Click here to switch to the map view.

The map label for this gene is hmuU [H]

Identifier: 66048328

GI number: 66048328

Start: 6055558

End: 6056601

Strand: Direct

Name: hmuU [H]

Synonym: Psyr_5104

Alternate gene names: 66048328

Gene position: 6055558-6056601 (Clockwise)

Preceding gene: 66048327

Following gene: 66048329

Centisome position: 99.37

GC content: 63.12

Gene sequence:

>1044_bases
ATGACGCTGGCGCAGTGGCTGACCGAACGGCCGCGCCGTTACCTGGGCCTGTTGATCGCTCTGACGCTTTTGCTGCTGAC
GTCGTGCCTGGTGTGCATCACCTTCGGCGCGGCCCCTGTGCCCTTGAGCCGGGTGATGGCTATCCTGATGTTCAAACTCT
CCGGTACTGCCGAACACCCACCGCTCTGGACAACGGGACAGGAAACCATCGTCTGGCTGATACGTACGCCCCGCGTCTTG
CTGGGCGCGCTGGCAGGCGCAGGGCTGGCGTTGATCGGCAGCGTTCTGCAAGCCGCGACCCGTAATCCGCTGGCCGATCC
GCATTTGCTGGGGGCGACCTCGGGCGCCACGCTTGGCGCCGTGATCGTGGTCATGCATGTGGGGGAAGTGTTTGGCATGC
TGACATTGCCACTGGCCGCCTTTGTCGGCTCGCTGGTCAGCCTGTGCCTGGTGCTGTGGCTGGCCAGTCACCAAGGCCGG
CTGGACAGCCAGCGCCTGCTGCTCGGCGGTGTGGCCGTGTCCTTCGTGATGATGGCAATCGCCAACCTGTCGTTGTTTCT
GGGCGACCACCGCGCCAATTCCTCGGTGCTGTTCTGGATGCTGGGCGGGCTGGGTCTGGCCCGCTGGGAATTGCTTGCGG
TGCCGTTTATCACGGTGCTATGCGGTTGGATCCTGCTGCAAGGGCTGGGTCGTTCACTGAACGCGCTGATGGGCGGCGAC
CAGACCGCCGTGAGCCTTGGCCTGCAAGTGCGCAATATGCGCCTGCTGGTTTTTCTGATCGCCTCACTGATGACCGGCGT
ACTGGTCGCCCTGTGCGGCTCCATCGGTTTTGTCGGCCTGATGGTGCCGCACATGGCCAGACGTCTGGTGGGCTCGGAGC
ATCGACGACTGTTGCCTGTCGCCACCCTTCTGGGCGCATTGTTGATGGTCTGGGTCGACGTCATCTCCCGCACGCTGATC
GCCCCCGAAGACCTGCCGATAGGCATTACGACCGCCTTGTTGGGAGGGCTGTTTTTCATTTTCATGATGAAGCGCGGTCA
GTAA

Upstream 100 bases:

>100_bases
ACCGGCGTTATGTCGTGCTGCCCTATGTGGCAGTGACGCCCGGCATCGACAATGTCACGGCCATCGAGACGCTTGCAGCG
GCATTTCATGACGTGAAGCG

Downstream 100 bases:

>100_bases
TCGGCAAGGTGTTTGCCGTGGGCAAACAGGACTGCCCGCGGCCCTTCCGACTACATGACAAACTCGTGTCATCGTTCCTT
AACACCTTTATGACATTTAT

Product: transport system permease protein

Products: ADP; phosphate; iron dicitrate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MTLAQWLTERPRRYLGLLIALTLLLLTSCLVCITFGAAPVPLSRVMAILMFKLSGTAEHPPLWTTGQETIVWLIRTPRVL
LGALAGAGLALIGSVLQAATRNPLADPHLLGATSGATLGAVIVVMHVGEVFGMLTLPLAAFVGSLVSLCLVLWLASHQGR
LDSQRLLLGGVAVSFVMMAIANLSLFLGDHRANSSVLFWMLGGLGLARWELLAVPFITVLCGWILLQGLGRSLNALMGGD
QTAVSLGLQVRNMRLLVFLIASLMTGVLVALCGSIGFVGLMVPHMARRLVGSEHRRLLPVATLLGALLMVWVDVISRTLI
APEDLPIGITTALLGGLFFIFMMKRGQ

Sequences:

>Translated_347_residues
MTLAQWLTERPRRYLGLLIALTLLLLTSCLVCITFGAAPVPLSRVMAILMFKLSGTAEHPPLWTTGQETIVWLIRTPRVL
LGALAGAGLALIGSVLQAATRNPLADPHLLGATSGATLGAVIVVMHVGEVFGMLTLPLAAFVGSLVSLCLVLWLASHQGR
LDSQRLLLGGVAVSFVMMAIANLSLFLGDHRANSSVLFWMLGGLGLARWELLAVPFITVLCGWILLQGLGRSLNALMGGD
QTAVSLGLQVRNMRLLVFLIASLMTGVLVALCGSIGFVGLMVPHMARRLVGSEHRRLLPVATLLGALLMVWVDVISRTLI
APEDLPIGITTALLGGLFFIFMMKRGQ
>Mature_346_residues
TLAQWLTERPRRYLGLLIALTLLLLTSCLVCITFGAAPVPLSRVMAILMFKLSGTAEHPPLWTTGQETIVWLIRTPRVLL
GALAGAGLALIGSVLQAATRNPLADPHLLGATSGATLGAVIVVMHVGEVFGMLTLPLAAFVGSLVSLCLVLWLASHQGRL
DSQRLLLGGVAVSFVMMAIANLSLFLGDHRANSSVLFWMLGGLGLARWELLAVPFITVLCGWILLQGLGRSLNALMGGDQ
TAVSLGLQVRNMRLLVFLIASLMTGVLVALCGSIGFVGLMVPHMARRLVGSEHRRLLPVATLLGALLMVWVDVISRTLIA
PEDLPIGITTALLGGLFFIFMMKRGQ

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790741, Length=286, Percent_Identity=34.6153846153846, Blast_Score=141, Evalue=7e-35,
Organism=Escherichia coli, GI1790740, Length=334, Percent_Identity=34.1317365269461, Blast_Score=140, Evalue=9e-35,
Organism=Escherichia coli, GI1788004, Length=290, Percent_Identity=36.551724137931, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1786805, Length=312, Percent_Identity=35.5769230769231, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1786347, Length=315, Percent_Identity=30.7936507936508, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786804, Length=325, Percent_Identity=30.4615384615385, Blast_Score=99, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 36993; Mature: 36861

Theoretical pI: Translated: 11.10; Mature: 11.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLAQWLTERPRRYLGLLIALTLLLLTSCLVCITFGAAPVPLSRVMAILMFKLSGTAEHP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCC
PLWTTGQETIVWLIRTPRVLLGALAGAGLALIGSVLQAATRNPLADPHLLGATSGATLGA
CCCCCCCHHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
VIVVMHVGEVFGMLTLPLAAFVGSLVSLCLVLWLASHQGRLDSQRLLLGGVAVSFVMMAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
ANLSLFLGDHRANSSVLFWMLGGLGLARWELLAVPFITVLCGWILLQGLGRSLNALMGGD
HHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCC
QTAVSLGLQVRNMRLLVFLIASLMTGVLVALCGSIGFVGLMVPHMARRLVGSEHRRLLPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
ATLLGALLMVWVDVISRTLIAPEDLPIGITTALLGGLFFIFMMKRGQ
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TLAQWLTERPRRYLGLLIALTLLLLTSCLVCITFGAAPVPLSRVMAILMFKLSGTAEHP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCC
PLWTTGQETIVWLIRTPRVLLGALAGAGLALIGSVLQAATRNPLADPHLLGATSGATLGA
CCCCCCCHHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
VIVVMHVGEVFGMLTLPLAAFVGSLVSLCLVLWLASHQGRLDSQRLLLGGVAVSFVMMAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
ANLSLFLGDHRANSSVLFWMLGGLGLARWELLAVPFITVLCGWILLQGLGRSLNALMGGD
HHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCC
QTAVSLGLQVRNMRLLVFLIASLMTGVLVALCGSIGFVGLMVPHMARRLVGSEHRRLLPV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
ATLLGALLMVWVDVISRTLIAPEDLPIGITTALLGGLFFIFMMKRGQ
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron dicitrate [Periplasm]; H2O [C]

Specific reaction: ATP + iron dicitrate [Periplasm] + H2O = ADP + phosphate + iron dicitrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]