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The map label for this gene is iunH1 [H]

Identifier: 68535298

GI number: 68535298

Start: 288028

End: 289200

Strand: Direct

Name: iunH1 [H]

Synonym: jk0233

Alternate gene names: 68535298

Gene position: 288028-289200 (Clockwise)

Preceding gene: 68535296

Following gene: 68535300

Centisome position: 11.7

GC content: 63.68

Gene sequence:

>1173_bases
ATGAAAGATTTTCGGACTTCTATGATTCAAAATTCATCTTCGACGGGCATGCAGAAGCCGCGCGTTGTGGCGGATGTGGA
TACAGGGATCGATGACAGTCTGGCGCTGATTTACTTGGCCGGCCTGCATTCCACCGGAGAGATTGATTTAGTGGTGACGA
CCAGCGCGGGAAACACGACCGCACGGCAGGCGGCTGTGAATTCTGCAGAGGTTCTGCGGCTGGCCGGAGCGGCGGACGTG
CCCGTTGTGGCAGGTGCGCGATCGCCGTTGAAGGTTCCATTGACGACGACTCCGGAAACGCACGGAGAAAAAGGTTTAGG
TTATTATTCGCCTCTGGATGGGGGTGGTGCAGCTGGCGATGTGGGCTCGGCGGGCGATGCGCGGGCGGCGGTGGAGTTGT
GGCGCGGAGCCTCGCACATCCTGGTTGCGGGCCCGGCTACGAACCTCGCCTGGGCGCTGCGGCACGCGCCGGAGGTAGTG
GGTGGTGCAGCTGGGAGTGGCGCGACTGGAAGCGGCAAGGCTGGGGCCGAGATCACCCTGATGACCGGTGCCTTTAACTA
CCCCGGTAACACCACGCCGACGGCCGAGTGGAATGCCTGGGTCGACCCCCACGCGCTGAAGGAGGTCTTCGCCGCTCCCG
CCTCCACTCCTGCAACCGTCGATGCTCCTATCATTGCGCGCCCGGCCGTCCGCCCGTTGCCGACGATCTGCCCGCTCAAC
GTCACCGAGCAAGTTCTGCTTTATCCCGAACGTTTGCGCAGGTGGCAGCAGGCACTGCGCCCCACGCGCCCGGAGCTGGC
TACCTTCCTCGGCGACGCCCTCCGCTTCTACTTCGAATTCCACCAGTCGGTCGGCGTCGGCTATTGCGCGCAGATCCACG
ACCTCGCCGCGGCCATGGTGATGCTGCGGCGTGTTCCTTGTTCTTTTTATGACGCCACCGTGGACGTCGAGGCAGACTCT
CCCCTCATGCGTGGCACTACCGTGGCTGACCGAGTTGCGGAGGCTTCCGCCAGTGAAGGGGCTGCGACCAGTGGGGCAGC
AGAGGCGCGAGGAACGTACTGGAATCGCCCGGCGAATGCCCGGATTCTAGAGTCCCTGAACCCGGCCGATGTGTTCGCGG
AGTTCGAGCGGGTAGTGTGCGGGCGGCATTTAGAGGGCTGTAGCCTGGGCTAG

Upstream 100 bases:

>100_bases
GGTGCCACGTGGGTAATTATTTGAAGCTTCTCGCGAGCTTCCATAGTCGTGGGCCATGGCCTCCATTGTATAAGACTTAA
ACCCTATTAACTAAACAATA

Downstream 100 bases:

>100_bases
AAGGCCGGTAATCAAGGGCTTTGAGGGGGTAAATGTCGTTAGAACGGGAATGCGTTAAGGGCAATAATTTGCATTAGTCT
AAACTCGCAGGTCAGAGCGT

Product: putative inosine-uridine preferring nucleoside hydrolase

Products: uracil; ribose; cytosine [C]

Alternate protein names: Cytidine/uridine-specific hydrolase [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MKDFRTSMIQNSSSTGMQKPRVVADVDTGIDDSLALIYLAGLHSTGEIDLVVTTSAGNTTARQAAVNSAEVLRLAGAADV
PVVAGARSPLKVPLTTTPETHGEKGLGYYSPLDGGGAAGDVGSAGDARAAVELWRGASHILVAGPATNLAWALRHAPEVV
GGAAGSGATGSGKAGAEITLMTGAFNYPGNTTPTAEWNAWVDPHALKEVFAAPASTPATVDAPIIARPAVRPLPTICPLN
VTEQVLLYPERLRRWQQALRPTRPELATFLGDALRFYFEFHQSVGVGYCAQIHDLAAAMVMLRRVPCSFYDATVDVEADS
PLMRGTTVADRVAEASASEGAATSGAAEARGTYWNRPANARILESLNPADVFAEFERVVCGRHLEGCSLG

Sequences:

>Translated_390_residues
MKDFRTSMIQNSSSTGMQKPRVVADVDTGIDDSLALIYLAGLHSTGEIDLVVTTSAGNTTARQAAVNSAEVLRLAGAADV
PVVAGARSPLKVPLTTTPETHGEKGLGYYSPLDGGGAAGDVGSAGDARAAVELWRGASHILVAGPATNLAWALRHAPEVV
GGAAGSGATGSGKAGAEITLMTGAFNYPGNTTPTAEWNAWVDPHALKEVFAAPASTPATVDAPIIARPAVRPLPTICPLN
VTEQVLLYPERLRRWQQALRPTRPELATFLGDALRFYFEFHQSVGVGYCAQIHDLAAAMVMLRRVPCSFYDATVDVEADS
PLMRGTTVADRVAEASASEGAATSGAAEARGTYWNRPANARILESLNPADVFAEFERVVCGRHLEGCSLG
>Mature_390_residues
MKDFRTSMIQNSSSTGMQKPRVVADVDTGIDDSLALIYLAGLHSTGEIDLVVTTSAGNTTARQAAVNSAEVLRLAGAADV
PVVAGARSPLKVPLTTTPETHGEKGLGYYSPLDGGGAAGDVGSAGDARAAVELWRGASHILVAGPATNLAWALRHAPEVV
GGAAGSGATGSGKAGAEITLMTGAFNYPGNTTPTAEWNAWVDPHALKEVFAAPASTPATVDAPIIARPAVRPLPTICPLN
VTEQVLLYPERLRRWQQALRPTRPELATFLGDALRFYFEFHQSVGVGYCAQIHDLAAAMVMLRRVPCSFYDATVDVEADS
PLMRGTTVADRVAEASASEGAATSGAAEARGTYWNRPANARILESLNPADVFAEFERVVCGRHLEGCSLG

Specific function: Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively [H]

COG id: COG1957

COG function: function code F; Inosine-uridine nucleoside N-ribohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IUNH family. RihA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786871, Length=318, Percent_Identity=27.9874213836478, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786213, Length=294, Percent_Identity=25.1700680272109, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI32565474, Length=210, Percent_Identity=30, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015910
- InterPro:   IPR023186
- InterPro:   IPR001910
- InterPro:   IPR022975 [H]

Pfam domain/function: PF01156 IU_nuc_hydro [H]

EC number: NA

Molecular weight: Translated: 40762; Mature: 40762

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDFRTSMIQNSSSTGMQKPRVVADVDTGIDDSLALIYLAGLHSTGEIDLVVTTSAGNTT
CCCHHHHHHHCCCCCCCCCCCEEEECCCCCCCCEEEEEEECCCCCCCEEEEEEECCCCCH
ARQAAVNSAEVLRLAGAADVPVVAGARSPLKVPLTTTPETHGEKGLGYYSPLDGGGAAGD
HHHHHCCHHHHHHHCCCCCCCEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCC
VGSAGDARAAVELWRGASHILVAGPATNLAWALRHAPEVVGGAAGSGATGSGKAGAEITL
CCCCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHCHHHHCCCCCCCCCCCCCCCCEEEE
MTGAFNYPGNTTPTAEWNAWVDPHALKEVFAAPASTPATVDAPIIARPAVRPLPTICPLN
EEECCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
VTEQVLLYPERLRRWQQALRPTRPELATFLGDALRFYFEFHQSVGVGYCAQIHDLAAAMV
CHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
MLRRVPCSFYDATVDVEADSPLMRGTTVADRVAEASASEGAATSGAAEARGTYWNRPANA
HHHHCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCCH
RILESLNPADVFAEFERVVCGRHLEGCSLG
HHHHCCCHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKDFRTSMIQNSSSTGMQKPRVVADVDTGIDDSLALIYLAGLHSTGEIDLVVTTSAGNTT
CCCHHHHHHHCCCCCCCCCCCEEEECCCCCCCCEEEEEEECCCCCCCEEEEEEECCCCCH
ARQAAVNSAEVLRLAGAADVPVVAGARSPLKVPLTTTPETHGEKGLGYYSPLDGGGAAGD
HHHHHCCHHHHHHHCCCCCCCEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCC
VGSAGDARAAVELWRGASHILVAGPATNLAWALRHAPEVVGGAAGSGATGSGKAGAEITL
CCCCCCHHHHHHHHCCCCEEEEECCCCHHHHHHHHCHHHHCCCCCCCCCCCCCCCCEEEE
MTGAFNYPGNTTPTAEWNAWVDPHALKEVFAAPASTPATVDAPIIARPAVRPLPTICPLN
EEECCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
VTEQVLLYPERLRRWQQALRPTRPELATFLGDALRFYFEFHQSVGVGYCAQIHDLAAAMV
CHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
MLRRVPCSFYDATVDVEADSPLMRGTTVADRVAEASASEGAATSGAAEARGTYWNRPANA
HHHHCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCCH
RILESLNPADVFAEFERVVCGRHLEGCSLG
HHHHCCCHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: uridine; H2O; cytidine [C]

Specific reaction: uridine + H2O = uracil + ribose cytidine + H2O = cytosine + ribose [C]

General reaction: Pyrimidine-specific nucleoside hydrolase [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA