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The map label for this gene is gmk [H]

Identifier: 66767290

GI number: 66767290

Start: 1151832

End: 1152443

Strand: Reverse

Name: gmk [H]

Synonym: XC_0958

Alternate gene names: 66767290

Gene position: 1152443-1151832 (Counterclockwise)

Preceding gene: 66767291

Following gene: 66767289

Centisome position: 22.38

GC content: 66.67

Gene sequence:

>612_bases
ATGCGCGGCACCCTCTATATCGTTGCGGCCCCTTCCGGCGCCGGCAAGAGCAGCATCGTCAACGCCACCCTGGCGCGTGA
CCCCAAGATCGCCTTGTCGATCTCCTTCACCTCGCGCGCGCCGCGCCCGGGTGAGCGGCATGCCGAGCACTACCATTTCG
TCTCTGCCGAGGAATTCCAGGGCATGATCGAAGCCGGTGACTTCTTCGAGTACGCGCTGGTGCATGGCGACTGGAAAGGC
ACCGCGCGGCAGTCGGTGGAGCCGCAGCTGGCCGCCGGGCACGACGTGCTGCTGGAGATCGATTGGCAGGGCGCGCGCCA
GGTGCGGCAGAAGGTGCCGGACGCGGTCAGCGTGTTCATCCTGCCGCCGTCGCGCCAGGCTTTGGACGAGCGCATGCGCA
AGCGCGGGCAGGACAGCGAGGACGTGATGGCGCAACGCCTGGCCGCCGCCCGCGAGGAAATGCTGCATTTCGAGGAATTC
GACTACGTGATCATCAACGAGACCTTCGACACCGCGGTCTCGGAAATGTGCGCCATCTTCACCGCCAGCCGGCTGCGTCG
GCAGGCGCAGCAGCAACGCCATGCCGGGCTGATCCAGGCGTTGCTGGACTGA

Upstream 100 bases:

>100_bases
CAATCGGGAATGGGGAATCGTCAAAGCAGGTACGATTCCCCACGGCCTGCATGCCTGGCGCGGCGCCCCATTCCCTATTC
CCGACTCTCGATTCCCTAAA

Downstream 100 bases:

>100_bases
ATCTGCCAGCTAGCGGGCAGGGCACCGCATGGTGCCGGGCCGCTGCTCGCCGCATCGAACTGGGCGCAGCAGGCAGCGCC
AACGCGCGCCGCAGCGTCAT

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MRGTLYIVAAPSGAGKSSIVNATLARDPKIALSISFTSRAPRPGERHAEHYHFVSAEEFQGMIEAGDFFEYALVHGDWKG
TARQSVEPQLAAGHDVLLEIDWQGARQVRQKVPDAVSVFILPPSRQALDERMRKRGQDSEDVMAQRLAAAREEMLHFEEF
DYVIINETFDTAVSEMCAIFTASRLRRQAQQQRHAGLIQALLD

Sequences:

>Translated_203_residues
MRGTLYIVAAPSGAGKSSIVNATLARDPKIALSISFTSRAPRPGERHAEHYHFVSAEEFQGMIEAGDFFEYALVHGDWKG
TARQSVEPQLAAGHDVLLEIDWQGARQVRQKVPDAVSVFILPPSRQALDERMRKRGQDSEDVMAQRLAAAREEMLHFEEF
DYVIINETFDTAVSEMCAIFTASRLRRQAQQQRHAGLIQALLD
>Mature_203_residues
MRGTLYIVAAPSGAGKSSIVNATLARDPKIALSISFTSRAPRPGERHAEHYHFVSAEEFQGMIEAGDFFEYALVHGDWKG
TARQSVEPQLAAGHDVLLEIDWQGARQVRQKVPDAVSVFILPPSRQALDERMRKRGQDSEDVMAQRLAAAREEMLHFEEF
DYVIINETFDTAVSEMCAIFTASRLRRQAQQQRHAGLIQALLD

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=174, Percent_Identity=36.7816091954023, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI4504221, Length=174, Percent_Identity=36.7816091954023, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI226874831, Length=174, Percent_Identity=36.7816091954023, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI4505237, Length=180, Percent_Identity=30, Blast_Score=81, Evalue=6e-16,
Organism=Homo sapiens, GI262118259, Length=180, Percent_Identity=30, Blast_Score=81, Evalue=6e-16,
Organism=Homo sapiens, GI262118255, Length=180, Percent_Identity=30, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI262118263, Length=180, Percent_Identity=30, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI21361598, Length=196, Percent_Identity=26.0204081632653, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI38570142, Length=180, Percent_Identity=25.5555555555556, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI52630447, Length=184, Percent_Identity=25.5434782608696, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1790080, Length=203, Percent_Identity=54.679802955665, Blast_Score=230, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI193203132, Length=179, Percent_Identity=34.6368715083799, Blast_Score=126, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI17508835, Length=179, Percent_Identity=34.6368715083799, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6320662, Length=175, Percent_Identity=36, Blast_Score=120, Evalue=2e-28,
Organism=Drosophila melanogaster, GI21356141, Length=189, Percent_Identity=33.8624338624339, Blast_Score=110, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 22738; Mature: 22738

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGTLYIVAAPSGAGKSSIVNATLARDPKIALSISFTSRAPRPGERHAEHYHFVSAEEFQ
CCCEEEEEECCCCCCCHHHEEHHHCCCCCEEEEEEECCCCCCCCCHHHHHHEECCHHHHH
GMIEAGDFFEYALVHGDWKGTARQSVEPQLAAGHDVLLEIDWQGARQVRQKVPDAVSVFI
HHHHCCCHHEEEEEECCCCCCHHCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCEEEEE
LPPSRQALDERMRKRGQDSEDVMAQRLAAAREEMLHFEEFDYVIINETFDTAVSEMCAIF
ECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHH
TASRLRRQAQQQRHAGLIQALLD
HHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRGTLYIVAAPSGAGKSSIVNATLARDPKIALSISFTSRAPRPGERHAEHYHFVSAEEFQ
CCCEEEEEECCCCCCCHHHEEHHHCCCCCEEEEEEECCCCCCCCCHHHHHHEECCHHHHH
GMIEAGDFFEYALVHGDWKGTARQSVEPQLAAGHDVLLEIDWQGARQVRQKVPDAVSVFI
HHHHCCCHHEEEEEECCCCCCHHCCCCCCCCCCCEEEEEECCCHHHHHHHHCCCCEEEEE
LPPSRQALDERMRKRGQDSEDVMAQRLAAAREEMLHFEEFDYVIINETFDTAVSEMCAIF
ECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECHHHHHHHHHHHHH
TASRLRRQAQQQRHAGLIQALLD
HHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]