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The map label for this gene is cvrA [H]

Identifier: 66048034

GI number: 66048034

Start: 5704737

End: 5705996

Strand: Direct

Name: cvrA [H]

Synonym: Psyr_4810

Alternate gene names: 66048034

Gene position: 5704737-5705996 (Clockwise)

Preceding gene: 66048033

Following gene: 66048036

Centisome position: 93.62

GC content: 61.83

Gene sequence:

>1260_bases
ATGCTTGAACTCGCTGCTGGTTTTATCTGCCTCACTGCGCTGCTGACCTACGTGAACTACCGTTTCATCGGCCTGCCGCC
CACCATCGGCGTGATGGTCACCGCGCTGATGTTCTCGTTGCTGCTGCAGGGTCTGAGCTTTCTGGGCTATCCCGGCCTGG
AAGATCGCGTTCAACAATTGATCGGCCAGATCGACTTCGGCGACCTGCTGATGAACTGGATGCTGTCCTTTCTGCTGTTC
GCCGGGGCGCTGCACGTCAACCTGGGCGATTTGAGGAGCTACCGTTGGCCCATCGGCCTGTTGGCGACTTTCGGGGTGCT
GATTGCCACCACTGTGATCGGCGCACTGGCCTACTGGATCTTTGCCCTGTTCGGCTGGCACGTCAGCCCGTTGTACTGCC
TGCTGTTTGGTGCGCTGATCTCGCCTACCGATCCGATTGCGGTGCTTGGTGTGTTGCGTACCGCCAACGCCTCGAAACCG
CTGAAGACCACGATCGTCGGCGAAAGCCTGTTCAACGACGGCACCGCGGTGGTGGTGTTCACCGTGCTGTTGGGTATCGC
GCAGTTGGGCGAGACGCCGACGGTTGGCGAAACCGCTCTGCTGTTCGTTCACGAAGCGGTGGGCGGGGTGCTGTTCGGCG
GCCTGATCGGTTACGCCGTGTACCTGATGATCAAGAGCATCGAGCAATATCAGATCGAGGTCATGCTCACGCTGGCACTG
GTGATCGGCGGCTCGGCGATGGCGTCTGAACTGCATGTGTCCGGTCCTATCGCGATGGTCGTGGCTGGCCTGATCATCGG
CAACCTGGGACGCAATCTGGCGATGAACGACATGACCCGTCGCTACATGGACGGTTTCTGGGAGTTGCTGGATGACATGC
TCAACGCGCTGCTGTTCGCGCTGATCGGTATGGAGCTGTTGCTGTTGCCGTTCTCATGGCAGCACCTGATTGCAGCCAGC
CTGCTGGCGGCGGCGATTCTGCTGTCGCGCTTCGTCACCGTCGCTCCGGCCATCCTGCTCCTGCGTCGCTGGCGCAAGGT
GCCGCACGGCACGATCCGCATCCTCACCTGGGGTGGCTTGCGCGGCGGTGTCTCGGTTGCGCTGGCCCTGGCGCTGCCGA
CCGGGCCGGAACGCGATCTGCTGCTGAGCATCACCTACATCGTGGTGCTGCTGTCGATTCTCTTGCAGGGCCTGACCATC
GGCAAGCTGGTGAATGCCGTCACCCGCGCCCCGCAGGCGAAAGACCCGGCAGAGCATTGA

Upstream 100 bases:

>100_bases
CTGTGGCGTGTCGAGATGTGTCTGGACGTAGTTCCGGTCCATCAAACACAGGCTCGGTTACGGTGATCGAGACACTGCAA
TTACGGATTTGGAATGACCG

Downstream 100 bases:

>100_bases
TCAGGCGGATGCAGCGGCGCGCCGGTATTCACTGGGCGTCTGCTGCATCTCCACGCGGAAGTGTCGGTTGAAGTTGGACA
AATTGGCATAGCCGACTTCA

Product: Sodium/hydrogen exchanger

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MLELAAGFICLTALLTYVNYRFIGLPPTIGVMVTALMFSLLLQGLSFLGYPGLEDRVQQLIGQIDFGDLLMNWMLSFLLF
AGALHVNLGDLRSYRWPIGLLATFGVLIATTVIGALAYWIFALFGWHVSPLYCLLFGALISPTDPIAVLGVLRTANASKP
LKTTIVGESLFNDGTAVVVFTVLLGIAQLGETPTVGETALLFVHEAVGGVLFGGLIGYAVYLMIKSIEQYQIEVMLTLAL
VIGGSAMASELHVSGPIAMVVAGLIIGNLGRNLAMNDMTRRYMDGFWELLDDMLNALLFALIGMELLLLPFSWQHLIAAS
LLAAAILLSRFVTVAPAILLLRRWRKVPHGTIRILTWGGLRGGVSVALALALPTGPERDLLLSITYIVVLLSILLQGLTI
GKLVNAVTRAPQAKDPAEH

Sequences:

>Translated_419_residues
MLELAAGFICLTALLTYVNYRFIGLPPTIGVMVTALMFSLLLQGLSFLGYPGLEDRVQQLIGQIDFGDLLMNWMLSFLLF
AGALHVNLGDLRSYRWPIGLLATFGVLIATTVIGALAYWIFALFGWHVSPLYCLLFGALISPTDPIAVLGVLRTANASKP
LKTTIVGESLFNDGTAVVVFTVLLGIAQLGETPTVGETALLFVHEAVGGVLFGGLIGYAVYLMIKSIEQYQIEVMLTLAL
VIGGSAMASELHVSGPIAMVVAGLIIGNLGRNLAMNDMTRRYMDGFWELLDDMLNALLFALIGMELLLLPFSWQHLIAAS
LLAAAILLSRFVTVAPAILLLRRWRKVPHGTIRILTWGGLRGGVSVALALALPTGPERDLLLSITYIVVLLSILLQGLTI
GKLVNAVTRAPQAKDPAEH
>Mature_419_residues
MLELAAGFICLTALLTYVNYRFIGLPPTIGVMVTALMFSLLLQGLSFLGYPGLEDRVQQLIGQIDFGDLLMNWMLSFLLF
AGALHVNLGDLRSYRWPIGLLATFGVLIATTVIGALAYWIFALFGWHVSPLYCLLFGALISPTDPIAVLGVLRTANASKP
LKTTIVGESLFNDGTAVVVFTVLLGIAQLGETPTVGETALLFVHEAVGGVLFGGLIGYAVYLMIKSIEQYQIEVMLTLAL
VIGGSAMASELHVSGPIAMVVAGLIIGNLGRNLAMNDMTRRYMDGFWELLDDMLNALLFALIGMELLLLPFSWQHLIAAS
LLAAAILLSRFVTVAPAILLLRRWRKVPHGTIRILTWGGLRGGVSVALALALPTGPERDLLLSITYIVVLLSILLQGLTI
GKLVNAVTRAPQAKDPAEH

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI148727259, Length=318, Percent_Identity=26.1006289308176, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI15529998, Length=283, Percent_Identity=26.5017667844523, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI194239733, Length=297, Percent_Identity=29.2929292929293, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI27734935, Length=333, Percent_Identity=25.8258258258258, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI294997330, Length=398, Percent_Identity=23.1155778894472, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI110227626, Length=402, Percent_Identity=23.3830845771144, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI41872703, Length=407, Percent_Identity=22.6044226044226, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI5454070, Length=332, Percent_Identity=24.6987951807229, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI14211919, Length=430, Percent_Identity=22.7906976744186, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI4759144, Length=295, Percent_Identity=28.4745762711864, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1790501, Length=339, Percent_Identity=24.4837758112094, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71999819, Length=338, Percent_Identity=25.7396449704142, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71999817, Length=338, Percent_Identity=25.7396449704142, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71999821, Length=338, Percent_Identity=25.7396449704142, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI25150332, Length=319, Percent_Identity=24.7648902821317, Blast_Score=85, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI71980847, Length=344, Percent_Identity=22.9651162790698, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71990924, Length=316, Percent_Identity=24.0506329113924, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71990932, Length=350, Percent_Identity=23.4285714285714, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI25147678, Length=305, Percent_Identity=25.2459016393443, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71987535, Length=308, Percent_Identity=23.7012987012987, Blast_Score=71, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI71987537, Length=308, Percent_Identity=23.7012987012987, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71993590, Length=337, Percent_Identity=25.2225519287834, Blast_Score=68, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71993582, Length=337, Percent_Identity=25.2225519287834, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71992107, Length=306, Percent_Identity=25.1633986928105, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71987559, Length=346, Percent_Identity=22.5433526011561, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71992101, Length=306, Percent_Identity=25.1633986928105, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71987545, Length=346, Percent_Identity=22.5433526011561, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320663, Length=306, Percent_Identity=28.4313725490196, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI281364513, Length=322, Percent_Identity=24.8447204968944, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI221473212, Length=322, Percent_Identity=24.8447204968944, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI221510740, Length=335, Percent_Identity=24.7761194029851, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24585580, Length=335, Percent_Identity=24.7761194029851, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24585578, Length=335, Percent_Identity=24.7761194029851, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI221473222, Length=322, Percent_Identity=24.8447204968944, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI221473215, Length=322, Percent_Identity=24.8447204968944, Blast_Score=85, Evalue=9e-17,
Organism=Drosophila melanogaster, GI281360447, Length=337, Percent_Identity=24.3323442136499, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI221510734, Length=332, Percent_Identity=24.3975903614458, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI221510738, Length=332, Percent_Identity=24.3975903614458, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI221510736, Length=333, Percent_Identity=24.6246246246246, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221510732, Length=333, Percent_Identity=24.6246246246246, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 45138; Mature: 45138

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLELAAGFICLTALLTYVNYRFIGLPPTIGVMVTALMFSLLLQGLSFLGYPGLEDRVQQL
CCHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
IGQIDFGDLLMNWMLSFLLFAGALHVNLGDLRSYRWPIGLLATFGVLIATTVIGALAYWI
HCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
FALFGWHVSPLYCLLFGALISPTDPIAVLGVLRTANASKPLKTTIVGESLFNDGTAVVVF
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHH
TVLLGIAQLGETPTVGETALLFVHEAVGGVLFGGLIGYAVYLMIKSIEQYQIEVMLTLAL
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIGGSAMASELHVSGPIAMVVAGLIIGNLGRNLAMNDMTRRYMDGFWELLDDMLNALLFA
HHCCHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIGMELLLLPFSWQHLIAASLLAAAILLSRFVTVAPAILLLRRWRKVPHGTIRILTWGGL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCC
RGGVSVALALALPTGPERDLLLSITYIVVLLSILLQGLTIGKLVNAVTRAPQAKDPAEH
CHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MLELAAGFICLTALLTYVNYRFIGLPPTIGVMVTALMFSLLLQGLSFLGYPGLEDRVQQL
CCHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
IGQIDFGDLLMNWMLSFLLFAGALHVNLGDLRSYRWPIGLLATFGVLIATTVIGALAYWI
HCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
FALFGWHVSPLYCLLFGALISPTDPIAVLGVLRTANASKPLKTTIVGESLFNDGTAVVVF
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHH
TVLLGIAQLGETPTVGETALLFVHEAVGGVLFGGLIGYAVYLMIKSIEQYQIEVMLTLAL
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIGGSAMASELHVSGPIAMVVAGLIIGNLGRNLAMNDMTRRYMDGFWELLDDMLNALLFA
HHCCHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIGMELLLLPFSWQHLIAASLLAAAILLSRFVTVAPAILLLRRWRKVPHGTIRILTWGGL
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCC
RGGVSVALALALPTGPERDLLLSITYIVVLLSILLQGLTIGKLVNAVTRAPQAKDPAEH
CHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA