Click here to switch to the map view.

The map label for this gene is ccmE2

Identifier: 66768215

GI number: 66768215

Start: 2291328

End: 2291786

Strand: Reverse

Name: ccmE2

Synonym: XC_1894

Alternate gene names: 66768215

Gene position: 2291786-2291328 (Counterclockwise)

Preceding gene: 66768216

Following gene: 66768214

Centisome position: 44.51

GC content: 67.1

Gene sequence:

>459_bases
ATGAACCCGCAACGTCGCCGCCGTCTGTGGCTGGTGCTGGCGCTGGTGCTGGCCGGTGGCCTGGCGACCACGCTGGTGGC
CATGGCCCTGCAGCGCAACGTGGCGTATCTGTACACGCCGGCCGAGGTGTTGCGCGGCGAGGCCGGGGAGCATGCGCGTT
TCCGTTTGGGTGGCATGGTGGAAAAAGGCTCGTTCCGGCGCGAAGCCGGCTCGCTGGAAGCGCACTTCCGCGTCACCGAC
GGCGACGCGCAATTGCCGGTGCGCTATGACCGCATCCTTCCCGACCTGTTCCGCGAGGGTCAGGCGGTGGTGGCCACCGG
CCGCATGCAGCAAGGTGTGTTCGTGGCCGAGGACGTGCTGGCCAAGCATGATGAGACCTACATGCCCAAGGAAGTCGCCG
ACAAGATGGGTAGTGCGCATCGCAAGCACCAGGTCGCGCCGGCGAAGGTGACCCAGTGA

Upstream 100 bases:

>100_bases
TCGCCGGCCGCTGGCAGGTGCGCAAAGCCTTGAAAGTGGCGCAGGCGCGGCGCCTGCGCGAGCGCAAGCGCACACTGCCC
ACCGATGTGGAGCTGACCCG

Downstream 100 bases:

>100_bases
CGGTGACCTCCCTGGTAGACCGCGACGCACAGATCGACGGCACCGCGACTGACGGCCATACGCTGCCACGCAGGCGCGCG
GTATCGCCGGCCATCCGACG

Product: cytochrome c-type biogenesis protein CcmE

Products: NA

Alternate protein names: Cytochrome c maturation protein E 2; Heme chaperone CcmE 2

Number of amino acids: Translated: 152; Mature: 152

Protein sequence:

>152_residues
MNPQRRRRLWLVLALVLAGGLATTLVAMALQRNVAYLYTPAEVLRGEAGEHARFRLGGMVEKGSFRREAGSLEAHFRVTD
GDAQLPVRYDRILPDLFREGQAVVATGRMQQGVFVAEDVLAKHDETYMPKEVADKMGSAHRKHQVAPAKVTQ

Sequences:

>Translated_152_residues
MNPQRRRRLWLVLALVLAGGLATTLVAMALQRNVAYLYTPAEVLRGEAGEHARFRLGGMVEKGSFRREAGSLEAHFRVTD
GDAQLPVRYDRILPDLFREGQAVVATGRMQQGVFVAEDVLAKHDETYMPKEVADKMGSAHRKHQVAPAKVTQ
>Mature_152_residues
MNPQRRRRLWLVLALVLAGGLATTLVAMALQRNVAYLYTPAEVLRGEAGEHARFRLGGMVEKGSFRREAGSLEAHFRVTD
GDAQLPVRYDRILPDLFREGQAVVATGRMQQGVFVAEDVLAKHDETYMPKEVADKMGSAHRKHQVAPAKVTQ

Specific function: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH

COG id: COG2332

COG function: function code O; Cytochrome c-type biogenesis protein CcmE

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CcmE/CycJ family

Homologues:

Organism=Escherichia coli, GI1788525, Length=159, Percent_Identity=42.7672955974843, Blast_Score=121, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCME2_XANC8 (Q4UVG6)

Other databases:

- EMBL:   CP000050
- RefSeq:   YP_242977.1
- ProteinModelPortal:   Q4UVG6
- SMR:   Q4UVG6
- STRING:   Q4UVG6
- GeneID:   3380441
- GenomeReviews:   CP000050_GR
- KEGG:   xcb:XC_1894
- eggNOG:   COG2332
- HOGENOM:   HBG296631
- OMA:   HVEFAVH
- PhylomeDB:   Q4UVG6
- ProtClustDB:   PRK13254
- BioCyc:   XCAM314565:XC_1894-MONOMER
- HAMAP:   MF_01959
- InterPro:   IPR004329
- InterPro:   IPR012340
- Gene3D:   G3DSA:2.40.50.140

Pfam domain/function: PF03100 CcmE; SSF82093 Pyrv/PenolPyrv_Kinase_cat

EC number: NA

Molecular weight: Translated: 16909; Mature: 16909

Theoretical pI: Translated: 10.31; Mature: 10.31

Prosite motif: NA

Important sites: BINDING 123-123

Signals:

None

Transmembrane regions:

HASH(0x1523ec44)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPQRRRRLWLVLALVLAGGLATTLVAMALQRNVAYLYTPAEVLRGEAGEHARFRLGGMV
CCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCEEEECCHHHHCCCCCCCCEEEECCCC
EKGSFRREAGSLEAHFRVTDGDAQLPVRYDRILPDLFREGQAVVATGRMQQGVFVAEDVL
CCCCCHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHH
AKHDETYMPKEVADKMGSAHRKHQVAPAKVTQ
HHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCH
>Mature Secondary Structure
MNPQRRRRLWLVLALVLAGGLATTLVAMALQRNVAYLYTPAEVLRGEAGEHARFRLGGMV
CCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCEEEECCHHHHCCCCCCCCEEEECCCC
EKGSFRREAGSLEAHFRVTDGDAQLPVRYDRILPDLFREGQAVVATGRMQQGVFVAEDVL
CCCCCHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHH
AKHDETYMPKEVADKMGSAHRKHQVAPAKVTQ
HHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA