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The map label for this gene is tpiA [H]

Identifier: 66767911

GI number: 66767911

Start: 1906980

End: 1907735

Strand: Direct

Name: tpiA [H]

Synonym: XC_1587

Alternate gene names: 66767911

Gene position: 1906980-1907735 (Clockwise)

Preceding gene: 66767908

Following gene: 162017104

Centisome position: 37.04

GC content: 64.68

Gene sequence:

>756_bases
ATGCGTCGAAAGATCGTTGCTGGAAATTGGAAGCTGCATGGCACGCGTGCCTTCGCCACCGAACTGGTGGCGCAGGTGGC
CGCGCACATGCCCCTGGCGGGTGTCGATGTCGTCATCCTGCCGCCCTTGCCGTATCTCGGTGATCTGATCGAGGACTTCG
AGGCCCACCACCTGGCATTCGGTGCACAGGACGTCAGTAGCAACGAGAAGGGCGCCTACACCGGTGAAGTGTCCGCCTCG
ATGCTGGTGGATGTCGGTGCCGAATACGGCCTGGTCGGGCATTCGGAGCGCCGTCAGTATCACCAGGAAAGTAGCGAGCT
GGTCGCGCGCAAGTTTGCCGCCGCAATGCATGCCGGGTTGATCCCGGTGCTGTGCGTTGGCGAATCGCTGGAACAGCGCG
AGGCAGGTCAGACTGAGGCAATCCTACGTGCCCAGTTGGAGCCGGTCCTGAGCCTGGTCGGCAGTGCCGGATTCGCCCGC
GCCGTGGTGGCCTACGAGCCGATCTGGGCCATCGGGACCGGGCGCACCGCCACGCCGGACCAGGCCCAGGCCGTGCACGC
CTTCATTCGTGGCGAAGTCGCGAAGGCGGATGCTAGAATTGCCGATTCACTGCCCATCCTGTACGGGGGGAGTGTCAAGC
CCGACAACGCCAGCGAGCTGTTTTCCCAGCCCGACGTCGACGGTGGGCTGGTCGGCGGCGCATCACTGGTTGCCGAAGAC
TTCCTGGCCATTGCGCGTGCGGCGGCCGCTTGTTAA

Upstream 100 bases:

>100_bases
GTTAGGGCGAAATGGGACACGCATCGGACACAAGTCTGCCGGGTACCGACAGGGCATGGGCTATTCTCACGCCTGTCTTC
AACTCAGGAACCTGCACCTG

Downstream 100 bases:

>100_bases
CCCATTAAGTTTTGTCCGGGGACGGATTTCGAAATGCTGATGTTGATCCTCAATGTGGTCTACGTGCTGGTCGCGCTGGC
GATGATTGCGCTGATCCTGA

Product: triosephosphate isomerase

Products: NA

Alternate protein names: TIM; Triose-phosphate isomerase [H]

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MRRKIVAGNWKLHGTRAFATELVAQVAAHMPLAGVDVVILPPLPYLGDLIEDFEAHHLAFGAQDVSSNEKGAYTGEVSAS
MLVDVGAEYGLVGHSERRQYHQESSELVARKFAAAMHAGLIPVLCVGESLEQREAGQTEAILRAQLEPVLSLVGSAGFAR
AVVAYEPIWAIGTGRTATPDQAQAVHAFIRGEVAKADARIADSLPILYGGSVKPDNASELFSQPDVDGGLVGGASLVAED
FLAIARAAAAC

Sequences:

>Translated_251_residues
MRRKIVAGNWKLHGTRAFATELVAQVAAHMPLAGVDVVILPPLPYLGDLIEDFEAHHLAFGAQDVSSNEKGAYTGEVSAS
MLVDVGAEYGLVGHSERRQYHQESSELVARKFAAAMHAGLIPVLCVGESLEQREAGQTEAILRAQLEPVLSLVGSAGFAR
AVVAYEPIWAIGTGRTATPDQAQAVHAFIRGEVAKADARIADSLPILYGGSVKPDNASELFSQPDVDGGLVGGASLVAED
FLAIARAAAAC
>Mature_251_residues
MRRKIVAGNWKLHGTRAFATELVAQVAAHMPLAGVDVVILPPLPYLGDLIEDFEAHHLAFGAQDVSSNEKGAYTGEVSAS
MLVDVGAEYGLVGHSERRQYHQESSELVARKFAAAMHAGLIPVLCVGESLEQREAGQTEAILRAQLEPVLSLVGSAGFAR
AVVAYEPIWAIGTGRTATPDQAQAVHAFIRGEVAKADARIADSLPILYGGSVKPDNASELFSQPDVDGGLVGGASLVAED
FLAIARAAAAC

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI4507645, Length=248, Percent_Identity=43.9516129032258, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI226529917, Length=248, Percent_Identity=43.9516129032258, Blast_Score=185, Evalue=3e-47,
Organism=Escherichia coli, GI1790353, Length=251, Percent_Identity=53.3864541832669, Blast_Score=270, Evalue=5e-74,
Organism=Caenorhabditis elegans, GI17536593, Length=247, Percent_Identity=44.5344129554656, Blast_Score=196, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6320255, Length=239, Percent_Identity=42.2594142259414, Blast_Score=176, Evalue=4e-45,
Organism=Drosophila melanogaster, GI28572008, Length=247, Percent_Identity=42.5101214574899, Blast_Score=181, Evalue=3e-46,
Organism=Drosophila melanogaster, GI28572006, Length=247, Percent_Identity=42.5101214574899, Blast_Score=181, Evalue=3e-46,
Organism=Drosophila melanogaster, GI28572004, Length=247, Percent_Identity=42.5101214574899, Blast_Score=181, Evalue=4e-46,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652
- InterPro:   IPR020861 [H]

Pfam domain/function: PF00121 TIM [H]

EC number: =5.3.1.1 [H]

Molecular weight: Translated: 26351; Mature: 26351

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00171 TIM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRKIVAGNWKLHGTRAFATELVAQVAAHMPLAGVDVVILPPLPYLGDLIEDFEAHHLAF
CCCCEEECCEEECCHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHC
GAQDVSSNEKGAYTGEVSASMLVDVGAEYGLVGHSERRQYHQESSELVARKFAAAMHAGL
CCHHCCCCCCCCEECCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
IPVLCVGESLEQREAGQTEAILRAQLEPVLSLVGSAGFARAVVAYEPIWAIGTGRTATPD
HHEEECCCCHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCEEEECCCCCCCCH
QAQAVHAFIRGEVAKADARIADSLPILYGGSVKPDNASELFSQPDVDGGLVGGASLVAED
HHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHH
FLAIARAAAAC
HHHHHHHHHCC
>Mature Secondary Structure
MRRKIVAGNWKLHGTRAFATELVAQVAAHMPLAGVDVVILPPLPYLGDLIEDFEAHHLAF
CCCCEEECCEEECCHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHC
GAQDVSSNEKGAYTGEVSASMLVDVGAEYGLVGHSERRQYHQESSELVARKFAAAMHAGL
CCHHCCCCCCCCEECCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
IPVLCVGESLEQREAGQTEAILRAQLEPVLSLVGSAGFARAVVAYEPIWAIGTGRTATPD
HHEEECCCCHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCEEEECCCCCCCCH
QAQAVHAFIRGEVAKADARIADSLPILYGGSVKPDNASELFSQPDVDGGLVGGASLVAED
HHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHH
FLAIARAAAAC
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]