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The map label for this gene is accD3 [H]

Identifier: 68535204

GI number: 68535204

Start: 168631

End: 170223

Strand: Direct

Name: accD3 [H]

Synonym: jk0139

Alternate gene names: 68535204

Gene position: 168631-170223 (Clockwise)

Preceding gene: 68535203

Following gene: 68535209

Centisome position: 6.85

GC content: 65.47

Gene sequence:

>1593_bases
GTGACTGCTGCCGATGAGGGAGCACCCGCCGCCAACGGCACCGAAGCCACCGGCGCTACCGCAGAGAAGCTGGCGGAGCT
GCACCGGAGGTTGGAACAGGCGCAGGACCCGGGCTCCGAGAAGGCCAAGGCCAGGCGCGATGAGGCCGGGCTGACCACGC
CCCGCCAGCGCATCGACGTGCTGCTGGACGAGGGCACGTTCGTGGAGATCGGCGCGCTGGGACGCACCCCCGGCGAGGAG
GATGCCCCCTACGGCGACGGCGTGGTCACCGGCTACGGTCGGGTCGGCGGCCGCACCGTGGCGGTGTACGCCCACGATAA
AACGGTGTACGGCGGCTCGGTGGGCGAGACCTTCGGCAAGAAGGTCTGCGAGGTCATGGACATGGCCATCCGCATCGGTT
GCCCGGTCATCGGCATTAACGATTCCGGCGGCGCCCGCATTCAGGATGCCGTGATGTCCCTGGCGATGTACTCCGAGATC
TCCCGCCGTCAACTGCCGCTGAGTGGCCAGTCCCCGCAGATCTCCATCCTGCTCGGCCCGTCCGCCGGTGGCGCCGTTTA
CGCGCCTGTGACCACCGACTTTGTAGTGGCAGTCGAAGGCCGCACGCAGATGTTCGTAACGGGCCCGGCGGTCATCGAAT
CGGTGACGGGCGAGAAGATTTCGATGGAAGAGCTCGGTGGGGCGCGTCAGCAAGCCCGCAACGGCAACGTCTCCTACGTC
GCAACCAGCGAGGAAGACGCTTTCAACTACGTCAAGGACCTGCTGGACTTCCTGCCTTCCAGCTCCTTCGACGAGACCCC
GGAGTTCTGGGCGCCTAACGACGAGCTCACCGAACGCGACTTCGAGCTGAACGACATCATCCCGGACGATCCGAACGCGG
GCTACGACATCATGGAGGTGCTCACCCGCATCTTCGACGACGACAACGTGCTGGAGGTGCAGGGCGATTACGGCTCCAAC
GTCGTCACTGCCTTCGCCCGCATCGACGGCCATGCGGTGGGCGTGGTGGCCAACCAGCCGATGGAGCTGGCCGGTTGCCT
GGACGCCGACGCTGCGGATAAGGCCGCGCGTTTTATCCGTATTTGTGACGCCTACAATGTCCCCCTCGTCTGGGTCGTGG
ATACACCCGGGTACATGCCCGGTGTGGAGCAGGAAAAGGCCGGCCTGATTCACCGCGGAGCGAAGCTGGGCTTCGCCACT
GTGGAGGCGACGGTGCCGAAGGTGACCGTGGTCGTGCGCAAGGCCTTTGGCGGTGGCTATGCCGTGATGGGCTCGAAGAA
CCTGGGTGCGGACATCAACCTGGTGTGGCCGACGGCGCAGATCGCTGTGATGGGTGCGGAGGCCGCCGTGGTGATGATGC
AGGGCAAGGCCCTGGCCGCCATGCCGGAAGAGCAGCGCCCGGCGGCGAAGAAGATGTTTATGGACTTCTACAACGCGAAC
ATGACCAGCCCCTATGTGGCGGCCGAACGCGGCTACGTGGACTCCGTCATCACCCCGGACCAGACCCGCATCCGCCTGCG
CCAGGCGATGCGCCAGCTGCGCAACAAGCAGGTGGTGGATACTCCGAAGAAGCACACCATCATGCCGATGTAG

Upstream 100 bases:

>100_bases
CCAAGCACATTGCGGACGGCGTTTAGCTGAAACACGCACGGCGACTAAATAGATAGCCCCTTAGTAGAAGGGGTTTGTCG
AATACGAAGGGACTTTCACT

Downstream 100 bases:

>100_bases
TCAGCTGCCCTACAGGCCGATGTTGGTTCCCGCGGGCAGTTTCAGAGTGTCGGCCTTCACGAAGTAGGTGTGCATCGTGC
CATTCGTCATCTCCAAGTGA

Product: acyl-CoA carboxylase, beta subunit

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 530; Mature: 529

Protein sequence:

>530_residues
MTAADEGAPAANGTEATGATAEKLAELHRRLEQAQDPGSEKAKARRDEAGLTTPRQRIDVLLDEGTFVEIGALGRTPGEE
DAPYGDGVVTGYGRVGGRTVAVYAHDKTVYGGSVGETFGKKVCEVMDMAIRIGCPVIGINDSGGARIQDAVMSLAMYSEI
SRRQLPLSGQSPQISILLGPSAGGAVYAPVTTDFVVAVEGRTQMFVTGPAVIESVTGEKISMEELGGARQQARNGNVSYV
ATSEEDAFNYVKDLLDFLPSSSFDETPEFWAPNDELTERDFELNDIIPDDPNAGYDIMEVLTRIFDDDNVLEVQGDYGSN
VVTAFARIDGHAVGVVANQPMELAGCLDADAADKAARFIRICDAYNVPLVWVVDTPGYMPGVEQEKAGLIHRGAKLGFAT
VEATVPKVTVVVRKAFGGGYAVMGSKNLGADINLVWPTAQIAVMGAEAAVVMMQGKALAAMPEEQRPAAKKMFMDFYNAN
MTSPYVAAERGYVDSVITPDQTRIRLRQAMRQLRNKQVVDTPKKHTIMPM

Sequences:

>Translated_530_residues
MTAADEGAPAANGTEATGATAEKLAELHRRLEQAQDPGSEKAKARRDEAGLTTPRQRIDVLLDEGTFVEIGALGRTPGEE
DAPYGDGVVTGYGRVGGRTVAVYAHDKTVYGGSVGETFGKKVCEVMDMAIRIGCPVIGINDSGGARIQDAVMSLAMYSEI
SRRQLPLSGQSPQISILLGPSAGGAVYAPVTTDFVVAVEGRTQMFVTGPAVIESVTGEKISMEELGGARQQARNGNVSYV
ATSEEDAFNYVKDLLDFLPSSSFDETPEFWAPNDELTERDFELNDIIPDDPNAGYDIMEVLTRIFDDDNVLEVQGDYGSN
VVTAFARIDGHAVGVVANQPMELAGCLDADAADKAARFIRICDAYNVPLVWVVDTPGYMPGVEQEKAGLIHRGAKLGFAT
VEATVPKVTVVVRKAFGGGYAVMGSKNLGADINLVWPTAQIAVMGAEAAVVMMQGKALAAMPEEQRPAAKKMFMDFYNAN
MTSPYVAAERGYVDSVITPDQTRIRLRQAMRQLRNKQVVDTPKKHTIMPM
>Mature_529_residues
TAADEGAPAANGTEATGATAEKLAELHRRLEQAQDPGSEKAKARRDEAGLTTPRQRIDVLLDEGTFVEIGALGRTPGEED
APYGDGVVTGYGRVGGRTVAVYAHDKTVYGGSVGETFGKKVCEVMDMAIRIGCPVIGINDSGGARIQDAVMSLAMYSEIS
RRQLPLSGQSPQISILLGPSAGGAVYAPVTTDFVVAVEGRTQMFVTGPAVIESVTGEKISMEELGGARQQARNGNVSYVA
TSEEDAFNYVKDLLDFLPSSSFDETPEFWAPNDELTERDFELNDIIPDDPNAGYDIMEVLTRIFDDDNVLEVQGDYGSNV
VTAFARIDGHAVGVVANQPMELAGCLDADAADKAARFIRICDAYNVPLVWVVDTPGYMPGVEQEKAGLIHRGAKLGFATV
EATVPKVTVVVRKAFGGGYAVMGSKNLGADINLVWPTAQIAVMGAEAAVVMMQGKALAAMPEEQRPAAKKMFMDFYNANM
TSPYVAAERGYVDSVITPDQTRIRLRQAMRQLRNKQVVDTPKKHTIMPM

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=531, Percent_Identity=41.2429378531073, Blast_Score=408, Evalue=1e-114,
Organism=Homo sapiens, GI295821216, Length=551, Percent_Identity=39.9274047186933, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI11545863, Length=501, Percent_Identity=30.5389221556886, Blast_Score=206, Evalue=4e-53,
Organism=Escherichia coli, GI1788655, Length=221, Percent_Identity=29.8642533936652, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI25147359, Length=537, Percent_Identity=40.5959031657356, Blast_Score=400, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI25147362, Length=528, Percent_Identity=40.719696969697, Blast_Score=400, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17552936, Length=515, Percent_Identity=30.4854368932039, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24586065, Length=531, Percent_Identity=30.6967984934087, Blast_Score=213, Evalue=4e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 56831; Mature: 56700

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAADEGAPAANGTEATGATAEKLAELHRRLEQAQDPGSEKAKARRDEAGLTTPRQRIDV
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHEE
LLDEGTFVEIGALGRTPGEEDAPYGDGVVTGYGRVGGRTVAVYAHDKTVYGGSVGETFGK
EECCCCEEEEECCCCCCCCCCCCCCCCEEEECCCCCCEEEEEEEECCEEECCCHHHHHHH
KVCEVMDMAIRIGCPVIGINDSGGARIQDAVMSLAMYSEISRRQLPLSGQSPQISILLGP
HHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECC
SAGGAVYAPVTTDFVVAVEGRTQMFVTGPAVIESVTGEKISMEELGGARQQARNGNVSYV
CCCCEEEECCCCEEEEEECCCEEEEEECHHHHHHCCCCEEEHHHHCCHHHHHCCCCEEEE
ATSEEDAFNYVKDLLDFLPSSSFDETPEFWAPNDELTERDFELNDIIPDDPNAGYDIMEV
ECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
LTRIFDDDNVLEVQGDYGSNVVTAFARIDGHAVGVVANQPMELAGCLDADAADKAARFIR
HHHHCCCCCEEEEECCCCCCCEEHEEHHCCEEEEEEECCCHHHHHCCCCCHHHHHHHHHH
ICDAYNVPLVWVVDTPGYMPGVEQEKAGLIHRGAKLGFATVEATVPKVTVVVRKAFGGGY
HHCCCCCCEEEEECCCCCCCCCCHHHCCHHHCCCCCCEEEEECCCCEEEEEEEHHCCCCE
AVMGSKNLGADINLVWPTAQIAVMGAEAAVVMMQGKALAAMPEEQRPAAKKMFMDFYNAN
EEEECCCCCCEEEEECCCEEEEEECCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCC
MTSPYVAAERGYVDSVITPDQTRIRLRQAMRQLRNKQVVDTPKKHTIMPM
CCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TAADEGAPAANGTEATGATAEKLAELHRRLEQAQDPGSEKAKARRDEAGLTTPRQRIDV
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHEE
LLDEGTFVEIGALGRTPGEEDAPYGDGVVTGYGRVGGRTVAVYAHDKTVYGGSVGETFGK
EECCCCEEEEECCCCCCCCCCCCCCCCEEEECCCCCCEEEEEEEECCEEECCCHHHHHHH
KVCEVMDMAIRIGCPVIGINDSGGARIQDAVMSLAMYSEISRRQLPLSGQSPQISILLGP
HHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECC
SAGGAVYAPVTTDFVVAVEGRTQMFVTGPAVIESVTGEKISMEELGGARQQARNGNVSYV
CCCCEEEECCCCEEEEEECCCEEEEEECHHHHHHCCCCEEEHHHHCCHHHHHCCCCEEEE
ATSEEDAFNYVKDLLDFLPSSSFDETPEFWAPNDELTERDFELNDIIPDDPNAGYDIMEV
ECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
LTRIFDDDNVLEVQGDYGSNVVTAFARIDGHAVGVVANQPMELAGCLDADAADKAARFIR
HHHHCCCCCEEEEECCCCCCCEEHEEHHCCEEEEEEECCCHHHHHCCCCCHHHHHHHHHH
ICDAYNVPLVWVVDTPGYMPGVEQEKAGLIHRGAKLGFATVEATVPKVTVVVRKAFGGGY
HHCCCCCCEEEEECCCCCCCCCCHHHCCHHHCCCCCCEEEEECCCCEEEEEEEHHCCCCE
AVMGSKNLGADINLVWPTAQIAVMGAEAAVVMMQGKALAAMPEEQRPAAKKMFMDFYNAN
EEEECCCCCCEEEEECCCEEEEEECCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCC
MTSPYVAAERGYVDSVITPDQTRIRLRQAMRQLRNKQVVDTPKKHTIMPM
CCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]