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The map label for this gene is msrA [H]

Identifier: 66047995

GI number: 66047995

Start: 5649673

End: 5650320

Strand: Direct

Name: msrA [H]

Synonym: Psyr_4771

Alternate gene names: 66047995

Gene position: 5649673-5650320 (Clockwise)

Preceding gene: 66047994

Following gene: 66047997

Centisome position: 92.71

GC content: 59.26

Gene sequence:

>648_bases
ATGACTTTGCGCTCGGAAATTCTAGTGAACAAAAATGTACTGCCTACCGCCGAACAAGCATTGCCGGGTCGTGAAACACC
TATGGCGCTTCCGGAATTTCACTTCGTCAACGGCAATCCGCTGCTGGGGCCGTTTTCGAGCAACGTCGAATTCGCCATCT
TCGGCATGGGTTGCTTCTGGGGCGCAGAACGCCGTCTGTGGCAACAGGAAGGTGTGGTGAGCACTGTCGCCGGCTACGCA
GGCGGATTTACCCCGAACCCGACCTACGAAGAAGTCTGCTCCGGGCTGACCGGTCACACCGAGGTGGTGCTGGTGGTCTA
CGAGCCAGCAAAAATCAGCTACGAAGAACTGCTCAAGGTGTTCTGGGAAGTGCACAACCCGACTCAGGGCATGCGCCAGG
GCAACGACATCGGCACGCAGTATCGCTCGGTGATCTACTGCACGACGCCCGAACAGCTCGACGCCGCCAAAGCCAGTGCC
GAAACGTTCCAGGCGCAATTGAACAAGGCCGGCAAGGGCACCATCACCACCGAAATCGAGCAGGCACCGACGGTTTACTT
TGCCGAGGCCTACCACCAGCAATACCTGGCCAAGAACCCACAGGGCTACTGCGGGCTGGGCGGCACGGGCGTGTGCATGC
CGGCTTGA

Upstream 100 bases:

>100_bases
TTACACGGCAGCACTTGTTTCTACGTGTAACGGGACCTATGTAATTGCATTCATTCGTCCTGGCCCCTGCTGCCTGTCTC
TAAACGAGAGGATATGGTTC

Downstream 100 bases:

>100_bases
TTCGCGCCTAGCGGCCAGAAAACAGCGTTTTTCAGGCTTCTGCCCGCAGGGCGTAGGAGCGAACTTGTTCGCGAAGATAG
TAGTTCAGGTGACGCATTTT

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 215; Mature: 214

Protein sequence:

>215_residues
MTLRSEILVNKNVLPTAEQALPGRETPMALPEFHFVNGNPLLGPFSSNVEFAIFGMGCFWGAERRLWQQEGVVSTVAGYA
GGFTPNPTYEEVCSGLTGHTEVVLVVYEPAKISYEELLKVFWEVHNPTQGMRQGNDIGTQYRSVIYCTTPEQLDAAKASA
ETFQAQLNKAGKGTITTEIEQAPTVYFAEAYHQQYLAKNPQGYCGLGGTGVCMPA

Sequences:

>Translated_215_residues
MTLRSEILVNKNVLPTAEQALPGRETPMALPEFHFVNGNPLLGPFSSNVEFAIFGMGCFWGAERRLWQQEGVVSTVAGYA
GGFTPNPTYEEVCSGLTGHTEVVLVVYEPAKISYEELLKVFWEVHNPTQGMRQGNDIGTQYRSVIYCTTPEQLDAAKASA
ETFQAQLNKAGKGTITTEIEQAPTVYFAEAYHQQYLAKNPQGYCGLGGTGVCMPA
>Mature_214_residues
TLRSEILVNKNVLPTAEQALPGRETPMALPEFHFVNGNPLLGPFSSNVEFAIFGMGCFWGAERRLWQQEGVVSTVAGYAG
GFTPNPTYEEVCSGLTGHTEVVLVVYEPAKISYEELLKVFWEVHNPTQGMRQGNDIGTQYRSVIYCTTPEQLDAAKASAE
TFQAQLNKAGKGTITTEIEQAPTVYFAEAYHQQYLAKNPQGYCGLGGTGVCMPA

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=199, Percent_Identity=59.7989949748744, Blast_Score=254, Evalue=6e-68,
Organism=Homo sapiens, GI208609995, Length=181, Percent_Identity=62.9834254143646, Blast_Score=244, Evalue=5e-65,
Organism=Homo sapiens, GI208609993, Length=199, Percent_Identity=45.7286432160804, Blast_Score=172, Evalue=2e-43,
Organism=Escherichia coli, GI1790665, Length=208, Percent_Identity=60.0961538461538, Blast_Score=232, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17533973, Length=147, Percent_Identity=38.0952380952381, Blast_Score=93, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6320881, Length=158, Percent_Identity=37.9746835443038, Blast_Score=99, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24664627, Length=144, Percent_Identity=43.0555555555556, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24664631, Length=144, Percent_Identity=42.3611111111111, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI45553131, Length=140, Percent_Identity=42.1428571428571, Blast_Score=89, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 23495; Mature: 23364

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLRSEILVNKNVLPTAEQALPGRETPMALPEFHFVNGNPLLGPFSSNVEFAIFGMGCFW
CCCCCCEEECCCCCCCHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEEEEHHHH
GAERRLWQQEGVVSTVAGYAGGFTPNPTYEEVCSGLTGHTEVVLVVYEPAKISYEELLKV
HHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHH
FWEVHNPTQGMRQGNDIGTQYRSVIYCTTPEQLDAAKASAETFQAQLNKAGKGTITTEIE
HHHHCCCHHHHHCCCHHCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCEEEECC
QAPTVYFAEAYHQQYLAKNPQGYCGLGGTGVCMPA
CCCEEEHHHHHHHHHHHCCCCCCCCCCCCEEECCC
>Mature Secondary Structure 
TLRSEILVNKNVLPTAEQALPGRETPMALPEFHFVNGNPLLGPFSSNVEFAIFGMGCFW
CCCCCEEECCCCCCCHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEEEEHHHH
GAERRLWQQEGVVSTVAGYAGGFTPNPTYEEVCSGLTGHTEVVLVVYEPAKISYEELLKV
HHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHH
FWEVHNPTQGMRQGNDIGTQYRSVIYCTTPEQLDAAKASAETFQAQLNKAGKGTITTEIE
HHHHCCCHHHHHCCCHHCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCEEEECC
QAPTVYFAEAYHQQYLAKNPQGYCGLGGTGVCMPA
CCCEEEHHHHHHHHHHHCCCCCCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA