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The map label for this gene is pyrE [H]

Identifier: 68535278

GI number: 68535278

Start: 266015

End: 266557

Strand: Direct

Name: pyrE [H]

Synonym: jk0213

Alternate gene names: 68535278

Gene position: 266015-266557 (Clockwise)

Preceding gene: 68535277

Following gene: 68535279

Centisome position: 10.8

GC content: 65.01

Gene sequence:

>543_bases
ATGATCGATGAATCCAAGAAGCAGCGCCTCGCTGAGCTCGTAAAGGAGCTGGCGGTGGTGCACGGGCGCGTGACCCTTTC
CTCCGGCAAGGAGGCCGACTATTACGTCGACCTGCGCCGTGCGACCCTGCACCACGAGGCATCGCCGCTGATCGGCGAGC
TGCTGCGCGAGCTGACCGCCGATTGGGACTATGTACACGTCGGCGGGCTGACCCTGGGCGCGGACCCGGTGGCGACGGCG
ATTATGCATGCAGACGGCACCCCTATTGACGCTTTTGTAGTGCGCAAGGAAGCCAAGAAGCACGGCATGCAGCGCCGCAT
TGAAGGCCCGGATATTGAGGGCAAGCGGGTGCTGATTGTCGAGGACACGACCACCACGGGTAACTCCCCGCTGACCGCCG
TCGCCGCCGCTCGCGAGGCTGGCGCGACTGTCGTTGGCGTGGCCACCGTCGTGGATCGCGCGACCGGCGCTAAGGATGTT
ATTGAGGCCGAGGGAGTCGAGTACCGCTCGCTGCTGGGCCTGTCCGACCTGGGTCTTTCCTAG

Upstream 100 bases:

>100_bases
ACGCCACGCCCGCCCCGAACCCATCGAACCGATTGAGTACGAAACCGTCGACGGCGAGGTCGTCGAAGACGACCAGCAAT
AGCAAAAAGGAGCAACCGCA

Downstream 100 bases:

>100_bases
GTATTTTTGATGACGCCCACCTCCCCCGAATCACACGATAAACCCGGACCGACGGAGTGGCTGGAGCATCCCCGTGGGGT
GCGTAGCTGGGAAGAAGAAC

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 180; Mature: 180

Protein sequence:

>180_residues
MIDESKKQRLAELVKELAVVHGRVTLSSGKEADYYVDLRRATLHHEASPLIGELLRELTADWDYVHVGGLTLGADPVATA
IMHADGTPIDAFVVRKEAKKHGMQRRIEGPDIEGKRVLIVEDTTTTGNSPLTAVAAAREAGATVVGVATVVDRATGAKDV
IEAEGVEYRSLLGLSDLGLS

Sequences:

>Translated_180_residues
MIDESKKQRLAELVKELAVVHGRVTLSSGKEADYYVDLRRATLHHEASPLIGELLRELTADWDYVHVGGLTLGADPVATA
IMHADGTPIDAFVVRKEAKKHGMQRRIEGPDIEGKRVLIVEDTTTTGNSPLTAVAAAREAGATVVGVATVVDRATGAKDV
IEAEGVEYRSLLGLSDLGLS
>Mature_180_residues
MIDESKKQRLAELVKELAVVHGRVTLSSGKEADYYVDLRRATLHHEASPLIGELLRELTADWDYVHVGGLTLGADPVATA
IMHADGTPIDAFVVRKEAKKHGMQRRIEGPDIEGKRVLIVEDTTTTGNSPLTAVAAAREAGATVVGVATVVDRATGAKDV
IEAEGVEYRSLLGLSDLGLS

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=164, Percent_Identity=30.4878048780488, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17554964, Length=173, Percent_Identity=29.4797687861272, Blast_Score=67, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 19221; Mature: 19221

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00589 PTS_HPR_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDESKKQRLAELVKELAVVHGRVTLSSGKEADYYVDLRRATLHHEASPLIGELLRELTA
CCCHHHHHHHHHHHHHHHHHHCEEEECCCCCCCEEEEHHHHHHHCCCCHHHHHHHHHHHC
DWDYVHVGGLTLGADPVATAIMHADGTPIDAFVVRKEAKKHGMQRRIEGPDIEGKRVLIV
CCCEEEECCEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEE
EDTTTTGNSPLTAVAAAREAGATVVGVATVVDRATGAKDVIEAEGVEYRSLLGLSDLGLS
ECCCCCCCCCHHHHHHHHHCCCCEEHHHHHHHHCCCCHHHHHHCCCCHHHHHCCCCCCCC
>Mature Secondary Structure
MIDESKKQRLAELVKELAVVHGRVTLSSGKEADYYVDLRRATLHHEASPLIGELLRELTA
CCCHHHHHHHHHHHHHHHHHHCEEEECCCCCCCEEEEHHHHHHHCCCCHHHHHHHHHHHC
DWDYVHVGGLTLGADPVATAIMHADGTPIDAFVVRKEAKKHGMQRRIEGPDIEGKRVLIV
CCCEEEECCEEECCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEE
EDTTTTGNSPLTAVAAAREAGATVVGVATVVDRATGAKDVIEAEGVEYRSLLGLSDLGLS
ECCCCCCCCCHHHHHHHHHCCCCEEHHHHHHHHCCCCHHHHHHCCCCHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA