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The map label for this gene is mscS [H]

Identifier: 66048227

GI number: 66048227

Start: 5933543

End: 5934343

Strand: Direct

Name: mscS [H]

Synonym: Psyr_5003

Alternate gene names: 66048227

Gene position: 5933543-5934343 (Clockwise)

Preceding gene: 66048224

Following gene: 66048228

Centisome position: 97.37

GC content: 57.43

Gene sequence:

>801_bases
ATGGATGCGCTGAATGTCATCAATATCGACACTGACGGAATCAACTCGCTGTTCACTATCGTTCTGCAATACGGAGCGAC
TGTTGTTTTGAGGTTGGTGATCGCCGCATTGCTGTGGATTGTCGGTCGCTGGCTGATCGGTGTGCTGGTCAGGATGGCGC
AGCGTTCGCTGACGCGGCAGCGGTTTGATCCGACGGTTCTGCGCTATGTCGGCTCGTTCATCACGGTGACGCTGCATATC
ATTCTGGTGATCGCCATTCTGAGCTATTGCGGCATCGAGACCACCAGTTTTGCGGCGCTGCTGGCGGCCGTGGCGCTGGC
GATCGGCATGGCCTGGTCGGGTTTGCTGGCCAATCTGGCAGCGGGGGGTTTCATCATCGTGCTGCGGCCTTTCAAGGTCG
GCGATATGATTTCGGCGGCGGGCGTGACCGGAACCGTGGTCGAAATCGGCTTGTTCGTCACGTCGATCAACACTCCGGAA
AACGTGCTGAATCTGGTGGGCAACAACAAGATCTTCTCTGACACGATCGTCAATTTTTCCAGCAATGCTTTTCGCAGCGT
CGAACTGACCGCGATATTGCCCGGCAGCGCCGACGAGCAGAAGATCATCCCGCGCCTCAAGGATCAGATCGCACGCCTGC
CCAATGTACTGAGCAGCCCCGCTGTCGATGTGCACCTGTCCTCCACAACGGCCGACTCCATCACCCTGTCGGTACGGCCC
TATTGCCACAATGATCATTATGATTCGGTGCATCGCCAGACGCTCGCCCTCATCAGAGCGTTGATGCTGCACCTGTCCTG
A

Upstream 100 bases:

>100_bases
TCAAAACTACCAGTAGCCGCCTCCCCGCTTTGCCCTTCAATGTACGGCTCCGCTCGTCAGGCCATCTGCCGGGCGAGCCT
AGCAGTCGGGAGTAGCGGTG

Downstream 100 bases:

>100_bases
GCGGCACGCATAGGCAAAATTCATCGCCCTTCAAGCTCACCCCAACCTGTTGGCAGCCGATCAATAAGGATCGGTCCATA
TTCCGCGTGGCCTCTGCTTT

Product: MscS mechanosensitive ion channel

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MDALNVINIDTDGINSLFTIVLQYGATVVLRLVIAALLWIVGRWLIGVLVRMAQRSLTRQRFDPTVLRYVGSFITVTLHI
ILVIAILSYCGIETTSFAALLAAVALAIGMAWSGLLANLAAGGFIIVLRPFKVGDMISAAGVTGTVVEIGLFVTSINTPE
NVLNLVGNNKIFSDTIVNFSSNAFRSVELTAILPGSADEQKIIPRLKDQIARLPNVLSSPAVDVHLSSTTADSITLSVRP
YCHNDHYDSVHRQTLALIRALMLHLS

Sequences:

>Translated_266_residues
MDALNVINIDTDGINSLFTIVLQYGATVVLRLVIAALLWIVGRWLIGVLVRMAQRSLTRQRFDPTVLRYVGSFITVTLHI
ILVIAILSYCGIETTSFAALLAAVALAIGMAWSGLLANLAAGGFIIVLRPFKVGDMISAAGVTGTVVEIGLFVTSINTPE
NVLNLVGNNKIFSDTIVNFSSNAFRSVELTAILPGSADEQKIIPRLKDQIARLPNVLSSPAVDVHLSSTTADSITLSVRP
YCHNDHYDSVHRQTLALIRALMLHLS
>Mature_266_residues
MDALNVINIDTDGINSLFTIVLQYGATVVLRLVIAALLWIVGRWLIGVLVRMAQRSLTRQRFDPTVLRYVGSFITVTLHI
ILVIAILSYCGIETTSFAALLAAVALAIGMAWSGLLANLAAGGFIIVLRPFKVGDMISAAGVTGTVVEIGLFVTSINTPE
NVLNLVGNNKIFSDTIVNFSSNAFRSVELTAILPGSADEQKIIPRLKDQIARLPNVLSSPAVDVHLSSTTADSITLSVRP
YCHNDHYDSVHRQTLALIRALMLHLS

Specific function: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1789291, Length=263, Percent_Identity=27.3764258555133, Blast_Score=101, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685
- InterPro:   IPR006686
- InterPro:   IPR011014
- InterPro:   IPR008910 [H]

Pfam domain/function: PF00924 MS_channel; PF05552 TM_helix [H]

EC number: NA

Molecular weight: Translated: 28720; Mature: 28720

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDALNVINIDTDGINSLFTIVLQYGATVVLRLVIAALLWIVGRWLIGVLVRMAQRSLTRQ
CCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFDPTVLRYVGSFITVTLHIILVIAILSYCGIETTSFAALLAAVALAIGMAWSGLLANLA
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
AGGFIIVLRPFKVGDMISAAGVTGTVVEIGLFVTSINTPENVLNLVGNNKIFSDTIVNFS
CCCEEEEEECCCCCHHHHHCCCHHHHHHHHHHHEECCCHHHHHHHHCCCCCHHHHHHHCC
SNAFRSVELTAILPGSADEQKIIPRLKDQIARLPNVLSSPAVDVHLSSTTADSITLSVRP
CCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEC
YCHNDHYDSVHRQTLALIRALMLHLS
CCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDALNVINIDTDGINSLFTIVLQYGATVVLRLVIAALLWIVGRWLIGVLVRMAQRSLTRQ
CCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RFDPTVLRYVGSFITVTLHIILVIAILSYCGIETTSFAALLAAVALAIGMAWSGLLANLA
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHC
AGGFIIVLRPFKVGDMISAAGVTGTVVEIGLFVTSINTPENVLNLVGNNKIFSDTIVNFS
CCCEEEEEECCCCCHHHHHCCCHHHHHHHHHHHEECCCHHHHHHHHCCCCCHHHHHHHCC
SNAFRSVELTAILPGSADEQKIIPRLKDQIARLPNVLSSPAVDVHLSSTTADSITLSVRP
CCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEC
YCHNDHYDSVHRQTLALIRALMLHLS
CCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12542086 [H]