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The map label for this gene is ispA [H]

Identifier: 66767842

GI number: 66767842

Start: 1825091

End: 1825966

Strand: Reverse

Name: ispA [H]

Synonym: XC_1516

Alternate gene names: 66767842

Gene position: 1825966-1825091 (Counterclockwise)

Preceding gene: 66767843

Following gene: 66767841

Centisome position: 35.46

GC content: 68.84

Gene sequence:

>876_bases
GTGAGCGCGGCGTTGTTTGAGCGCTGGGTTGCTCGCACCGAACGGCAGCTGGACGCCTGCCTTCCCAGCCCCGCCCTCGC
CCCGCAGCGTCTGCACGCGGCCATGCGCCACGCCGTGCTCGGTGGCGGCAAGCGCATGCGTCCGCTGTTGGTCTATGCAA
GCGGTGCCTTGTTCGGCGCCGAAGAAGGCAGCCTGGATGCGCCGGCGGTGGCGGTGGAACTGATCCACGCGTATTCGCTG
GTGCACGATGACCTACCCGCGATGGACGATGACGCGCTGCGTCGCGGCCACCCTACGGTGCACATCGCCTTCGACGAAGC
CACTGCGATCCTGGCCGGCGATGCCTTGCAGGCACGCGCATTCGAACTGCTGGCCGAGGCACCGGCAGATGCGGCACTGC
GGGTGGGCTGGTTGCAGAGCCTGGCATCTGCCGCCGGTGCGGCCGGCATGTGTGGCGGGCAGGCGCTGGATATCGACGCC
ACCGGGCAGGTGCAGGCGCTGGAGGCACTGCAGCGCATGCATGCACTCAAGACCGGTGCGCTGATCCGCGCCGCGGTGCG
CATGGGCGTGCTGACAGGCGGCGCGGGTATTGCCGACCAGCAGCGCCTGGATGCGTTTGCCGACGCGCTGGGGCTCGCGT
TCCAGGTGCGTGACGACATCCTGGATGTGGAATCAAGCTCCGCCCAGCTCGGCAAGACTGCCGGCAAGGATGCGGCGCAG
TCCAAGTCCACCTACCCCGCCTTGCTGGGCATGGACGGCGCCAAAACCAAGCTGGCGGAACTGGCCAGCCATATGCATGC
GCTGTTGCTGCCCTACGGCGAATCCGGCGCCACCTTGGCCAGCCTCGGCCGCTTCGCGGTCGACCGCGCCCACTAG

Upstream 100 bases:

>100_bases
GGCGCTGGAACAGGCGGAATTGCGCGTGCGTCTGGTGACCGACCCCGCACGCCCCGAACAGGCAGAAGCATTCGAGCCGC
CGTCGCTGGATGGCGGCTGA

Downstream 100 bases:

>100_bases
GCACGGCTAACCAGGCCTCATGCGCGGCTGCCAAGCGCGTGTGATGGTGCGTGGGTGTCTGGCGCGGCGACATCCGACGC
ATCGCTCCGCACATCACCGC

Product: geranyltranstransferase; farnesyl-diphosphate synthase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 291; Mature: 290

Protein sequence:

>291_residues
MSAALFERWVARTERQLDACLPSPALAPQRLHAAMRHAVLGGGKRMRPLLVYASGALFGAEEGSLDAPAVAVELIHAYSL
VHDDLPAMDDDALRRGHPTVHIAFDEATAILAGDALQARAFELLAEAPADAALRVGWLQSLASAAGAAGMCGGQALDIDA
TGQVQALEALQRMHALKTGALIRAAVRMGVLTGGAGIADQQRLDAFADALGLAFQVRDDILDVESSSAQLGKTAGKDAAQ
SKSTYPALLGMDGAKTKLAELASHMHALLLPYGESGATLASLGRFAVDRAH

Sequences:

>Translated_291_residues
MSAALFERWVARTERQLDACLPSPALAPQRLHAAMRHAVLGGGKRMRPLLVYASGALFGAEEGSLDAPAVAVELIHAYSL
VHDDLPAMDDDALRRGHPTVHIAFDEATAILAGDALQARAFELLAEAPADAALRVGWLQSLASAAGAAGMCGGQALDIDA
TGQVQALEALQRMHALKTGALIRAAVRMGVLTGGAGIADQQRLDAFADALGLAFQVRDDILDVESSSAQLGKTAGKDAAQ
SKSTYPALLGMDGAKTKLAELASHMHALLLPYGESGATLASLGRFAVDRAH
>Mature_290_residues
SAALFERWVARTERQLDACLPSPALAPQRLHAAMRHAVLGGGKRMRPLLVYASGALFGAEEGSLDAPAVAVELIHAYSLV
HDDLPAMDDDALRRGHPTVHIAFDEATAILAGDALQARAFELLAEAPADAALRVGWLQSLASAAGAAGMCGGQALDIDAT
GQVQALEALQRMHALKTGALIRAAVRMGVLTGGAGIADQQRLDAFADALGLAFQVRDDILDVESSSAQLGKTAGKDAAQS
KSTYPALLGMDGAKTKLAELASHMHALLLPYGESGATLASLGRFAVDRAH

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Escherichia coli, GI1786623, Length=266, Percent_Identity=53.3834586466165, Blast_Score=228, Evalue=3e-61,
Organism=Escherichia coli, GI1789578, Length=225, Percent_Identity=30.6666666666667, Blast_Score=97, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6325188, Length=227, Percent_Identity=25.9911894273128, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 30228; Mature: 30097

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAALFERWVARTERQLDACLPSPALAPQRLHAAMRHAVLGGGKRMRPLLVYASGALFGA
CCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCEECC
EEGSLDAPAVAVELIHAYSLVHDDLPAMDDDALRRGHPTVHIAFDEATAILAGDALQARA
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCEEEEEECCCEEEHCCCHHHHHH
FELLAEAPADAALRVGWLQSLASAAGAAGMCGGQALDIDATGQVQALEALQRMHALKTGA
HHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHH
LIRAAVRMGVLTGGAGIADQQRLDAFADALGLAFQVRDDILDVESSSAQLGKTAGKDAAQ
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHH
SKSTYPALLGMDGAKTKLAELASHMHALLLPYGESGATLASLGRFAVDRAH
CCCCCCHHCCCCCHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
SAALFERWVARTERQLDACLPSPALAPQRLHAAMRHAVLGGGKRMRPLLVYASGALFGA
CHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCEECC
EEGSLDAPAVAVELIHAYSLVHDDLPAMDDDALRRGHPTVHIAFDEATAILAGDALQARA
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCEEEEEECCCEEEHCCCHHHHHH
FELLAEAPADAALRVGWLQSLASAAGAAGMCGGQALDIDATGQVQALEALQRMHALKTGA
HHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHH
LIRAAVRMGVLTGGAGIADQQRLDAFADALGLAFQVRDDILDVESSSAQLGKTAGKDAAQ
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHH
SKSTYPALLGMDGAKTKLAELASHMHALLLPYGESGATLASLGRFAVDRAH
CCCCCCHHCCCCCHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]