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The map label for this gene is mdtD [H]

Identifier: 66767590

GI number: 66767590

Start: 1551750

End: 1553171

Strand: Reverse

Name: mdtD [H]

Synonym: XC_1263

Alternate gene names: 66767590

Gene position: 1553171-1551750 (Counterclockwise)

Preceding gene: 66767591

Following gene: 66767586

Centisome position: 30.17

GC content: 65.89

Gene sequence:

>1422_bases
ATGTCTCAGCCCGTTCCCGTCATGCGCGCCTATGCCACCATCAAGCCGCTGTTGTGGCTGGTGTCGCTGGCCATCTTCAT
GCAGATGCTGGATGCGACCATCGTCAATACGGCGCTGCCGTCGATGGCGCGCAGCTTGCGCGAGAGCCCGCTGCAGATGC
AGTCGGTGGTCTTCAGCTATGCGTTGGCGGTGGCGATGTTCATCCCGGCCTCGGGATGGATCGCCGACCGTTTCGGCACG
CGCCGGACCTTCCTCGCCGCGATCATCGTGTTCACGCTGGGCTCGTTGCTGTGCGCCGCCGCGCAGCAGTTGCCGCAGCT
GGTGGCCGCACGCGTGGTGCAAGGCATTGGCGGTGCGATGTTGCTGCCGGTCGGCCGGCTGGCGGTGCTCAAGACCGTGG
CGCGCGCCGACTTCCTGCGGGCGATGAGCTTCATCGCGATCCCGGCGCTGATCGGGCCGCTGATCGGGCCGACGCTGGGC
GGCTGGCTGGTGGAGATCGCCTCCTGGCATTGGGTGTTTCTGATCAATCTGCCGATCGGCGTGATCGGATTCATCGCCGC
ACTGAAGATCATGCCGGACCATTACGGCGACGCACGCAAGCGCTTCGATCTGGTCGGCTATCTGATGCTGGCGTTCGGCA
TGGTGGCGCTCTCGCTGGCGTTGGACGGCATTGCCGAGCTCGGCCTGCGGCATGCGTTCGTGATGTTGCTGGCGATCGGC
GGGCTGGCCGCACTGGCCGGCTATTGGCTGCATGCGGCCAGTGCACCGGCGGCGCTGTTCCCCTTGGCGTTGTTCAAGGT
GGCCAGTTACCGCATCGGCATTCTGGGCAATCTGTTCGCGCGCGTGGGCAGCGGCTCGATGCCGTTCCTGATCCCGCTGC
TGCTGCAGGTGGGCCTGGGCATGAGCCCGATGAATGCCGGGCTGATGATGGTGCCGGTGGCACTGGCCGGCATGGCCGCC
AAGCGCGCTGCGGTGAAGCTGGTCGGCCGCTTCGGCTACCGCCGCATCCTGATGCTCAACACCGTGCTGGTGGGCCTGGC
GATGGCCAGCTTCGCGCTGATCAGTGCGGGCCAGCCGCTATGGCTACGGGTGCTGCAGCTGGCCTGCTTCGGCGCAGTGA
ACTCGCTGCAATTTACCGTCATGAACACGGTGACCTTGCGCGACCTGGATCGCGACCAAGCCAGCCCCGGCAACAGCCTG
TTGTCGATGGTGATGATGCTGGCCACCGGGTTTGGCGCGGCGGCGGCAGGCAGCTTGCTGGCGGCGTTCAACACGCATCT
TGGCGACAGCCACGGCGCTACTGCGGCGTTGCACGCCACCTTCCTGTGCGTCGGCGCGATCACCTTGTCGTCGACGCTGA
TCTTCTGGCAGCTGGCCGAAACGCTGCCGCATCCCAAGCAAGTGGAAGAAGTTGCCGAGTGA

Upstream 100 bases:

>100_bases
ACCAACCCATCGCTCGATAAAGCCCCGCAAATGCGCACACCCTTCTGAGTTCCTGCACAGCGCGGCGGAGATAATGCCCC
GTCCTCTCGACGGAGCCCCC

Downstream 100 bases:

>100_bases
GCGGGCTTGGGTGATGCGGGTGGCGGCGCGCTGATGGCGGTTGATTGCTGTCGCGGCATGCGCGTGCGGTGCTGCGTTAC
GGCAGTTATGTGACTGCAGT

Product: MFS transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MSQPVPVMRAYATIKPLLWLVSLAIFMQMLDATIVNTALPSMARSLRESPLQMQSVVFSYALAVAMFIPASGWIADRFGT
RRTFLAAIIVFTLGSLLCAAAQQLPQLVAARVVQGIGGAMLLPVGRLAVLKTVARADFLRAMSFIAIPALIGPLIGPTLG
GWLVEIASWHWVFLINLPIGVIGFIAALKIMPDHYGDARKRFDLVGYLMLAFGMVALSLALDGIAELGLRHAFVMLLAIG
GLAALAGYWLHAASAPAALFPLALFKVASYRIGILGNLFARVGSGSMPFLIPLLLQVGLGMSPMNAGLMMVPVALAGMAA
KRAAVKLVGRFGYRRILMLNTVLVGLAMASFALISAGQPLWLRVLQLACFGAVNSLQFTVMNTVTLRDLDRDQASPGNSL
LSMVMMLATGFGAAAAGSLLAAFNTHLGDSHGATAALHATFLCVGAITLSSTLIFWQLAETLPHPKQVEEVAE

Sequences:

>Translated_473_residues
MSQPVPVMRAYATIKPLLWLVSLAIFMQMLDATIVNTALPSMARSLRESPLQMQSVVFSYALAVAMFIPASGWIADRFGT
RRTFLAAIIVFTLGSLLCAAAQQLPQLVAARVVQGIGGAMLLPVGRLAVLKTVARADFLRAMSFIAIPALIGPLIGPTLG
GWLVEIASWHWVFLINLPIGVIGFIAALKIMPDHYGDARKRFDLVGYLMLAFGMVALSLALDGIAELGLRHAFVMLLAIG
GLAALAGYWLHAASAPAALFPLALFKVASYRIGILGNLFARVGSGSMPFLIPLLLQVGLGMSPMNAGLMMVPVALAGMAA
KRAAVKLVGRFGYRRILMLNTVLVGLAMASFALISAGQPLWLRVLQLACFGAVNSLQFTVMNTVTLRDLDRDQASPGNSL
LSMVMMLATGFGAAAAGSLLAAFNTHLGDSHGATAALHATFLCVGAITLSSTLIFWQLAETLPHPKQVEEVAE
>Mature_472_residues
SQPVPVMRAYATIKPLLWLVSLAIFMQMLDATIVNTALPSMARSLRESPLQMQSVVFSYALAVAMFIPASGWIADRFGTR
RTFLAAIIVFTLGSLLCAAAQQLPQLVAARVVQGIGGAMLLPVGRLAVLKTVARADFLRAMSFIAIPALIGPLIGPTLGG
WLVEIASWHWVFLINLPIGVIGFIAALKIMPDHYGDARKRFDLVGYLMLAFGMVALSLALDGIAELGLRHAFVMLLAIGG
LAALAGYWLHAASAPAALFPLALFKVASYRIGILGNLFARVGSGSMPFLIPLLLQVGLGMSPMNAGLMMVPVALAGMAAK
RAAVKLVGRFGYRRILMLNTVLVGLAMASFALISAGQPLWLRVLQLACFGAVNSLQFTVMNTVTLRDLDRDQASPGNSLL
SMVMMLATGFGAAAAGSLLAAFNTHLGDSHGATAALHATFLCVGAITLSSTLIFWQLAETLPHPKQVEEVAE

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=443, Percent_Identity=45.5981941309255, Blast_Score=386, Evalue=1e-108,
Organism=Escherichia coli, GI1788392, Length=420, Percent_Identity=50.2380952380952, Blast_Score=371, Evalue=1e-104,
Organism=Escherichia coli, GI1789042, Length=408, Percent_Identity=28.6764705882353, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI87081983, Length=415, Percent_Identity=28.6746987951807, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1788710, Length=323, Percent_Identity=30.3405572755418, Blast_Score=133, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6325455, Length=196, Percent_Identity=30.1020408163265, Blast_Score=78, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6321663, Length=150, Percent_Identity=29.3333333333333, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323735, Length=234, Percent_Identity=26.9230769230769, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322958, Length=160, Percent_Identity=28.75, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 50138; Mature: 50007

Theoretical pI: Translated: 10.52; Mature: 10.52

Prosite motif: PS00213 LIPOCALIN ; PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQPVPVMRAYATIKPLLWLVSLAIFMQMLDATIVNTALPSMARSLRESPLQMQSVVFSY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
ALAVAMFIPASGWIADRFGTRRTFLAAIIVFTLGSLLCAAAQQLPQLVAARVVQGIGGAM
HHHHHHHHCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
LLPVGRLAVLKTVARADFLRAMSFIAIPALIGPLIGPTLGGWLVEIASWHWVFLINLPIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECHHH
VIGFIAALKIMPDHYGDARKRFDLVGYLMLAFGMVALSLALDGIAELGLRHAFVMLLAIG
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLAALAGYWLHAASAPAALFPLALFKVASYRIGILGNLFARVGSGSMPFLIPLLLQVGLG
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
MSPMNAGLMMVPVALAGMAAKRAAVKLVGRFGYRRILMLNTVLVGLAMASFALISAGQPL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
WLRVLQLACFGAVNSLQFTVMNTVTLRDLDRDQASPGNSLLSMVMMLATGFGAAAAGSLL
HHHHHHHHHHHHHHHHEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHH
AAFNTHLGDSHGATAALHATFLCVGAITLSSTLIFWQLAETLPHPKQVEEVAE
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCC
>Mature Secondary Structure 
SQPVPVMRAYATIKPLLWLVSLAIFMQMLDATIVNTALPSMARSLRESPLQMQSVVFSY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH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HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA