPATVLFWVGLLLGAYTFAPGAIRNLVTKR
KLGIGLLMTISAVGAVILGYVGEAAALAFLYSIAEALEDKAMDRAQGGLRALLKLVPQTATVLRDGTSVKVAAKDLVAGE
LMLVRPGERIATDGIIRSGRSSLDTSAITGESIPEEVAPGDEVPAGAINSAGVLEVETTAAGTDNSLTTLVDLVEQAQAE
KGDRARIADRIAQPLVPGVMILAVLVGVIGSLLGDPETWITRALVVLVAASPCALAISVPLTVVAAIGAASQFGVVIKSG
AAFERLGGIRHLAVDKTGTLTRNQPEVTDVVPADGFDPAQVLAFAAAVEQQSTHPLAAAIAAAVPEAPAAQDISEEAGHG
IGGTVEGRRVLVGSPRWIDAGPLKADVERMESEGQTCVLVTVDDALSGAIGVRDELRPEVPEAVQTLHANDVEVSMLTGD
NTRTARALAEIAGIDDVRAELRPEDKANIVAELSSKTPTAMIGDGINDAPALAGATVGIAMGATGSDAAIESADVAFTGH
DLRLIPQALQHARRGSRIINQNIVLSLAIIIVLMPLAISGVLGLAAVVLVHEVAEVIVILNGLRAARAKR

Sequences:

>Translated_630_residues
MSSACGCAHEPATEIEELDRPWWKDPELLLPIFSGVALGIGLALDWSGVETPATVLFWVGLLLGAYTFAPGAIRNLVTKR
KLGIGLLMTISAVGAVILGYVGEAAALAFLYSIAEALEDKAMDRAQGGLRALLKLVPQTATVLRDGTSVKVAAKDLVAGE
LMLVRPGERIATDGIIRSGRSSLDTSAITGESIPEEVAPGDEVPAGAINSAGVLEVETTAAGTDNSLTTLVDLVEQAQAE
KGDRARIADRIAQPLVPGVMILAVLVGVIGSLLGDPETWITRALVVLVAASPCALAISVPLTVVAAIGAASQFGVVIKSG
AAFERLGGIRHLAVDKTGTLTRNQPEVTDVVPADGFDPAQVLAFAAAVEQQSTHPLAAAIAAAVPEAPAAQDISEEAGHG
IGGTVEGRRVLVGSPRWIDAGPLKADVERMESEGQTCVLVTVDDALSGAIGVRDELRPEVPEAVQTLHANDVEVSMLTGD
NTRTARALAEIAGIDDVRAELRPEDKANIVAELSSKTPTAMIGDGINDAPALAGATVGIAMGATGSDAAIESADVAFTGH
DLRLIPQALQHARRGSRIINQNIVLSLAIIIVLMPLAISGVLGLAAVVLVHEVAEVIVILNGLRAARAKR
>Mature_629_residues
SSACGCAHEPATEIEELDRPWWKDPELLLPIFSGVALGIGLALDWSGVETPATVLFWVGLLLGAYTFAPGAIRNLVTKRK
LGIGLLMTISAVGAVILGYVGEAAALAFLYSIAEALEDKAMDRAQGGLRALLKLVPQTATVLRDGTSVKVAAKDLVAGEL
MLVRPGERIATDGIIRSGRSSLDTSAITGESIPEEVAPGDEVPAGAINSAGVLEVETTAAGTDNSLTTLVDLVEQAQAEK
GDRARIADRIAQPLVPGVMILAVLVGVIGSLLGDPETWITRALVVLVAASPCALAISVPLTVVAAIGAASQFGVVIKSGA
AFERLGGIRHLAVDKTGTLTRNQPEVTDVVPADGFDPAQVLAFAAAVEQQSTHPLAAAIAAAVPEAPAAQDISEEAGHGI
GGTVEGRRVLVGSPRWIDAGPLKADVERMESEGQTCVLVTVDDALSGAIGVRDELRPEVPEAVQTLHANDVEVSMLTGDN
TRTARALAEIAGIDDVRAELRPEDKANIVAELSSKTPTAMIGDGINDAPALAGATVGIAMGATGSDAAIESADVAFTGHD
LRLIPQALQHARRGSRIINQNIVLSLAIIIVLMPLAISGVLGLAAVVLVHEVAEVIVILNGLRAARAKR

Specific function: Involved In Export Of Lead, Cadmium, Zinc And Mercury. [C]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=583, Percent_Identity=31.7324185248714, Blast_Score=233, Evalue=5e-61,
Organism=Homo sapiens, GI115529486, Length=530, Percent_Identity=30.9433962264151, Blast_Score=210, Evalue=3e-54,
Organism=Homo sapiens, GI55743073, Length=502, Percent_Identity=33.4661354581673, Blast_Score=209, Evalue=7e-54,
Organism=Homo sapiens, GI48762687, Length=154, Percent_Identity=33.7662337662338, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI48762685, Length=154, Percent_Identity=33.7662337662338, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI48762689, Length=154, Percent_Identity=33.7662337662338, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI48762691, Length=154, Percent_Identity=33.7662337662338, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI28373107, Length=240, Percent_Identity=28.75, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI28373105, Length=240, Percent_Identity=28.75, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI28373115, Length=240, Percent_Identity=28.75, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI28373111, Length=240, Percent_Identity=28.75, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI28373109, Length=240, Percent_Identity=28.75, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI28373113, Length=240, Percent_Identity=28.75, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI28373103, Length=240, Percent_Identity=28.75, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI4502271, Length=306, Percent_Identity=26.1437908496732, Blast_Score=71, Evalue=4e-12,
Organism=Homo sapiens, GI237681109, Length=305, Percent_Identity=25.5737704918033, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI118498343, Length=204, Percent_Identity=30.3921568627451, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI21361181, Length=305, Percent_Identity=25.5737704918033, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI237681111, Length=305, Percent_Identity=25.5737704918033, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI22748667, Length=230, Percent_Identity=27.3913043478261, Blast_Score=67, Evalue=8e-11,
Organism=Escherichia coli, GI1789879, Length=579, Percent_Identity=38.860103626943, Blast_Score=332, Evalue=4e-92,
Organism=Escherichia coli, GI1786691, Length=515, Percent_Identity=35.7281553398058, Blast_Score=248, Evalue=1e-66,
Organism=Escherichia coli, GI1786914, Length=437, Percent_Identity=28.1464530892449, Blast_Score=107, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17556548, Length=582, Percent_Identity=29.8969072164948, Blast_Score=191, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI71997262, Length=577, Percent_Identity=23.9168110918544, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71997275, Length=239, Percent_Identity=28.0334728033473, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71997269, Length=240, Percent_Identity=28.75, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17559224, Length=313, Percent_Identity=28.1150159744409, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6320475, Length=540, Percent_Identity=30.1851851851852, Blast_Score=205, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6319772, Length=576, Percent_Identity=25.6944444444444, Blast_Score=163, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6325221, Length=553, Percent_Identity=26.0397830018083, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6321430, Length=549, Percent_Identity=25.6830601092896, Blast_Score=104, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6321271, Length=161, Percent_Identity=32.9192546583851, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI221329854, Length=438, Percent_Identity=30.1369863013699, Blast_Score=129, Evalue=6e-30,
Organism=Drosophila melanogaster, GI281366617, Length=159, Percent_Identity=31.4465408805031, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24668708, Length=159, Percent_Identity=31.4465408805031, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24668704, Length=159, Percent_Identity=31.4465408805031, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24668696, Length=159, Percent_Identity=31.4465408805031, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI161085803, Length=159, Percent_Identity=31.4465408805031, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45553441, Length=232, Percent_Identity=30.6034482758621, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24648580, Length=232, Percent_Identity=30.6034482758621, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24648578, Length=232, Percent_Identity=30.6034482758621, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281362164, Length=232, Percent_Identity=30.6034482758621, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24648576, Length=232, Percent_Identity=30.6034482758621, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45553435, Length=232, Percent_Identity=30.6034482758621, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45553439, Length=232, Percent_Identity=30.6034482758621, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45553437, Length=232, Percent_Identity=30.6034482758621, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24648582, Length=310, Percent_Identity=26.4516129032258, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00702 Hydrolase [H]

EC number: 3.6.3.3 [C]

Molecular weight: Translated: 64916; Mature: 64785

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: PS00154 ATPASE_E1_E2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSACGCAHEPATEIEELDRPWWKDPELLLPIFSGVALGIGLALDWSGVETPATVLFWVG
CCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHH
LLLGAYTFAPGAIRNLVTKRKLGIGLLMTISAVGAVILGYVGEAAALAFLYSIAEALEDK
HHHHHHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMDRAQGGLRALLKLVPQTATVLRDGTSVKVAAKDLVAGELMLVRPGERIATDGIIRSGR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHCCEEEECCCCHHHHHHHHHCCC
SSLDTSAITGESIPEEVAPGDEVPAGAINSAGVLEVETTAAGTDNSLTTLVDLVEQAQAE
CCCCCHHCCCCCCCHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHC
KGDRARIADRIAQPLVPGVMILAVLVGVIGSLLGDPETWITRALVVLVAASPCALAISVP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEHHH
LTVVAAIGAASQFGVVIKSGAAFERLGGIRHLAVDKTGTLTRNQPEVTDVVPADGFDPAQ
HHHHHHHCCHHHCCEEEECCCHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHH
VLAFAAAVEQQSTHPLAAAIAAAVPEAPAAQDISEEAGHGIGGTVEGRRVLVGSPRWIDA
HHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCEEEECCCCCCCC
GPLKADVERMESEGQTCVLVTVDDALSGAIGVRDELRPEVPEAVQTLHANDVEVSMLTGD
CCCHHHHHHHHCCCCEEEEEEECCHHCCCCCCCHHCCCCHHHHHHHHCCCCEEEEEEECC
NTRTARALAEIAGIDDVRAELRPEDKANIVAELSSKTPTAMIGDGINDAPALAGATVGIA
CCHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHCCCCCCEEECCCCCCCHHHHCCHHHEE
MGATGSDAAIESADVAFTGHDLRLIPQALQHARRGSRIINQNIVLSLAIIIVLMPLAISG
ECCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
VLGLAAVVLVHEVAEVIVILNGLRAARAKR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSACGCAHEPATEIEELDRPWWKDPELLLPIFSGVALGIGLALDWSGVETPATVLFWVG
CCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHH
LLLGAYTFAPGAIRNLVTKRKLGIGLLMTISAVGAVILGYVGEAAALAFLYSIAEALEDK
HHHHHHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMDRAQGGLRALLKLVPQTATVLRDGTSVKVAAKDLVAGELMLVRPGERIATDGIIRSGR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHCCEEEECCCCHHHHHHHHHCCC
SSLDTSAITGESIPEEVAPGDEVPAGAINSAGVLEVETTAAGTDNSLTTLVDLVEQAQAE
CCCCCHHCCCCCCCHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHC
KGDRARIADRIAQPLVPGVMILAVLVGVIGSLLGDPETWITRALVVLVAASPCALAISVP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEHHH
LTVVAAIGAASQFGVVIKSGAAFERLGGIRHLAVDKTGTLTRNQPEVTDVVPADGFDPAQ
HHHHHHHCCHHHCCEEEECCCHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHH
VLAFAAAVEQQSTHPLAAAIAAAVPEAPAAQDISEEAGHGIGGTVEGRRVLVGSPRWIDA
HHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCEEEECCCCCCCC
GPLKADVERMESEGQTCVLVTVDDALSGAIGVRDELRPEVPEAVQTLHANDVEVSMLTGD
CCCHHHHHHHHCCCCEEEEEEECCHHCCCCCCCHHCCCCHHHHHHHHCCCCEEEEEEECC
NTRTARALAEIAGIDDVRAELRPEDKANIVAELSSKTPTAMIGDGINDAPALAGATVGIA
CCHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHCCCCCCEEECCCCCCCHHHHCCHHHEE
MGATGSDAAIESADVAFTGHDLRLIPQALQHARRGSRIINQNIVLSLAIIIVLMPLAISG
ECCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHH
VLGLAAVVLVHEVAEVIVILNGLRAARAKR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]