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The map label for this gene is argB [H]

Identifier: 66768194

GI number: 66768194

Start: 2267246

End: 2268589

Strand: Direct

Name: argB [H]

Synonym: XC_1873

Alternate gene names: 66768194

Gene position: 2267246-2268589 (Clockwise)

Preceding gene: 66768193

Following gene: 66768195

Centisome position: 44.04

GC content: 62.5

Gene sequence:

>1344_bases
ATGTCCCTTCCTGCACAGCCCCACAAACAGACCCGCCAGACCATCGTGCGCCTGCTTTCGAGCATGGCCAGCGCGAAAGA
GATCAGCCAGTACCTGAAGCGTTTCTCGCAGCTGGACGCCAAGCGCTTTGCGGTGGTCAAGGTGGGCGGCGCGGTGTTGC
GCGACGACCTGGAGGCGCTGACCTCGTCGTTGTCGTTCCTGCAGGAAGTAGGGCTCACCCCGATCGTGCTGCACGGCGCG
GGCCCGCAGCTGGATGCCGAGCTATCGGCCGCCGGCATCGAAAAGCAGACCGTCAACGGCCTGCGCGTGACCTCGCCGCA
TGCCCTGGCGATCGTGCGCAAGGTGTTTCAGGCCTCCAACCTCAAGCTGGTGGAAGCGCTGCAGCAGAACGGCGCGCGTG
CGACTTCGATCACCGGCGGCGTTTTTGAAGCCGAATATCTGAATCGCGACACCTACGGCCTGGTCGGCGAGGTCAAGGCA
GTGAATCTGGCGCCGATCGAGGCCAGCCTGCAGGCCGGTTCGATCCCGGTGATCACCAGCCTGGGCGAGACCCCGAGCGG
GCAGATCCTCAACGTCAACGCCGATTTTGCCGCCAACGAATTGGTGCAGGAACTGCAGCCGTACAAGATCATCTTCCTCA
CCGGCACCGGCGGCTTGCTGGATGCCGAAGGCAAGCTGATCGACTCGATCAACCTGTCCACCGAATACGACCATCTGATG
CAGCAGCCGTGGATCAACGGCGGCATGCGGGTGAAGATCGAACAGATCAAGGATCTGCTCGATCGGCTGCCGCTGGAGTC
GTCGGTGTCGATCACCCGGCCGGCGGATCTGGCCAAGGAACTGTTCACCCACAAGGGTTCCGGCACGTTGGTGCGGCGTG
GCGAGCGCGTACTGCGCGCGACCTCGTGGGACGAACTGGATCTGCCGCGGCTCACCTCGCTGATCGAATCCAGCTTCGGC
CGTACGCTGGTGCCCGATTACTTCAGCAACACCAAGTTGCTGCGTGCCTATGTCAGCGAGAACTATCGCGCGGCGGTGAT
CCTCACCGATGAGGGCATGCTGGGTGCAAGCGCGCTGATCTATCTGGACAAGTTTGCCGTGCTCGACGATGCGCAAGGCG
AGGGCCTGGGCCGTGCGGTCTGGAACGTGATGCGCGAAGAAACCCCGCAGCTGTTCTGGCGCTCGCGTCACAACAACCAG
GTCAACATCTTCTACTACGCCGAATCCGACGGCTGCATCAAGCAGGAAAAGTGGAAGGTGTTCTGGTATGGGCTGGAGAA
CTTCGAGCAGATCCAGCACTGCGTGGCGCATTGCGCGACGCGTCAACCCACCTTGCTGGGGTGA

Upstream 100 bases:

>100_bases
GTTGCAGCGCTACGTCGAGTCGGTCAACCGCATCATCAACGGCTCGCACTGAGCCTGCGTTCCGCGCCTGGCGCGGCCAT
TCCTCCCAACGATCACCGCA

Downstream 100 bases:

>100_bases
GTGCAATGACGGCCGCCGCATCGCAAACGCTCTGGCGCGAGGTGCCCACCTTGCGCGGCCAGCACGTCACGCTGGAGCCA
TTGCGCGCTGCCCACGCCGA

Product: acetylglutamate kinase

Products: NA

Alternate protein names: N-acetyl-L-glutamate 5-phosphotransferase; NAG kinase; AGK [H]

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MSLPAQPHKQTRQTIVRLLSSMASAKEISQYLKRFSQLDAKRFAVVKVGGAVLRDDLEALTSSLSFLQEVGLTPIVLHGA
GPQLDAELSAAGIEKQTVNGLRVTSPHALAIVRKVFQASNLKLVEALQQNGARATSITGGVFEAEYLNRDTYGLVGEVKA
VNLAPIEASLQAGSIPVITSLGETPSGQILNVNADFAANELVQELQPYKIIFLTGTGGLLDAEGKLIDSINLSTEYDHLM
QQPWINGGMRVKIEQIKDLLDRLPLESSVSITRPADLAKELFTHKGSGTLVRRGERVLRATSWDELDLPRLTSLIESSFG
RTLVPDYFSNTKLLRAYVSENYRAAVILTDEGMLGASALIYLDKFAVLDDAQGEGLGRAVWNVMREETPQLFWRSRHNNQ
VNIFYYAESDGCIKQEKWKVFWYGLENFEQIQHCVAHCATRQPTLLG

Sequences:

>Translated_447_residues
MSLPAQPHKQTRQTIVRLLSSMASAKEISQYLKRFSQLDAKRFAVVKVGGAVLRDDLEALTSSLSFLQEVGLTPIVLHGA
GPQLDAELSAAGIEKQTVNGLRVTSPHALAIVRKVFQASNLKLVEALQQNGARATSITGGVFEAEYLNRDTYGLVGEVKA
VNLAPIEASLQAGSIPVITSLGETPSGQILNVNADFAANELVQELQPYKIIFLTGTGGLLDAEGKLIDSINLSTEYDHLM
QQPWINGGMRVKIEQIKDLLDRLPLESSVSITRPADLAKELFTHKGSGTLVRRGERVLRATSWDELDLPRLTSLIESSFG
RTLVPDYFSNTKLLRAYVSENYRAAVILTDEGMLGASALIYLDKFAVLDDAQGEGLGRAVWNVMREETPQLFWRSRHNNQ
VNIFYYAESDGCIKQEKWKVFWYGLENFEQIQHCVAHCATRQPTLLG
>Mature_446_residues
SLPAQPHKQTRQTIVRLLSSMASAKEISQYLKRFSQLDAKRFAVVKVGGAVLRDDLEALTSSLSFLQEVGLTPIVLHGAG
PQLDAELSAAGIEKQTVNGLRVTSPHALAIVRKVFQASNLKLVEALQQNGARATSITGGVFEAEYLNRDTYGLVGEVKAV
NLAPIEASLQAGSIPVITSLGETPSGQILNVNADFAANELVQELQPYKIIFLTGTGGLLDAEGKLIDSINLSTEYDHLMQ
QPWINGGMRVKIEQIKDLLDRLPLESSVSITRPADLAKELFTHKGSGTLVRRGERVLRATSWDELDLPRLTSLIESSFGR
TLVPDYFSNTKLLRAYVSENYRAAVILTDEGMLGASALIYLDKFAVLDDAQGEGLGRAVWNVMREETPQLFWRSRHNNQV
NIFYYAESDGCIKQEKWKVFWYGLENFEQIQHCVAHCATRQPTLLG

Specific function: Arginine biosynthesis; second step. [C]

COG id: COG0548

COG function: function code E; Acetylglutamate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the N-terminal section; belongs to the acetylglutamate kinase family [H]

Homologues:

Organism=Homo sapiens, GI23308587, Length=422, Percent_Identity=34.5971563981043, Blast_Score=228, Evalue=7e-60,
Organism=Escherichia coli, GI145693208, Length=243, Percent_Identity=27.9835390946502, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789181, Length=284, Percent_Identity=21.830985915493, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320913, Length=445, Percent_Identity=41.7977528089888, Blast_Score=344, Evalue=1e-95,
Organism=Saccharomyces cerevisiae, GI6322390, Length=138, Percent_Identity=34.0579710144928, Blast_Score=71, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011242
- InterPro:   IPR004662
- InterPro:   IPR001048
- InterPro:   IPR006855 [H]

Pfam domain/function: PF00696 AA_kinase; PF04768 DUF619 [H]

EC number: =2.7.2.8 [H]

Molecular weight: Translated: 49327; Mature: 49196

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLPAQPHKQTRQTIVRLLSSMASAKEISQYLKRFSQLDAKRFAVVKVGGAVLRDDLEAL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEECHHHHHHHHHHH
TSSLSFLQEVGLTPIVLHGAGPQLDAELSAAGIEKQTVNGLRVTSPHALAIVRKVFQASN
HHHHHHHHHCCCCEEEEECCCCCCCCHHHHCCCCHHHCCCEEECCCHHHHHHHHHHHCCC
LKLVEALQQNGARATSITGGVFEAEYLNRDTYGLVGEVKAVNLAPIEASLQAGSIPVITS
HHHHHHHHHCCCEEEEECCCCEEHHHHCCCCCCCCCCEEEEEEECCHHCCCCCCCCEEEE
LGETPSGQILNVNADFAANELVQELQPYKIIFLTGTGGLLDAEGKLIDSINLSTEYDHLM
CCCCCCCCEEEECCCHHHHHHHHHCCCEEEEEEECCCCEEECCCCEEEEECCCHHHHHHH
QQPWINGGMRVKIEQIKDLLDRLPLESSVSITRPADLAKELFTHKGSGTLVRRGERVLRA
HCCCCCCCCEEEHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHCCHHHHHC
TSWDELDLPRLTSLIESSFGRTLVPDYFSNTKLLRAYVSENYRAAVILTDEGMLGASALI
CCCCCCCHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHCCCCEEEEEEECCCCCCHHHHH
YLDKFAVLDDAQGEGLGRAVWNVMREETPQLFWRSRHNNQVNIFYYAESDGCIKQEKWKV
HHHHHHEECCCCCCCHHHHHHHHHHHHCHHHHHHCCCCCEEEEEEEECCCCCCCCCCEEE
FWYGLENFEQIQHCVAHCATRQPTLLG
EEEEHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SLPAQPHKQTRQTIVRLLSSMASAKEISQYLKRFSQLDAKRFAVVKVGGAVLRDDLEAL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEECHHHHHHHHHHH
TSSLSFLQEVGLTPIVLHGAGPQLDAELSAAGIEKQTVNGLRVTSPHALAIVRKVFQASN
HHHHHHHHHCCCCEEEEECCCCCCCCHHHHCCCCHHHCCCEEECCCHHHHHHHHHHHCCC
LKLVEALQQNGARATSITGGVFEAEYLNRDTYGLVGEVKAVNLAPIEASLQAGSIPVITS
HHHHHHHHHCCCEEEEECCCCEEHHHHCCCCCCCCCCEEEEEEECCHHCCCCCCCCEEEE
LGETPSGQILNVNADFAANELVQELQPYKIIFLTGTGGLLDAEGKLIDSINLSTEYDHLM
CCCCCCCCEEEECCCHHHHHHHHHCCCEEEEEEECCCCEEECCCCEEEEECCCHHHHHHH
QQPWINGGMRVKIEQIKDLLDRLPLESSVSITRPADLAKELFTHKGSGTLVRRGERVLRA
HCCCCCCCCEEEHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHCCHHHHHC
TSWDELDLPRLTSLIESSFGRTLVPDYFSNTKLLRAYVSENYRAAVILTDEGMLGASALI
CCCCCCCHHHHHHHHHHHCCCCCCCHHHCCHHHHHHHHCCCCEEEEEEECCCCCCHHHHH
YLDKFAVLDDAQGEGLGRAVWNVMREETPQLFWRSRHNNQVNIFYYAESDGCIKQEKWKV
HHHHHHEECCCCCCCHHHHHHHHHHHHCHHHHHHCCCCCEEEEEEEECCCCCCCCCCEEE
FWYGLENFEQIQHCVAHCATRQPTLLG
EEEEHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]