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The map label for this gene is cysS

Identifier: 66768188

GI number: 66768188

Start: 2260796

End: 2262169

Strand: Reverse

Name: cysS

Synonym: XC_1867

Alternate gene names: 66768188

Gene position: 2262169-2260796 (Counterclockwise)

Preceding gene: 66768203

Following gene: 66768187

Centisome position: 43.94

GC content: 67.69

Gene sequence:

>1374_bases
ATGCCGATGAGCCTGCGCCTGCACAACAACCTGACGCGGCGGGTCGAGCCGTTCGCACCGCTCGATCCGTCCAGCCCCAC
CCTGTATGTGTGCGGGCCCACGGTCTACAACTATGCGCATATCGGCAATGCGCGTGGCCCGGTGGTGTTCGATGTGCTGG
CGGCGCTGCTGCGCCGGCGCTATGGCGCGCTGCGCTACGCACGCAACATCACTGACGTGGACGACAAGATCAACGCCGCC
GCCCAGGCCCAGGGCGTGCCGATCTCCACCATCACTGACCGCTTCGCGGCGATCTACCGCCAGGACATGGCCGCGCTCGG
TGTGGTGCCGCCGGATATCGAGCCGGAGGCAACCGCGCACATCCCGCAGATCGTGGCGATGATCGAACAGCTGATCGCCA
GCGCGCATGCCTATGCCGCCGAAGGCCATGTGCTGTTCGCGGTGGCCAGCTTTGCCGACTACGGCAAGCTGTCACGCCGC
GATCCCGATGAAATGCTGGCCGGCGCACGCGTCGATGTGGCGCCCTACAAACGCGACCCTGGCGACTTCGTGCTGTGGAA
GCCCTCCAGCGACGACCTGCCCGGCTGGGACTCGCCGTGGGGCCGCGGCCGCCCCGGCTGGCATATCGAATGCTCGGCAA
TGGCCGCCACGCATCTCGGGCCGACCATCGACATCCACGCCGGCGGCGTGGACCTGCAGTTCCCGCATCACGAAAACGAA
ATTGCGCAGAGCGAGTGCGCCCACGGCGGCGCCGTCTTCGCACGGTTCTGGTTGCACAACGGCATGCTCAACTTCAGCGG
CGCCAAGATGAGCAAGTCGCTGGGCAACATCGAGACCGTGCACGACCTGATCGCCAAGCACCCGCCCGAAGCGCTGCGTT
ATGCGTTGTTGAGCGCGCACTACCGGCAACCGCTGGACTGGTCGGATGGCTTGATCGAACAGGCCAAGAACACCCTGGAC
CGGCTGTACGGCACGCTGCGCGACCTGCATGACGTGGCTGCAAGCGCGGTGATCCCCGCACCGGTCGAGGCCGCGCTGGA
CGACGACCTCAACACCCCGCAGGCGCTGGCCGAAGTGGCGCGCATCGCCGGCGAGGCACGCAAGGCCAATGACGCCGCCG
ACCGGGCCCGGTTGAAGGCCGAGCTGCTCGGTGCGGGCCTCGCGTTGGGGCTGCTGCAGCAGGAACCGGCCGCGTGGTTT
TCGCGTGGTGCCGACGCCGGCGACGATGCCCGTATCGCCGCCCTGGTCGACGAACGCAGCGCGGCGAAAAAAGCCAAGGA
TTTCGCCCGCGCCGATGCCATCCGCCAGCAGCTGGCCGACGAAGGCATCGTGCTGGAAGACACTGCGCAGGGCGTGCGCT
GGAAGCGCGCATGA

Upstream 100 bases:

>100_bases
GAGACCTTGGGCTGAACGCAGCCCATCCGTTGCCATCGCTTGTCTGCCGGTTCGCCGCATCGCCGCGACCGGCTAGAATC
GCGCAGTTACCCTCGCCAAG

Downstream 100 bases:

>100_bases
CTTTATTCCCTTCTCCCTCCGGGAGAAGGTGCCCCGCAGGGGCGGATGAGGGTACTAGCGAAGCCACGTGCATCGATTTT
TTTGAGGTAAGCGCGAAGCC

Product: cysteinyl-tRNA synthetase

Products: NA

Alternate protein names: Cysteine--tRNA ligase; CysRS

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MPMSLRLHNNLTRRVEPFAPLDPSSPTLYVCGPTVYNYAHIGNARGPVVFDVLAALLRRRYGALRYARNITDVDDKINAA
AQAQGVPISTITDRFAAIYRQDMAALGVVPPDIEPEATAHIPQIVAMIEQLIASAHAYAAEGHVLFAVASFADYGKLSRR
DPDEMLAGARVDVAPYKRDPGDFVLWKPSSDDLPGWDSPWGRGRPGWHIECSAMAATHLGPTIDIHAGGVDLQFPHHENE
IAQSECAHGGAVFARFWLHNGMLNFSGAKMSKSLGNIETVHDLIAKHPPEALRYALLSAHYRQPLDWSDGLIEQAKNTLD
RLYGTLRDLHDVAASAVIPAPVEAALDDDLNTPQALAEVARIAGEARKANDAADRARLKAELLGAGLALGLLQQEPAAWF
SRGADAGDDARIAALVDERSAAKKAKDFARADAIRQQLADEGIVLEDTAQGVRWKRA

Sequences:

>Translated_457_residues
MPMSLRLHNNLTRRVEPFAPLDPSSPTLYVCGPTVYNYAHIGNARGPVVFDVLAALLRRRYGALRYARNITDVDDKINAA
AQAQGVPISTITDRFAAIYRQDMAALGVVPPDIEPEATAHIPQIVAMIEQLIASAHAYAAEGHVLFAVASFADYGKLSRR
DPDEMLAGARVDVAPYKRDPGDFVLWKPSSDDLPGWDSPWGRGRPGWHIECSAMAATHLGPTIDIHAGGVDLQFPHHENE
IAQSECAHGGAVFARFWLHNGMLNFSGAKMSKSLGNIETVHDLIAKHPPEALRYALLSAHYRQPLDWSDGLIEQAKNTLD
RLYGTLRDLHDVAASAVIPAPVEAALDDDLNTPQALAEVARIAGEARKANDAADRARLKAELLGAGLALGLLQQEPAAWF
SRGADAGDDARIAALVDERSAAKKAKDFARADAIRQQLADEGIVLEDTAQGVRWKRA
>Mature_456_residues
PMSLRLHNNLTRRVEPFAPLDPSSPTLYVCGPTVYNYAHIGNARGPVVFDVLAALLRRRYGALRYARNITDVDDKINAAA
QAQGVPISTITDRFAAIYRQDMAALGVVPPDIEPEATAHIPQIVAMIEQLIASAHAYAAEGHVLFAVASFADYGKLSRRD
PDEMLAGARVDVAPYKRDPGDFVLWKPSSDDLPGWDSPWGRGRPGWHIECSAMAATHLGPTIDIHAGGVDLQFPHHENEI
AQSECAHGGAVFARFWLHNGMLNFSGAKMSKSLGNIETVHDLIAKHPPEALRYALLSAHYRQPLDWSDGLIEQAKNTLDR
LYGTLRDLHDVAASAVIPAPVEAALDDDLNTPQALAEVARIAGEARKANDAADRARLKAELLGAGLALGLLQQEPAAWFS
RGADAGDDARIAALVDERSAAKKAKDFARADAIRQQLADEGIVLEDTAQGVRWKRA

Specific function: Unknown

COG id: COG0215

COG function: function code J; Cysteinyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI13375695, Length=483, Percent_Identity=35.6107660455487, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI10835051, Length=247, Percent_Identity=40.4858299595142, Blast_Score=201, Evalue=8e-52,
Organism=Homo sapiens, GI62240992, Length=247, Percent_Identity=40.4858299595142, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI21269877, Length=247, Percent_Identity=40.4858299595142, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI303304987, Length=247, Percent_Identity=40.4858299595142, Blast_Score=201, Evalue=1e-51,
Organism=Escherichia coli, GI1786737, Length=460, Percent_Identity=48.2608695652174, Blast_Score=394, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17509797, Length=249, Percent_Identity=37.7510040160643, Blast_Score=178, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI17509795, Length=249, Percent_Identity=37.7510040160643, Blast_Score=178, Evalue=5e-45,
Organism=Saccharomyces cerevisiae, GI6324082, Length=302, Percent_Identity=34.4370860927152, Blast_Score=197, Evalue=2e-51,
Organism=Drosophila melanogaster, GI19922218, Length=504, Percent_Identity=33.7301587301587, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI19922364, Length=250, Percent_Identity=40.8, Blast_Score=204, Evalue=1e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYC_XANC8 (Q4UVJ3)

Other databases:

- EMBL:   CP000050
- RefSeq:   YP_242950.1
- ProteinModelPortal:   Q4UVJ3
- SMR:   Q4UVJ3
- STRING:   Q4UVJ3
- GeneID:   3380414
- GenomeReviews:   CP000050_GR
- KEGG:   xcb:XC_1867
- eggNOG:   COG0215
- HOGENOM:   HBG327651
- OMA:   PEEMLAG
- PhylomeDB:   Q4UVJ3
- ProtClustDB:   PRK00260
- BioCyc:   XCAM314565:XC_1867-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00041_B
- InterPro:   IPR015803
- InterPro:   IPR015273
- InterPro:   IPR014729
- InterPro:   IPR009080
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR10890
- PRINTS:   PR00983
- SMART:   SM00840
- TIGRFAMs:   TIGR00435

Pfam domain/function: PF09190 DALR_2; PF01406 tRNA-synt_1e; SSF47323 tRNAsyn_1a_bind

EC number: =6.1.1.16

Molecular weight: Translated: 49558; Mature: 49427

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: BINDING 272-272

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMSLRLHNNLTRRVEPFAPLDPSSPTLYVCGPTVYNYAHIGNARGPVVFDVLAALLRRR
CCCEEEHHCCHHHHCCCCCCCCCCCCEEEEECCCHHHHHHCCCCCCCHHHHHHHHHHHHH
YGALRYARNITDVDDKINAAAQAQGVPISTITDRFAAIYRQDMAALGVVPPDIEPEATAH
HHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
IPQIVAMIEQLIASAHAYAAEGHVLFAVASFADYGKLSRRDPDEMLAGARVDVAPYKRDP
HHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHCCCCCHHHHHCCCCEEECCCCCCC
GDFVLWKPSSDDLPGWDSPWGRGRPGWHIECSAMAATHLGPTIDIHAGGVDLQFPHHENE
CCEEEECCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHCCCEEEEECCCEEEECCCCHHH
IAQSECAHGGAVFARFWLHNGMLNFSGAKMSKSLGNIETVHDLIAKHPPEALRYALLSAH
HHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHH
YRQPLDWSDGLIEQAKNTLDRLYGTLRDLHDVAASAVIPAPVEAALDDDLNTPQALAEVA
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHH
RIAGEARKANDAADRARLKAELLGAGLALGLLQQEPAAWFSRGADAGDDARIAALVDERS
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCEEEHHHHHHH
AAKKAKDFARADAIRQQLADEGIVLEDTAQGVRWKRA
HHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCEECCC
>Mature Secondary Structure 
PMSLRLHNNLTRRVEPFAPLDPSSPTLYVCGPTVYNYAHIGNARGPVVFDVLAALLRRR
CCEEEHHCCHHHHCCCCCCCCCCCCEEEEECCCHHHHHHCCCCCCCHHHHHHHHHHHHH
YGALRYARNITDVDDKINAAAQAQGVPISTITDRFAAIYRQDMAALGVVPPDIEPEATAH
HHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
IPQIVAMIEQLIASAHAYAAEGHVLFAVASFADYGKLSRRDPDEMLAGARVDVAPYKRDP
HHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHCCCCCHHHHHCCCCEEECCCCCCC
GDFVLWKPSSDDLPGWDSPWGRGRPGWHIECSAMAATHLGPTIDIHAGGVDLQFPHHENE
CCEEEECCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHCCCEEEEECCCEEEECCCCHHH
IAQSECAHGGAVFARFWLHNGMLNFSGAKMSKSLGNIETVHDLIAKHPPEALRYALLSAH
HHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHH
YRQPLDWSDGLIEQAKNTLDRLYGTLRDLHDVAASAVIPAPVEAALDDDLNTPQALAEVA
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHH
RIAGEARKANDAADRARLKAELLGAGLALGLLQQEPAAWFSRGADAGDDARIAALVDERS
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCEEEHHHHHHH
AAKKAKDFARADAIRQQLADEGIVLEDTAQGVRWKRA
HHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA