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The map label for this gene is lysA [H]

Identifier: 66767699

GI number: 66767699

Start: 1656510

End: 1659119

Strand: Direct

Name: lysA [H]

Synonym: XC_1372

Alternate gene names: 66767699

Gene position: 1656510-1659119 (Clockwise)

Preceding gene: 66767696

Following gene: 66767700

Centisome position: 32.17

GC content: 65.71

Gene sequence:

>2610_bases
ATGTCAGCTTCCCTTTCTACCGATCGTTGGATCGTCCTCAAGTTCGGCGGCACCTCGGTGTCGCGTCGTCATCGCTGGGA
CACGATTGGAAAACTGGCGAGCAAACGGGCGAACGAAACCGGCGGCCGCGTGCTGGTGGTGGTGTCTGCGTTGTCGGGCG
TCACCAACGAGCTCACTGCCATCGCCGATGGTGCTGCCGACAGCGCGCAGCGCGTGGCGGCACTGGAACTGCGGCATCGC
GAATTCCTTGCCGAGCTTGAGCTCGATGCCGACGCAGTGCTGGGCGCGCGGCTTGCCGCGTTGCACGCGTTGGTGGGCGA
TGCACGCGCTGCCAGCCGCACGCTCGACTGGCAGGCCGAGGTGCTGGGGCAAGGCGAATTGCTGTCTTCCACCATCGGTG
CGGCCTATCTGCATGCCAATGGCCTGGACATGGGCTGGCTGGATGCGCGGGAGTGGTTGTCGGCGTTGCCGCCGCAGCCC
AACCAGAGCGAGTGGTCCAAGCGCTTGTCGGTGTCGTGCCAGTGGCAATCCGATGCCGCATGGCGGGCGCGTTTCGATGC
GCAGCCCACGCGGCTGCTGATCACGCAGGGCTTTATCTCGCGGCACGCCGATGGCGGCACCGCGATCCTGGGCCGTGGCG
GCTCGGACACCTCGGCGGCGTATTTCGGTGCATTGCTCGGCGCCAGCCGGGTGGAAATCTGGACCGACGTGCCCGGCATG
TTCAGCGCCAACCCGAAGGAAGTGCCGGATGCGCGTCTGCTGACCCGCCTGGACTATTACGAAGCGCAGGAAATCGCCAC
CACCGGCGCCAAGGTGCTGCATCCGCGCTCGATCAAGCCCTGCCGCGATTCCGGCGTGCCGATGGCGATCCTGGATACCG
AACGCCCGGATCTGCCAGGCACCAGCATCGATGGCAGCGCCGAACCAGTACTCGGCGTCAAGGCGATCAGCCGCCGCAAC
GGCATCGTGCTGGTGTCGATGGAAGGCATCGGCATGTGGCAGCAGGTCGGCTTCCTGGCCGATGTGTTCACGCTGTTCAA
GAAGCATGGCTTGTCGGTGGATCTGATCGGCTCGGCCGAAACCAACGTCACCGTCTCGCTGGACCCGTCCGAAAACCTGG
TCAACACCGATGTGCTGGCGGCGTTGTCGGCAGACCTGTCGCAGATCTGCAAGGTCAAGATCATCGTGCCGTGCGCGGCG
ATCACGCTGGTCGGGCGCGGCATGCGCTCGCTGCTGCACAAGCTGTCCGACGTGTGGGCCACGTTCGGTCAGGAGCGCGT
GCACATGATTTCGCAGTCGTCCAACGACTTGAACCTGACCTTCGTCATCGACGAATCCGATGCCGACGGCCTGTTGCCGA
TTTTGCATGCGGAATTGATCGATAGCGGCGCCATGCCGGTCAGCGAAGGTGAGGTGTTTGGCCCACGCTGGCGTGACATC
ATCGGTTCGGTGCGGCCGCGGCCCACGCCGTGGTGGCATGCCGAGCGCGCGCATCTGCTGACGCTGTCCAAGGCCGGCAC
GCCGCGTTACGTGTACCACCTGCCCACGGTGCGCGCGCGCGCGCAAGCGCTGGCGCAGATTGCCGCAGTGGATCAGCGCT
ATTACGCGATCAAGGCCAACTCGCATCCGGCCATCCTGATGGCGCTGGAACAGGCTGGATTCGGCCTGGAATGCGTCTCG
CACGGCGAATTGCGCCGCGTGTTCGACACGTTGCCTGAGCTGTCGCCACGCCGCGTGTTGTTCACGCCGAGCTTCGCGCC
GCGTAGCGAATACGAGGCCGCGTTTGCGCTGGGCGTAACCGTCACCGTGGACAACGTCGAAGCGCTCAAGCGCTGGCCGG
AGTTGTTCCGCGGCCGCAACGTGTGGCTGCGCATCGACCTGGGCCACGGCGATGGCCACCACGAGAAGGTCAACACCGGT
GGCAAGGCGTCCAAGTTCGGGCTGTCGTCCACGCGCGTGGATGAGTTCGTCGAGTTGGCACGCACGCTGGAAGTCACCAT
CACCGGCGTGCATGCGCATCTGGGCAGCGGCGTGGAGACCGGCGAACACTGGCGGATGATGTACGACGAACTGGCCGGCT
TCGCGCGCCGCATCGGCACCGTGGAGACCATCGACATCGGCGGTGGGCTGCCGATTCCCTACAGCGCCGAAGACGAGCCG
TTCGACCTGGAGCTGTGGGCCAAGGGCCTGGCCGAGGTCAAGGCCGTGCATCCGGGCTTCCGCCTGGCGATCGAGCCTGG
CCGTTATCTGGTGGCCGAGGCCGGCGTGTTGCTGGCCCAGGCGACCCAGGTGATCGAAAAGGACGGCGTCCATCGCGTTG
GCCTGGATGCCGGCATGAATAGCCTGATCCGCCCGGCGCTGTACGACGCCTGGCACGACATCGAAAACCTCAGCCAGCTC
GGTGCGCCTGCCGATGGCAGCTTCGATGTGGTGGGGCCGATCTGCGAATCCTCCGATGTGTTCGGCAAGCGCCGCCGCCT
GCCCGCGGCGACCGCACCGGGCAATGTGATGCTGATCGCTGATGCCGGCGCGTATGGGTATTCCATGGCCAGCACCTACA
ACCAGCGGGAGTTGCCGCGCGAAGAGGTGATCGATGCGGCCGCTGGCTGA

Upstream 100 bases:

>100_bases
TGTGACGCGAGGAGGGGTCATGGCTGGGATATTGGCAGTAGAATCGGAGGTTCCGCCCGGCGTACCGGGCAACTCCCCCC
ATCCTAAACGCCCACATCTA

Downstream 100 bases:

>100_bases
GTTCATCGCGCTGAGCACGCTGGCCGGTGGTGTGTCGATGGTGGTGTCCACCGCCATCGACATGGCCGGCCAGGCGATGC
CGTGGACCGATAGCCTAAAG

Product: bifunctional aspartate kinase/diaminopimelate decarboxylase protein

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 869; Mature: 868

Protein sequence:

>869_residues
MSASLSTDRWIVLKFGGTSVSRRHRWDTIGKLASKRANETGGRVLVVVSALSGVTNELTAIADGAADSAQRVAALELRHR
EFLAELELDADAVLGARLAALHALVGDARAASRTLDWQAEVLGQGELLSSTIGAAYLHANGLDMGWLDAREWLSALPPQP
NQSEWSKRLSVSCQWQSDAAWRARFDAQPTRLLITQGFISRHADGGTAILGRGGSDTSAAYFGALLGASRVEIWTDVPGM
FSANPKEVPDARLLTRLDYYEAQEIATTGAKVLHPRSIKPCRDSGVPMAILDTERPDLPGTSIDGSAEPVLGVKAISRRN
GIVLVSMEGIGMWQQVGFLADVFTLFKKHGLSVDLIGSAETNVTVSLDPSENLVNTDVLAALSADLSQICKVKIIVPCAA
ITLVGRGMRSLLHKLSDVWATFGQERVHMISQSSNDLNLTFVIDESDADGLLPILHAELIDSGAMPVSEGEVFGPRWRDI
IGSVRPRPTPWWHAERAHLLTLSKAGTPRYVYHLPTVRARAQALAQIAAVDQRYYAIKANSHPAILMALEQAGFGLECVS
HGELRRVFDTLPELSPRRVLFTPSFAPRSEYEAAFALGVTVTVDNVEALKRWPELFRGRNVWLRIDLGHGDGHHEKVNTG
GKASKFGLSSTRVDEFVELARTLEVTITGVHAHLGSGVETGEHWRMMYDELAGFARRIGTVETIDIGGGLPIPYSAEDEP
FDLELWAKGLAEVKAVHPGFRLAIEPGRYLVAEAGVLLAQATQVIEKDGVHRVGLDAGMNSLIRPALYDAWHDIENLSQL
GAPADGSFDVVGPICESSDVFGKRRRLPAATAPGNVMLIADAGAYGYSMASTYNQRELPREEVIDAAAG

Sequences:

>Translated_869_residues
MSASLSTDRWIVLKFGGTSVSRRHRWDTIGKLASKRANETGGRVLVVVSALSGVTNELTAIADGAADSAQRVAALELRHR
EFLAELELDADAVLGARLAALHALVGDARAASRTLDWQAEVLGQGELLSSTIGAAYLHANGLDMGWLDAREWLSALPPQP
NQSEWSKRLSVSCQWQSDAAWRARFDAQPTRLLITQGFISRHADGGTAILGRGGSDTSAAYFGALLGASRVEIWTDVPGM
FSANPKEVPDARLLTRLDYYEAQEIATTGAKVLHPRSIKPCRDSGVPMAILDTERPDLPGTSIDGSAEPVLGVKAISRRN
GIVLVSMEGIGMWQQVGFLADVFTLFKKHGLSVDLIGSAETNVTVSLDPSENLVNTDVLAALSADLSQICKVKIIVPCAA
ITLVGRGMRSLLHKLSDVWATFGQERVHMISQSSNDLNLTFVIDESDADGLLPILHAELIDSGAMPVSEGEVFGPRWRDI
IGSVRPRPTPWWHAERAHLLTLSKAGTPRYVYHLPTVRARAQALAQIAAVDQRYYAIKANSHPAILMALEQAGFGLECVS
HGELRRVFDTLPELSPRRVLFTPSFAPRSEYEAAFALGVTVTVDNVEALKRWPELFRGRNVWLRIDLGHGDGHHEKVNTG
GKASKFGLSSTRVDEFVELARTLEVTITGVHAHLGSGVETGEHWRMMYDELAGFARRIGTVETIDIGGGLPIPYSAEDEP
FDLELWAKGLAEVKAVHPGFRLAIEPGRYLVAEAGVLLAQATQVIEKDGVHRVGLDAGMNSLIRPALYDAWHDIENLSQL
GAPADGSFDVVGPICESSDVFGKRRRLPAATAPGNVMLIADAGAYGYSMASTYNQRELPREEVIDAAAG
>Mature_868_residues
SASLSTDRWIVLKFGGTSVSRRHRWDTIGKLASKRANETGGRVLVVVSALSGVTNELTAIADGAADSAQRVAALELRHRE
FLAELELDADAVLGARLAALHALVGDARAASRTLDWQAEVLGQGELLSSTIGAAYLHANGLDMGWLDAREWLSALPPQPN
QSEWSKRLSVSCQWQSDAAWRARFDAQPTRLLITQGFISRHADGGTAILGRGGSDTSAAYFGALLGASRVEIWTDVPGMF
SANPKEVPDARLLTRLDYYEAQEIATTGAKVLHPRSIKPCRDSGVPMAILDTERPDLPGTSIDGSAEPVLGVKAISRRNG
IVLVSMEGIGMWQQVGFLADVFTLFKKHGLSVDLIGSAETNVTVSLDPSENLVNTDVLAALSADLSQICKVKIIVPCAAI
TLVGRGMRSLLHKLSDVWATFGQERVHMISQSSNDLNLTFVIDESDADGLLPILHAELIDSGAMPVSEGEVFGPRWRDII
GSVRPRPTPWWHAERAHLLTLSKAGTPRYVYHLPTVRARAQALAQIAAVDQRYYAIKANSHPAILMALEQAGFGLECVSH
GELRRVFDTLPELSPRRVLFTPSFAPRSEYEAAFALGVTVTVDNVEALKRWPELFRGRNVWLRIDLGHGDGHHEKVNTGG
KASKFGLSSTRVDEFVELARTLEVTITGVHAHLGSGVETGEHWRMMYDELAGFARRIGTVETIDIGGGLPIPYSAEDEPF
DLELWAKGLAEVKAVHPGFRLAIEPGRYLVAEAGVLLAQATQVIEKDGVHRVGLDAGMNSLIRPALYDAWHDIENLSQLG
APADGSFDVVGPICESSDVFGKRRRLPAATAPGNVMLIADAGAYGYSMASTYNQRELPREEVIDAAAG

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=356, Percent_Identity=25.8426966292135, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI22538418, Length=300, Percent_Identity=26.3333333333333, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI21361583, Length=300, Percent_Identity=26.3333333333333, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI1789203, Length=383, Percent_Identity=34.2036553524804, Blast_Score=190, Evalue=4e-49,
Organism=Escherichia coli, GI1786183, Length=477, Percent_Identity=31.0272536687631, Blast_Score=178, Evalue=1e-45,
Organism=Escherichia coli, GI1790455, Length=457, Percent_Identity=29.9781181619256, Blast_Score=172, Evalue=6e-44,
Organism=Escherichia coli, GI1790376, Length=321, Percent_Identity=31.4641744548287, Blast_Score=127, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6320893, Length=501, Percent_Identity=26.9461077844311, Blast_Score=144, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6322664, Length=358, Percent_Identity=23.463687150838, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24586472, Length=347, Percent_Identity=27.3775216138329, Blast_Score=86, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24586474, Length=361, Percent_Identity=25.4847645429363, Blast_Score=67, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 94019; Mature: 93888

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS00324 ASPARTOKINASE ; PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASLSTDRWIVLKFGGTSVSRRHRWDTIGKLASKRANETGGRVLVVVSALSGVTNELTA
CCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHCCCHHHHHH
IADGAADSAQRVAALELRHREFLAELELDADAVLGARLAALHALVGDARAASRTLDWQAE
HCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCHHHHHCCCCCHHH
VLGQGELLSSTIGAAYLHANGLDMGWLDAREWLSALPPQPNQSEWSKRLSVSCQWQSDAA
HCCCCHHHHHHHCEEEEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHCEEEEEECCCCC
WRARFDAQPTRLLITQGFISRHADGGTAILGRGGSDTSAAYFGALLGASRVEIWTDVPGM
HHEECCCCCCEEEEEHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCC
FSANPKEVPDARLLTRLDYYEAQEIATTGAKVLHPRSIKPCRDSGVPMAILDTERPDLPG
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCEEEEECCCCCCCC
TSIDGSAEPVLGVKAISRRNGIVLVSMEGIGMWQQVGFLADVFTLFKKHGLSVDLIGSAE
CCCCCCCCCEEEHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCC
TNVTVSLDPSENLVNTDVLAALSADLSQICKVKIIVPCAAITLVGRGMRSLLHKLSDVWA
CEEEEEECCCCCCCCHHHHHHHHHHHHHHCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
TFGQERVHMISQSSNDLNLTFVIDESDADGLLPILHAELIDSGAMPVSEGEVFGPRWRDI
HHCHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
IGSVRPRPTPWWHAERAHLLTLSKAGTPRYVYHLPTVRARAQALAQIAAVDQRYYAIKAN
HCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHCCEEEEEECC
SHPAILMALEQAGFGLECVSHGELRRVFDTLPELSPRRVLFTPSFAPRSEYEAAFALGVT
CCCEEEEEEECCCCCEEECCCHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEEEEEEE
VTVDNVEALKRWPELFRGRNVWLRIDLGHGDGHHEKVNTGGKASKFGLSSTRVDEFVELA
EEECCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
RTLEVTITGVHAHLGSGVETGEHWRMMYDELAGFARRIGTVETIDIGGGLPIPYSAEDEP
HEEEEEEEEEEHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCC
FDLELWAKGLAEVKAVHPGFRLAIEPGRYLVAEAGVLLAQATQVIEKDGVHRVGLDAGMN
CCHHHHHHHHHHHHHCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHCCCEEEEHHHCHH
SLIRPALYDAWHDIENLSQLGAPADGSFDVVGPICESSDVFGKRRRLPAATAPGNVMLIA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHCCCCCCCCCCEEEEE
DAGAYGYSMASTYNQRELPREEVIDAAAG
CCCCCCCHHHHCCCHHCCCHHHHHHCCCC
>Mature Secondary Structure 
SASLSTDRWIVLKFGGTSVSRRHRWDTIGKLASKRANETGGRVLVVVSALSGVTNELTA
CCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHCCCHHHHHH
IADGAADSAQRVAALELRHREFLAELELDADAVLGARLAALHALVGDARAASRTLDWQAE
HCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCHHHHHCCCCCHHH
VLGQGELLSSTIGAAYLHANGLDMGWLDAREWLSALPPQPNQSEWSKRLSVSCQWQSDAA
HCCCCHHHHHHHCEEEEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHCEEEEEECCCCC
WRARFDAQPTRLLITQGFISRHADGGTAILGRGGSDTSAAYFGALLGASRVEIWTDVPGM
HHEECCCCCCEEEEEHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCC
FSANPKEVPDARLLTRLDYYEAQEIATTGAKVLHPRSIKPCRDSGVPMAILDTERPDLPG
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCEEEEECCCCCCCC
TSIDGSAEPVLGVKAISRRNGIVLVSMEGIGMWQQVGFLADVFTLFKKHGLSVDLIGSAE
CCCCCCCCCEEEHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCC
TNVTVSLDPSENLVNTDVLAALSADLSQICKVKIIVPCAAITLVGRGMRSLLHKLSDVWA
CEEEEEECCCCCCCCHHHHHHHHHHHHHHCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHH
TFGQERVHMISQSSNDLNLTFVIDESDADGLLPILHAELIDSGAMPVSEGEVFGPRWRDI
HHCHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
IGSVRPRPTPWWHAERAHLLTLSKAGTPRYVYHLPTVRARAQALAQIAAVDQRYYAIKAN
HCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHCCEEEEEECC
SHPAILMALEQAGFGLECVSHGELRRVFDTLPELSPRRVLFTPSFAPRSEYEAAFALGVT
CCCEEEEEEECCCCCEEECCCHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEEEEEEE
VTVDNVEALKRWPELFRGRNVWLRIDLGHGDGHHEKVNTGGKASKFGLSSTRVDEFVELA
EEECCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
RTLEVTITGVHAHLGSGVETGEHWRMMYDELAGFARRIGTVETIDIGGGLPIPYSAEDEP
HEEEEEEEEEEHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCC
FDLELWAKGLAEVKAVHPGFRLAIEPGRYLVAEAGVLLAQATQVIEKDGVHRVGLDAGMN
CCHHHHHHHHHHHHHCCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHCCCEEEEHHHCHH
SLIRPALYDAWHDIENLSQLGAPADGSFDVVGPICESSDVFGKRRRLPAATAPGNVMLIA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCHHHHHHCCCCCCCCCCEEEEE
DAGAYGYSMASTYNQRELPREEVIDAAAG
CCCCCCCHHHHCCCHHCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]