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The map label for this gene is csd [H]

Identifier: 66767671

GI number: 66767671

Start: 1630337

End: 1631578

Strand: Reverse

Name: csd [H]

Synonym: XC_1344

Alternate gene names: 66767671

Gene position: 1631578-1630337 (Counterclockwise)

Preceding gene: 66767672

Following gene: 66767670

Centisome position: 31.69

GC content: 66.34

Gene sequence:

>1242_bases
ATGAACGCCTCCGTCGCCGCCACTCCGGCACCGGACTGGGAGCGCGTACGCTCCGATTTCCCGCTGCTGATGCGGCAGGT
GCACGGCAAGCCGCTGATCTATTTCGACAACGCCAACACCGGGCAGAAGCCGCTGCAGGTGATCGCTGCCACCGACGAGT
TCTATCGCCGGCAGAACGCCAATGTCAGCCGCGCGGTGCATGCACTGGGCACCGAAGCCACCGACGCGTTCGAGGGCGCA
CGCAGCAAGCTGGCGCGTTTTCTCAACGTGCGCGCCGACGAGCTGGTGCTGTGCAGCGGCACCACCTTCGCGATCAATCT
GGTGGCCTATTCCTGGGCGCTGCCGCGCCTGGGGCCGAGCGATGTGATCCTGGTATCGCGCATGGAGCACCACGCCAATA
TCGTGCCGTGGCAGTTGGTGGCCCAGCGCACCGGCGCCACCATCCGCGTGGCCGAGATCACGCCTGAGGGCGCGCTGGAT
CTGGATGCACTGCGTAAGGCGATGACCCCCGAGGTCAAGCTGCTGGCGATCACCCACGTGTCCAACGTGCTGGGCACAGT
GAACCCGGTGCGCGAGATCTGCCGTGAGGCACGCAAGCGCGGCATCGTCACCGTAGTGGACGGCTCGCAAGCCGCACCGC
ACCGCCGCGTCGACGTGGCCGGCATCGGCTGCGATTTCTACGCCATCACCGGCCACAAGATGTGCGGCCCCACCGGCACC
GGAGCATTGTGGGCGCGCCGCGAACATCTGCAGGCCATGCCGCCGTTTTTGGGCGGCGGCGAGATGATCAAGGAAGTGAG
CTTCGAAGGCACCGTATTCAACGACGGCCCGCACAAGTTCGAAGCCGGCACGCCGAATATCGCTGGCTTCATCGGCTTGG
GCGCGGCGGTTGACTATCTGGACGCAGTCGGCCTGGCGCACGTGGAAGCGCGCGAGACCGAGCTGCTCGCGCACTTCACC
GAAGAGCTGCAGCGCATCGACGGCCTGCGCATCTTCGGCACCACGCCGGACAAGGCGGCGGTGGTGTCGTTCCTGATCGA
AGGCGCACATGCGCACGATCTGGCCACCCTGCTCGACCTGGAAGGCGTGGCCGTCCGCTCCGGCCAGCACTGCGCACACC
CGCTGCTGCAGTACTACGGCGTGGCCGCCACCTGCCGCGCCTCGCTGGCGTTCTACAACACGCATGACGAGATCGAGCGT
TTTGTTGCCGCGTTGGTGAAGGTGCGTCAGCTTTTGGGCTGA

Upstream 100 bases:

>100_bases
GCGCCGCGTTCTGCCATGAGCCGTTGCGCGCACTGCCGTCGCCATTGCGCGATCTGCTGGCCGTGCAGCTGGACCGCGCC
CTGAATTCGGCGGGCGTGGC

Downstream 100 bases:

>100_bases
TTGACTGCGGGAATCGGGAATGGAGAATCGAACAAGCGGGTCTCCCACATGCTGTCGCTGGTCGACAGAGGGGGAGTAGC
TCATTGAGCGGCGCAACGCT

Product: cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 413; Mature: 413

Protein sequence:

>413_residues
MNASVAATPAPDWERVRSDFPLLMRQVHGKPLIYFDNANTGQKPLQVIAATDEFYRRQNANVSRAVHALGTEATDAFEGA
RSKLARFLNVRADELVLCSGTTFAINLVAYSWALPRLGPSDVILVSRMEHHANIVPWQLVAQRTGATIRVAEITPEGALD
LDALRKAMTPEVKLLAITHVSNVLGTVNPVREICREARKRGIVTVVDGSQAAPHRRVDVAGIGCDFYAITGHKMCGPTGT
GALWARREHLQAMPPFLGGGEMIKEVSFEGTVFNDGPHKFEAGTPNIAGFIGLGAAVDYLDAVGLAHVEARETELLAHFT
EELQRIDGLRIFGTTPDKAAVVSFLIEGAHAHDLATLLDLEGVAVRSGQHCAHPLLQYYGVAATCRASLAFYNTHDEIER
FVAALVKVRQLLG

Sequences:

>Translated_413_residues
MNASVAATPAPDWERVRSDFPLLMRQVHGKPLIYFDNANTGQKPLQVIAATDEFYRRQNANVSRAVHALGTEATDAFEGA
RSKLARFLNVRADELVLCSGTTFAINLVAYSWALPRLGPSDVILVSRMEHHANIVPWQLVAQRTGATIRVAEITPEGALD
LDALRKAMTPEVKLLAITHVSNVLGTVNPVREICREARKRGIVTVVDGSQAAPHRRVDVAGIGCDFYAITGHKMCGPTGT
GALWARREHLQAMPPFLGGGEMIKEVSFEGTVFNDGPHKFEAGTPNIAGFIGLGAAVDYLDAVGLAHVEARETELLAHFT
EELQRIDGLRIFGTTPDKAAVVSFLIEGAHAHDLATLLDLEGVAVRSGQHCAHPLLQYYGVAATCRASLAFYNTHDEIER
FVAALVKVRQLLG
>Mature_413_residues
MNASVAATPAPDWERVRSDFPLLMRQVHGKPLIYFDNANTGQKPLQVIAATDEFYRRQNANVSRAVHALGTEATDAFEGA
RSKLARFLNVRADELVLCSGTTFAINLVAYSWALPRLGPSDVILVSRMEHHANIVPWQLVAQRTGATIRVAEITPEGALD
LDALRKAMTPEVKLLAITHVSNVLGTVNPVREICREARKRGIVTVVDGSQAAPHRRVDVAGIGCDFYAITGHKMCGPTGT
GALWARREHLQAMPPFLGGGEMIKEVSFEGTVFNDGPHKFEAGTPNIAGFIGLGAAVDYLDAVGLAHVEARETELLAHFT
EELQRIDGLRIFGTTPDKAAVVSFLIEGAHAHDLATLLDLEGVAVRSGQHCAHPLLQYYGVAATCRASLAFYNTHDEIER
FVAALVKVRQLLG

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=354, Percent_Identity=23.4463276836158, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI156713448, Length=299, Percent_Identity=27.4247491638796, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1787970, Length=402, Percent_Identity=47.7611940298507, Blast_Score=389, Evalue=1e-109,
Organism=Escherichia coli, GI1789175, Length=399, Percent_Identity=41.3533834586466, Blast_Score=291, Evalue=6e-80,
Organism=Escherichia coli, GI48994898, Length=223, Percent_Identity=28.6995515695067, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI25143064, Length=349, Percent_Identity=23.7822349570201, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI193211090, Length=298, Percent_Identity=24.1610738255034, Blast_Score=78, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6319831, Length=230, Percent_Identity=28.695652173913, Blast_Score=105, Evalue=9e-24,
Organism=Drosophila melanogaster, GI20129463, Length=262, Percent_Identity=27.4809160305344, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 44792; Mature: 44792

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNASVAATPAPDWERVRSDFPLLMRQVHGKPLIYFDNANTGQKPLQVIAATDEFYRRQNA
CCCCCCCCCCCCHHHHHCCHHHHHHHHCCCEEEEECCCCCCCCCCEEEECCHHHHHHCCC
NVSRAVHALGTEATDAFEGARSKLARFLNVRADELVLCSGTTFAINLVAYSWALPRLGPS
CHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCEEEEEEHHHHHHCCCCCCC
DVILVSRMEHHANIVPWQLVAQRTGATIRVAEITPEGALDLDALRKAMTPEVKLLAITHV
CEEEEEEHHHCCCCCHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHCCCCEEEEEHHHH
SNVLGTVNPVREICREARKRGIVTVVDGSQAAPHRRVDVAGIGCDFYAITGHKMCGPTGT
HHHHHCCHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEEEEECCEEEEECCCCCCCCCCC
GALWARREHLQAMPPFLGGGEMIKEVSFEGTVFNDGPHKFEAGTPNIAGFIGLGAAVDYL
CHHHHHHHHHHHCCCCCCCHHHHHHHCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHH
DAVGLAHVEARETELLAHFTEELQRIDGLRIFGTTPDKAAVVSFLIEGAHAHDLATLLDL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHC
EGVAVRSGQHCAHPLLQYYGVAATCRASLAFYNTHDEIERFVAALVKVRQLLG
CCEEECCCCHHHHHHHHHHCCHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MNASVAATPAPDWERVRSDFPLLMRQVHGKPLIYFDNANTGQKPLQVIAATDEFYRRQNA
CCCCCCCCCCCCHHHHHCCHHHHHHHHCCCEEEEECCCCCCCCCCEEEECCHHHHHHCCC
NVSRAVHALGTEATDAFEGARSKLARFLNVRADELVLCSGTTFAINLVAYSWALPRLGPS
CHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCEEEEEEHHHHHHCCCCCCC
DVILVSRMEHHANIVPWQLVAQRTGATIRVAEITPEGALDLDALRKAMTPEVKLLAITHV
CEEEEEEHHHCCCCCHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHCCCCEEEEEHHHH
SNVLGTVNPVREICREARKRGIVTVVDGSQAAPHRRVDVAGIGCDFYAITGHKMCGPTGT
HHHHHCCHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEEEEECCEEEEECCCCCCCCCCC
GALWARREHLQAMPPFLGGGEMIKEVSFEGTVFNDGPHKFEAGTPNIAGFIGLGAAVDYL
CHHHHHHHHHHHCCCCCCCHHHHHHHCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHH
DAVGLAHVEARETELLAHFTEELQRIDGLRIFGTTPDKAAVVSFLIEGAHAHDLATLLDL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHCCCCHHHHHHHHHC
EGVAVRSGQHCAHPLLQYYGVAATCRASLAFYNTHDEIERFVAALVKVRQLLG
CCEEECCCCHHHHHHHHHHCCHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]