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The map label for this gene is nadC [H]

Identifier: 66767935

GI number: 66767935

Start: 1934796

End: 1935668

Strand: Reverse

Name: nadC [H]

Synonym: XC_1611

Alternate gene names: 66767935

Gene position: 1935668-1934796 (Counterclockwise)

Preceding gene: 66767936

Following gene: 66767934

Centisome position: 37.6

GC content: 68.96

Gene sequence:

>873_bases
ATGACCACCACCGCACCTGTCGCGCCAGCCGATGCGCTGGTGGAGGCAGACGTGGCGCGCGCACTGGCCGAAGACATCGG
CAGCGGCGATGTCACCGCCGCACTGCTGCCCGACGCGCCGGACACGGCCTATCTACTGTGCAAGCAGGACGCGGTGATCG
CCGGGCGGCCGTGGTTCGACGCCACGCACCGCGCGCTGGATCCGCAGGTGCAGATCGCATGGCGTATCCAGGAAGGCGAC
CGCGTCGGCGCCGGCACCGTGCTGGCCACCCTGCACGGTCGCAGCCGCAGCCTGGTCAGCGCCGAACGCACCTCGCTCAA
CTTCCTGCAGACACTTTCTGCCACGGCAACCACCACCGCGGCCTACGTCGCAGCGGTGGCCGGCACCGGTGCACGCATCC
TGGACACCCGCAAGACCCTGCCCGGCCTGCGCGCCGCACAGAAATACGCGGTGCGCTGCGGCGGCGGCGACAACCACCGC
ATCGGCCTGTTCGACACCGTGATGCTGAAGGAAAACCACATCCGTGCGGCGGGCTCGCTGAGCGCCGCCGTGCACGCTGC
ACGCGTGCAGCAACCACAGTTGCCGCTGGTGGTGGAGGTGGAAACGCTGGAGCAGCTGCGCGAGGCGCTGCAGGTGGGGT
GCACACGCATCCTCATCGATGATTTCGACCCGGCAATGCGGCGCGCCGCCGTGCAGATCGTGGCCGCGTTGCCGCCAGCG
CAACGCATCCCGCTGGAAGTCTCCGGCAGTGTGGATCTGGCCGGCATTCGCGCCATTGCGCAGGACGGCGTGGATTGCAT
TTCCATCGGCGGCCTGACCAAGCATGTGCAGGCGGTGGATCTGTCGCTCAAGCTGGGGCCGGCGCCTTACTGA

Upstream 100 bases:

>100_bases
AACAGATCTTCCGCGTCGACGATGGCATCCCGGTGCTGCTGGCCGAAGAAGCCATCAACCCCAGCCAGATCGCCGACTTC
CCCGAGAAGTGAGTTCGGCC

Downstream 100 bases:

>100_bases
TTTCACGCCTGTCCGCAGGCAGCTCTGTCAGCCTGCGCGCAGTGTTCTATGCGGAATCGGTAATGACTGCAAAACCTTGG
CCATGGATCTGCCTGCTGCT

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MTTTAPVAPADALVEADVARALAEDIGSGDVTAALLPDAPDTAYLLCKQDAVIAGRPWFDATHRALDPQVQIAWRIQEGD
RVGAGTVLATLHGRSRSLVSAERTSLNFLQTLSATATTTAAYVAAVAGTGARILDTRKTLPGLRAAQKYAVRCGGGDNHR
IGLFDTVMLKENHIRAAGSLSAAVHAARVQQPQLPLVVEVETLEQLREALQVGCTRILIDDFDPAMRRAAVQIVAALPPA
QRIPLEVSGSVDLAGIRAIAQDGVDCISIGGLTKHVQAVDLSLKLGPAPY

Sequences:

>Translated_290_residues
MTTTAPVAPADALVEADVARALAEDIGSGDVTAALLPDAPDTAYLLCKQDAVIAGRPWFDATHRALDPQVQIAWRIQEGD
RVGAGTVLATLHGRSRSLVSAERTSLNFLQTLSATATTTAAYVAAVAGTGARILDTRKTLPGLRAAQKYAVRCGGGDNHR
IGLFDTVMLKENHIRAAGSLSAAVHAARVQQPQLPLVVEVETLEQLREALQVGCTRILIDDFDPAMRRAAVQIVAALPPA
QRIPLEVSGSVDLAGIRAIAQDGVDCISIGGLTKHVQAVDLSLKLGPAPY
>Mature_289_residues
TTTAPVAPADALVEADVARALAEDIGSGDVTAALLPDAPDTAYLLCKQDAVIAGRPWFDATHRALDPQVQIAWRIQEGDR
VGAGTVLATLHGRSRSLVSAERTSLNFLQTLSATATTTAAYVAAVAGTGARILDTRKTLPGLRAAQKYAVRCGGGDNHRI
GLFDTVMLKENHIRAAGSLSAAVHAARVQQPQLPLVVEVETLEQLREALQVGCTRILIDDFDPAMRRAAVQIVAALPPAQ
RIPLEVSGSVDLAGIRAIAQDGVDCISIGGLTKHVQAVDLSLKLGPAPY

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=268, Percent_Identity=35.0746268656716, Blast_Score=126, Evalue=3e-29,
Organism=Escherichia coli, GI1786299, Length=275, Percent_Identity=45.4545454545455, Blast_Score=208, Evalue=3e-55,
Organism=Saccharomyces cerevisiae, GI6321162, Length=296, Percent_Identity=31.0810810810811, Blast_Score=135, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30426; Mature: 30295

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTAPVAPADALVEADVARALAEDIGSGDVTAALLPDAPDTAYLLCKQDAVIAGRPWFD
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEECCCEEECCCCCC
ATHRALDPQVQIAWRIQEGDRVGAGTVLATLHGRSRSLVSAERTSLNFLQTLSATATTTA
HHHHCCCCCEEEEEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AYVAAVAGTGARILDTRKTLPGLRAAQKYAVRCGGGDNHRIGLFDTVMLKENHIRAAGSL
HHHHHHHCCCCEEEECHHHCCCHHHHHHHEEEECCCCCCEEEEEEEEEEECCCCCCCCHH
SAAVHAARVQQPQLPLVVEVETLEQLREALQVGCTRILIDDFDPAMRRAAVQIVAALPPA
HHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHCCCC
QRIPLEVSGSVDLAGIRAIAQDGVDCISIGGLTKHVQAVDLSLKLGPAPY
CCCCEEECCCCCHHHHHHHHHCCCCEEEECCHHHEEEEEEEEEECCCCCC
>Mature Secondary Structure 
TTTAPVAPADALVEADVARALAEDIGSGDVTAALLPDAPDTAYLLCKQDAVIAGRPWFD
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEEEEECCCEEECCCCCC
ATHRALDPQVQIAWRIQEGDRVGAGTVLATLHGRSRSLVSAERTSLNFLQTLSATATTTA
HHHHCCCCCEEEEEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AYVAAVAGTGARILDTRKTLPGLRAAQKYAVRCGGGDNHRIGLFDTVMLKENHIRAAGSL
HHHHHHHCCCCEEEECHHHCCCHHHHHHHEEEECCCCCCEEEEEEEEEEECCCCCCCCHH
SAAVHAARVQQPQLPLVVEVETLEQLREALQVGCTRILIDDFDPAMRRAAVQIVAALPPA
HHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHHCCCC
QRIPLEVSGSVDLAGIRAIAQDGVDCISIGGLTKHVQAVDLSLKLGPAPY
CCCCEEECCCCCHHHHHHHHHCCCCEEEECCHHHEEEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 2430961; 8419294 [H]