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The map label for this gene is clcA [H]

Identifier: 66767788

GI number: 66767788

Start: 1762276

End: 1763640

Strand: Reverse

Name: clcA [H]

Synonym: XC_1462

Alternate gene names: 66767788

Gene position: 1763640-1762276 (Counterclockwise)

Preceding gene: 66767789

Following gene: 66767785

Centisome position: 34.25

GC content: 69.82

Gene sequence:

>1365_bases
ATGTCTGCTCCCGATCCTTCCCCCCGGCGGCTGCGGCCGCTGTTGTCCAGCGAAGGCTGGCGTCGTCGTGTCGCTCTGTG
GGGCGGCGCCATTGCGGTCGCGCTGGTGGCCATCGTGTTCGCCAAAGCCAGCGACGCGGCTTTCCACCTGTTCCAGCGCA
TCACTGCCCACTCCATCTGGTGGGCGCTGCTGCTCACCCCGGGCATCTTCGCGCTGCTGGCCTGGCTTACCTCCGGCGCG
TTGCGGCCCACCCGCGGCAGCGGCATCCCGCAGGTGATCGCCGCGCTGGAACACCCGGACCCGGCCTTTCGCGAAACCAA
TCTGTCGCTGCGCGTGTCGGTGGGCAAACTGGCGCTCACCACCTTGTCGCTGCTGGGTGGTGCGTCAGTGGGCCGCGAAG
GCCCCACGGTGCATGTGGGCGCCAGCCTGATGCATGTGTTCGGGCGCTGGTTCGGCTTCCGCGAGCCACGTGAGCTGTCG
CACTTCCTGCTGGCCGGCGGCGCCGCCGGCATCGCCGCCGCGTTCAACACGCCACTGGCCGGGGTGGTGTTTGCGATCGA
GGAATTGAGCGGGCGCTTCGAGCACCGTTTCTCCGGCACCTTGCTCACTGCGGTGATCGTGGGCGGCGTGGTGTCGCTGG
GCCTGCTCGGCAACTACACCTATTTCGGCAAGGTGGCCGTGGCCTTGCCGCTGGGCAAGGCGTGGCTGGCGATCCTGTTA
TGCGGCAGCGTGGCCGGGCTGCTCGGTGGCCTGTTCGCACGCATGGTGCTGGCCAGTGTGTCCGGCCGGCCGCGCTGGCT
GGCGGCACTGCGGCAACGGCACCCGGTGCTGCTGGCCGCGCTGTGCGGGGTTGCGCTGGTGGGTCTGGCGCTGGTGTTCG
GGCAAGGTGCGTTCGGCACCGGCTACGAGCAGGCGCGCAGCCTGGTGCAAGGGCACGCGGTGGTCGGCCATGAGTTCGGG
CTGATGAAGCTGGTGGCCAATCTGGTGTCGTACGTGGCCGGCATCCCGGGCGGGTTGTTTTCGCCGGCGTTGGCGGTGGG
CGCCGGGCTGGGGCACAACCTGTCGGTGTTGATGCCCAGCGTGGACCCGCGCACCTTCGTGCTGCTGGGCATGTGCGCGT
ATCTCACCGGCGTGACCCAGGCCCCGCTGACCTCGGCGGTAATCTCGCTGGAACTCACCGACACCAGCCAGATGCTGCTG
CCGATCCTGGCCACGGTGCTGCTCGCACGCGCGGTCTCCGGGCTGGTCTGCAAGACGCCGATCTATCGCGGCCTGGCCGA
ACAGTTGCTGGTGCCGGCTGCAGGCACGCCCGCGCCGCCGTCCACGCCTACGCCCCCAACACCGCCGCCGCCAAGCGCGC
ACTGA

Upstream 100 bases:

>100_bases
CAACCCGCAGCGCCTGCTGCCGGCGCTGCGCACGCCACCGCCCGGCACGCCCTGAGCCCGCGGCGGCCCGCGCGCGCCGC
AGCGGTGCGACAATAGGGCG

Downstream 100 bases:

>100_bases
CTGCTGACGGTGCGCCGCAGCCTGGCAGGCTATGGCGCATCGACCCACTGGCACTGCCGCAGAAGACGACAGTTGCGCAT
CGGTGGCAGCCGCTCTGCTG

Product: chloride channel

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MSAPDPSPRRLRPLLSSEGWRRRVALWGGAIAVALVAIVFAKASDAAFHLFQRITAHSIWWALLLTPGIFALLAWLTSGA
LRPTRGSGIPQVIAALEHPDPAFRETNLSLRVSVGKLALTTLSLLGGASVGREGPTVHVGASLMHVFGRWFGFREPRELS
HFLLAGGAAGIAAAFNTPLAGVVFAIEELSGRFEHRFSGTLLTAVIVGGVVSLGLLGNYTYFGKVAVALPLGKAWLAILL
CGSVAGLLGGLFARMVLASVSGRPRWLAALRQRHPVLLAALCGVALVGLALVFGQGAFGTGYEQARSLVQGHAVVGHEFG
LMKLVANLVSYVAGIPGGLFSPALAVGAGLGHNLSVLMPSVDPRTFVLLGMCAYLTGVTQAPLTSAVISLELTDTSQMLL
PILATVLLARAVSGLVCKTPIYRGLAEQLLVPAAGTPAPPSTPTPPTPPPPSAH

Sequences:

>Translated_454_residues
MSAPDPSPRRLRPLLSSEGWRRRVALWGGAIAVALVAIVFAKASDAAFHLFQRITAHSIWWALLLTPGIFALLAWLTSGA
LRPTRGSGIPQVIAALEHPDPAFRETNLSLRVSVGKLALTTLSLLGGASVGREGPTVHVGASLMHVFGRWFGFREPRELS
HFLLAGGAAGIAAAFNTPLAGVVFAIEELSGRFEHRFSGTLLTAVIVGGVVSLGLLGNYTYFGKVAVALPLGKAWLAILL
CGSVAGLLGGLFARMVLASVSGRPRWLAALRQRHPVLLAALCGVALVGLALVFGQGAFGTGYEQARSLVQGHAVVGHEFG
LMKLVANLVSYVAGIPGGLFSPALAVGAGLGHNLSVLMPSVDPRTFVLLGMCAYLTGVTQAPLTSAVISLELTDTSQMLL
PILATVLLARAVSGLVCKTPIYRGLAEQLLVPAAGTPAPPSTPTPPTPPPPSAH
>Mature_453_residues
SAPDPSPRRLRPLLSSEGWRRRVALWGGAIAVALVAIVFAKASDAAFHLFQRITAHSIWWALLLTPGIFALLAWLTSGAL
RPTRGSGIPQVIAALEHPDPAFRETNLSLRVSVGKLALTTLSLLGGASVGREGPTVHVGASLMHVFGRWFGFREPRELSH
FLLAGGAAGIAAAFNTPLAGVVFAIEELSGRFEHRFSGTLLTAVIVGGVVSLGLLGNYTYFGKVAVALPLGKAWLAILLC
GSVAGLLGGLFARMVLASVSGRPRWLAALRQRHPVLLAALCGVALVGLALVFGQGAFGTGYEQARSLVQGHAVVGHEFGL
MKLVANLVSYVAGIPGGLFSPALAVGAGLGHNLSVLMPSVDPRTFVLLGMCAYLTGVTQAPLTSAVISLELTDTSQMLLP
ILATVLLARAVSGLVCKTPIYRGLAEQLLVPAAGTPAPPSTPTPPTPPPPSAH

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786350, Length=362, Percent_Identity=30.6629834254144, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI87081943, Length=311, Percent_Identity=28.6173633440514, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71996455, Length=430, Percent_Identity=24.6511627906977, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71996452, Length=430, Percent_Identity=24.6511627906977, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322500, Length=414, Percent_Identity=25.6038647342995, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 47142; Mature: 47011

Theoretical pI: Translated: 10.88; Mature: 10.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPDPSPRRLRPLLSSEGWRRRVALWGGAIAVALVAIVFAKASDAAFHLFQRITAHSIW
CCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
WALLLTPGIFALLAWLTSGALRPTRGSGIPQVIAALEHPDPAFRETNLSLRVSVGKLALT
HHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCHHHCCCEEEEEHHHHHHH
TLSLLGGASVGREGPTVHVGASLMHVFGRWFGFREPRELSHFLLAGGAAGIAAAFNTPLA
HHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHCCCHH
GVVFAIEELSGRFEHRFSGTLLTAVIVGGVVSLGLLGNYTYFGKVAVALPLGKAWLAILL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHEECCHHHHHHHHH
CGSVAGLLGGLFARMVLASVSGRPRWLAALRQRHPVLLAALCGVALVGLALVFGQGAFGT
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCC
GYEQARSLVQGHAVVGHEFGLMKLVANLVSYVAGIPGGLFSPALAVGAGLGHNLSVLMPS
CHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEECC
VDPRTFVLLGMCAYLTGVTQAPLTSAVISLELTDTSQMLLPILATVLLARAVSGLVCKTP
CCCHHHHHHHHHHHHHCCCCCCHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHCHHHCCH
IYRGLAEQLLVPAAGTPAPPSTPTPPTPPPPSAH
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SAPDPSPRRLRPLLSSEGWRRRVALWGGAIAVALVAIVFAKASDAAFHLFQRITAHSIW
CCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
WALLLTPGIFALLAWLTSGALRPTRGSGIPQVIAALEHPDPAFRETNLSLRVSVGKLALT
HHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCHHHCCCEEEEEHHHHHHH
TLSLLGGASVGREGPTVHVGASLMHVFGRWFGFREPRELSHFLLAGGAAGIAAAFNTPLA
HHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHCCCHH
GVVFAIEELSGRFEHRFSGTLLTAVIVGGVVSLGLLGNYTYFGKVAVALPLGKAWLAILL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHEECCHHHHHHHHH
CGSVAGLLGGLFARMVLASVSGRPRWLAALRQRHPVLLAALCGVALVGLALVFGQGAFGT
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCC
GYEQARSLVQGHAVVGHEFGLMKLVANLVSYVAGIPGGLFSPALAVGAGLGHNLSVLMPS
CHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEECC
VDPRTFVLLGMCAYLTGVTQAPLTSAVISLELTDTSQMLLPILATVLLARAVSGLVCKTP
CCCHHHHHHHHHHHHHCCCCCCHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHCHHHCCH
IYRGLAEQLLVPAAGTPAPPSTPTPPTPPPPSAH
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA