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The map label for this gene is betA [H]

Identifier: 68536266

GI number: 68536266

Start: 1391667

End: 1393451

Strand: Direct

Name: betA [H]

Synonym: jk1189

Alternate gene names: 68536266

Gene position: 1391667-1393451 (Clockwise)

Preceding gene: 68536253

Following gene: 68536276

Centisome position: 56.51

GC content: 63.53

Gene sequence:

>1785_bases
ATGAGCTTCATTGACAAGCTGATTCCAGGAAAGAAGAACGACACCACAGGCCAGGTAATCGAAGACCGTCGTCGGGACAT
CGTCATCGTTGGCGGCGGTTCCGCAGGTTCCGTATTGGCCAACCGACTCTCTGAAGACTCCACCAAGGACGTCATGGTCC
TGGAGGCCGGCCGCCCGGACTCCCTGTGGGATCTGTTCATCCACATGCCGGCGGCGTTCTCCTTCCCCATCGGCGACAAG
CACTACGACTGGCAGTACGAATCCGAGCCGGAACCGGAGATGAACGGCCGTCGTATCTACCACGCCCGCGGCAAGGTGCT
GGGTGGCTCCTCCTCCATCAACGGCATGATCTTCCAGCGCGGCAACCCGATGGACTACGAGAAGTGGGGCAAGCTGCCTG
GCATGTCCAACTGGGGTTGGAGCCACGTCCTGCCCTACTTCAACAAGATGGAAACCGCTCTGGGCGCCGACGCTAACGAC
CCGCGCCGCGGCCACAACGGCCCGCTGAAGCTGACCCGCGGCCCGGCCACCAGCCCGCTGTTCCAGGCCTTCTTCAAGTC
CGTCCAGCAGGCCGGCTACAACCTCACCAACGACGTCAACGGCTACCGCCAGGAGGGCTTCGCTCCCTTCGACCGCAACA
TCTTGGGCGGCAAGCGCCTCTCCGCCGCTCGCGCCTACCTGCACCCGGTCATGAACCGCAAGAACCTGGACGTGCGCACT
CGCGCCTACACCACGCAGGTCATCATCGAAAATGGCAAGGCGGTAGGCCTGGAGTACCAGTGGAAGGGCCAGACCCACCG
TGTCTTCGCCGACAAGGTCATCCTCTGTGGCGGCGCCTTCAACACCCCACAGCTGCTGGAGCTGTCCGGCATCGGTGACC
GCGAGGTCCTGGAAAAGGCTGGCGTCGAGGTCAAGAAGCACCTGCCCGGCGTGGGCAACAACCTGCAGGACCACCTCGAG
GTCTACGTGCAGTACAACTGCACCCAGCCAGTGAGCTCCCAGCCGTACTACAAGATGATCAACCGCCCGTTCATCGGCCT
GCAGTGGCTGCTGACCCGCCGCGGCCCGGTTGCTTCCTCCCACTTCGAGGCCGGCGGCTTCGCCCGCTCCAACGAGAACG
AGGACTACCCGAACCTGATGTTCCACTTCCTGCCGATGGCGATCCGTTACGACGGTTCCCAGCCGGAGGGCGAGCACGGC
TTCCAGTTCCACGTCGGCCCGATGTACTCCGACACCAAGGGCCACGTGCACATCAAGTCGAACGACCCGAAGGACAAGCC
GGAGATCCTGTTCAACTACCTGGCCACCGAACAGGACCGCCGCGAGTGGGTCGAGGCCGTGCGCACCTCCCGCAAGCTGC
TGGATACCCCGGCAATGAAGGAATTCACCGACGGCGAGATCTCCCCCGGCTCCGCTGTGGAGACCGACGAGGAGATCCTG
GAGTGGGTACGCAACGACGCAGAGACCGCTCTGCACCCGTCTTGCACCGCCAAGATGGGCCCGGCGGACGACGAGATGGC
CGTTGTCGACCCGGAGACCATGCAGGTCCACGGTGTTGAGGGTCTGTACATCGCCGATGCATCGGTCATGCCGATCATCA
CCAACGGCAACATCTACGCGCCGGTCATCATGCTGGCAGAGAAGGCCGCCGACCTGATCAAGGGCGACAAGCCCCTGGAT
CCGATCGACATCCCCTTCTACCACGCCAAGCAGGACATGCCGCTGTACGCAGAAGGCGACGAGCCCCGCGATCACGTCAA
CGCCATCCCGGGCGCTGACCACTAG

Upstream 100 bases:

>100_bases
GGTATATTAATCATGCCTTTTACCTGCCATCTAGCGATCTGTAAAAGAAAATGGCATACTGGTTTACGTTCAGTCATTTA
ACTAGGAGGCGAGTGAATAG

Downstream 100 bases:

>100_bases
TTGCTAGAGCTCCAGCCCGTCCAGATACGCCCGATCTGCCTTGGATAGCTCCACGCTATCCAGCAGGTCCGGGCGTATTT
TTTTGGTTCGGGCGAGGGAT

Product: choline dehydrogenase

Products: NA

Alternate protein names: CDH; CHD [H]

Number of amino acids: Translated: 594; Mature: 593

Protein sequence:

>594_residues
MSFIDKLIPGKKNDTTGQVIEDRRRDIVIVGGGSAGSVLANRLSEDSTKDVMVLEAGRPDSLWDLFIHMPAAFSFPIGDK
HYDWQYESEPEPEMNGRRIYHARGKVLGGSSSINGMIFQRGNPMDYEKWGKLPGMSNWGWSHVLPYFNKMETALGADAND
PRRGHNGPLKLTRGPATSPLFQAFFKSVQQAGYNLTNDVNGYRQEGFAPFDRNILGGKRLSAARAYLHPVMNRKNLDVRT
RAYTTQVIIENGKAVGLEYQWKGQTHRVFADKVILCGGAFNTPQLLELSGIGDREVLEKAGVEVKKHLPGVGNNLQDHLE
VYVQYNCTQPVSSQPYYKMINRPFIGLQWLLTRRGPVASSHFEAGGFARSNENEDYPNLMFHFLPMAIRYDGSQPEGEHG
FQFHVGPMYSDTKGHVHIKSNDPKDKPEILFNYLATEQDRREWVEAVRTSRKLLDTPAMKEFTDGEISPGSAVETDEEIL
EWVRNDAETALHPSCTAKMGPADDEMAVVDPETMQVHGVEGLYIADASVMPIITNGNIYAPVIMLAEKAADLIKGDKPLD
PIDIPFYHAKQDMPLYAEGDEPRDHVNAIPGADH

Sequences:

>Translated_594_residues
MSFIDKLIPGKKNDTTGQVIEDRRRDIVIVGGGSAGSVLANRLSEDSTKDVMVLEAGRPDSLWDLFIHMPAAFSFPIGDK
HYDWQYESEPEPEMNGRRIYHARGKVLGGSSSINGMIFQRGNPMDYEKWGKLPGMSNWGWSHVLPYFNKMETALGADAND
PRRGHNGPLKLTRGPATSPLFQAFFKSVQQAGYNLTNDVNGYRQEGFAPFDRNILGGKRLSAARAYLHPVMNRKNLDVRT
RAYTTQVIIENGKAVGLEYQWKGQTHRVFADKVILCGGAFNTPQLLELSGIGDREVLEKAGVEVKKHLPGVGNNLQDHLE
VYVQYNCTQPVSSQPYYKMINRPFIGLQWLLTRRGPVASSHFEAGGFARSNENEDYPNLMFHFLPMAIRYDGSQPEGEHG
FQFHVGPMYSDTKGHVHIKSNDPKDKPEILFNYLATEQDRREWVEAVRTSRKLLDTPAMKEFTDGEISPGSAVETDEEIL
EWVRNDAETALHPSCTAKMGPADDEMAVVDPETMQVHGVEGLYIADASVMPIITNGNIYAPVIMLAEKAADLIKGDKPLD
PIDIPFYHAKQDMPLYAEGDEPRDHVNAIPGADH
>Mature_593_residues
SFIDKLIPGKKNDTTGQVIEDRRRDIVIVGGGSAGSVLANRLSEDSTKDVMVLEAGRPDSLWDLFIHMPAAFSFPIGDKH
YDWQYESEPEPEMNGRRIYHARGKVLGGSSSINGMIFQRGNPMDYEKWGKLPGMSNWGWSHVLPYFNKMETALGADANDP
RRGHNGPLKLTRGPATSPLFQAFFKSVQQAGYNLTNDVNGYRQEGFAPFDRNILGGKRLSAARAYLHPVMNRKNLDVRTR
AYTTQVIIENGKAVGLEYQWKGQTHRVFADKVILCGGAFNTPQLLELSGIGDREVLEKAGVEVKKHLPGVGNNLQDHLEV
YVQYNCTQPVSSQPYYKMINRPFIGLQWLLTRRGPVASSHFEAGGFARSNENEDYPNLMFHFLPMAIRYDGSQPEGEHGF
QFHVGPMYSDTKGHVHIKSNDPKDKPEILFNYLATEQDRREWVEAVRTSRKLLDTPAMKEFTDGEISPGSAVETDEEILE
WVRNDAETALHPSCTAKMGPADDEMAVVDPETMQVHGVEGLYIADASVMPIITNGNIYAPVIMLAEKAADLIKGDKPLDP
IDIPFYHAKQDMPLYAEGDEPRDHVNAIPGADH

Specific function: Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine [H]

COG id: COG2303

COG function: function code E; Choline dehydrogenase and related flavoproteins

Gene ontology:

Cell location: Membrane-Bound [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GMC oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI217272839, Length=549, Percent_Identity=46.448087431694, Blast_Score=488, Evalue=1e-138,
Organism=Escherichia coli, GI1786503, Length=558, Percent_Identity=48.7455197132617, Blast_Score=520, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI17532301, Length=566, Percent_Identity=43.9929328621908, Blast_Score=470, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24642048, Length=578, Percent_Identity=34.7750865051903, Blast_Score=295, Evalue=6e-80,
Organism=Drosophila melanogaster, GI24642042, Length=574, Percent_Identity=35.8885017421603, Blast_Score=287, Evalue=2e-77,
Organism=Drosophila melanogaster, GI45551458, Length=573, Percent_Identity=34.2059336823735, Blast_Score=283, Evalue=3e-76,
Organism=Drosophila melanogaster, GI45549471, Length=573, Percent_Identity=34.2059336823735, Blast_Score=282, Evalue=4e-76,
Organism=Drosophila melanogaster, GI18859995, Length=582, Percent_Identity=33.5051546391753, Blast_Score=259, Evalue=3e-69,
Organism=Drosophila melanogaster, GI17137792, Length=557, Percent_Identity=31.5978456014363, Blast_Score=254, Evalue=8e-68,
Organism=Drosophila melanogaster, GI24642059, Length=584, Percent_Identity=33.3904109589041, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24642039, Length=581, Percent_Identity=34.2512908777969, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24650267, Length=605, Percent_Identity=32.7272727272727, Blast_Score=236, Evalue=5e-62,
Organism=Drosophila melanogaster, GI24642051, Length=572, Percent_Identity=31.2937062937063, Blast_Score=217, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24642037, Length=578, Percent_Identity=29.5847750865052, Blast_Score=214, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24642035, Length=581, Percent_Identity=29.2598967297762, Blast_Score=211, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24642055, Length=314, Percent_Identity=39.171974522293, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI18859993, Length=579, Percent_Identity=28.8428324697755, Blast_Score=201, Evalue=1e-51,
Organism=Drosophila melanogaster, GI24642057, Length=593, Percent_Identity=27.8246205733558, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24645930, Length=582, Percent_Identity=26.6323024054983, Blast_Score=120, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011533
- InterPro:   IPR012132
- InterPro:   IPR000172
- InterPro:   IPR007867 [H]

Pfam domain/function: PF05199 GMC_oxred_C; PF00732 GMC_oxred_N [H]

EC number: =1.1.99.1 [H]

Molecular weight: Translated: 66359; Mature: 66227

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00623 GMC_OXRED_1 ; PS00624 GMC_OXRED_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFIDKLIPGKKNDTTGQVIEDRRRDIVIVGGGSAGSVLANRLSEDSTKDVMVLEAGRPD
CCHHHHHCCCCCCCCCHHHHHCCCCEEEEEECCCHHHHHHHHHCCCCCCCEEEEECCCCC
SLWDLFIHMPAAFSFPIGDKHYDWQYESEPEPEMNGRRIYHARGKVLGGSSSINGMIFQR
HHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCCEECCCCCCCEEEEEC
GNPMDYEKWGKLPGMSNWGWSHVLPYFNKMETALGADANDPRRGHNGPLKLTRGPATSPL
CCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCHH
FQAFFKSVQQAGYNLTNDVNGYRQEGFAPFDRNILGGKRLSAARAYLHPVMNRKNLDVRT
HHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEE
RAYTTQVIIENGKAVGLEYQWKGQTHRVFADKVILCGGAFNTPQLLELSGIGDREVLEKA
EEEEEEEEEECCCEEEEEEEECCCCEEEEECEEEEECCCCCCCCEEEECCCCCHHHHHHC
GVEVKKHLPGVGNNLQDHLEVYVQYNCTQPVSSQPYYKMINRPFIGLQWLLTRRGPVASS
CCHHHHHCCCCCCCHHHEEEEEEEECCCCCCCCCCHHHHHCCCCCCCEEHHHCCCCCCCC
HFEAGGFARSNENEDYPNLMFHFLPMAIRYDGSQPEGEHGFQFHVGPMYSDTKGHVHIKS
CCCCCCCCCCCCCCCCHHHHHHHHHHHEEECCCCCCCCCCCEEEECCCCCCCCCEEEECC
NDPKDKPEILFNYLATEQDRREWVEAVRTSRKLLDTPAMKEFTDGEISPGSAVETDEEIL
CCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCHHHHH
EWVRNDAETALHPSCTAKMGPADDEMAVVDPETMQVHGVEGLYIADASVMPIITNGNIYA
HHHHCCHHHHCCCCCCCCCCCCCCCEEEECCCCEEEECCCEEEEECCCEEEEEECCCCHH
PVIMLAEKAADLIKGDKPLDPIDIPFYHAKQDMPLYAEGDEPRDHVNAIPGADH
HHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCEEECCCCCHHHHCCCCCCCC
>Mature Secondary Structure 
SFIDKLIPGKKNDTTGQVIEDRRRDIVIVGGGSAGSVLANRLSEDSTKDVMVLEAGRPD
CHHHHHCCCCCCCCCHHHHHCCCCEEEEEECCCHHHHHHHHHCCCCCCCEEEEECCCCC
SLWDLFIHMPAAFSFPIGDKHYDWQYESEPEPEMNGRRIYHARGKVLGGSSSINGMIFQR
HHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCCEECCCCCCCEEEEEC
GNPMDYEKWGKLPGMSNWGWSHVLPYFNKMETALGADANDPRRGHNGPLKLTRGPATSPL
CCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCHH
FQAFFKSVQQAGYNLTNDVNGYRQEGFAPFDRNILGGKRLSAARAYLHPVMNRKNLDVRT
HHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEE
RAYTTQVIIENGKAVGLEYQWKGQTHRVFADKVILCGGAFNTPQLLELSGIGDREVLEKA
EEEEEEEEEECCCEEEEEEEECCCCEEEEECEEEEECCCCCCCCEEEECCCCCHHHHHHC
GVEVKKHLPGVGNNLQDHLEVYVQYNCTQPVSSQPYYKMINRPFIGLQWLLTRRGPVASS
CCHHHHHCCCCCCCHHHEEEEEEEECCCCCCCCCCHHHHHCCCCCCCEEHHHCCCCCCCC
HFEAGGFARSNENEDYPNLMFHFLPMAIRYDGSQPEGEHGFQFHVGPMYSDTKGHVHIKS
CCCCCCCCCCCCCCCCHHHHHHHHHHHEEECCCCCCCCCCCEEEECCCCCCCCCEEEECC
NDPKDKPEILFNYLATEQDRREWVEAVRTSRKLLDTPAMKEFTDGEISPGSAVETDEEIL
CCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCHHHHH
EWVRNDAETALHPSCTAKMGPADDEMAVVDPETMQVHGVEGLYIADASVMPIITNGNIYA
HHHHCCHHHHCCCCCCCCCCCCCCCEEEECCCCEEEECCCEEEEECCCEEEEEECCCCHH
PVIMLAEKAADLIKGDKPLDPIDIPFYHAKQDMPLYAEGDEPRDHVNAIPGADH
HHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCEEECCCCCHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA