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The map label for this gene is argH [H]

Identifier: 66768197

GI number: 66768197

Start: 2270229

End: 2271524

Strand: Direct

Name: argH [H]

Synonym: XC_1876

Alternate gene names: 66768197

Gene position: 2270229-2271524 (Clockwise)

Preceding gene: 66768196

Following gene: 66768198

Centisome position: 44.09

GC content: 67.67

Gene sequence:

>1296_bases
ATGACCAATCTGTTGTGGCAAAAACCCGGCGTGGCGGTGGACGCCAAGATCCAGACCTTCCTGGCCGGCGATGACGTCAT
CCTGGACCGCGAGTTCTTCCTGTATGACATCGCGGCCAGCAAGGCGCATGCGCAGGGGCTGCAGCACATCGGCATCCTGT
CGCTGGAGGAACTGGGCGGGCTGAGCGAGCAGCTGGATCTGCTGGCCGACGACTTCCGTAGCGGCGCGTTCGTGCTCGAT
GCGCATTACGAGGATTGCCATTCGGCCATCGAAGCGCGGCTGACCGAATGCCTGGGCGATGCCGGCCGCAAGATCCACAC
CGGGCGCAGCCGCAACGACCAGATCCTGGTGGCCACGCGGCTATGGTTGAAGGACAAGCTGCAGCGCGTGGCCGCGCTCA
GCACCGAGGTGGCCAAGGTGGCGCTGGACCGCGCACAGGCCGAAGCCGAGCTACCGGTGCCCGGCTACACGCACATCCAG
CGAGCGGTGGTGTCCTCGGCCGGCATGTGGTGGGCGGGGTGGGCCGAGGCCTTCATCGACAACGCCGTGCGCGCCAACGA
CACCTTCAAGCTGGTAGACACCAACCCGCTGGGCACCGCCGCGGGTTATGGCGTCAATCTGCCGCTGGACCGAGCGCACA
CCACCGCCGAACTTGGCTTCGCGCGCCTGCAGGTCTCGCCCATCTACGCACAGCTCTCGCGTGGCAAGTTCGAACTGGCT
GCACTGGAAGCGCTGGGTGGCGCAACGCTGGACCTGCGCCGGATTGCCTGGGATCTGTCGTTGTTCACCAGCGGCGAATT
CGCCTTTGTCGCGCTGCCGGCGCAGTACACCACGGGCAGTTCGATCATGCCGAACAAGCGCAACCCCGATGTCATCGAAT
TGATGCGCGCCACCCACGCCAGCGTGGCAGCGGCGCGCACCGAGATCGAACAGCTGCTGTCGCTGCCGTCCGGCTACCAC
CGCGATCTGCAGAGCAGCAAGGGCGCGATCGTGCACGGCTTTGCGCGCGGCCTGGCCGCGCTGGAGCTTTTGCCGGCCTT
GCTGGCCAACCTGGAATGGCGGCCGGACAAGCTGCGTTCGGCGATCGATTCGGGCATGTACGCCACCGATGTGGCGGTGG
AAGCCGCCGTGGCCGGGGTGCCGTTCCGCGACGCCTACAAGGCGGCCGCCGCCGCGTCTGACAGCGCAGGGCAGGGACGC
ACACCGGAAGGCAGCCTGGCCGCACGCGTGTCGCCCGGTGCGGCGGCCGACCTGCAGCTGGATGTGCTGCGCGCCCGCTG
GGAGGCGCTGCAGTGA

Upstream 100 bases:

>100_bases
GGACGAATTGACCGCAATTGGCTGATGCGCGTCCCTCGCAAGCGCCCGCACATCCATCTGCGGGGATTCAATTGGACGAC
TTATTTCGAGACGCTTTCCG

Downstream 100 bases:

>100_bases
TCCCCACCCTCAGTGCCGACACCGCCGAGCACTATCCCTGGGGCGAGGCCTGCGATGGCTGGCACCTGCTGCGCGACCCG
GGGCTCAGCGTGCTCGAAGA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MTNLLWQKPGVAVDAKIQTFLAGDDVILDREFFLYDIAASKAHAQGLQHIGILSLEELGGLSEQLDLLADDFRSGAFVLD
AHYEDCHSAIEARLTECLGDAGRKIHTGRSRNDQILVATRLWLKDKLQRVAALSTEVAKVALDRAQAEAELPVPGYTHIQ
RAVVSSAGMWWAGWAEAFIDNAVRANDTFKLVDTNPLGTAAGYGVNLPLDRAHTTAELGFARLQVSPIYAQLSRGKFELA
ALEALGGATLDLRRIAWDLSLFTSGEFAFVALPAQYTTGSSIMPNKRNPDVIELMRATHASVAAARTEIEQLLSLPSGYH
RDLQSSKGAIVHGFARGLAALELLPALLANLEWRPDKLRSAIDSGMYATDVAVEAAVAGVPFRDAYKAAAAASDSAGQGR
TPEGSLAARVSPGAAADLQLDVLRARWEALQ

Sequences:

>Translated_431_residues
MTNLLWQKPGVAVDAKIQTFLAGDDVILDREFFLYDIAASKAHAQGLQHIGILSLEELGGLSEQLDLLADDFRSGAFVLD
AHYEDCHSAIEARLTECLGDAGRKIHTGRSRNDQILVATRLWLKDKLQRVAALSTEVAKVALDRAQAEAELPVPGYTHIQ
RAVVSSAGMWWAGWAEAFIDNAVRANDTFKLVDTNPLGTAAGYGVNLPLDRAHTTAELGFARLQVSPIYAQLSRGKFELA
ALEALGGATLDLRRIAWDLSLFTSGEFAFVALPAQYTTGSSIMPNKRNPDVIELMRATHASVAAARTEIEQLLSLPSGYH
RDLQSSKGAIVHGFARGLAALELLPALLANLEWRPDKLRSAIDSGMYATDVAVEAAVAGVPFRDAYKAAAAASDSAGQGR
TPEGSLAARVSPGAAADLQLDVLRARWEALQ
>Mature_430_residues
TNLLWQKPGVAVDAKIQTFLAGDDVILDREFFLYDIAASKAHAQGLQHIGILSLEELGGLSEQLDLLADDFRSGAFVLDA
HYEDCHSAIEARLTECLGDAGRKIHTGRSRNDQILVATRLWLKDKLQRVAALSTEVAKVALDRAQAEAELPVPGYTHIQR
AVVSSAGMWWAGWAEAFIDNAVRANDTFKLVDTNPLGTAAGYGVNLPLDRAHTTAELGFARLQVSPIYAQLSRGKFELAA
LEALGGATLDLRRIAWDLSLFTSGEFAFVALPAQYTTGSSIMPNKRNPDVIELMRATHASVAAARTEIEQLLSLPSGYHR
DLQSSKGAIVHGFARGLAALELLPALLANLEWRPDKLRSAIDSGMYATDVAVEAAVAGVPFRDAYKAAAAASDSAGQGRT
PEGSLAARVSPGAAADLQLDVLRARWEALQ

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=382, Percent_Identity=34.5549738219895, Blast_Score=212, Evalue=5e-55,
Organism=Homo sapiens, GI68303542, Length=382, Percent_Identity=34.5549738219895, Blast_Score=212, Evalue=5e-55,
Organism=Homo sapiens, GI68303549, Length=382, Percent_Identity=33.5078534031414, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI68303547, Length=381, Percent_Identity=33.0708661417323, Blast_Score=193, Evalue=3e-49,
Organism=Escherichia coli, GI1790398, Length=397, Percent_Identity=31.9899244332494, Blast_Score=192, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6321806, Length=374, Percent_Identity=29.6791443850267, Blast_Score=171, Evalue=2e-43,
Organism=Drosophila melanogaster, GI221473854, Length=359, Percent_Identity=31.4763231197772, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI78706858, Length=359, Percent_Identity=31.4763231197772, Blast_Score=184, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 46319; Mature: 46188

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNLLWQKPGVAVDAKIQTFLAGDDVILDREFFLYDIAASKAHAQGLQHIGILSLEELGG
CCCCCCCCCCCEEECEEEEEECCCCEEECCCEEEEEHHHHHHHHHHHHHCCCEEHHHHCC
LSEQLDLLADDFRSGAFVLDAHYEDCHSAIEARLTECLGDAGRKIHTGRSRNDQILVATR
CHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCEEEEEHH
LWLKDKLQRVAALSTEVAKVALDRAQAEAELPVPGYTHIQRAVVSSAGMWWAGWAEAFID
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHH
NAVRANDTFKLVDTNPLGTAAGYGVNLPLDRAHTTAELGFARLQVSPIYAQLSRGKFELA
CCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHEEEHHHHHHHCCCCCHHH
ALEALGGATLDLRRIAWDLSLFTSGEFAFVALPAQYTTGSSIMPNKRNPDVIELMRATHA
HHHHHCCCCHHHHHHHHHHHEEECCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHH
SVAAARTEIEQLLSLPSGYHRDLQSSKGAIVHGFARGLAALELLPALLANLEWRPDKLRS
HHHHHHHHHHHHHCCCCCHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
AIDSGMYATDVAVEAAVAGVPFRDAYKAAAAASDSAGQGRTPEGSLAARVSPGAAADLQL
HHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCHHH
DVLRARWEALQ
HHHHHHHHHCC
>Mature Secondary Structure 
TNLLWQKPGVAVDAKIQTFLAGDDVILDREFFLYDIAASKAHAQGLQHIGILSLEELGG
CCCCCCCCCCEEECEEEEEECCCCEEECCCEEEEEHHHHHHHHHHHHHCCCEEHHHHCC
LSEQLDLLADDFRSGAFVLDAHYEDCHSAIEARLTECLGDAGRKIHTGRSRNDQILVATR
CHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCEEEEEHH
LWLKDKLQRVAALSTEVAKVALDRAQAEAELPVPGYTHIQRAVVSSAGMWWAGWAEAFID
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHH
NAVRANDTFKLVDTNPLGTAAGYGVNLPLDRAHTTAELGFARLQVSPIYAQLSRGKFELA
CCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHEEEHHHHHHHCCCCCHHH
ALEALGGATLDLRRIAWDLSLFTSGEFAFVALPAQYTTGSSIMPNKRNPDVIELMRATHA
HHHHHCCCCHHHHHHHHHHHEEECCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHH
SVAAARTEIEQLLSLPSGYHRDLQSSKGAIVHGFARGLAALELLPALLANLEWRPDKLRS
HHHHHHHHHHHHHCCCCCHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
AIDSGMYATDVAVEAAVAGVPFRDAYKAAAAASDSAGQGRTPEGSLAARVSPGAAADLQL
HHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCHHH
DVLRARWEALQ
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]