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The map label for this gene is puuP [H]

Identifier: 66767620

GI number: 66767620

Start: 1581739

End: 1583118

Strand: Reverse

Name: puuP [H]

Synonym: XC_1293

Alternate gene names: 66767620

Gene position: 1583118-1581739 (Counterclockwise)

Preceding gene: 66767624

Following gene: 66767619

Centisome position: 30.75

GC content: 64.2

Gene sequence:

>1380_bases
ATGACCGACACCCCAGGCCGCAGCGACGCGGCCACGCTGGAACGCTTCGGCTACGCCCAGGAACTCAAGCGGCAGCTCAG
CCTGAAGGACCTGCTGATCTATGGCCTGGTGTTCATGGTGCCGACCGCGCCGTTCTCGATTTTCGGCGGGGTATTCGACA
TCAGCGCGGGAATGGTGCCGCTGACCTATCTGGTGGGCTTCGTGGCAATGCTGTTCACCGCACTAAGCTACCAGCAGATG
TCGCAGGCGTTTCCGGTGGCCGGTTCGGTGTATGCGTATGTGGGGCGGGGCTTGAGCGGCGGCATGGGATTTCTGGCCGG
CTGGGCCATCCTGCTGGACTATTTACTGGTACCCACCCTGCTCTACGTGGTCGGCGCCAACGCCATGCACAACGTGCTGC
CACAGGTGCCGCAGCCAGCGTGGATCGCCTTCTTCGTGGTGCTCAACACGGTGGTCAATCTGCGCGGCATCGAGACCACT
GCGCGTGCCAATCGCTTCTTCCTGTATGCGCAGCTCATCGTGCTGGCGCTGTTCGTGGTGCTGGCCACACTGGCCATCCA
GCGCGGCGTCAACGGCGCACAGTGGACCCTGCGCCCGTTCTACAACCCGCAGGCGTTTTCGCCGCAGTTGATTTTCAGTG
CACTGTCGGTGGCGGTGGTGTCGTTCCTGGGCTTCGATGCGATCTCCACGCTGTCGGAGGAAACCCGCGGCGGCAACCGG
GTGGTCGGACGCGCGACGCTGTTGGCGTTGGTGCTGGTGGCCGGCCTGTTCGTGCTGCAGACCTGGCTGGCAGCGTTGCT
GCAGCCGCACTTGCAGCGCTACCCCAGCGCGCAAGCGTCCAACGATGCGTTCTTCGAGATCGGGCGGCTGATTGCCGGGC
CGTGGATGCAGATTGTGATTGCGCTGACGGTGGCCATCAGTGCGGCGATTGCCAATTCGTTGGTGGCACAGGCGGCCACC
TCGCGGCTACTGTTCGCAATGGCACGCGACCGCCAATTGCCCGCGTTCCTCCGCTATATCCATCCGCGCACTGGCGTGCC
GCAGCGGGCGATCCTGCTGGTGGCGGCCCTGAGCATGGTGCTGGGGGAAGTGTTCGTCGGGCAGATCGCGTTGCTGTCCT
CGCTATGCAATGTGGGTGCGCTTACCGCCTTCGTGCTGCTGCATGTGGCGGTGCTTTGGCACTTTCGCGCGCATGGCCGC
AAGGTGCTGCACGGAGTGGTGCCAGTGATCGGCATCGTGATCCTGGCCTATGTGCTGATCAATGCCGACCTGCATGCGCA
GCTGGGCGGCAGCGCCTGGATGGTGGTCGGCCTGGCCGTGCTGGCCTTCCTCAAGTTCAGCGGGCGCTCGACCGAATTCC
GCGCTACTGACGCGTTGTAA

Upstream 100 bases:

>100_bases
GCTTTATGTTCACAATGCCGGGCAACACCCGCCCCCACGGCACTGGCTGCGCGCCCGCGCCGCCAGGCACCGCCCGGCCC
TTCCCTCAGCGGATATCTGC

Downstream 100 bases:

>100_bases
ATTCCAATGCTGCGTGCGTGCCTGCGCGTGTGCGCGTGCATGCGTACGTGCGGTGAGCGCACGTCGAAGCTACCGCGCCA
TCTTCGACGTTGAATGCAGC

Product: amino acid transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MTDTPGRSDAATLERFGYAQELKRQLSLKDLLIYGLVFMVPTAPFSIFGGVFDISAGMVPLTYLVGFVAMLFTALSYQQM
SQAFPVAGSVYAYVGRGLSGGMGFLAGWAILLDYLLVPTLLYVVGANAMHNVLPQVPQPAWIAFFVVLNTVVNLRGIETT
ARANRFFLYAQLIVLALFVVLATLAIQRGVNGAQWTLRPFYNPQAFSPQLIFSALSVAVVSFLGFDAISTLSEETRGGNR
VVGRATLLALVLVAGLFVLQTWLAALLQPHLQRYPSAQASNDAFFEIGRLIAGPWMQIVIALTVAISAAIANSLVAQAAT
SRLLFAMARDRQLPAFLRYIHPRTGVPQRAILLVAALSMVLGEVFVGQIALLSSLCNVGALTAFVLLHVAVLWHFRAHGR
KVLHGVVPVIGIVILAYVLINADLHAQLGGSAWMVVGLAVLAFLKFSGRSTEFRATDAL

Sequences:

>Translated_459_residues
MTDTPGRSDAATLERFGYAQELKRQLSLKDLLIYGLVFMVPTAPFSIFGGVFDISAGMVPLTYLVGFVAMLFTALSYQQM
SQAFPVAGSVYAYVGRGLSGGMGFLAGWAILLDYLLVPTLLYVVGANAMHNVLPQVPQPAWIAFFVVLNTVVNLRGIETT
ARANRFFLYAQLIVLALFVVLATLAIQRGVNGAQWTLRPFYNPQAFSPQLIFSALSVAVVSFLGFDAISTLSEETRGGNR
VVGRATLLALVLVAGLFVLQTWLAALLQPHLQRYPSAQASNDAFFEIGRLIAGPWMQIVIALTVAISAAIANSLVAQAAT
SRLLFAMARDRQLPAFLRYIHPRTGVPQRAILLVAALSMVLGEVFVGQIALLSSLCNVGALTAFVLLHVAVLWHFRAHGR
KVLHGVVPVIGIVILAYVLINADLHAQLGGSAWMVVGLAVLAFLKFSGRSTEFRATDAL
>Mature_458_residues
TDTPGRSDAATLERFGYAQELKRQLSLKDLLIYGLVFMVPTAPFSIFGGVFDISAGMVPLTYLVGFVAMLFTALSYQQMS
QAFPVAGSVYAYVGRGLSGGMGFLAGWAILLDYLLVPTLLYVVGANAMHNVLPQVPQPAWIAFFVVLNTVVNLRGIETTA
RANRFFLYAQLIVLALFVVLATLAIQRGVNGAQWTLRPFYNPQAFSPQLIFSALSVAVVSFLGFDAISTLSEETRGGNRV
VGRATLLALVLVAGLFVLQTWLAALLQPHLQRYPSAQASNDAFFEIGRLIAGPWMQIVIALTVAISAAIANSLVAQAATS
RLLFAMARDRQLPAFLRYIHPRTGVPQRAILLVAALSMVLGEVFVGQIALLSSLCNVGALTAFVLLHVAVLWHFRAHGRK
VLHGVVPVIGIVILAYVLINADLHAQLGGSAWMVVGLAVLAFLKFSGRSTEFRATDAL

Specific function: Imports putrescine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Escherichia coli, GI87081869, Length=433, Percent_Identity=30.715935334873, Blast_Score=202, Evalue=3e-53,
Organism=Escherichia coli, GI87082023, Length=439, Percent_Identity=30.2961275626424, Blast_Score=192, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI17532491, Length=401, Percent_Identity=26.4339152119701, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17533459, Length=402, Percent_Identity=22.636815920398, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17531343, Length=399, Percent_Identity=22.8070175438596, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI21357367, Length=392, Percent_Identity=26.0204081632653, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24666159, Length=402, Percent_Identity=23.8805970149254, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI221512776, Length=402, Percent_Identity=23.8805970149254, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24667468, Length=395, Percent_Identity=24.8101265822785, Blast_Score=69, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49493; Mature: 49362

Theoretical pI: Translated: 10.19; Mature: 10.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TDTPGRSDAATLERFGYAQELKRQLSLKDLLIYGLVFMVPTAPFSIFGGVFDISAGMVP
CCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHH
LTYLVGFVAMLFTALSYQQMSQAFPVAGSVYAYVGRGLSGGMGFLAGWAILLDYLLVPTL
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
LYVVGANAMHNVLPQVPQPAWIAFFVVLNTVVNLRGIETTARANRFFLYAQLIVLALFVV
HHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
LATLAIQRGVNGAQWTLRPFYNPQAFSPQLIFSALSVAVVSFLGFDAISTLSEETRGGNR
HHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VVGRATLLALVLVAGLFVLQTWLAALLQPHLQRYPSAQASNDAFFEIGRLIAGPWMQIVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
ALTVAISAAIANSLVAQAATSRLLFAMARDRQLPAFLRYIHPRTGVPQRAILLVAALSMV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHH
LGEVFVGQIALLSSLCNVGALTAFVLLHVAVLWHFRAHGRKVLHGVVPVIGIVILAYVLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NADLHAQLGGSAWMVVGLAVLAFLKFSGRSTEFRATDAL
CCCHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]