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The map label for this gene is iciA [C]

Identifier: 66767481

GI number: 66767481

Start: 1394404

End: 1395321

Strand: Reverse

Name: iciA [C]

Synonym: XC_1153

Alternate gene names: 66767481

Gene position: 1395321-1394404 (Counterclockwise)

Preceding gene: 66767484

Following gene: 66767479

Centisome position: 27.1

GC content: 67.86

Gene sequence:

>918_bases
ATGGAGTTGCTGCACCCCCAACTGGCCGCGTTCGCTGCCGTGCTTGATGAAGGCAGCTTCGAGTTGGCTGCACGCAGGCT
GTCGGTGACCTCTTCGGCGATTTCGCAGCGGATCAAGGCACTGGAAGACCGGCTCGGCCAGGTTCTGGTGTTGCGCACAG
CGCCCTGCCGCGCGACCCCGGCCGGCCAGCGTCTGCTCCGCAGGCTGCGGCCGATGCAGGTGCTACAAGCCGAGGCCATG
GCCGATTTCCTGCCTGACGCGGGAGTGGGCGGCACGCCGCGCACGCTGTCCATCGCCGTCAACGACGACTCCTTGCAGAC
CTGGGTGCTGTCCGCATTGGCCGAGTTGCACCAGGCGCACGGCTTGTTGTTCGACGTGCATGTGGATGACCAGGACCACA
CCCTGGAGCTGCTGCGCGCCGGCACGGTACTGGGTGCGGTCACCGCCGAACGCCGGCCACTGCAAGGCTGCAATGTGCAG
CCGCTGGGCACCATGCGCTACCACGCCATCGCGTCGCCGGATGTTGTGGCCCGCTACTTCAGCAGCGGCCTGGACGCCGC
CGGATTGAGCCGCGCACCGATGATGGTGTTCAACCGCAAGGACGCACTGCAGGCACGCTTTGCGCGACGCATCACGCGCA
TGCAGTTGTCGCCGCCGATCCACTACCTGCCCACATCCACCGGCTTCGTGGACGCCGCCGCGCGTGGGCTGGGCTGGTGC
CTGGCGCCGGAGGCGATGGTGTTGCCGGCAGTCGAGCGCAAGACGCTGCTCATCATCGACCCGACGCGCTGGCTGGATGT
GCCGCTGTACTGGCAGCATGCCGCGGTGCGCTCGACGACCTTGCAGCGCCTGGGCGATAGCTTGCGAACCGCAGCGGCGG
CGAGCTTGCGCGTTGGCAAGCAGGGACCCGCTCACTGA

Upstream 100 bases:

>100_bases
TGTCTGTTGGTTGCGTGCGGCAAGACTGCCGCCGCCCCTAGGATTAGGAAACCTAAATATTCTGTATGCTCCAAAGGAAA
TCTAATCCCACCGAGTTCGC

Downstream 100 bases:

>100_bases
GCGCTGCTCGAAGCGCTTCGCGTGTCGCGTTCCAGGCTCCGCGCGGCCCACGCCCACGCGGCCAACGCACGCTCACTCCT
CGCCAGTCCCGCGCTCGCCC

Product: chromosome replication initiation inhibitor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MELLHPQLAAFAAVLDEGSFELAARRLSVTSSAISQRIKALEDRLGQVLVLRTAPCRATPAGQRLLRRLRPMQVLQAEAM
ADFLPDAGVGGTPRTLSIAVNDDSLQTWVLSALAELHQAHGLLFDVHVDDQDHTLELLRAGTVLGAVTAERRPLQGCNVQ
PLGTMRYHAIASPDVVARYFSSGLDAAGLSRAPMMVFNRKDALQARFARRITRMQLSPPIHYLPTSTGFVDAAARGLGWC
LAPEAMVLPAVERKTLLIIDPTRWLDVPLYWQHAAVRSTTLQRLGDSLRTAAAASLRVGKQGPAH

Sequences:

>Translated_305_residues
MELLHPQLAAFAAVLDEGSFELAARRLSVTSSAISQRIKALEDRLGQVLVLRTAPCRATPAGQRLLRRLRPMQVLQAEAM
ADFLPDAGVGGTPRTLSIAVNDDSLQTWVLSALAELHQAHGLLFDVHVDDQDHTLELLRAGTVLGAVTAERRPLQGCNVQ
PLGTMRYHAIASPDVVARYFSSGLDAAGLSRAPMMVFNRKDALQARFARRITRMQLSPPIHYLPTSTGFVDAAARGLGWC
LAPEAMVLPAVERKTLLIIDPTRWLDVPLYWQHAAVRSTTLQRLGDSLRTAAAASLRVGKQGPAH
>Mature_305_residues
MELLHPQLAAFAAVLDEGSFELAARRLSVTSSAISQRIKALEDRLGQVLVLRTAPCRATPAGQRLLRRLRPMQVLQAEAM
ADFLPDAGVGGTPRTLSIAVNDDSLQTWVLSALAELHQAHGLLFDVHVDDQDHTLELLRAGTVLGAVTAERRPLQGCNVQ
PLGTMRYHAIASPDVVARYFSSGLDAAGLSRAPMMVFNRKDALQARFARRITRMQLSPPIHYLPTSTGFVDAAARGLGWC
LAPEAMVLPAVERKTLLIIDPTRWLDVPLYWQHAAVRSTTLQRLGDSLRTAAAASLRVGKQGPAH

Specific function: Specific Inhibitor Of Chromosomal Initiation Of Replication In VItro. Binds The Three 13-Mers In The Origin (Oric) To Block Initiation Of Replication. [C]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789283, Length=293, Percent_Identity=35.4948805460751, Blast_Score=166, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR017685
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33194; Mature: 33194

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELLHPQLAAFAAVLDEGSFELAARRLSVTSSAISQRIKALEDRLGQVLVLRTAPCRATP
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCH
AGQRLLRRLRPMQVLQAEAMADFLPDAGVGGTPRTLSIAVNDDSLQTWVLSALAELHQAH
HHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHC
GLLFDVHVDDQDHTLELLRAGTVLGAVTAERRPLQGCNVQPLGTMRYHAIASPDVVARYF
CEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCHHHHHHHH
SSGLDAAGLSRAPMMVFNRKDALQARFARRITRMQLSPPIHYLPTSTGFVDAAARGLGWC
HCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHCCEE
LAPEAMVLPAVERKTLLIIDPTRWLDVPLYWQHAAVRSTTLQRLGDSLRTAAAASLRVGK
ECCCHHEECCCCCCEEEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QGPAH
CCCCC
>Mature Secondary Structure
MELLHPQLAAFAAVLDEGSFELAARRLSVTSSAISQRIKALEDRLGQVLVLRTAPCRATP
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCH
AGQRLLRRLRPMQVLQAEAMADFLPDAGVGGTPRTLSIAVNDDSLQTWVLSALAELHQAH
HHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHC
GLLFDVHVDDQDHTLELLRAGTVLGAVTAERRPLQGCNVQPLGTMRYHAIASPDVVARYF
CEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCHHHHHHHH
SSGLDAAGLSRAPMMVFNRKDALQARFARRITRMQLSPPIHYLPTSTGFVDAAARGLGWC
HCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHCCEE
LAPEAMVLPAVERKTLLIIDPTRWLDVPLYWQHAAVRSTTLQRLGDSLRTAAAASLRVGK
ECCCHHEECCCCCCEEEEECCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QGPAH
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]