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The map label for this gene is aspA [H]

Identifier: 66767776

GI number: 66767776

Start: 1746249

End: 1747613

Strand: Reverse

Name: aspA [H]

Synonym: XC_1450

Alternate gene names: 66767776

Gene position: 1747613-1746249 (Counterclockwise)

Preceding gene: 66767777

Following gene: 66767775

Centisome position: 33.94

GC content: 64.18

Gene sequence:

>1365_bases
ATGCAACTACATCGCAGGCGATACCTCGCGCTGTTGATCGGCGCCTTGGTGATCGGAACTCCCCCCATGCTGGCCAGCGC
CGCACAGCCGGCAAGCACTGCGCGTGCCAGCGCCGCAGGCGACCCGCTGTATCGCTACCAATGGCATCTCTCCAACCAGG
GGCAGCCGGTGATTGGCGACAGCCGTCCCGTGCCCGGCGTCGACATGGATGTAGATCTCCTGCATGCACTGGGCATTCGC
GGCCGCGGCGTGCGTGTGGCCGTGGTGGATAACGGCCTGGAGATCGGCCACGAAGATCTCGCTGGCAACATCATCCCGAA
TGGGTCGCACAATTTCGGCAATGGCTCGCACGATCCCACGCCCAGTGACCCGGGCTTTGGTCACGGCACTTCGGTGGCGG
GCATCATCGCTGCGGTTGGCTGGAATGGCCGTGGCGGTCGCGGCGTTGCACCCGAGGCCTTGCTGGCCGGATTCGATTTT
CTAGGCAGCGATTCTGCCGGAAGTTATGCCGAGGTCCGCTATTCCTGGGGTGATGGGCCGGAGGCGCGCACCCTCGATGT
CTTCAACAACAGCTGGGGCTCGGCGCCGGACTTCTACCCCGACGTTTCATTGGAAGAGGGTCAGTCCTGGGAAGCGCTGA
TGCGCTCGACACGCGGCGGGCTGGGCGGCATCTACATCAAGTCGGCCGGCAACAGCTTCAGGCGTGTTCGCGTCCGCGAT
GCCGAGGGCAGGATCGTCAATCTCTGCAGCGACCTGTCACGCACGTTGAATGTCGGTTGCCTGCTCACCAACGTGGACCC
ACTCAGCAATATGCCCGCCACCGTCGTCGTCGCCAGCCTGGACGCCACCGGCAAGCGGGCCTCGTACTCGTCATCCGGTT
CGGCGTTGTGGATCTCCGGTCTGGGCGGTGAGTTCGGCTACCAGCGCAAGTTCTATCCCAATGCGGCCCAGGTTTTCGCT
CCTGAAACCGCGCCCTTCGCCTACGATCCGGCGATCGTCACCACCGATCTCAGCGGTTGCAGCGCGGGTGACAACGTGGA
TGGCACCACCGTGGAAAATGCACTGACCGGCAGCACGTCAAGGATCGACGCATCCTGCAACTACAGCGCGCTGATGAACG
GCACATCTGCGGCGGCGCCAACCGTCTCCGGTGTTGCAGCGCTCATTCTCGGTGCCAACCCCAGCCTGACCGCGCGCGAT
GTCAAATACATCCTGGCCAAGACCGCGCGCCAGATCGATCCCTGGCAGCCCGCATCGGTCTACCAGGGCAGCGTGATCGA
CCCTGGCTGGATCACCAACGCCGCCGGGCATCATTTCAGCAACTGGTATGGCTTCGGCCTGGCCGACGGCGCCGCAGCCG
TCTAA

Upstream 100 bases:

>100_bases
CCTACCTGCGCGATGGAGTGTGAGCCGGCCGATTTTTGATCGGTCGGACGGGTGTCTGTGCCACTTCGACTGTGTCACCC
CTCCACTGGAGTCAAACGGA

Downstream 100 bases:

>100_bases
GAAGCGACCTACTTCAAGCCGCTGCCGCCGGTGCGTGATACGCAATGGGTTGCCTCCACCGCGGCTGCAAGCCAGATCGG
TGGACCGGCGCGACCGGCCA

Product: extracellular serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MQLHRRRYLALLIGALVIGTPPMLASAAQPASTARASAAGDPLYRYQWHLSNQGQPVIGDSRPVPGVDMDVDLLHALGIR
GRGVRVAVVDNGLEIGHEDLAGNIIPNGSHNFGNGSHDPTPSDPGFGHGTSVAGIIAAVGWNGRGGRGVAPEALLAGFDF
LGSDSAGSYAEVRYSWGDGPEARTLDVFNNSWGSAPDFYPDVSLEEGQSWEALMRSTRGGLGGIYIKSAGNSFRRVRVRD
AEGRIVNLCSDLSRTLNVGCLLTNVDPLSNMPATVVVASLDATGKRASYSSSGSALWISGLGGEFGYQRKFYPNAAQVFA
PETAPFAYDPAIVTTDLSGCSAGDNVDGTTVENALTGSTSRIDASCNYSALMNGTSAAAPTVSGVAALILGANPSLTARD
VKYILAKTARQIDPWQPASVYQGSVIDPGWITNAAGHHFSNWYGFGLADGAAAV

Sequences:

>Translated_454_residues
MQLHRRRYLALLIGALVIGTPPMLASAAQPASTARASAAGDPLYRYQWHLSNQGQPVIGDSRPVPGVDMDVDLLHALGIR
GRGVRVAVVDNGLEIGHEDLAGNIIPNGSHNFGNGSHDPTPSDPGFGHGTSVAGIIAAVGWNGRGGRGVAPEALLAGFDF
LGSDSAGSYAEVRYSWGDGPEARTLDVFNNSWGSAPDFYPDVSLEEGQSWEALMRSTRGGLGGIYIKSAGNSFRRVRVRD
AEGRIVNLCSDLSRTLNVGCLLTNVDPLSNMPATVVVASLDATGKRASYSSSGSALWISGLGGEFGYQRKFYPNAAQVFA
PETAPFAYDPAIVTTDLSGCSAGDNVDGTTVENALTGSTSRIDASCNYSALMNGTSAAAPTVSGVAALILGANPSLTARD
VKYILAKTARQIDPWQPASVYQGSVIDPGWITNAAGHHFSNWYGFGLADGAAAV
>Mature_454_residues
MQLHRRRYLALLIGALVIGTPPMLASAAQPASTARASAAGDPLYRYQWHLSNQGQPVIGDSRPVPGVDMDVDLLHALGIR
GRGVRVAVVDNGLEIGHEDLAGNIIPNGSHNFGNGSHDPTPSDPGFGHGTSVAGIIAAVGWNGRGGRGVAPEALLAGFDF
LGSDSAGSYAEVRYSWGDGPEARTLDVFNNSWGSAPDFYPDVSLEEGQSWEALMRSTRGGLGGIYIKSAGNSFRRVRVRD
AEGRIVNLCSDLSRTLNVGCLLTNVDPLSNMPATVVVASLDATGKRASYSSSGSALWISGLGGEFGYQRKFYPNAAQVFA
PETAPFAYDPAIVTTDLSGCSAGDNVDGTTVENALTGSTSRIDASCNYSALMNGTSAAAPTVSGVAALILGANPSLTARD
VKYILAKTARQIDPWQPASVYQGSVIDPGWITNAAGHHFSNWYGFGLADGAAAV

Specific function: Agent of furonculosis [H]

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Homo sapiens, GI20336180, Length=436, Percent_Identity=28.4403669724771, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI4505577, Length=436, Percent_Identity=28.4403669724771, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI20336188, Length=437, Percent_Identity=28.604118993135, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI27894285, Length=437, Percent_Identity=28.604118993135, Blast_Score=109, Evalue=6e-24,
Organism=Homo sapiens, GI20336182, Length=436, Percent_Identity=28.4403669724771, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI299523015, Length=435, Percent_Identity=26.4367816091954, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI20336190, Length=437, Percent_Identity=28.604118993135, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI20336184, Length=436, Percent_Identity=28.4403669724771, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI76443679, Length=425, Percent_Identity=27.2941176470588, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI4505579, Length=427, Percent_Identity=27.8688524590164, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI20336246, Length=435, Percent_Identity=26.4367816091954, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI20336244, Length=422, Percent_Identity=27.9620853080569, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI20336186, Length=420, Percent_Identity=27.6190476190476, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI20336248, Length=431, Percent_Identity=26.9141531322506, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI20336242, Length=213, Percent_Identity=31.4553990610329, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI295424143, Length=213, Percent_Identity=30.9859154929577, Blast_Score=77, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71988321, Length=421, Percent_Identity=27.5534441805226, Blast_Score=105, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI71987206, Length=441, Percent_Identity=27.437641723356, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71983555, Length=429, Percent_Identity=26.1072261072261, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71988297, Length=420, Percent_Identity=26.6666666666667, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI25141268, Length=424, Percent_Identity=26.1792452830189, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71988312, Length=215, Percent_Identity=31.1627906976744, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71988308, Length=215, Percent_Identity=31.1627906976744, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI71988315, Length=203, Percent_Identity=31.5270935960591, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71988301, Length=203, Percent_Identity=31.5270935960591, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324091, Length=186, Percent_Identity=32.258064516129, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24642488, Length=425, Percent_Identity=28, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24642484, Length=425, Percent_Identity=28, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24642486, Length=425, Percent_Identity=28, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI281360987, Length=425, Percent_Identity=27.7647058823529, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24642494, Length=425, Percent_Identity=27.7647058823529, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24642490, Length=425, Percent_Identity=27.7647058823529, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI45555723, Length=425, Percent_Identity=27.7647058823529, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24642492, Length=425, Percent_Identity=27.7647058823529, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17136192, Length=422, Percent_Identity=27.9620853080569, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI281360985, Length=158, Percent_Identity=33.5443037974684, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008979
- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500
- InterPro:   IPR002884 [H]

Pfam domain/function: PF01483 P_proprotein; PF00082 Peptidase_S8 [H]

EC number: NA

Molecular weight: Translated: 47314; Mature: 47314

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS00137 SUBTILASE_HIS ; PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLHRRRYLALLIGALVIGTPPMLASAAQPASTARASAAGDPLYRYQWHLSNQGQPVIGD
CCHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHCCCCCCEEEEEEEECCCCCCCCCC
SRPVPGVDMDVDLLHALGIRGRGVRVAVVDNGLEIGHEDLAGNIIPNGSHNFGNGSHDPT
CCCCCCCCCCHHHHHHCCCCCCCEEEEEECCCCCCCCHHHCCCCCCCCCCCCCCCCCCCC
PSDPGFGHGTSVAGIIAAVGWNGRGGRGVAPEALLAGFDFLGSDSAGSYAEVRYSWGDGP
CCCCCCCCCCHHHHHHEEECCCCCCCCCCCHHHHHHCCHHCCCCCCCCEEEEEEECCCCC
EARTLDVFNNSWGSAPDFYPDVSLEEGQSWEALMRSTRGGLGGIYIKSAGNSFRRVRVRD
CCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCEEEEEEEC
AEGRIVNLCSDLSRTLNVGCLLTNVDPLSNMPATVVVASLDATGKRASYSSSGSALWISG
CCCCCHHHHHHHHHHHCCEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEEC
LGGEFGYQRKFYPNAAQVFAPETAPFAYDPAIVTTDLSGCSAGDNVDGTTVENALTGSTS
CCCCCCCCCEECCCHHHEECCCCCCCEECCEEEEECCCCCCCCCCCCCCCHHHHHCCCCC
RIDASCNYSALMNGTSAAAPTVSGVAALILGANPSLTARDVKYILAKTARQIDPWQPASV
EEECCCCHHHHCCCCCCCCCHHHCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCHH
YQGSVIDPGWITNAAGHHFSNWYGFGLADGAAAV
CCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCC
>Mature Secondary Structure
MQLHRRRYLALLIGALVIGTPPMLASAAQPASTARASAAGDPLYRYQWHLSNQGQPVIGD
CCHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHCCCCCCEEEEEEEECCCCCCCCCC
SRPVPGVDMDVDLLHALGIRGRGVRVAVVDNGLEIGHEDLAGNIIPNGSHNFGNGSHDPT
CCCCCCCCCCHHHHHHCCCCCCCEEEEEECCCCCCCCHHHCCCCCCCCCCCCCCCCCCCC
PSDPGFGHGTSVAGIIAAVGWNGRGGRGVAPEALLAGFDFLGSDSAGSYAEVRYSWGDGP
CCCCCCCCCCHHHHHHEEECCCCCCCCCCCHHHHHHCCHHCCCCCCCCEEEEEEECCCCC
EARTLDVFNNSWGSAPDFYPDVSLEEGQSWEALMRSTRGGLGGIYIKSAGNSFRRVRVRD
CCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCEEEEEEEC
AEGRIVNLCSDLSRTLNVGCLLTNVDPLSNMPATVVVASLDATGKRASYSSSGSALWISG
CCCCCHHHHHHHHHHHCCEEEEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEEC
LGGEFGYQRKFYPNAAQVFAPETAPFAYDPAIVTTDLSGCSAGDNVDGTTVENALTGSTS
CCCCCCCCCEECCCHHHEECCCCCCCEECCEEEEECCCCCCCCCCCCCCCHHHHHCCCCC
RIDASCNYSALMNGTSAAAPTVSGVAALILGANPSLTARDVKYILAKTARQIDPWQPASV
EEECCCCHHHHCCCCCCCCCHHHCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCHH
YQGSVIDPGWITNAAGHHFSNWYGFGLADGAAAV
CCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1468618 [H]