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The map label for this gene is tipA [H]

Identifier: 68536504

GI number: 68536504

Start: 1678759

End: 1679535

Strand: Direct

Name: tipA [H]

Synonym: jk1418

Alternate gene names: 68536504

Gene position: 1678759-1679535 (Clockwise)

Preceding gene: 68536499

Following gene: 68536505

Centisome position: 68.17

GC content: 59.46

Gene sequence:

>777_bases
ATGACCGAATACACGATTGGTGATGCTGCAGATTTTTTGGGTGTGACGCCCAAAGCCCTGCGCCATTGGGATTCCATTGG
GCTACTCAGCCCACAGTGGCGCACACTGGGCGACTACCGCCTCTATACCGAGGAAGATCTGCGCGTCGGCGCGGCCATTG
TGCTGTACCGGGACATGGGTTTCAAGCTGGCGGAGATTCCCGACCTGATTGAAGCGCCTTCCGACGCTGCCCTTGACCGT
GCCCTCCGCGCCCATCGGGAAGCCTTGGCGCGCAAGCGCGACGAGGTGGAGAGCCAATTGCGTGCGGTCGAGGATTTGAT
AACAACAACCCGAGTGGAGGGATACACCATGGAACAAATGGACAAGATCAAGCAGTACTTCGGCGAGCAGATGCCCGCCT
ACCAGGAGGAAGCTCGCGAGCGTTGGGGCGACACCCCTGAATACCAGCAGTCCCAGGAAAAGCTGGCCTCTATGGGTGAC
GGCGACTTCCAGGAGGTTAAGGCCAACCACGACCGCTTCGTGGCGGATCTGGTAGCTGCCCGAGATGGTGGCGTCACCCC
CGATAGCGAAGAAGCACAAGAACTCGTGGAGCGGCACCGCGCAACGATTAACCAGTGGTACGAGGTTACGACCTCGCGGC
AGCTGATTCTGGCACGGATGTACGTGGACGACGAGCGTTTTGCCGAGGCATACCAGGGCGCACAGGATTACCTGCTTTCG
CTAGTGGAACACCGTGCGAAGCAGGAGGGAATCACCAATCCCAGCTGGGATGACTAG

Upstream 100 bases:

>100_bases
TTTCCTGAAGATGAATTCATAACAACTTCGCGTCTTCCCTCTCCACCGCTTGACCACTTCGCTTGACCTTGCCGTTGCGG
CAACCGAAAGGATGTAGCCC

Downstream 100 bases:

>100_bases
CTAGGGTTGCTACGATTGCGCCATGAAAGGCTACCGCACCGGAGAACATGCACTGGCGATCTACTTATCCTCCATTGCAG
GATTCGTAGATACGCTGGGC

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MTEYTIGDAADFLGVTPKALRHWDSIGLLSPQWRTLGDYRLYTEEDLRVGAAIVLYRDMGFKLAEIPDLIEAPSDAALDR
ALRAHREALARKRDEVESQLRAVEDLITTTRVEGYTMEQMDKIKQYFGEQMPAYQEEARERWGDTPEYQQSQEKLASMGD
GDFQEVKANHDRFVADLVAARDGGVTPDSEEAQELVERHRATINQWYEVTTSRQLILARMYVDDERFAEAYQGAQDYLLS
LVEHRAKQEGITNPSWDD

Sequences:

>Translated_258_residues
MTEYTIGDAADFLGVTPKALRHWDSIGLLSPQWRTLGDYRLYTEEDLRVGAAIVLYRDMGFKLAEIPDLIEAPSDAALDR
ALRAHREALARKRDEVESQLRAVEDLITTTRVEGYTMEQMDKIKQYFGEQMPAYQEEARERWGDTPEYQQSQEKLASMGD
GDFQEVKANHDRFVADLVAARDGGVTPDSEEAQELVERHRATINQWYEVTTSRQLILARMYVDDERFAEAYQGAQDYLLS
LVEHRAKQEGITNPSWDD
>Mature_257_residues
TEYTIGDAADFLGVTPKALRHWDSIGLLSPQWRTLGDYRLYTEEDLRVGAAIVLYRDMGFKLAEIPDLIEAPSDAALDRA
LRAHREALARKRDEVESQLRAVEDLITTTRVEGYTMEQMDKIKQYFGEQMPAYQEEARERWGDTPEYQQSQEKLASMGDG
DFQEVKANHDRFVADLVAARDGGVTPDSEEAQELVERHRATINQWYEVTTSRQLILARMYVDDERFAEAYQGAQDYLLSL
VEHRAKQEGITNPSWDD

Specific function: Transcriptional activator. Is activated when bound to the antibiotic thiostrepton [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR012925
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind; PF07739 TipAS [H]

EC number: NA

Molecular weight: Translated: 29629; Mature: 29498

Theoretical pI: Translated: 4.35; Mature: 4.35

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEYTIGDAADFLGVTPKALRHWDSIGLLSPQWRTLGDYRLYTEEDLRVGAAIVLYRDMG
CCCCCCCCHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHHHHHHHEEHHCCC
FKLAEIPDLIEAPSDAALDRALRAHREALARKRDEVESQLRAVEDLITTTRVEGYTMEQM
CCHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
DKIKQYFGEQMPAYQEEARERWGDTPEYQQSQEKLASMGDGDFQEVKANHDRFVADLVAA
HHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
RDGGVTPDSEEAQELVERHRATINQWYEVTTSRQLILARMYVDDERFAEAYQGAQDYLLS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHH
LVEHRAKQEGITNPSWDD
HHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TEYTIGDAADFLGVTPKALRHWDSIGLLSPQWRTLGDYRLYTEEDLRVGAAIVLYRDMG
CCCCCCCHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHHHHHHHEEHHCCC
FKLAEIPDLIEAPSDAALDRALRAHREALARKRDEVESQLRAVEDLITTTRVEGYTMEQM
CCHHHCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
DKIKQYFGEQMPAYQEEARERWGDTPEYQQSQEKLASMGDGDFQEVKANHDRFVADLVAA
HHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
RDGGVTPDSEEAQELVERHRATINQWYEVTTSRQLILARMYVDDERFAEAYQGAQDYLLS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCHHHHHHH
LVEHRAKQEGITNPSWDD
HHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]