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The map label for this gene is virB10 [H]

Identifier: 66767958

GI number: 66767958

Start: 1960414

End: 1961595

Strand: Direct

Name: virB10 [H]

Synonym: XC_1634

Alternate gene names: 66767958

Gene position: 1960414-1961595 (Clockwise)

Preceding gene: 66767957

Following gene: 66767959

Centisome position: 38.08

GC content: 56.85

Gene sequence:

>1182_bases
GTGAACTCAAACATTCCAAACAGCCCCGAAGAACGCTCCCGGGACAATCGATCGGACGGGCCAGCGACAAACGAGCACGA
TGAGCGTAACAATCCATATTTCGCACGCCAGCAGGCGGCTGCTGAGCCGGATCTGGATGCGAATGAGCCTGTGCTGCGTT
CTAGCGATATGAAGCGGTTGAACCGGAAGGCGCTGGTGTTCCTCGCGTTGCTTGCCGGGCTACTGCTTTTGGCTATTTTC
TGGTTGGCAAATCGGAGTTCTGAAGACTCTGCACCGGTCAAGCCTCGCACCGAAACGGTTGTCGCACCGGCGCTGCCACA
GAGCATGACCGCGCCTGTCGAGATGGCTCCGGTGCCTTTAGCTCAGCAGCCGAGTTTGCCTCCTTTGCCGCCCATGCCTA
CCGATGAAAGCGAGATCGTAGCTTCCGCTCCTCAGCAGCCTCGGGGTCCGACCTTATTGGAGCGACGCATTCTGGCCGAG
CAGTCCGCTACTGCTGGCAGCTCTGATGGTCCCGGTCTGCCGGGCGAACCTAGTGCTCAGCCTAGGGGCCAAGAACAGGA
ACAGGTGACGTTGGCCAAGCCGATTAGCAATCCTGATGGGTTGCTCGTACGTGGCACTTATATCCGTTGTATTCTGGAGA
CGCGGATCATTTCGGATTTCGGTGGCTATACGTCCTGCATCGTTACCGAGCCTGTATACTCGATCAATGGGCACAACCTG
TTGTTACCCAAGGGCTCAAAAATGTTGGGTCAATACGGCGCGGGTGAGCCAACGACCCAGCGTCTGCAGGTTGTTTGGGA
CCGGGTGACCACGCCCACTGGCCTTGATGTCACTCTAATGGGTCCAGGTATCGACACGCTGGGCAGCGCTGGTCATCCTG
GCGACTACAACGCCCACTGGGGCAACAAGATCGCCTCGGCATTGTTTATTAGCCTTTTAAGCGATGCTTTCAAATACGCC
GCTGCAGAATACGGTCCAGAGACGACTACTATTGGCGTTGGCTCCGGGATCGTTACGCAGAGGCCATTCGAGAGCAACAC
TGCAGAGAGCATGCAGCAGCTTGCACAGCAGGCCATGGAAAAGTCAGGTCGTCGCCCGGCAACGCTGACGATCAATCAGG
GAACAGTCCTGAACGTTTACGTTGCAAAGGATGTCGATTTCTCAGCGGTGCTGCCTAAGTGA

Upstream 100 bases:

>100_bases
CGACTGTTGAGGGTAATACCTTGATCGTGCATGGAACCTATCCTTTTCTGGTGGTTCGTCATGGCGATAACGTCGTTGGT
CTGCGAAGGAACAAGCAAAA

Downstream 100 bases:

>100_bases
GCGCGACCACGGCCATGACGATCGACGATTCGCCGACAGCGCGGATCTCGAATGATTTCCTGGATTATCAGTACTCCGTA
CTGGGAATCCTGGATTATCT

Product: VirB10 protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MNSNIPNSPEERSRDNRSDGPATNEHDERNNPYFARQQAAAEPDLDANEPVLRSSDMKRLNRKALVFLALLAGLLLLAIF
WLANRSSEDSAPVKPRTETVVAPALPQSMTAPVEMAPVPLAQQPSLPPLPPMPTDESEIVASAPQQPRGPTLLERRILAE
QSATAGSSDGPGLPGEPSAQPRGQEQEQVTLAKPISNPDGLLVRGTYIRCILETRIISDFGGYTSCIVTEPVYSINGHNL
LLPKGSKMLGQYGAGEPTTQRLQVVWDRVTTPTGLDVTLMGPGIDTLGSAGHPGDYNAHWGNKIASALFISLLSDAFKYA
AAEYGPETTTIGVGSGIVTQRPFESNTAESMQQLAQQAMEKSGRRPATLTINQGTVLNVYVAKDVDFSAVLPK

Sequences:

>Translated_393_residues
MNSNIPNSPEERSRDNRSDGPATNEHDERNNPYFARQQAAAEPDLDANEPVLRSSDMKRLNRKALVFLALLAGLLLLAIF
WLANRSSEDSAPVKPRTETVVAPALPQSMTAPVEMAPVPLAQQPSLPPLPPMPTDESEIVASAPQQPRGPTLLERRILAE
QSATAGSSDGPGLPGEPSAQPRGQEQEQVTLAKPISNPDGLLVRGTYIRCILETRIISDFGGYTSCIVTEPVYSINGHNL
LLPKGSKMLGQYGAGEPTTQRLQVVWDRVTTPTGLDVTLMGPGIDTLGSAGHPGDYNAHWGNKIASALFISLLSDAFKYA
AAEYGPETTTIGVGSGIVTQRPFESNTAESMQQLAQQAMEKSGRRPATLTINQGTVLNVYVAKDVDFSAVLPK
>Mature_393_residues
MNSNIPNSPEERSRDNRSDGPATNEHDERNNPYFARQQAAAEPDLDANEPVLRSSDMKRLNRKALVFLALLAGLLLLAIF
WLANRSSEDSAPVKPRTETVVAPALPQSMTAPVEMAPVPLAQQPSLPPLPPMPTDESEIVASAPQQPRGPTLLERRILAE
QSATAGSSDGPGLPGEPSAQPRGQEQEQVTLAKPISNPDGLLVRGTYIRCILETRIISDFGGYTSCIVTEPVYSINGHNL
LLPKGSKMLGQYGAGEPTTQRLQVVWDRVTTPTGLDVTLMGPGIDTLGSAGHPGDYNAHWGNKIASALFISLLSDAFKYA
AAEYGPETTTIGVGSGIVTQRPFESNTAESMQQLAQQAMEKSGRRPATLTINQGTVLNVYVAKDVDFSAVLPK

Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-

COG id: COG2948

COG function: function code U; Type IV secretory pathway, VirB10 components

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trbI/virB10 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005498 [H]

Pfam domain/function: PF03743 TrbI [H]

EC number: NA

Molecular weight: Translated: 42140; Mature: 42140

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSNIPNSPEERSRDNRSDGPATNEHDERNNPYFARQQAAAEPDLDANEPVLRSSDMKRL
CCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHH
NRKALVFLALLAGLLLLAIFWLANRSSEDSAPVKPRTETVVAPALPQSMTAPVEMAPVPL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCCCEECCCCC
AQQPSLPPLPPMPTDESEIVASAPQQPRGPTLLERRILAEQSATAGSSDGPGLPGEPSAQ
CCCCCCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
PRGQEQEQVTLAKPISNPDGLLVRGTYIRCILETRIISDFGGYTSCIVTEPVYSINGHNL
CCCCCHHHEEEECCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCEEEEEECCEEECCCCEE
LLPKGSKMLGQYGAGEPTTQRLQVVWDRVTTPTGLDVTLMGPGIDTLGSAGHPGDYNAHW
ECCCCHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCHHHHCCCCCCCCCCCHH
GNKIASALFISLLSDAFKYAAAEYGPETTTIGVGSGIVTQRPFESNTAESMQQLAQQAME
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHH
KSGRRPATLTINQGTVLNVYVAKDVDFSAVLPK
HCCCCCEEEEECCCEEEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MNSNIPNSPEERSRDNRSDGPATNEHDERNNPYFARQQAAAEPDLDANEPVLRSSDMKRL
CCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHHHHHH
NRKALVFLALLAGLLLLAIFWLANRSSEDSAPVKPRTETVVAPALPQSMTAPVEMAPVPL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCCCEECCCCC
AQQPSLPPLPPMPTDESEIVASAPQQPRGPTLLERRILAEQSATAGSSDGPGLPGEPSAQ
CCCCCCCCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
PRGQEQEQVTLAKPISNPDGLLVRGTYIRCILETRIISDFGGYTSCIVTEPVYSINGHNL
CCCCCHHHEEEECCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCEEEEEECCEEECCCCEE
LLPKGSKMLGQYGAGEPTTQRLQVVWDRVTTPTGLDVTLMGPGIDTLGSAGHPGDYNAHW
ECCCCHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCHHHHCCCCCCCCCCCHH
GNKIASALFISLLSDAFKYAAAEYGPETTTIGVGSGIVTQRPFESNTAESMQQLAQQAME
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHH
KSGRRPATLTINQGTVLNVYVAKDVDFSAVLPK
HCCCCCEEEEECCCEEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10882236 [H]