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The map label for this gene is mutY [H]

Identifier: 66768018

GI number: 66768018

Start: 2033091

End: 2034161

Strand: Reverse

Name: mutY [H]

Synonym: XC_1694

Alternate gene names: 66768018

Gene position: 2034161-2033091 (Counterclockwise)

Preceding gene: 66768019

Following gene: 66768017

Centisome position: 39.51

GC content: 66.76

Gene sequence:

>1071_bases
ATGCCCGTACCCGCCACGCTCACCACCGATGCGTTCGTCGACCGTCTGCTGCACTGGTTCGACGGCCACGGCCGGCACGA
CCTGCCCTGGCAGCATCCGCGCGCGCCCTACCGGGTGTGGTTGTCGGAAATCATGTTGCAGCAGACCCAGGTCGCGGTGG
TGATCCCGTACTTCCAGAAGTTCGTCGCCAGCTTCCCGACCCTGGCCGATCTGGCCGCCGCCGACAACGACACGGTGATG
GCGCACTGGGCCGGGCTGGGTTACTACGCGCGTGCTCGCAACCTGCATGCCGCCGCCAAGCAGTGCGTGGCCTTGCATGC
AGGCGAGTTGCCGCGCGATTTCGATGCGCTGCTGGCGCTGCCCGGCATCGGCCGCAGCACCGCCGGCGCGATCCTCAGCC
AGGCCTGGAACGACCGCTTTCCAATCATGGATGGCAACGTCAAACGCGTACTCACGCGCATCCACGGCATTGCCGGCTAT
CCCGGCTTGCCAGTCGTGGAAAAACAGCTATGGCAGTTGGCGGCGAACCATGTCGCCCACGTGCCCGCCGGCCGCCTGGC
CGACTACACGCAGGCACAGATGGATTTCGGCGCCACGCTGTGCACGCGCGCCAGACCGGCGTGCATGGTGTGCCCGCTGC
AGGAAAACTGCGTGGCGCGCCGCGAAGGCCTGGTCGAGGCACTGCCCACGCCCAAGCCCGGCAAGCAATTGCCCGAGCGC
GAGGCCACCGCGCTGCTGCTGGAAAACGCGCACAACGAGATCCTGCTGCAACGCCGCCCGCCCACCGGCATCTGGGCGTC
GCTGTGGACGCTGCCACAAGCCGAAACCGACAGCGACCTGCGTGAGTGGTTCGCCGCGCATATCGATGGCGATTACGACC
GTGCCGACGAAATGCCGATGATCGTGCACACCTTCAGCCACTACCGTCTGCATTTGCAGCCACTGCGCCTGCGCAAGGTC
GCGCTGCGCCAGGTGCTGCGCGACAACGACGACCTGCGTTGGGTGGCACGCGCAGACCTTGCAACGCTGGGTCTGCCGGC
GCCGATCCGCAAATTGCTCGACGCGTTGTAA

Upstream 100 bases:

>100_bases
TCGCACGAAGCGCGCAGCCGCATGCGGGATGAAGTCACCACCCCGCTTTTTTTGCACACCAACCGCCTTGACCCTTCGCC
TTCCCACGCCAGCAGACCCC

Downstream 100 bases:

>100_bases
ACGCGCCGCACGAGAACCACGTGCGCAGGCAACCGCGGCTCGGCTTTGACAGAACACGGGCTTACACTGCGACTCCAGCG
CACCGTGTGTTGGTTGAGCC

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MPVPATLTTDAFVDRLLHWFDGHGRHDLPWQHPRAPYRVWLSEIMLQQTQVAVVIPYFQKFVASFPTLADLAAADNDTVM
AHWAGLGYYARARNLHAAAKQCVALHAGELPRDFDALLALPGIGRSTAGAILSQAWNDRFPIMDGNVKRVLTRIHGIAGY
PGLPVVEKQLWQLAANHVAHVPAGRLADYTQAQMDFGATLCTRARPACMVCPLQENCVARREGLVEALPTPKPGKQLPER
EATALLLENAHNEILLQRRPPTGIWASLWTLPQAETDSDLREWFAAHIDGDYDRADEMPMIVHTFSHYRLHLQPLRLRKV
ALRQVLRDNDDLRWVARADLATLGLPAPIRKLLDAL

Sequences:

>Translated_356_residues
MPVPATLTTDAFVDRLLHWFDGHGRHDLPWQHPRAPYRVWLSEIMLQQTQVAVVIPYFQKFVASFPTLADLAAADNDTVM
AHWAGLGYYARARNLHAAAKQCVALHAGELPRDFDALLALPGIGRSTAGAILSQAWNDRFPIMDGNVKRVLTRIHGIAGY
PGLPVVEKQLWQLAANHVAHVPAGRLADYTQAQMDFGATLCTRARPACMVCPLQENCVARREGLVEALPTPKPGKQLPER
EATALLLENAHNEILLQRRPPTGIWASLWTLPQAETDSDLREWFAAHIDGDYDRADEMPMIVHTFSHYRLHLQPLRLRKV
ALRQVLRDNDDLRWVARADLATLGLPAPIRKLLDAL
>Mature_355_residues
PVPATLTTDAFVDRLLHWFDGHGRHDLPWQHPRAPYRVWLSEIMLQQTQVAVVIPYFQKFVASFPTLADLAAADNDTVMA
HWAGLGYYARARNLHAAAKQCVALHAGELPRDFDALLALPGIGRSTAGAILSQAWNDRFPIMDGNVKRVLTRIHGIAGYP
GLPVVEKQLWQLAANHVAHVPAGRLADYTQAQMDFGATLCTRARPACMVCPLQENCVARREGLVEALPTPKPGKQLPERE
ATALLLENAHNEILLQRRPPTGIWASLWTLPQAETDSDLREWFAAHIDGDYDRADEMPMIVHTFSHYRLHLQPLRLRKVA
LRQVLRDNDDLRWVARADLATLGLPAPIRKLLDAL

Specific function: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine (8-oxo-dGTP) [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI115298650, Length=407, Percent_Identity=33.9066339066339, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI115298648, Length=407, Percent_Identity=33.9066339066339, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI115298654, Length=407, Percent_Identity=33.9066339066339, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI115298652, Length=407, Percent_Identity=33.9066339066339, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI190358497, Length=407, Percent_Identity=33.9066339066339, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI6912520, Length=407, Percent_Identity=33.9066339066339, Blast_Score=187, Evalue=1e-47,
Organism=Escherichia coli, GI1789331, Length=350, Percent_Identity=45.4285714285714, Blast_Score=317, Evalue=5e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 39859; Mature: 39728

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: PS00764 ENDONUCLEASE_III_1 ; PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVPATLTTDAFVDRLLHWFDGHGRHDLPWQHPRAPYRVWLSEIMLQQTQVAVVIPYFQK
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEHHHHHH
FVASFPTLADLAAADNDTVMAHWAGLGYYARARNLHAAAKQCVALHAGELPRDFDALLAL
HHHHCCHHHHHHHCCCCEEEEEHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHC
PGIGRSTAGAILSQAWNDRFPIMDGNVKRVLTRIHGIAGYPGLPVVEKQLWQLAANHVAH
CCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHC
VPAGRLADYTQAQMDFGATLCTRARPACMVCPLQENCVARREGLVEALPTPKPGKQLPER
CCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCHH
EATALLLENAHNEILLQRRPPTGIWASLWTLPQAETDSDLREWFAAHIDGDYDRADEMPM
HHHHHHHHCCCCCEEEEECCCCCHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCH
IVHTFSHYRLHLQPLRLRKVALRQVLRDNDDLRWVARADLATLGLPAPIRKLLDAL
HEEHHHHHHEEECHHHHHHHHHHHHHCCCCCEEEHHHHHHHHCCCCHHHHHHHHCC
>Mature Secondary Structure 
PVPATLTTDAFVDRLLHWFDGHGRHDLPWQHPRAPYRVWLSEIMLQQTQVAVVIPYFQK
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEHHHHHH
FVASFPTLADLAAADNDTVMAHWAGLGYYARARNLHAAAKQCVALHAGELPRDFDALLAL
HHHHCCHHHHHHHCCCCEEEEEHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHC
PGIGRSTAGAILSQAWNDRFPIMDGNVKRVLTRIHGIAGYPGLPVVEKQLWQLAANHVAH
CCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHC
VPAGRLADYTQAQMDFGATLCTRARPACMVCPLQENCVARREGLVEALPTPKPGKQLPER
CCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCHH
EATALLLENAHNEILLQRRPPTGIWASLWTLPQAETDSDLREWFAAHIDGDYDRADEMPM
HHHHHHHHCCCCCEEEEECCCCCHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCH
IVHTFSHYRLHLQPLRLRKVALRQVLRDNDDLRWVARADLATLGLPAPIRKLLDAL
HEEHHHHHHEEECHHHHHHHHHHHHHCCCCCEEEHHHHHHHHCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2197596; 2001994; 9278503; 9846876 [H]