Click here to switch to the map view.

The map label for this gene is oprM [H]

Identifier: 66767760

GI number: 66767760

Start: 1731551

End: 1733044

Strand: Direct

Name: oprM [H]

Synonym: XC_1434

Alternate gene names: 66767760

Gene position: 1731551-1733044 (Clockwise)

Preceding gene: 66767759

Following gene: 66767761

Centisome position: 33.63

GC content: 67.47

Gene sequence:

>1494_bases
ATGACACCGATCCGAATGACGCTTGCCGCACTCGCGGTGACCAGCGTGTTGTCTGGCTGCACGCTGATGCCGCGTTATGC
GCGGCCCGACGCACCGGTGCCGGCGCAGTTTGCCGGTGCCACCGCGGCGGCGACCGTTGCCAGCGAAGCGGCAGCGAGCG
CAGAAACTCCCGTCATCGCCGATATCGGCTGGCGGGAGGTGTTCACCGACCCGGCGCTGCAACAGGTGATCCAGCTGGCG
CTGGACAATAACCGCGACCTGCGTGTGGCCGCGCTCAATATCGAAGTGGCACGCGCGCAATACCGGGTGGAGCGTGCAGC
GCTGGTGCCCGGCGTGGATGCCACCGGCACTGCCAACAACGCGCGTACCCCGAGCGAACTGGCGGTGCCCGGGCAGCCGC
CGGTGTTCCGCACCTACAGCGCCAATGTGGGCGTGAGCGCGTACGAGCTGGATTTGTTCGGGCGCGTGCGCAGCCTCAAG
GAACAGGCGCTGCAGCAATTTCTCTCCACTGCCGAAGCCCGCCGTAGCACGCACATCAGTCTGGTCGCCGATGTGGCCAC
CGCGTATCTCACCCTGGCCGCTGACCAGGAGCTGCTGCAGCTAGCGCAATCCACGCTGACCAGCCAAAGCGACAGCTACC
GCTTGCAGCAGCGCAGTTTCGAGCTGGGCGTGGCCTCGCAGCTCACCTTGCGGCAGGCACAGACCACCGTGGAAAGCGCG
CGTGTGGATGTGGAGCGTTACACCGCGCAGGTGGCGCAGGACCGCAACGCGTTGGTGCTGCTGGTCGGCACCCAGTTGCC
GGAGAGTCTGTTGCCACGCGCGTTGCCCGATGGCGCAAGCGTGGAAGGCAATGTGCTGGCCGCCGTGCCGGCGGGCGTGC
CGTCGCAGCTGTTGCAGCGTCGCCCGGACATCCTGGAGGCCGAGCGCAACCTGCGCGCGGCCAATGCCAACATCGGCGCG
GCGCGCGCGGCGTTCTTTCCCAGCATCAGCTTGACCGCCACGCTGGGCTCGTCCAGCAGCAGTCTGTCCGGGCTGTTCGA
GTCGGGCACGCGGGCCTGGAGTTTCGTGCCGCAGCTGACCTTGCCACTGTTCAATGCCGGGCGTAACCGCGCCAATCTGG
ACATGGCCAAGGCCAACCGCGACATTGAAGTGGCCCGCTACGAAAAGTCGATCCAGACTGCGTTCCGCGAGGTGTCCGAT
GCGCTCGCGCAGCGCGACACCCTGGGCCGCCAGCTGCAGGCACAGCAGGCCCTGGTGGATGCCACCGCAGACAGTTACCG
GTTGTCGCAGGCGCGCTTCGAACGCGGGATCGACAGCTATCTGCAGGCGCTGGATGCGCAGCGCTCGCTGTATGGCGCGC
AGCAGACCTTGATCACCACGCAGTTGTCGCGCATCACCAACCTGGTGACGTTCTACAAGGCGATGGGCGGCGGCTGGCTG
CAGGCCGATGGGCCGGACGTGGCCGCCGCCGACACGGCGTCGCCCCGTGGCTGA

Upstream 100 bases:

>100_bases
GCCATCTTCTTCGTGCCGTTGTTCTTCGTACTGGTGCGTGGGCTGTTCGAACGCCGCGCGCAGCCTGATGCCTCCGTTCC
GCAACATGCAGGGCACTGAC

Downstream 100 bases:

>100_bases
TACGGCCCCGGCGCAAGGCCCGGCCTTGCCGGCGCCGGGCCGGCGCGTGCCGCATGCCAAGCGTGGCGCGACCCTGGCCG
CCGCGCAGCAGTTGTTTACA

Product: outer membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 497; Mature: 496

Protein sequence:

>497_residues
MTPIRMTLAALAVTSVLSGCTLMPRYARPDAPVPAQFAGATAAATVASEAAASAETPVIADIGWREVFTDPALQQVIQLA
LDNNRDLRVAALNIEVARAQYRVERAALVPGVDATGTANNARTPSELAVPGQPPVFRTYSANVGVSAYELDLFGRVRSLK
EQALQQFLSTAEARRSTHISLVADVATAYLTLAADQELLQLAQSTLTSQSDSYRLQQRSFELGVASQLTLRQAQTTVESA
RVDVERYTAQVAQDRNALVLLVGTQLPESLLPRALPDGASVEGNVLAAVPAGVPSQLLQRRPDILEAERNLRAANANIGA
ARAAFFPSISLTATLGSSSSSLSGLFESGTRAWSFVPQLTLPLFNAGRNRANLDMAKANRDIEVARYEKSIQTAFREVSD
ALAQRDTLGRQLQAQQALVDATADSYRLSQARFERGIDSYLQALDAQRSLYGAQQTLITTQLSRITNLVTFYKAMGGGWL
QADGPDVAAADTASPRG

Sequences:

>Translated_497_residues
MTPIRMTLAALAVTSVLSGCTLMPRYARPDAPVPAQFAGATAAATVASEAAASAETPVIADIGWREVFTDPALQQVIQLA
LDNNRDLRVAALNIEVARAQYRVERAALVPGVDATGTANNARTPSELAVPGQPPVFRTYSANVGVSAYELDLFGRVRSLK
EQALQQFLSTAEARRSTHISLVADVATAYLTLAADQELLQLAQSTLTSQSDSYRLQQRSFELGVASQLTLRQAQTTVESA
RVDVERYTAQVAQDRNALVLLVGTQLPESLLPRALPDGASVEGNVLAAVPAGVPSQLLQRRPDILEAERNLRAANANIGA
ARAAFFPSISLTATLGSSSSSLSGLFESGTRAWSFVPQLTLPLFNAGRNRANLDMAKANRDIEVARYEKSIQTAFREVSD
ALAQRDTLGRQLQAQQALVDATADSYRLSQARFERGIDSYLQALDAQRSLYGAQQTLITTQLSRITNLVTFYKAMGGGWL
QADGPDVAAADTASPRG
>Mature_496_residues
TPIRMTLAALAVTSVLSGCTLMPRYARPDAPVPAQFAGATAAATVASEAAASAETPVIADIGWREVFTDPALQQVIQLAL
DNNRDLRVAALNIEVARAQYRVERAALVPGVDATGTANNARTPSELAVPGQPPVFRTYSANVGVSAYELDLFGRVRSLKE
QALQQFLSTAEARRSTHISLVADVATAYLTLAADQELLQLAQSTLTSQSDSYRLQQRSFELGVASQLTLRQAQTTVESAR
VDVERYTAQVAQDRNALVLLVGTQLPESLLPRALPDGASVEGNVLAAVPAGVPSQLLQRRPDILEAERNLRAANANIGAA
RAAFFPSISLTATLGSSSSSLSGLFESGTRAWSFVPQLTLPLFNAGRNRANLDMAKANRDIEVARYEKSIQTAFREVSDA
LAQRDTLGRQLQAQQALVDATADSYRLSQARFERGIDSYLQALDAQRSLYGAQQTLITTQLSRITNLVTFYKAMGGGWLQ
ADGPDVAAADTASPRG

Specific function: The ability to export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the mexB

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor. Note=Attached to the outer membrane by a lipid anchor and via the transmembrane beta-barrel. The membrane anchor is not necessary for antibiotic efflux. In one report (PubMed:10889211) the Cys-18- Gly mutant is reported

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=480, Percent_Identity=39.7916666666667, Blast_Score=337, Evalue=1e-93,
Organism=Escherichia coli, GI2367348, Length=489, Percent_Identity=27.19836400818, Blast_Score=151, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 53174; Mature: 53043

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPIRMTLAALAVTSVLSGCTLMPRYARPDAPVPAQFAGATAAATVASEAAASAETPVIA
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHCCCCCCEEE
DIGWREVFTDPALQQVIQLALDNNRDLRVAALNIEVARAQYRVERAALVPGVDATGTANN
CCCHHHHHCCHHHHHHHHHHHCCCCCEEEEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCC
ARTPSELAVPGQPPVFRTYSANVGVSAYELDLFGRVRSLKEQALQQFLSTAEARRSTHIS
CCCCCCCCCCCCCCEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVADVATAYLTLAADQELLQLAQSTLTSQSDSYRLQQRSFELGVASQLTLRQAQTTVESA
HHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
RVDVERYTAQVAQDRNALVLLVGTQLPESLLPRALPDGASVEGNVLAAVPAGVPSQLLQR
HHHHHHHHHHHHCCCCCEEEEEECCCCHHHCCCCCCCCCCCCCCEEEEECCCCHHHHHHC
RPDILEAERNLRAANANIGAARAAFFPSISLTATLGSSSSSLSGLFESGTRAWSFVPQLT
CCCHHHHHHCCHHCCCCCCHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCHHHHHHHHHH
LPLFNAGRNRANLDMAKANRDIEVARYEKSIQTAFREVSDALAQRDTLGRQLQAQQALVD
HHHHHCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATADSYRLSQARFERGIDSYLQALDAQRSLYGAQQTLITTQLSRITNLVTFYKAMGGGWL
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
QADGPDVAAADTASPRG
ECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TPIRMTLAALAVTSVLSGCTLMPRYARPDAPVPAQFAGATAAATVASEAAASAETPVIA
CCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHCCCCCCEEE
DIGWREVFTDPALQQVIQLALDNNRDLRVAALNIEVARAQYRVERAALVPGVDATGTANN
CCCHHHHHCCHHHHHHHHHHHCCCCCEEEEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCC
ARTPSELAVPGQPPVFRTYSANVGVSAYELDLFGRVRSLKEQALQQFLSTAEARRSTHIS
CCCCCCCCCCCCCCEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVADVATAYLTLAADQELLQLAQSTLTSQSDSYRLQQRSFELGVASQLTLRQAQTTVESA
HHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
RVDVERYTAQVAQDRNALVLLVGTQLPESLLPRALPDGASVEGNVLAAVPAGVPSQLLQR
HHHHHHHHHHHHCCCCCEEEEEECCCCHHHCCCCCCCCCCCCCCEEEEECCCCHHHHHHC
RPDILEAERNLRAANANIGAARAAFFPSISLTATLGSSSSSLSGLFESGTRAWSFVPQLT
CCCHHHHHHCCHHCCCCCCHHHHHHCCCCEEEEEECCCCHHHHHHHHCCCHHHHHHHHHH
LPLFNAGRNRANLDMAKANRDIEVARYEKSIQTAFREVSDALAQRDTLGRQLQAQQALVD
HHHHHCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATADSYRLSQARFERGIDSYLQALDAQRSLYGAQQTLITTQLSRITNLVTFYKAMGGGWL
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
QADGPDVAAADTASPRG
ECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8226684; 10889211; 10984043; 7968531; 8540696; 9401051; 9603892; 10952562 [H]