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The map label for this gene is ybdL [H]

Identifier: 66768220

GI number: 66768220

Start: 2294310

End: 2295458

Strand: Direct

Name: ybdL [H]

Synonym: XC_1899

Alternate gene names: 66768220

Gene position: 2294310-2295458 (Clockwise)

Preceding gene: 66768208

Following gene: 66768221

Centisome position: 44.56

GC content: 66.23

Gene sequence:

>1149_bases
ATGCCCGTCACGACCAAGCTGCCCAAGGTGGGCACCACCATCTTCACCGTCATGTCGCAGCTGGCGGCCGAGCACGGCGC
GGTCAACCTGGGCCAGGGCTTCCCGGATTTCGCGGTGCCGCAGCGGCTGGTCGACGCACTCGGCCAGGCCATGGCCGCCG
GACACAACCAGTACCCGCCGATGACCGGTGTGGCCGCGTTGCGCCAGGCCATCGCCGGCAAGGCGCAGCGCTGCTATGGC
GCGCAGGTGGATGCCGACACCGAAATCACCGTCACCAGCGGCGCCACCGAGGCCATCTTCAACGCCATCCACGCGGTGGT
GCGCGCGGGCGAAGAAGTGATCGTGCTGGACCCGGCCTACGACTGTTACGAGCCGGCGATCGATCTGGCCGGCGCACGCG
CCGTGCACGTGGCACTGGACCCGCAGACCTTTGCCGTGGATTGGGACGCGCTGCGCGCGGCGATCACGCCGAAGACGCGC
TTGCTGATGATCAACTCGCCGCACAATCCCTCCGGCGCGATGCTTTCGGCCGCCGACATGCAGACTCTCACCGAGCTGCT
GCATGGCACCGACATCTTCCTGCTGTCTGACGAGGTCTACGAGCACATCGTGTTCGACGGCCGCCGGCACGAATCGGTGC
TGCGCTGGCCGGAATTGCGCGCGCGCGCGTTCGTGATTTCCAGCTTCGGCAAGACCTACCATTGCACCGGCTGGAAGATC
GGGTATGCCATCGCGCCGCCCGCGCTGAGTGCTGAATTCCGCAAGGTGCACCAGTACAACACCTTCACCAGCTTCGGCCC
GGCGCAGCACGCGTTTGCCGCGATGCTGCGCGACGAACCCGAGCACGACGAACAACTGGGCGCGTTCTATCAGGCCAAGC
GCGACCGCTTCCGCGAGCAGCTGCTGACCACACGGCTGGTCCCGCTGCCGGTGCCGGGTGGTTATTTCCAGCTGGTTGAC
TATTCGGCCATCAGCGACCTGCCCGACACCGAGTTCGTGAAGTGGCTGACGGTGGAGAAAGGGGTGGCGGCGATTCCGCT
GTCGCCGTTCTACGAAACCGCACCGGCCGGGCAACGCCTGGCGCGGCTGTGTTTCGCCAAGAACGATGCCACGTTGGATG
CGGCGATTGCGCGGTTACAGCAGCTTTGA

Upstream 100 bases:

>100_bases
GTGATGTGTCCGGGAACGCTGTTTTGCGCATCGCCCGGCGCACTGGCTGGGCGGGTTTGCGTACACTCGCGGTCCCCTGT
TTGTCGACCGGAACCGCGCG

Downstream 100 bases:

>100_bases
GGAGCTGGGATTCGGGAATCGGGATTGGGGATTCGCAAAAAGCATAGCCATCGCCTGGCGTGATCCTGATCTCTGCCCGT
TGACCTCGCGCCTGCTGGTG

Product: putative aminotransferase

Products: N-succinyl-2-L-amino-6-oxoheptanedioate; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MPVTTKLPKVGTTIFTVMSQLAAEHGAVNLGQGFPDFAVPQRLVDALGQAMAAGHNQYPPMTGVAALRQAIAGKAQRCYG
AQVDADTEITVTSGATEAIFNAIHAVVRAGEEVIVLDPAYDCYEPAIDLAGARAVHVALDPQTFAVDWDALRAAITPKTR
LLMINSPHNPSGAMLSAADMQTLTELLHGTDIFLLSDEVYEHIVFDGRRHESVLRWPELRARAFVISSFGKTYHCTGWKI
GYAIAPPALSAEFRKVHQYNTFTSFGPAQHAFAAMLRDEPEHDEQLGAFYQAKRDRFREQLLTTRLVPLPVPGGYFQLVD
YSAISDLPDTEFVKWLTVEKGVAAIPLSPFYETAPAGQRLARLCFAKNDATLDAAIARLQQL

Sequences:

>Translated_382_residues
MPVTTKLPKVGTTIFTVMSQLAAEHGAVNLGQGFPDFAVPQRLVDALGQAMAAGHNQYPPMTGVAALRQAIAGKAQRCYG
AQVDADTEITVTSGATEAIFNAIHAVVRAGEEVIVLDPAYDCYEPAIDLAGARAVHVALDPQTFAVDWDALRAAITPKTR
LLMINSPHNPSGAMLSAADMQTLTELLHGTDIFLLSDEVYEHIVFDGRRHESVLRWPELRARAFVISSFGKTYHCTGWKI
GYAIAPPALSAEFRKVHQYNTFTSFGPAQHAFAAMLRDEPEHDEQLGAFYQAKRDRFREQLLTTRLVPLPVPGGYFQLVD
YSAISDLPDTEFVKWLTVEKGVAAIPLSPFYETAPAGQRLARLCFAKNDATLDAAIARLQQL
>Mature_381_residues
PVTTKLPKVGTTIFTVMSQLAAEHGAVNLGQGFPDFAVPQRLVDALGQAMAAGHNQYPPMTGVAALRQAIAGKAQRCYGA
QVDADTEITVTSGATEAIFNAIHAVVRAGEEVIVLDPAYDCYEPAIDLAGARAVHVALDPQTFAVDWDALRAAITPKTRL
LMINSPHNPSGAMLSAADMQTLTELLHGTDIFLLSDEVYEHIVFDGRRHESVLRWPELRARAFVISSFGKTYHCTGWKIG
YAIAPPALSAEFRKVHQYNTFTSFGPAQHAFAAMLRDEPEHDEQLGAFYQAKRDRFREQLLTTRLVPLPVPGGYFQLVDY
SAISDLPDTEFVKWLTVEKGVAAIPLSPFYETAPAGQRLARLCFAKNDATLDAAIARLQQL

Specific function: Shows aminotransferase activity with methionine and histidine as substrates, and to a lesser extent also with phenylalanine [H]

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI56713254, Length=399, Percent_Identity=34.5864661654135, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI56713256, Length=399, Percent_Identity=34.5864661654135, Blast_Score=239, Evalue=2e-63,
Organism=Homo sapiens, GI95147551, Length=396, Percent_Identity=33.5858585858586, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI169881279, Length=396, Percent_Identity=33.5858585858586, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI169881281, Length=394, Percent_Identity=29.9492385786802, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI4507369, Length=335, Percent_Identity=24.1791044776119, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1786816, Length=378, Percent_Identity=56.0846560846561, Blast_Score=409, Evalue=1e-115,
Organism=Escherichia coli, GI1788722, Length=389, Percent_Identity=24.1645244215938, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1788627, Length=221, Percent_Identity=29.4117647058824, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1787710, Length=314, Percent_Identity=29.9363057324841, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790797, Length=236, Percent_Identity=25, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71994472, Length=404, Percent_Identity=33.9108910891089, Blast_Score=219, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI71994476, Length=404, Percent_Identity=33.9108910891089, Blast_Score=219, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17567369, Length=400, Percent_Identity=31, Blast_Score=188, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI17567663, Length=342, Percent_Identity=20.4678362573099, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322401, Length=392, Percent_Identity=31.1224489795918, Blast_Score=186, Evalue=6e-48,
Organism=Drosophila melanogaster, GI28573069, Length=393, Percent_Identity=32.3155216284987, Blast_Score=201, Evalue=5e-52,
Organism=Drosophila melanogaster, GI24646114, Length=393, Percent_Identity=32.3155216284987, Blast_Score=201, Evalue=5e-52,
Organism=Drosophila melanogaster, GI28573067, Length=393, Percent_Identity=32.3155216284987, Blast_Score=201, Evalue=5e-52,
Organism=Drosophila melanogaster, GI28573065, Length=393, Percent_Identity=32.3155216284987, Blast_Score=201, Evalue=5e-52,
Organism=Drosophila melanogaster, GI18859735, Length=350, Percent_Identity=24.5714285714286, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.17

Molecular weight: Translated: 41736; Mature: 41605

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVTTKLPKVGTTIFTVMSQLAAEHGAVNLGQGFPDFAVPQRLVDALGQAMAAGHNQYPP
CCCCCCCCCHHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
MTGVAALRQAIAGKAQRCYGAQVDADTEITVTSGATEAIFNAIHAVVRAGEEVIVLDPAY
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEEECCCH
DCYEPAIDLAGARAVHVALDPQTFAVDWDALRAAITPKTRLLMINSPHNPSGAMLSAADM
HHHHHHHHHCCCEEEEEEECCCEEEEEHHHHHHHCCCCEEEEEEECCCCCCCCEEEHHHH
QTLTELLHGTDIFLLSDEVYEHIVFDGRRHESVLRWPELRARAFVISSFGKTYHCTGWKI
HHHHHHHCCCCEEEECHHHHHHHHCCCCCHHHHHHCHHHHHHHHHHHHCCCEEEECCEEE
GYAIAPPALSAEFRKVHQYNTFTSFGPAQHAFAAMLRDEPEHDEQLGAFYQAKRDRFREQ
CEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
LLTTRLVPLPVPGGYFQLVDYSAISDLPDTEFVKWLTVEKGVAAIPLSPFYETAPAGQRL
HHHHCCCCCCCCCCCEEEEEHHHHCCCCCHHHHHEEECCCCCEECCCCCCCCCCCHHHHH
ARLCFAKNDATLDAAIARLQQL
HHHHHCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
PVTTKLPKVGTTIFTVMSQLAAEHGAVNLGQGFPDFAVPQRLVDALGQAMAAGHNQYPP
CCCCCCCCHHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
MTGVAALRQAIAGKAQRCYGAQVDADTEITVTSGATEAIFNAIHAVVRAGEEVIVLDPAY
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEEECCCH
DCYEPAIDLAGARAVHVALDPQTFAVDWDALRAAITPKTRLLMINSPHNPSGAMLSAADM
HHHHHHHHHCCCEEEEEEECCCEEEEEHHHHHHHCCCCEEEEEEECCCCCCCCEEEHHHH
QTLTELLHGTDIFLLSDEVYEHIVFDGRRHESVLRWPELRARAFVISSFGKTYHCTGWKI
HHHHHHHCCCCEEEECHHHHHHHHCCCCCHHHHHHCHHHHHHHHHHHHCCCEEEECCEEE
GYAIAPPALSAEFRKVHQYNTFTSFGPAQHAFAAMLRDEPEHDEQLGAFYQAKRDRFREQ
CEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
LLTTRLVPLPVPGGYFQLVDYSAISDLPDTEFVKWLTVEKGVAAIPLSPFYETAPAGQRL
HHHHCCCCCCCCCCCEEEEEHHHHCCCCCHHHHHEEECCCCCEECCCCCCCCCCCHHHHH
ARLCFAKNDATLDAAIARLQQL
HHHHHCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-succinyl-L-2,6-diaminoheptanedioate; 2-oxoglutarate

Specific reaction: N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-succinyl-2-L-amino-6-oxoheptanedioate + L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]