Click here to switch to the map view.

The map label for this gene is hmuO [H]

Identifier: 68535385

GI number: 68535385

Start: 389709

End: 390383

Strand: Direct

Name: hmuO [H]

Synonym: jk0320

Alternate gene names: 68535385

Gene position: 389709-390383 (Clockwise)

Preceding gene: 68535384

Following gene: 68535386

Centisome position: 15.83

GC content: 54.96

Gene sequence:

>675_bases
ATGGCTTCGACCTCCACACTTTCAAACACAAGCTTTAACACAGCCGAGCCGATCTCTCAGGCACTGCGCAATGCCACTGC
GGAGGCGCACGGGCGCGCAGAAGGATCCGAGTTCATGAGCACCCTTTTCAAAGGCGAGCTTGACGCTCAAGCGGTGTATG
CGCTTTCGGGACAACTCTGGTTTGTCTACAGCGCTCTAGAGAACGCTGTAGAAAGAGTCTCCGGCACTCCCATCGGGTCG
GTTATTGCCGATCCGCGCCTGCAACGTTGCGCTGCGTTGGAACACGATCTGACGTATTGCCTCGGCTCCGATTGGCGCGA
ACAACTTGAACTACTGCCCGCCACCCGGCGGTATGTAGATCGCCTCGACTCTTTCGGAGAACAAGACGTTGTACGAGTGA
TCGCTCATCACTATGTCCGCTACCTCGGGGATATTTCCGGCGGTCAGGTCATCGCTGTACGTGTAGCAGACCTCTACAAT
GTCGCTCCTGAGGCATTGAAGTTCTATGACTTCTCCGCTATTGGCAAGATCCCTCCGTACCGAACCAGCTACCGTCAGCG
CCTCGATAGCCTGCCACTCACAGCACAGCAGCGTTCCGAATTGATTGAGGAAGCCATCGATGCTTTTGGTATGAATTTTT
CCCTGTTCACAGATCTTTACGGAGTCTGCGCGTGA

Upstream 100 bases:

>100_bases
GCCACCACAACTTGCGCTAATAACGAGTTCCCTTTTCTCGTTCAGCGACAAATTCCAGATTCCACGCGGATCTTGAAACT
CTTTCGAAAGGAATAACGTG

Downstream 100 bases:

>100_bases
ATACACCATTCTTGTCCAAGTCCAATTCCCGCCACTTCGTTGCCAGCGCCCTGGTCAGTTCCGTCGCGTTAAGCGGCATG
GCGGTTCCTGTAGCACAGGC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 223

Protein sequence:

>224_residues
MASTSTLSNTSFNTAEPISQALRNATAEAHGRAEGSEFMSTLFKGELDAQAVYALSGQLWFVYSALENAVERVSGTPIGS
VIADPRLQRCAALEHDLTYCLGSDWREQLELLPATRRYVDRLDSFGEQDVVRVIAHHYVRYLGDISGGQVIAVRVADLYN
VAPEALKFYDFSAIGKIPPYRTSYRQRLDSLPLTAQQRSELIEEAIDAFGMNFSLFTDLYGVCA

Sequences:

>Translated_224_residues
MASTSTLSNTSFNTAEPISQALRNATAEAHGRAEGSEFMSTLFKGELDAQAVYALSGQLWFVYSALENAVERVSGTPIGS
VIADPRLQRCAALEHDLTYCLGSDWREQLELLPATRRYVDRLDSFGEQDVVRVIAHHYVRYLGDISGGQVIAVRVADLYN
VAPEALKFYDFSAIGKIPPYRTSYRQRLDSLPLTAQQRSELIEEAIDAFGMNFSLFTDLYGVCA
>Mature_223_residues
ASTSTLSNTSFNTAEPISQALRNATAEAHGRAEGSEFMSTLFKGELDAQAVYALSGQLWFVYSALENAVERVSGTPIGSV
IADPRLQRCAALEHDLTYCLGSDWREQLELLPATRRYVDRLDSFGEQDVVRVIAHHYVRYLGDISGGQVIAVRVADLYNV
APEALKFYDFSAIGKIPPYRTSYRQRLDSLPLTAQQRSELIEEAIDAFGMNFSLFTDLYGVCA

Specific function: Allows the bacteria to use the host heme as an iron source. Involved in the oxidation of heme and subsequent release of iron from the heme moiety [H]

COG id: COG5398

COG function: function code P; Heme oxygenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme oxygenase family [H]

Homologues:

Organism=Homo sapiens, GI4504437, Length=206, Percent_Identity=39.3203883495146, Blast_Score=144, Evalue=4e-35,
Organism=Homo sapiens, GI187761311, Length=206, Percent_Identity=33.9805825242718, Blast_Score=133, Evalue=1e-31,
Organism=Homo sapiens, GI187761309, Length=206, Percent_Identity=33.9805825242718, Blast_Score=133, Evalue=1e-31,
Organism=Homo sapiens, GI187761307, Length=206, Percent_Identity=33.9805825242718, Blast_Score=133, Evalue=1e-31,
Organism=Homo sapiens, GI8051608, Length=206, Percent_Identity=33.9805825242718, Blast_Score=133, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002051
- InterPro:   IPR016053
- InterPro:   IPR016084
- InterPro:   IPR018207 [H]

Pfam domain/function: PF01126 Heme_oxygenase [H]

EC number: =1.14.99.3 [H]

Molecular weight: Translated: 24817; Mature: 24686

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASTSTLSNTSFNTAEPISQALRNATAEAHGRAEGSEFMSTLFKGELDAQAVYALSGQLW
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHCCCHH
FVYSALENAVERVSGTPIGSVIADPRLQRCAALEHDLTYCLGSDWREQLELLPATRRYVD
HHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RLDSFGEQDVVRVIAHHYVRYLGDISGGQVIAVRVADLYNVAPEALKFYDFSAIGKIPPY
HHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHCHHHHHHHHHHHHCCCCCC
RTSYRQRLDSLPLTAQQRSELIEEAIDAFGMNFSLFTDLYGVCA
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
>Mature Secondary Structure 
ASTSTLSNTSFNTAEPISQALRNATAEAHGRAEGSEFMSTLFKGELDAQAVYALSGQLW
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHCCCHH
FVYSALENAVERVSGTPIGSVIADPRLQRCAALEHDLTYCLGSDWREQLELLPATRRYVD
HHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
RLDSFGEQDVVRVIAHHYVRYLGDISGGQVIAVRVADLYNVAPEALKFYDFSAIGKIPPY
HHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHCHHHHHHHHHHHHCCCCCC
RTSYRQRLDSLPLTAQQRSELIEEAIDAFGMNFSLFTDLYGVCA
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9006041; 14602910 [H]