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The map label for this gene is hmuU [H]

Identifier: 68535382

GI number: 68535382

Start: 386589

End: 387638

Strand: Direct

Name: hmuU [H]

Synonym: jk0317

Alternate gene names: 68535382

Gene position: 386589-387638 (Clockwise)

Preceding gene: 68535381

Following gene: 68535383

Centisome position: 15.7

GC content: 55.43

Gene sequence:

>1050_bases
ATGACCCACACGGTTAATACGAACGAGTTTCTCCGGGCGCGAACGCGCCGATGGGTAGGGATTTTCGGTGCACTGGTGGT
GCTAATGCTTGTTGCTGCGGTGCTATCGATCGTGCTTGGACAGTACTACGTGCCACTGCAGGATTTAGGTTCAATCTTGC
TGGGGAAAGACCATCATTCAGGTCTGGCCTCCAGCGTAGTGTGGGATATTCGCTTGCCGCGCATCCTGCTGGGGTTCCTA
GTCGGCGCATGTTTGGGTGTGGCTGGAACATTGATGCAGGCGGTGTTTGCCAACCCTCTGGCCGAGCCATCGATTATTGG
CGTGACCTCGGGCGCCGGGGTTGGTGCGGCGTTGGCAATCGTCTTTAACCTTGCTTTCTTCGGCACGTTCACCGTTCCGT
TCTTCGCCTTTCTTTCCGCATTGGTTGCCGCTGGCCTGATTTACCAGCTAGCACGAAGTCAAGGCCGAGTTGTGGTTATC
AATCTGGTTCTCACAGGTATCGCGGTCAATGCCGTGTGTGGAGCAATTATCTCCTTCATGGTCTATTTGGCTCCGACCGC
CAGTCGGGAAGAGATCATCTTTTGGCAGATGGGATCCCTAAATGGTGCCCAGTGGAAGCACGTTTGGGCGGTTTTGCCGA
TCACGATGGTTGGAATTGCCGTAGCCCTACGGATGGGTGGGGCACTAGACGTGCTTGCTTTGGGTGAGAAAGCCGCTGGT
CACACAGGGATCAATGTAAGTCAATTGAGAGCGATTGTGATCATCGCTGCGACCGTACTCACTGCAGGTGCAGTTGCCTT
TGCTGGGCTCATCGGCTTCGTAGGGCTGATTATCCCGCACCTGTTGCGAACGGTCATGGGGCCGGAGAATTATCTCCTCA
TCCCTGCTTCTGCGCTTGGCGGGGCGGTCTTGATTGGTCTGGCTGATGTGGCTGCCCGCACGTTGATTGAATTCGCAGAT
TTGCCGATTGGCATCTTCACTGCCCTTGTCGGCGGCCCGACTTTCTTCGTTCTGCTGCGCCGAATGATGCGAAAGGGGAT
TCATGCATGA

Upstream 100 bases:

>100_bases
GCAGGACAGAAGCGGCGCGTAATCACGATTCCAGATGGTCAATCGTTGGCGTTCGGCCCTATGACTGGGCAAACACTTTT
GCGGACAGCGAAGGCGTTAT

Downstream 100 bases:

>100_bases
GTGCTCACGGTAGCGATGCGACTACTAACAGTATGGCTATCGGCGATAAGGCCATTGAGGTATCTGGCCTTACCGTCGAC
GTTGGCGCCAAGCGGTTGCT

Product: putative iron ABC transport system, permease protein

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 348

Protein sequence:

>349_residues
MTHTVNTNEFLRARTRRWVGIFGALVVLMLVAAVLSIVLGQYYVPLQDLGSILLGKDHHSGLASSVVWDIRLPRILLGFL
VGACLGVAGTLMQAVFANPLAEPSIIGVTSGAGVGAALAIVFNLAFFGTFTVPFFAFLSALVAAGLIYQLARSQGRVVVI
NLVLTGIAVNAVCGAIISFMVYLAPTASREEIIFWQMGSLNGAQWKHVWAVLPITMVGIAVALRMGGALDVLALGEKAAG
HTGINVSQLRAIVIIAATVLTAGAVAFAGLIGFVGLIIPHLLRTVMGPENYLLIPASALGGAVLIGLADVAARTLIEFAD
LPIGIFTALVGGPTFFVLLRRMMRKGIHA

Sequences:

>Translated_349_residues
MTHTVNTNEFLRARTRRWVGIFGALVVLMLVAAVLSIVLGQYYVPLQDLGSILLGKDHHSGLASSVVWDIRLPRILLGFL
VGACLGVAGTLMQAVFANPLAEPSIIGVTSGAGVGAALAIVFNLAFFGTFTVPFFAFLSALVAAGLIYQLARSQGRVVVI
NLVLTGIAVNAVCGAIISFMVYLAPTASREEIIFWQMGSLNGAQWKHVWAVLPITMVGIAVALRMGGALDVLALGEKAAG
HTGINVSQLRAIVIIAATVLTAGAVAFAGLIGFVGLIIPHLLRTVMGPENYLLIPASALGGAVLIGLADVAARTLIEFAD
LPIGIFTALVGGPTFFVLLRRMMRKGIHA
>Mature_348_residues
THTVNTNEFLRARTRRWVGIFGALVVLMLVAAVLSIVLGQYYVPLQDLGSILLGKDHHSGLASSVVWDIRLPRILLGFLV
GACLGVAGTLMQAVFANPLAEPSIIGVTSGAGVGAALAIVFNLAFFGTFTVPFFAFLSALVAAGLIYQLARSQGRVVVIN
LVLTGIAVNAVCGAIISFMVYLAPTASREEIIFWQMGSLNGAQWKHVWAVLPITMVGIAVALRMGGALDVLALGEKAAGH
TGINVSQLRAIVIIAATVLTAGAVAFAGLIGFVGLIIPHLLRTVMGPENYLLIPASALGGAVLIGLADVAARTLIEFADL
PIGIFTALVGGPTFFVLLRRMMRKGIHA

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788004, Length=288, Percent_Identity=34.7222222222222, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1790740, Length=312, Percent_Identity=33.974358974359, Blast_Score=147, Evalue=8e-37,
Organism=Escherichia coli, GI1790741, Length=290, Percent_Identity=33.448275862069, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1786805, Length=287, Percent_Identity=35.5400696864112, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI1786804, Length=285, Percent_Identity=31.9298245614035, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1786347, Length=303, Percent_Identity=28.3828382838284, Blast_Score=83, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 36515; Mature: 36384

Theoretical pI: Translated: 10.28; Mature: 10.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHTVNTNEFLRARTRRWVGIFGALVVLMLVAAVLSIVLGQYYVPLQDLGSILLGKDHHS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCC
GLASSVVWDIRLPRILLGFLVGACLGVAGTLMQAVFANPLAEPSIIGVTSGAGVGAALAI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHH
VFNLAFFGTFTVPFFAFLSALVAAGLIYQLARSQGRVVVINLVLTGIAVNAVCGAIISFM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHH
VYLAPTASREEIIFWQMGSLNGAQWKHVWAVLPITMVGIAVALRMGGALDVLALGEKAAG
HHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHCC
HTGINVSQLRAIVIIAATVLTAGAVAFAGLIGFVGLIIPHLLRTVMGPENYLLIPASALG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHC
GAVLIGLADVAARTLIEFADLPIGIFTALVGGPTFFVLLRRMMRKGIHA
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
THTVNTNEFLRARTRRWVGIFGALVVLMLVAAVLSIVLGQYYVPLQDLGSILLGKDHHS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCC
GLASSVVWDIRLPRILLGFLVGACLGVAGTLMQAVFANPLAEPSIIGVTSGAGVGAALAI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHH
VFNLAFFGTFTVPFFAFLSALVAAGLIYQLARSQGRVVVINLVLTGIAVNAVCGAIISFM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHH
VYLAPTASREEIIFWQMGSLNGAQWKHVWAVLPITMVGIAVALRMGGALDVLALGEKAAG
HHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHCC
HTGINVSQLRAIVIIAATVLTAGAVAFAGLIGFVGLIIPHLLRTVMGPENYLLIPASALG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHC
GAVLIGLADVAARTLIEFADLPIGIFTALVGGPTFFVLLRRMMRKGIHA
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]