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The map label for this gene is napA [H]

Identifier: 66767809

GI number: 66767809

Start: 1785919

End: 1787184

Strand: Direct

Name: napA [H]

Synonym: XC_1483

Alternate gene names: 66767809

Gene position: 1785919-1787184 (Clockwise)

Preceding gene: 66767808

Following gene: 66767810

Centisome position: 34.69

GC content: 64.45

Gene sequence:

>1266_bases
ATGACCACTCCGCAGATGTCGGTGTATTTCTTTTTGCAGGCCGCCGCGATCCTGCTGGCGTGCCGTGTGGTCGGTCTGCT
GGCCAAGCGCATAGGTCAACCGCAGGTGGTGGGCGAGATGATTGCCGGCGTGATGCTGGGGCCGTCGCTGTTCGGACTGG
TGCTGCCGGATCTGCAGACGGCGCTGTTTCCCAAGCAAACCATGGACGTGCTGTACGTATTCGCGCAGTTCGGCGTGGGC
CTGTACATGTTCCTGGTCGGCACCGACTTTCGTGGCGACCACTTCAAGGCGCGCTATCGCAGTGCCATGAGCGTGTCGTT
GGCCGGCATCGCAGTGCCGTTTGCGTTGGCGTTTGCGCTGTGCCCGTGGTTGATCAACGTGCAGGGCCTGTTCTCCGAAA
AGGCCAAGCTGATGGAGGCTTCGCTGTTCCTGGGTGCGGCCATCGCCATCACTGCCTTCCCGATGCTGGCGCGCATCATC
CACGAGCGCGGCCTCACCAACAGCCCGTTGGGCACGCTGGCGCTCACCGCCGGCGCGTTCGACGATGCGGCGGCGTGGTG
CATCCTGGCCGTGGTGCTGGCGAGCTTCGGTGGCAGCTGGGGTAGCGCGTATCTGGCCATCGGCGGCGGCGTGGCCTACG
CGTTGTTCATGCTTTTTGTCGGGCGCCACCTTCTGCGCCGGTTGTCTGATTACGTGGTGCCCGATCAGCCGCTCGGCAAC
GGCGTGTTGGCGGTCATCCTGATGCTGTTCTGCCTCAGCGCCTGGGCGATGGATGCGATCGGTATCCATGCGGTGTTCGG
CGGCTTCCTGCTCGGTGCCTGCCTGCCGAAGGGGGCGTTGACCGAAAAGCTGCGCGCGATGATGCAGCCGTTCGTGGTGG
TGTTGCTGCTGCCGCTGTTCTTCACTTACTCGGGGCTCAAGACCCAGCTCAGCGTGCTGATGCAGCCGCAGATCATGCTG
GCTGGCGTGGCGATCCTGGCGGCCTCGTTCATCGGCAAGGGCGTGGCCTGCTGGGCGGCGGCGCGTGCCACCGGCGAGAA
CAACCGCGACGCGATGGCGATCGGTTCGCTGATGAACGCGCGTGGCCTGATGGAGCTGATCATCATCAACATCGGCCTGC
AGGCCGGGGTGATCGAACAAGGCCTGTTCTCGGTGCTGGTGCTGATGGCGATTTTGTCCACCTTGATGGCCACGCCGCTA
TTCAACTGGATCATGCGCTGCCACGCCCACGTGAGCGACGCGGTGCCGAGCCTGCAGGGCCGCTGA

Upstream 100 bases:

>100_bases
CAACTGCTTGCAGGTCACCTGTGCGCGTAGCCCGTCGGCGCTATCGCCCACCGGCCTGGCTCGCTATGATCCGCGCAACT
CTCAGGGACGCCGTCCACGC

Downstream 100 bases:

>100_bases
GCCGGCAGCTGGTGCATGCCGCGTAGCGTGCACCGGCACAGCAGATTGCAATCATGAAGCTGCTTGATGGCGGCGTTGTG
CGCGGCCGCCGCCTTGCGTG

Product: cation:proton antiporter

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MTTPQMSVYFFLQAAAILLACRVVGLLAKRIGQPQVVGEMIAGVMLGPSLFGLVLPDLQTALFPKQTMDVLYVFAQFGVG
LYMFLVGTDFRGDHFKARYRSAMSVSLAGIAVPFALAFALCPWLINVQGLFSEKAKLMEASLFLGAAIAITAFPMLARII
HERGLTNSPLGTLALTAGAFDDAAAWCILAVVLASFGGSWGSAYLAIGGGVAYALFMLFVGRHLLRRLSDYVVPDQPLGN
GVLAVILMLFCLSAWAMDAIGIHAVFGGFLLGACLPKGALTEKLRAMMQPFVVVLLLPLFFTYSGLKTQLSVLMQPQIML
AGVAILAASFIGKGVACWAAARATGENNRDAMAIGSLMNARGLMELIIINIGLQAGVIEQGLFSVLVLMAILSTLMATPL
FNWIMRCHAHVSDAVPSLQGR

Sequences:

>Translated_421_residues
MTTPQMSVYFFLQAAAILLACRVVGLLAKRIGQPQVVGEMIAGVMLGPSLFGLVLPDLQTALFPKQTMDVLYVFAQFGVG
LYMFLVGTDFRGDHFKARYRSAMSVSLAGIAVPFALAFALCPWLINVQGLFSEKAKLMEASLFLGAAIAITAFPMLARII
HERGLTNSPLGTLALTAGAFDDAAAWCILAVVLASFGGSWGSAYLAIGGGVAYALFMLFVGRHLLRRLSDYVVPDQPLGN
GVLAVILMLFCLSAWAMDAIGIHAVFGGFLLGACLPKGALTEKLRAMMQPFVVVLLLPLFFTYSGLKTQLSVLMQPQIML
AGVAILAASFIGKGVACWAAARATGENNRDAMAIGSLMNARGLMELIIINIGLQAGVIEQGLFSVLVLMAILSTLMATPL
FNWIMRCHAHVSDAVPSLQGR
>Mature_420_residues
TTPQMSVYFFLQAAAILLACRVVGLLAKRIGQPQVVGEMIAGVMLGPSLFGLVLPDLQTALFPKQTMDVLYVFAQFGVGL
YMFLVGTDFRGDHFKARYRSAMSVSLAGIAVPFALAFALCPWLINVQGLFSEKAKLMEASLFLGAAIAITAFPMLARIIH
ERGLTNSPLGTLALTAGAFDDAAAWCILAVVLASFGGSWGSAYLAIGGGVAYALFMLFVGRHLLRRLSDYVVPDQPLGNG
VLAVILMLFCLSAWAMDAIGIHAVFGGFLLGACLPKGALTEKLRAMMQPFVVVLLLPLFFTYSGLKTQLSVLMQPQIMLA
GVAILAASFIGKGVACWAAARATGENNRDAMAIGSLMNARGLMELIIINIGLQAGVIEQGLFSVLVLMAILSTLMATPLF
NWIMRCHAHVSDAVPSLQGR

Specific function: This is a Na(+)/H(+) antiporter. It can mediate sodium uptake when a transmembrane pH gradient is applied [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6322367, Length=400, Percent_Identity=29.5, Blast_Score=181, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 44844; Mature: 44713

Theoretical pI: Translated: 8.85; Mature: 8.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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C
>Mature Secondary Structure 
TTPQMSVYFFLQAAAILLACRVVGLLAKRIGQPQVVGEMIAGVMLGPSLFGLVLPDLQT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALFPKQTMDVLYVFAQFGVGLYMFLVGTDFRGDHFKARYRSAMSVSLAGIAVPFALAFAL
HHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
CPWLINVQGLFSEKAKLMEASLFLGAAIAITAFPMLARIIHERGLTNSPLGTLALTAGAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHEECCCC
DDAAAWCILAVVLASFGGSWGSAYLAIGGGVAYALFMLFVGRHLLRRLSDYVVPDQPLGN
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GVLAVILMLFCLSAWAMDAIGIHAVFGGFLLGACLPKGALTEKLRAMMQPFVVVLLLPLF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
FTYSGLKTQLSVLMQPQIMLAGVAILAASFIGKGVACWAAARATGENNRDAMAIGSLMNA
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHH
RGLMELIIINIGLQAGVIEQGLFSVLVLMAILSTLMATPLFNWIMRCHAHVSDAVPSLQG
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1312090; 1325937 [H]