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The map label for this gene is proA

Identifier: 68535637

GI number: 68535637

Start: 685146

End: 686450

Strand: Direct

Name: proA

Synonym: jk0565

Alternate gene names: 68535637

Gene position: 685146-686450 (Clockwise)

Preceding gene: 68535635

Following gene: 68535639

Centisome position: 27.82

GC content: 61.23

Gene sequence:

>1305_bases
ATGACAAACTCCAACGAAGCTCAAGAGAACGCCCTTTCCCCGGAACGCCAGGCAGAACGCGACGAGGTTCTAGCCAAGGC
TAAAAAGGCCAAGGAAGTCAGTTCCCAGCTGCTGCTGAACACCCAGCAGAAGAACGATCTGCTAGCAGACGCGGCAGATG
CGCTGGAGGCTAACGCGGCTGACATCATCGCTGCCAATGAGAAGGACATTGCAACGGGCAAGGAGCGCGGCTTCGCCGAC
TCCCTGCTCGACCGTCTTGCGCTGGATACCGAGCGCATTTCCGGTATTGCCGGCGGCCTGCGCCAGGTCATCGGGCTATC
GGATCCGGTGGGTGAAATTGTCCGCGGACACACCCGCCCCAACGGTCTGCGCATGAAGCAGGTGCGCGTGCCACTGGGTG
TGATGGGCATGGTTTACGAGGCCCGCCCCAACGTCACGGTCGATGCTTTCGGCCTGGCCATCAAGTCCGGCAACGTGCCG
CTGCTACGCGGCTCCAAGTCTGCCCGCCACACCAACGAGAAGTTGGTGCAGATCCTGCAGGATGTTGCCGAAAGCCACAA
CCTGCCGCGTGAGCTAGTCCAGCTGCTACCGTGCGATACTCACGACTCGGTGCAGGACCTGATTACCGCCCGTGGCCTAG
TAGACCTGGTTATCCCGCGCGGTGGCGCTGGGCTGATCAACGCAGTGGTGCTGGGTGCTACCGTTCCCACCATCGAGACC
GGTACGGGCAACTGCCACTTCTACATCGACTCCTCTGCGGACATCGAGGAAGCCACCAAGTTGGTTATTAACGGCAAGAC
CCGCCGCTGCTCCGTCTGCAACGCCACCGAGGTTGTACTGCTGGATTCCGCCCTGCCGGACCCGGACAAAATCTACGTCC
TACAGGAACTGCAGAAGGCCGGTGTGACCCTGCACGGTGAGAAGAAGCAGCTGGATCCGCTGATCAACGACGTCGTCCAG
GCGGAAGAAACCGACTGGACCGACGAGTACCTGAGCTTTGACATTGCAGTGGCCATCGTCGACGGCGTGGAGGAGGCTGT
GGCCCACATCAACCGTTATGGCACCAGCCACACCGAGGGTATTGCCGCCCGCGACTACAAGACCACCAGCTACTTCGAGC
AGTACGTCGACGCAGCTGCTGTCTCCATCAACACCTCTACCGCGTGGACAGACGGAGAAATGTTCGGCTTCGGCGCGGAG
ATCGGTATCTCCACCCAGAAGCTGCACGCCCGCGGCCCGATGGGGCTGCCGGAGCTGACGAGCACCAAGTGGGTTATCAA
CGGCGAAGGCCAGGTTCGCCCCTAA

Upstream 100 bases:

>100_bases
AGCGAACCTTAAGCCACACTACTCTCAAAGAGCCAATGCTGATTCCGGTTTCCATGCAACATGGCGCAGCTTAGGGGCTA
GTTCGCTAGCATGGGTTGGT

Downstream 100 bases:

>100_bases
GTGTGGCGATGGCGCTCACTTTGCCAGTTGAAAAGTGGGCGTCATAAAGAAAGAACAGCTACACCACGAGCGTAAGGCTC
GCACCCAGCGCCAGTACCAG

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MTNSNEAQENALSPERQAERDEVLAKAKKAKEVSSQLLLNTQQKNDLLADAADALEANAADIIAANEKDIATGKERGFAD
SLLDRLALDTERISGIAGGLRQVIGLSDPVGEIVRGHTRPNGLRMKQVRVPLGVMGMVYEARPNVTVDAFGLAIKSGNVP
LLRGSKSARHTNEKLVQILQDVAESHNLPRELVQLLPCDTHDSVQDLITARGLVDLVIPRGGAGLINAVVLGATVPTIET
GTGNCHFYIDSSADIEEATKLVINGKTRRCSVCNATEVVLLDSALPDPDKIYVLQELQKAGVTLHGEKKQLDPLINDVVQ
AEETDWTDEYLSFDIAVAIVDGVEEAVAHINRYGTSHTEGIAARDYKTTSYFEQYVDAAAVSINTSTAWTDGEMFGFGAE
IGISTQKLHARGPMGLPELTSTKWVINGEGQVRP

Sequences:

>Translated_434_residues
MTNSNEAQENALSPERQAERDEVLAKAKKAKEVSSQLLLNTQQKNDLLADAADALEANAADIIAANEKDIATGKERGFAD
SLLDRLALDTERISGIAGGLRQVIGLSDPVGEIVRGHTRPNGLRMKQVRVPLGVMGMVYEARPNVTVDAFGLAIKSGNVP
LLRGSKSARHTNEKLVQILQDVAESHNLPRELVQLLPCDTHDSVQDLITARGLVDLVIPRGGAGLINAVVLGATVPTIET
GTGNCHFYIDSSADIEEATKLVINGKTRRCSVCNATEVVLLDSALPDPDKIYVLQELQKAGVTLHGEKKQLDPLINDVVQ
AEETDWTDEYLSFDIAVAIVDGVEEAVAHINRYGTSHTEGIAARDYKTTSYFEQYVDAAAVSINTSTAWTDGEMFGFGAE
IGISTQKLHARGPMGLPELTSTKWVINGEGQVRP
>Mature_433_residues
TNSNEAQENALSPERQAERDEVLAKAKKAKEVSSQLLLNTQQKNDLLADAADALEANAADIIAANEKDIATGKERGFADS
LLDRLALDTERISGIAGGLRQVIGLSDPVGEIVRGHTRPNGLRMKQVRVPLGVMGMVYEARPNVTVDAFGLAIKSGNVPL
LRGSKSARHTNEKLVQILQDVAESHNLPRELVQLLPCDTHDSVQDLITARGLVDLVIPRGGAGLINAVVLGATVPTIETG
TGNCHFYIDSSADIEEATKLVINGKTRRCSVCNATEVVLLDSALPDPDKIYVLQELQKAGVTLHGEKKQLDPLINDVVQA
EETDWTDEYLSFDIAVAIVDGVEEAVAHINRYGTSHTEGIAARDYKTTSYFEQYVDAAAVSINTSTAWTDGEMFGFGAEI
GISTQKLHARGPMGLPELTSTKWVINGEGQVRP

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family

Homologues:

Organism=Homo sapiens, GI62912457, Length=399, Percent_Identity=36.3408521303258, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI21361368, Length=399, Percent_Identity=36.3408521303258, Blast_Score=246, Evalue=2e-65,
Organism=Escherichia coli, GI1786438, Length=410, Percent_Identity=42.6829268292683, Blast_Score=329, Evalue=3e-91,
Organism=Caenorhabditis elegans, GI17569967, Length=411, Percent_Identity=34.7931873479319, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17569969, Length=411, Percent_Identity=34.7931873479319, Blast_Score=229, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6324899, Length=429, Percent_Identity=35.4312354312354, Blast_Score=242, Evalue=1e-64,
Organism=Drosophila melanogaster, GI21357643, Length=408, Percent_Identity=32.1078431372549, Blast_Score=209, Evalue=4e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PROA_CORJK (Q4JWT3)

Other databases:

- EMBL:   CR931997
- RefSeq:   YP_250342.1
- ProteinModelPortal:   Q4JWT3
- SMR:   Q4JWT3
- STRING:   Q4JWT3
- GeneID:   3432981
- GenomeReviews:   CR931997_GR
- KEGG:   cjk:jk0565
- NMPDR:   fig|306537.3.peg.682
- eggNOG:   COG0014
- HOGENOM:   HBG318080
- OMA:   HRIEAMA
- ProtClustDB:   PRK00197
- BioCyc:   CJEI306537:JK0565-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00412
- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134
- Gene3D:   G3DSA:3.40.309.10
- Gene3D:   G3DSA:3.40.605.10
- PANTHER:   PTHR11063:SF1
- PIRSF:   PIRSF000151
- TIGRFAMs:   TIGR00407

Pfam domain/function: PF00171 Aldedh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.2.1.41

Molecular weight: Translated: 46750; Mature: 46619

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNSNEAQENALSPERQAERDEVLAKAKKAKEVSSQLLLNTQQKNDLLADAADALEANAA
CCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCC
DIIAANEKDIATGKERGFADSLLDRLALDTERISGIAGGLRQVIGLSDPVGEIVRGHTRP
CEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCC
NGLRMKQVRVPLGVMGMVYEARPNVTVDAFGLAIKSGNVPLLRGSKSARHTNEKLVQILQ
CCCEEEEEECCHHHHHEEEECCCCCEEEEEEEEEECCCCCEEECCCHHHHHHHHHHHHHH
DVAESHNLPRELVQLLPCDTHDSVQDLITARGLVDLVIPRGGAGLINAVVLGATVPTIET
HHHHHCCCHHHHHHHCCCCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCCCEEEC
GTGNCHFYIDSSADIEEATKLVINGKTRRCSVCNATEVVLLDSALPDPDKIYVLQELQKA
CCCCEEEEECCCCCHHHHHEEEECCCCCEEECCCCCEEEEEECCCCCCHHHHHHHHHHHC
GVTLHGEKKQLDPLINDVVQAEETDWTDEYLSFDIAVAIVDGVEEAVAHINRYGTSHTEG
CCEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHEEHHHHHHHHHHHHHCCCCCCCC
IAARDYKTTSYFEQYVDAAAVSINTSTAWTDGEMFGFGAEIGISTQKLHARGPMGLPELT
CCCCCCCHHHHHHHHHHHHHEEECCCCCCCCCCEEECCCCCCCCHHHHHCCCCCCCCCCC
STKWVINGEGQVRP
CCEEEECCCCCCCC
>Mature Secondary Structure 
TNSNEAQENALSPERQAERDEVLAKAKKAKEVSSQLLLNTQQKNDLLADAADALEANAA
CCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCC
DIIAANEKDIATGKERGFADSLLDRLALDTERISGIAGGLRQVIGLSDPVGEIVRGHTRP
CEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCC
NGLRMKQVRVPLGVMGMVYEARPNVTVDAFGLAIKSGNVPLLRGSKSARHTNEKLVQILQ
CCCEEEEEECCHHHHHEEEECCCCCEEEEEEEEEECCCCCEEECCCHHHHHHHHHHHHHH
DVAESHNLPRELVQLLPCDTHDSVQDLITARGLVDLVIPRGGAGLINAVVLGATVPTIET
HHHHHCCCHHHHHHHCCCCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCCCEEEC
GTGNCHFYIDSSADIEEATKLVINGKTRRCSVCNATEVVLLDSALPDPDKIYVLQELQKA
CCCCEEEEECCCCCHHHHHEEEECCCCCEEECCCCCEEEEEECCCCCCHHHHHHHHHHHC
GVTLHGEKKQLDPLINDVVQAEETDWTDEYLSFDIAVAIVDGVEEAVAHINRYGTSHTEG
CCEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHEEHHHHHHHHHHHHHCCCCCCCC
IAARDYKTTSYFEQYVDAAAVSINTSTAWTDGEMFGFGAEIGISTQKLHARGPMGLPELT
CCCCCCCHHHHHHHHHHHHHEEECCCCCCCCCCEEECCCCCCCCHHHHHCCCCCCCCCCC
STKWVINGEGQVRP
CCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA