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The map label for this gene is putP [H]

Identifier: 68536448

GI number: 68536448

Start: 1615816

End: 1617402

Strand: Direct

Name: putP [H]

Synonym: jk1363

Alternate gene names: 68536448

Gene position: 1615816-1617402 (Clockwise)

Preceding gene: 68536443

Following gene: 68536449

Centisome position: 65.62

GC content: 59.55

Gene sequence:

>1587_bases
ATGTTTGTGACTGACCAAACATGGTTTGTCATAGCCATGGTGATCTATCTGGTCGTCATGCTGCTGATTGGACTTTATAG
TTTCAACCAGACCGACGAGTATGAGGATTACATGCTCGGCGGGCGTAACCTGCACCCCTTCGTCGCCGCATTGTCAGCCG
GCGCGTCGGACATGTCCGGCTGGCTCCTCATGGGGCTGCCAGGACTCATCTATGCATCAGGTTTCAGTGGAACATGGATG
GCCATCGGCCTGCTCATCGGTGCCGCGGTGAACTGGATCGTCACCGCTCCGCGCCTGCGCTCCTACACCGAGGTGGCGAA
CAACTCCATCACGATCCCCTCCTTCCTGGAGAATCGCTTTAACGACCGCAGCCACTTCCTGCGCATCGCCGCCGGCATCA
TCATCCTGGTGTTCTTCACCTTCTACGTAGCCTCCGGCATGGTCGCCGGTGGCGTCTACTTCGAGTCCACCTTCGAGGGC
GACTACCTGACCGGCATGATCATCATCGCCGCCGTAACCGTGGGCTACACCTTCATCGGTGGCTTCCTGGCCGTCTCCTT
CACCGATACCGTCCAGGGCTGCATCATGTTCGTCTCCCTGCTCCTGGTGCCGGTCATGGCACTGTTGCACATGGATGATC
CGGGCGCTATCTGGACCTACCAACTGGAAAACGCTTACGGCCTCGGGTCCATTGAGCCGAACCCGGATTGGTTCTCCCTG
TTCACCGGCGTTTCCTTCATCACCATCATCTCCAACGCCGCGTGGGGTCTCGGCTACTTCGGCCAGCCGCACATCATCGT
GCGATTCATGGCGCTGCGTAGCCCGTCCGATGCCCGCGCAGGTATGCGCTACGGTGTCGGCTGGATGTTCCTGTGCATGG
TCGGCTCCGTCATGGTTGCCATCATCGGCCCTGCGTTCTTCGGCATGGACCCCTCCATCGCCATCAATGACCAGGATAAA
TTCGAATCTATCTTCCTGGACATGGGTCGCATCCTATTCCACCCGCTGATCGCTGGCCTTATCCTGACCGCCGTTCTGGC
AGCGATCATGTCCACCATTTCCTCCCAGCTGCTGGTTGTCTCCTCCGCGCTGATCGAGGACATCTACAACGGCCTGATCA
ACAAGAACGCATCCGACCAGTCCTTGAAGAACCTCTCCCGCATCTCCGTGCTGGTTGTCGCCATCTTCGCCGGCGTGATT
GCTCTAAACCCGGAGTCCGGCATCCTGGGCCTGGTCGAGTTCGCCTGGGCGGGCTTCGGCGCCTCCTTCGGCCCGGTCAT
TCTGGCTTCGCTGTACTGGCGCCGCCTCAACGCTCCGGGTGCCGCCGCGGGCCTGGTCACCGGTGCTATCGTCGCCTTCA
TCTGGGGCGGTCTACCGCAGTTCGGTGTTATCGAAAAGCCGTTCGGCCTGTACGAGATGATCCCGGGCGTGGCTCTGAAC
GTCATCGTCATGGTCGCCGTCACTCTGCTGACCAAGGCTCCGTCCAAGGAGATCACCGATACCTTCGACGAAGTAACCAA
GCTCTCTAAGGTGGCCATCAAGAAGGACATCGACTTCGAGGAAGCCGCAGAGGTTACCGCCAAGTAG

Upstream 100 bases:

>100_bases
CGAGTTGTGCGCGTCACACATGCGCGCGCCTTCTGTACTTCGGAGCACAGAGAGCCCGAAAGCTGACGTATAGAACTTAT
ACATTCAACTTGAGGAGATG

Downstream 100 bases:

>100_bases
TGCAACCGCTATCTTGAGCGAACCTTTCTAGCGCCGCTGCAGTCTAAGACTGCATGCGGCGCTTTTTCCTGTCTCAGCCC
TTCACGATCTATTGCCTGTT

Product: sodium/proline symporter family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 528; Mature: 528

Protein sequence:

>528_residues
MFVTDQTWFVIAMVIYLVVMLLIGLYSFNQTDEYEDYMLGGRNLHPFVAALSAGASDMSGWLLMGLPGLIYASGFSGTWM
AIGLLIGAAVNWIVTAPRLRSYTEVANNSITIPSFLENRFNDRSHFLRIAAGIIILVFFTFYVASGMVAGGVYFESTFEG
DYLTGMIIIAAVTVGYTFIGGFLAVSFTDTVQGCIMFVSLLLVPVMALLHMDDPGAIWTYQLENAYGLGSIEPNPDWFSL
FTGVSFITIISNAAWGLGYFGQPHIIVRFMALRSPSDARAGMRYGVGWMFLCMVGSVMVAIIGPAFFGMDPSIAINDQDK
FESIFLDMGRILFHPLIAGLILTAVLAAIMSTISSQLLVVSSALIEDIYNGLINKNASDQSLKNLSRISVLVVAIFAGVI
ALNPESGILGLVEFAWAGFGASFGPVILASLYWRRLNAPGAAAGLVTGAIVAFIWGGLPQFGVIEKPFGLYEMIPGVALN
VIVMVAVTLLTKAPSKEITDTFDEVTKLSKVAIKKDIDFEEAAEVTAK

Sequences:

>Translated_528_residues
MFVTDQTWFVIAMVIYLVVMLLIGLYSFNQTDEYEDYMLGGRNLHPFVAALSAGASDMSGWLLMGLPGLIYASGFSGTWM
AIGLLIGAAVNWIVTAPRLRSYTEVANNSITIPSFLENRFNDRSHFLRIAAGIIILVFFTFYVASGMVAGGVYFESTFEG
DYLTGMIIIAAVTVGYTFIGGFLAVSFTDTVQGCIMFVSLLLVPVMALLHMDDPGAIWTYQLENAYGLGSIEPNPDWFSL
FTGVSFITIISNAAWGLGYFGQPHIIVRFMALRSPSDARAGMRYGVGWMFLCMVGSVMVAIIGPAFFGMDPSIAINDQDK
FESIFLDMGRILFHPLIAGLILTAVLAAIMSTISSQLLVVSSALIEDIYNGLINKNASDQSLKNLSRISVLVVAIFAGVI
ALNPESGILGLVEFAWAGFGASFGPVILASLYWRRLNAPGAAAGLVTGAIVAFIWGGLPQFGVIEKPFGLYEMIPGVALN
VIVMVAVTLLTKAPSKEITDTFDEVTKLSKVAIKKDIDFEEAAEVTAK
>Mature_528_residues
MFVTDQTWFVIAMVIYLVVMLLIGLYSFNQTDEYEDYMLGGRNLHPFVAALSAGASDMSGWLLMGLPGLIYASGFSGTWM
AIGLLIGAAVNWIVTAPRLRSYTEVANNSITIPSFLENRFNDRSHFLRIAAGIIILVFFTFYVASGMVAGGVYFESTFEG
DYLTGMIIIAAVTVGYTFIGGFLAVSFTDTVQGCIMFVSLLLVPVMALLHMDDPGAIWTYQLENAYGLGSIEPNPDWFSL
FTGVSFITIISNAAWGLGYFGQPHIIVRFMALRSPSDARAGMRYGVGWMFLCMVGSVMVAIIGPAFFGMDPSIAINDQDK
FESIFLDMGRILFHPLIAGLILTAVLAAIMSTISSQLLVVSSALIEDIYNGLINKNASDQSLKNLSRISVLVVAIFAGVI
ALNPESGILGLVEFAWAGFGASFGPVILASLYWRRLNAPGAAAGLVTGAIVAFIWGGLPQFGVIEKPFGLYEMIPGVALN
VIVMVAVTLLTKAPSKEITDTFDEVTKLSKVAIKKDIDFEEAAEVTAK

Specific function: Catalyzes the sodium-dependent uptake of extracellular amino acids [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=505, Percent_Identity=46.7326732673267, Blast_Score=432, Evalue=1e-121,
Organism=Homo sapiens, GI110835708, Length=571, Percent_Identity=22.9422066549912, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI4507031, Length=537, Percent_Identity=22.7188081936685, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI4507035, Length=364, Percent_Identity=22.5274725274725, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1787251, Length=499, Percent_Identity=46.8937875751503, Blast_Score=426, Evalue=1e-120,
Organism=Escherichia coli, GI87082237, Length=464, Percent_Identity=26.7241379310345, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790503, Length=460, Percent_Identity=23.0434782608696, Blast_Score=99, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17539284, Length=556, Percent_Identity=23.9208633093525, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI115533094, Length=407, Percent_Identity=23.5872235872236, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24651739, Length=473, Percent_Identity=24.3128964059197, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24645928, Length=393, Percent_Identity=24.9363867684478, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI281362918, Length=519, Percent_Identity=26.9749518304432, Blast_Score=75, Evalue=8e-14,
Organism=Drosophila melanogaster, GI161076631, Length=424, Percent_Identity=26.8867924528302, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221459582, Length=378, Percent_Identity=24.8677248677249, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI19920916, Length=447, Percent_Identity=27.2930648769575, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221379702, Length=450, Percent_Identity=25.7777777777778, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24640370, Length=338, Percent_Identity=23.9644970414201, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24648033, Length=412, Percent_Identity=22.5728155339806, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21356865, Length=412, Percent_Identity=22.5728155339806, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI28573698, Length=483, Percent_Identity=21.9461697722567, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011851
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 57019; Mature: 57019

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: PS00457 NA_SOLUT_SYMP_2 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVTDQTWFVIAMVIYLVVMLLIGLYSFNQTDEYEDYMLGGRNLHPFVAALSAGASDMSG
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCHHHHHHHHCCCCHHCC
WLLMGLPGLIYASGFSGTWMAIGLLIGAAVNWIVTAPRLRSYTEVANNSITIPSFLENRF
HHHHCCCHHHEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHC
NDRSHFLRIAAGIIILVFFTFYVASGMVAGGVYFESTFEGDYLTGMIIIAAVTVGYTFIG
CCHHHHHHHHHHHHHHHHHHHHHHHCHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHHH
GFLAVSFTDTVQGCIMFVSLLLVPVMALLHMDDPGAIWTYQLENAYGLGSIEPNPDWFSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCHHHHH
FTGVSFITIISNAAWGLGYFGQPHIIVRFMALRSPSDARAGMRYGVGWMFLCMVGSVMVA
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IIGPAFFGMDPSIAINDQDKFESIFLDMGRILFHPLIAGLILTAVLAAIMSTISSQLLVV
HHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSALIEDIYNGLINKNASDQSLKNLSRISVLVVAIFAGVIALNPESGILGLVEFAWAGFG
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHCCC
ASFGPVILASLYWRRLNAPGAAAGLVTGAIVAFIWGGLPQFGVIEKPFGLYEMIPGVALN
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
VIVMVAVTLLTKAPSKEITDTFDEVTKLSKVAIKKDIDFEEAAEVTAK
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCC
>Mature Secondary Structure
MFVTDQTWFVIAMVIYLVVMLLIGLYSFNQTDEYEDYMLGGRNLHPFVAALSAGASDMSG
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCHHHHHHHHCCCCHHCC
WLLMGLPGLIYASGFSGTWMAIGLLIGAAVNWIVTAPRLRSYTEVANNSITIPSFLENRF
HHHHCCCHHHEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHC
NDRSHFLRIAAGIIILVFFTFYVASGMVAGGVYFESTFEGDYLTGMIIIAAVTVGYTFIG
CCHHHHHHHHHHHHHHHHHHHHHHHCHHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHHH
GFLAVSFTDTVQGCIMFVSLLLVPVMALLHMDDPGAIWTYQLENAYGLGSIEPNPDWFSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCHHHHH
FTGVSFITIISNAAWGLGYFGQPHIIVRFMALRSPSDARAGMRYGVGWMFLCMVGSVMVA
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
IIGPAFFGMDPSIAINDQDKFESIFLDMGRILFHPLIAGLILTAVLAAIMSTISSQLLVV
HHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSALIEDIYNGLINKNASDQSLKNLSRISVLVVAIFAGVIALNPESGILGLVEFAWAGFG
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHCCC
ASFGPVILASLYWRRLNAPGAAAGLVTGAIVAFIWGGLPQFGVIEKPFGLYEMIPGVALN
CCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHH
VIVMVAVTLLTKAPSKEITDTFDEVTKLSKVAIKKDIDFEEAAEVTAK
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]