Click here to switch to the map view.

The map label for this gene is nuoD [H]

Identifier: 66767916

GI number: 66767916

Start: 1910184

End: 1911491

Strand: Direct

Name: nuoD [H]

Synonym: XC_1592

Alternate gene names: 66767916

Gene position: 1910184-1911491 (Clockwise)

Preceding gene: 66767915

Following gene: 66767917

Centisome position: 37.1

GC content: 61.85

Gene sequence:

>1308_bases
GTGAGTGAGTACCGCCAGGCAACCGATGCCTTCGCGAGCAATCCTGTGGAAAGCAAGCAGGAAATCCGCAATTACACGAT
GAACTTCGGCCCGCAGCATCCTGCGGCGCACGGCGTATTGCGCCTGATCCTGGAAATGGACGGCGAAACCGTGGTGCGTG
CCGACCCGCATATCGGCCTGCTGCACCGTGGCACCGAGAAGCTGGCCGAGTCCAAGCCGTTCAACCAGTCGGTTCCGTAC
ATGGACCGCCTGGATTACGTGTCGATGATGTGCAACGAGCACGCCTACGTGCGCGCGATCGAATCCCTGATGGGGATCGA
AGCGCCGGAGCGCGCGCAGTACATCCGCACGATGTTCGACGAGATCACCCGCATCAAGAACCACCTGATGTGGGTGGGTT
CCAATGCGCTCGACCTCGGCGCGATGGCGGTGATGCTCTACGCCTTCCGCGAGCGCGAAGAATTGATGGACGTCTACGAG
GCGGTCAGTGGCGCGCGCATGCACGCCGCCTATTACCGTCCGGGCGGCGTCTACCGCGATCTGCCTGACCGCATGCCCAA
GTACAAGGAATCGCGTTGGCATAAGGGCGGGGCGCTGACCAAGCTCAACGCCGCGCGCGAAGGCTCGATGCTGGATTTCC
TCGAGAACTTCACCGACACGTTCCCGTCCCGTGTGGACGAATACGAAACGTTGCTGACCGAGAATCGCATCTGGAAGCAG
CGCACCGTGGACGTGGGCATCATCAGCCCGGATCTGGCGCGCGCCTGGGGCATGACCGGTCCGATGCTGCGTGGTTCGGG
CATCGAATGGGATCTGCGCAAGAAGCAGCCGTACGCCAAGTACGACGCGGTGGACTTCGACGTGCCGGTCGGCACCAACG
GCGACTGCTACGACCGTTACCTGGTGCGCGTGGCCGAGATGCGCGAGTCCAACCGCATCATCAAGCAGTGCGTGAAGTGG
CTGAAGGCCAATCCAGGCCCGGTCATGGTCACCAATTTCAAGGTCGCTCCGCCAAGCCGCGAAGGCATGAAGGACGACAT
GGAAGCGCTGATCCATCACTTCAAGCTGTTCAGCGAAGGCTACTGCGTTCCCGCCGGCGAGACTTATTGCGCCGTTGAAG
CGCCCAAGGGCGAGTTCGGCTGCTACCTGATGTCCGATGGCGCCAACAAGCCGTTCCGCGTGCATCTGCGCGCACCGGGC
TTTGCGCATCTGTCCTCGATGGACGCGGTGGTGCGCGGGTATTTGCTGGCCGACGTCGTGGCGATGATCGGTACTTACGA
TTTGGTTTTCGGTGAGGTTGACCGATGA

Upstream 100 bases:

>100_bases
TGACCTCGGTGGAGCCGCGTGTCGGCGTGCCGCGCGTGATCCGCGACGACGCGCGTTATGAGACTGCCGCTGGTGAAGTG
GGCAAGTCGGAGACTGCCAA

Downstream 100 bases:

>100_bases
AGGCGACGGGTAATTTCGAAGCGGCGCGCGACGTCGATCCGCAGGTAGTGCTGAGCGACAAGACGCGCGCGCACATCGAT
CATTGGCTGAGCAAGTTCCC

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D [H]

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MSEYRQATDAFASNPVESKQEIRNYTMNFGPQHPAAHGVLRLILEMDGETVVRADPHIGLLHRGTEKLAESKPFNQSVPY
MDRLDYVSMMCNEHAYVRAIESLMGIEAPERAQYIRTMFDEITRIKNHLMWVGSNALDLGAMAVMLYAFREREELMDVYE
AVSGARMHAAYYRPGGVYRDLPDRMPKYKESRWHKGGALTKLNAAREGSMLDFLENFTDTFPSRVDEYETLLTENRIWKQ
RTVDVGIISPDLARAWGMTGPMLRGSGIEWDLRKKQPYAKYDAVDFDVPVGTNGDCYDRYLVRVAEMRESNRIIKQCVKW
LKANPGPVMVTNFKVAPPSREGMKDDMEALIHHFKLFSEGYCVPAGETYCAVEAPKGEFGCYLMSDGANKPFRVHLRAPG
FAHLSSMDAVVRGYLLADVVAMIGTYDLVFGEVDR

Sequences:

>Translated_435_residues
MSEYRQATDAFASNPVESKQEIRNYTMNFGPQHPAAHGVLRLILEMDGETVVRADPHIGLLHRGTEKLAESKPFNQSVPY
MDRLDYVSMMCNEHAYVRAIESLMGIEAPERAQYIRTMFDEITRIKNHLMWVGSNALDLGAMAVMLYAFREREELMDVYE
AVSGARMHAAYYRPGGVYRDLPDRMPKYKESRWHKGGALTKLNAAREGSMLDFLENFTDTFPSRVDEYETLLTENRIWKQ
RTVDVGIISPDLARAWGMTGPMLRGSGIEWDLRKKQPYAKYDAVDFDVPVGTNGDCYDRYLVRVAEMRESNRIIKQCVKW
LKANPGPVMVTNFKVAPPSREGMKDDMEALIHHFKLFSEGYCVPAGETYCAVEAPKGEFGCYLMSDGANKPFRVHLRAPG
FAHLSSMDAVVRGYLLADVVAMIGTYDLVFGEVDR
>Mature_434_residues
SEYRQATDAFASNPVESKQEIRNYTMNFGPQHPAAHGVLRLILEMDGETVVRADPHIGLLHRGTEKLAESKPFNQSVPYM
DRLDYVSMMCNEHAYVRAIESLMGIEAPERAQYIRTMFDEITRIKNHLMWVGSNALDLGAMAVMLYAFREREELMDVYEA
VSGARMHAAYYRPGGVYRDLPDRMPKYKESRWHKGGALTKLNAAREGSMLDFLENFTDTFPSRVDEYETLLTENRIWKQR
TVDVGIISPDLARAWGMTGPMLRGSGIEWDLRKKQPYAKYDAVDFDVPVGTNGDCYDRYLVRVAEMRESNRIIKQCVKWL
KANPGPVMVTNFKVAPPSREGMKDDMEALIHHFKLFSEGYCVPAGETYCAVEAPKGEFGCYLMSDGANKPFRVHLRAPGF
AHLSSMDAVVRGYLLADVVAMIGTYDLVFGEVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=414, Percent_Identity=57.487922705314, Blast_Score=486, Evalue=1e-137,
Organism=Homo sapiens, GI260898743, Length=408, Percent_Identity=56.6176470588235, Blast_Score=471, Evalue=1e-133,
Organism=Escherichia coli, GI145693162, Length=410, Percent_Identity=38.0487804878049, Blast_Score=308, Evalue=6e-85,
Organism=Escherichia coli, GI1789076, Length=439, Percent_Identity=27.1070615034169, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI1788832, Length=407, Percent_Identity=27.5184275184275, Blast_Score=120, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17555284, Length=431, Percent_Identity=52.9002320185615, Blast_Score=471, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI17568379, Length=419, Percent_Identity=52.9832935560859, Blast_Score=471, Evalue=1e-133,
Organism=Drosophila melanogaster, GI24638644, Length=422, Percent_Identity=58.0568720379147, Blast_Score=512, Evalue=1e-145,
Organism=Drosophila melanogaster, GI221459469, Length=414, Percent_Identity=53.8647342995169, Blast_Score=463, Evalue=1e-131,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 49410; Mature: 49279

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEYRQATDAFASNPVESKQEIRNYTMNFGPQHPAAHGVLRLILEMDGETVVRADPHIGL
CCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCH
LHRGTEKLAESKPFNQSVPYMDRLDYVSMMCNEHAYVRAIESLMGIEAPERAQYIRTMFD
HHCCHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
EITRIKNHLMWVGSNALDLGAMAVMLYAFREREELMDVYEAVSGARMHAAYYRPGGVYRD
HHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCCCCCCC
LPDRMPKYKESRWHKGGALTKLNAAREGSMLDFLENFTDTFPSRVDEYETLLTENRIWKQ
CHHHCCHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RTVDVGIISPDLARAWGMTGPMLRGSGIEWDLRKKQPYAKYDAVDFDVPVGTNGDCYDRY
HCCEEEEECHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHH
LVRVAEMRESNRIIKQCVKWLKANPGPVMVTNFKVAPPSREGMKDDMEALIHHFKLFSEG
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCC
YCVPAGETYCAVEAPKGEFGCYLMSDGANKPFRVHLRAPGFAHLSSMDAVVRGYLLADVV
CEECCCCEEEEEECCCCCCCEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHH
AMIGTYDLVFGEVDR
HHHHHHHHHHCCCCC
>Mature Secondary Structure 
SEYRQATDAFASNPVESKQEIRNYTMNFGPQHPAAHGVLRLILEMDGETVVRADPHIGL
CHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCH
LHRGTEKLAESKPFNQSVPYMDRLDYVSMMCNEHAYVRAIESLMGIEAPERAQYIRTMFD
HHCCHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
EITRIKNHLMWVGSNALDLGAMAVMLYAFREREELMDVYEAVSGARMHAAYYRPGGVYRD
HHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCCCCCCC
LPDRMPKYKESRWHKGGALTKLNAAREGSMLDFLENFTDTFPSRVDEYETLLTENRIWKQ
CHHHCCHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RTVDVGIISPDLARAWGMTGPMLRGSGIEWDLRKKQPYAKYDAVDFDVPVGTNGDCYDRY
HCCEEEEECHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHH
LVRVAEMRESNRIIKQCVKWLKANPGPVMVTNFKVAPPSREGMKDDMEALIHHFKLFSEG
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCC
YCVPAGETYCAVEAPKGEFGCYLMSDGANKPFRVHLRAPGFAHLSSMDAVVRGYLLADVV
CEECCCCEEEEEECCCCCCCEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHH
AMIGTYDLVFGEVDR
HHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]