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The map label for this gene is gor [H]

Identifier: 66767863

GI number: 66767863

Start: 1847313

End: 1848683

Strand: Direct

Name: gor [H]

Synonym: XC_1539

Alternate gene names: 66767863

Gene position: 1847313-1848683 (Clockwise)

Preceding gene: 66767862

Following gene: 66767864

Centisome position: 35.88

GC content: 64.92

Gene sequence:

>1371_bases
ATGAGCGCACGTTACGACTACGACGTGGTGGTGCTGGGCGGTGGCTCCGGTGGTCTTGCCGCAGCGTTCCGCGCAGCCAA
GCATGGCGCGCGTGTTGCGATCATGGAGCCGGGCGAGCTCGGCGGAACCTGCGTCAATCTCGGCTGCGTGCCGAAGAAGG
CGATGTGGTTGGCGGCCGATCTGGCGAGCAAGATCGAACTGGCTGGTGCACTCGGGTTTGATGTGGTGCGCCCGACCTTG
ACCTGGCAGGAATTGGTCACCCACCGGCAGGGCTACATCGGCAATATCCACGCCAGTTACCGGCGCCGCCTCGACGATGA
TGGTGTGGTGCTGATCCCGCAGCGTGGCGTGTTGCAGGACCGGCATACCTTGATGGGCGCCGACGGCGTGCCCGTCACTG
CCGAGCACATCGTCATCGCCACGGGCGCGCATCCATTGCGCCCGCACGTGGAGGGCGCCGAGCATGGTCATGTGTCCGAC
GACTTCTTCAACCTCTGCCATGCGCCGGACCATGTGGCCATCGTTGGAGGCGGCTACATCGCGGTGGAGATTGCGGGGCT
GTTGCAGGCGCTTGGCAGCCGCGTGCATCTGTTCGTGCAGGGCGAGCGGTTGCTGGAACGCTTCGACGCCGAACTCACGT
TGCAGCTGGCCGATAACCTGCGCCATCTCGGCGTGCGCCTGCACTTCGGTTTCCGCACCACCGGTGTGCAGCGCGATGAC
ACGGGCAAGCTACGCATGCGTGGCCACAGTGCGCATCCGGGCGAGTTGGGCAACGATGTCTTTGACCAGGTTTTCTTTGC
GATTGGCCGCCTTGCCAACACCGCCGGGCTGGGCCTGGAAGCGCTCGGCGTGGAACTCGGCAAGAAGGGCGAAATCGTCG
TGGACGACGGCCAGACCACCAACGTGCCCAACATTCATGCGGTAGGCGATGTGGACGGCAAGGTTGGGCTGACGCCGGTG
GCGATCGCGGCGGGGCGCAAGTTGATGGATCGCCTGTTCGGTGGTCAGCCGGATGCGCGCATGGATTACGACAACGTGCC
CAGCGTGGTGTTTTCGCACCCGCCGCTGGGTGCGGTGGGCCTCACCGAAGAGCAGGCGCGTGAGCGCTACGACGGTGCGG
TGCGCGTGTACCGCAGCAACTTCCGCCCGATGTTGCACGCATTGGCCGATGCGCCGCAGCGCAGCGTGTTCAAGCTGGTG
TGCGTGGGCGAGGAAGAGCGCGTGGTCGGCGTGCACCTGCTCGGCGAAAGCGCCGACGAGATGCTGCAGGGCTTTGCGGT
GGCGGTCAAAATGGGCGCCACCAAGCGCGACTTCGACGAGACCGTGGCGATCCATCCCACCTCATCCGAAGAAATTGTGT
TGATGCATTGA

Upstream 100 bases:

>100_bases
GCATCAGCATGAGTACTGCAAGTGGACAACTGATGGCCGACCTGATCACCGGGCGCGTACCCGCGCTGGACCCGCATCCC
TACCGCGCAGAGCGTTTCGC

Downstream 100 bases:

>100_bases
GCACTGCATGTTGGCCGCATGCGTTTGCGGTGGCCGCGTGGCAATCAGCGCAGAGGTCAGTCCCGGCACGTTGTTGCTCT
GGCAAAGCTGCAGGTCTCTC

Product: reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MSARYDYDVVVLGGGSGGLAAAFRAAKHGARVAIMEPGELGGTCVNLGCVPKKAMWLAADLASKIELAGALGFDVVRPTL
TWQELVTHRQGYIGNIHASYRRRLDDDGVVLIPQRGVLQDRHTLMGADGVPVTAEHIVIATGAHPLRPHVEGAEHGHVSD
DFFNLCHAPDHVAIVGGGYIAVEIAGLLQALGSRVHLFVQGERLLERFDAELTLQLADNLRHLGVRLHFGFRTTGVQRDD
TGKLRMRGHSAHPGELGNDVFDQVFFAIGRLANTAGLGLEALGVELGKKGEIVVDDGQTTNVPNIHAVGDVDGKVGLTPV
AIAAGRKLMDRLFGGQPDARMDYDNVPSVVFSHPPLGAVGLTEEQARERYDGAVRVYRSNFRPMLHALADAPQRSVFKLV
CVGEEERVVGVHLLGESADEMLQGFAVAVKMGATKRDFDETVAIHPTSSEEIVLMH

Sequences:

>Translated_456_residues
MSARYDYDVVVLGGGSGGLAAAFRAAKHGARVAIMEPGELGGTCVNLGCVPKKAMWLAADLASKIELAGALGFDVVRPTL
TWQELVTHRQGYIGNIHASYRRRLDDDGVVLIPQRGVLQDRHTLMGADGVPVTAEHIVIATGAHPLRPHVEGAEHGHVSD
DFFNLCHAPDHVAIVGGGYIAVEIAGLLQALGSRVHLFVQGERLLERFDAELTLQLADNLRHLGVRLHFGFRTTGVQRDD
TGKLRMRGHSAHPGELGNDVFDQVFFAIGRLANTAGLGLEALGVELGKKGEIVVDDGQTTNVPNIHAVGDVDGKVGLTPV
AIAAGRKLMDRLFGGQPDARMDYDNVPSVVFSHPPLGAVGLTEEQARERYDGAVRVYRSNFRPMLHALADAPQRSVFKLV
CVGEEERVVGVHLLGESADEMLQGFAVAVKMGATKRDFDETVAIHPTSSEEIVLMH
>Mature_455_residues
SARYDYDVVVLGGGSGGLAAAFRAAKHGARVAIMEPGELGGTCVNLGCVPKKAMWLAADLASKIELAGALGFDVVRPTLT
WQELVTHRQGYIGNIHASYRRRLDDDGVVLIPQRGVLQDRHTLMGADGVPVTAEHIVIATGAHPLRPHVEGAEHGHVSDD
FFNLCHAPDHVAIVGGGYIAVEIAGLLQALGSRVHLFVQGERLLERFDAELTLQLADNLRHLGVRLHFGFRTTGVQRDDT
GKLRMRGHSAHPGELGNDVFDQVFFAIGRLANTAGLGLEALGVELGKKGEIVVDDGQTTNVPNIHAVGDVDGKVGLTPVA
IAAGRKLMDRLFGGQPDARMDYDNVPSVVFSHPPLGAVGLTEEQARERYDGAVRVYRSNFRPMLHALADAPQRSVFKLVC
VGEEERVVGVHLLGESADEMLQGFAVAVKMGATKRDFDETVAIHPTSSEEIVLMH

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=462, Percent_Identity=46.3203463203463, Blast_Score=371, Evalue=1e-102,
Organism=Homo sapiens, GI22035672, Length=472, Percent_Identity=39.8305084745763, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI33519430, Length=473, Percent_Identity=36.5750528541226, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI33519428, Length=473, Percent_Identity=36.5750528541226, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI33519426, Length=473, Percent_Identity=36.5750528541226, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI148277065, Length=473, Percent_Identity=36.5750528541226, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI148277071, Length=473, Percent_Identity=36.5750528541226, Blast_Score=249, Evalue=3e-66,
Organism=Homo sapiens, GI291045266, Length=469, Percent_Identity=35.8208955223881, Blast_Score=241, Evalue=9e-64,
Organism=Homo sapiens, GI291045268, Length=468, Percent_Identity=32.6923076923077, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI91199540, Length=463, Percent_Identity=29.8056155507559, Blast_Score=166, Evalue=4e-41,
Organism=Escherichia coli, GI1789915, Length=434, Percent_Identity=47.4654377880184, Blast_Score=386, Evalue=1e-108,
Organism=Escherichia coli, GI1786307, Length=464, Percent_Identity=27.5862068965517, Blast_Score=151, Evalue=8e-38,
Organism=Escherichia coli, GI87082354, Length=462, Percent_Identity=28.3549783549784, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI87081717, Length=455, Percent_Identity=29.6703296703297, Blast_Score=140, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71983429, Length=461, Percent_Identity=44.2516268980477, Blast_Score=327, Evalue=6e-90,
Organism=Caenorhabditis elegans, GI71983419, Length=461, Percent_Identity=44.2516268980477, Blast_Score=327, Evalue=7e-90,
Organism=Caenorhabditis elegans, GI17557007, Length=477, Percent_Identity=32.9140461215933, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI71982272, Length=479, Percent_Identity=33.6116910229645, Blast_Score=224, Evalue=7e-59,
Organism=Caenorhabditis elegans, GI32565766, Length=474, Percent_Identity=26.5822784810127, Blast_Score=143, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6325166, Length=474, Percent_Identity=40.9282700421941, Blast_Score=348, Evalue=7e-97,
Organism=Saccharomyces cerevisiae, GI6321091, Length=478, Percent_Identity=28.0334728033473, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6325240, Length=465, Percent_Identity=25.8064516129032, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24640553, Length=472, Percent_Identity=38.135593220339, Blast_Score=266, Evalue=3e-71,
Organism=Drosophila melanogaster, GI24640549, Length=472, Percent_Identity=38.135593220339, Blast_Score=266, Evalue=3e-71,
Organism=Drosophila melanogaster, GI24640551, Length=475, Percent_Identity=37.8947368421053, Blast_Score=265, Evalue=4e-71,
Organism=Drosophila melanogaster, GI17737741, Length=475, Percent_Identity=37.4736842105263, Blast_Score=252, Evalue=3e-67,
Organism=Drosophila melanogaster, GI21358499, Length=472, Percent_Identity=27.5423728813559, Blast_Score=149, Evalue=3e-36,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006322
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 48991; Mature: 48859

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSARYDYDVVVLGGGSGGLAAAFRAAKHGARVAIMEPGELGGTCVNLGCVPKKAMWLAAD
CCCCCCEEEEEEECCCCCHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCCCHHHHHHHH
LASKIELAGALGFDVVRPTLTWQELVTHRQGYIGNIHASYRRRLDDDGVVLIPQRGVLQD
HHHHHHHHHHCCHHHHCCCCCHHHHHHHCCCCEECEEHHHHHCCCCCCEEEECCCCCCCC
RHTLMGADGVPVTAEHIVIATGAHPLRPHVEGAEHGHVSDDFFNLCHAPDHVAIVGGGYI
CHHEECCCCCCEEECEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHCCCCCEEEEECCEE
AVEIAGLLQALGSRVHLFVQGERLLERFDAELTLQLADNLRHLGVRLHFGFRTTGVQRDD
EEHHHHHHHHCCCEEEEEEECHHHHHHHCCCEEEHHHHCHHEEEEEEEECEEECCCCCCC
TGKLRMRGHSAHPGELGNDVFDQVFFAIGRLANTAGLGLEALGVELGKKGEIVVDDGQTT
CCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCEEEECCCCC
NVPNIHAVGDVDGKVGLTPVAIAAGRKLMDRLFGGQPDARMDYDNVPSVVFSHPPLGAVG
CCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCC
LTEEQARERYDGAVRVYRSNFRPMLHALADAPQRSVFKLVCVGEEERVVGVHLLGESADE
CCHHHHHHHCCCEEEEEHHCCHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEEECCCHHH
MLQGFAVAVKMGATKRDFDETVAIHPTSSEEIVLMH
HHHHHEEEEEECCCCCCCCCEEEECCCCCCCEEEEC
>Mature Secondary Structure 
SARYDYDVVVLGGGSGGLAAAFRAAKHGARVAIMEPGELGGTCVNLGCVPKKAMWLAAD
CCCCCEEEEEEECCCCCHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCCCHHHHHHHH
LASKIELAGALGFDVVRPTLTWQELVTHRQGYIGNIHASYRRRLDDDGVVLIPQRGVLQD
HHHHHHHHHHCCHHHHCCCCCHHHHHHHCCCCEECEEHHHHHCCCCCCEEEECCCCCCCC
RHTLMGADGVPVTAEHIVIATGAHPLRPHVEGAEHGHVSDDFFNLCHAPDHVAIVGGGYI
CHHEECCCCCCEEECEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHCCCCCEEEEECCEE
AVEIAGLLQALGSRVHLFVQGERLLERFDAELTLQLADNLRHLGVRLHFGFRTTGVQRDD
EEHHHHHHHHCCCEEEEEEECHHHHHHHCCCEEEHHHHCHHEEEEEEEECEEECCCCCCC
TGKLRMRGHSAHPGELGNDVFDQVFFAIGRLANTAGLGLEALGVELGKKGEIVVDDGQTT
CCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCEEEECCCCC
NVPNIHAVGDVDGKVGLTPVAIAAGRKLMDRLFGGQPDARMDYDNVPSVVFSHPPLGAVG
CCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCCCC
LTEEQARERYDGAVRVYRSNFRPMLHALADAPQRSVFKLVCVGEEERVVGVHLLGESADE
CCHHHHHHHCCCEEEEEHHCCHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEEECCCHHH
MLQGFAVAVKMGATKRDFDETVAIHPTSSEEIVLMH
HHHHHEEEEEECCCCCCCCCEEEECCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8525054 [H]