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The map label for this gene is mdtD [H]

Identifier: 66047993

GI number: 66047993

Start: 5645169

End: 5646581

Strand: Direct

Name: mdtD [H]

Synonym: Psyr_4769

Alternate gene names: 66047993

Gene position: 5645169-5646581 (Clockwise)

Preceding gene: 66047992

Following gene: 66047994

Centisome position: 92.64

GC content: 62.21

Gene sequence:

>1413_bases
ATGCAGAACTCAGCAGCGCCGATCATGGACGAAAAGACCCTGCGCTGGATGCCCTGGGTCATCGCCATCGCATTCTTCAT
GCAAAGCCTGGACGGCACGATTCTCAACACCGCCTTGCCGTCCATGGCCCGCTCACTGGCAGAAGACCCGTTGCGCATGC
AGTCGGTGGTCATCGCCTACATGCTGACCATTGCGCTGCTGATCCCGGCCTCGGGCTGGATCGCCGACCGGTTCGGGATC
AAGCGCATCTTCTTCAGCGCCATCCTGCTGTTCAGCTTCGGATCATTGCTGTGCGCGCTGTCCTGGTCACTGAACGTGCT
GGTGGCCGCCCGGGTGATTCAGGGGCTGGGGGGCGCGCTGATGCTGCCCATCGGGCGCCTGATCGTATTGCGCGCCTATC
CGCGCTCGGAGCTGGTGCGAATCATGGGTTTTATCACCGTGCCGGGCCTTTTGGGCCCATTGCTGGGCCCGACGCTTGGC
GGCTGGATGGTGGAGTACCTGAGCTGGCACTGGATTTTCCTGATCAACATTCCGGTCGGCATCCTCGGTTGCTATGCCGT
CAAACACTTCATCCCTGATCTTCCGGGAGGCGGTCGAACCCGGTTTGACGGCGTCGGCTTCATCCTGTTTGGCGCGGCGA
TGATACTGATCACCATTGCCCTGGAGGGCCTGGGCGAGCTGCACCTGCCACACATGCGCGTGGTACTGCTGCTGTTTGCC
GGAATGGGCTGTCTGGCAGCGTATTGGCTGCGTGCCGGGCACATCGAATCGCCGTTGTTTGCCCCTTCATTGTTCCGTAC
CCGGACGTTTGCCGTCGGTATCATGGGCAACCTGTTCGCCCGCCTGGGCAGCGGCGCGCTGCCCTTCCTGGTGCCATTGC
TGCTGCAAGTGGCCCTGGGGTATTCGCCGTCTCAGGCGGGTATGAGCATGTTGCCGCTGGCCGCCGCTGGCATGTTCGCC
AAGACTGTCGCCCGCTGGCTGATCGAGCGGCTGGGCTATCGCGTGATTCTGACCGGCAACACACTGCTGCTGGGCATCCT
GCTGGCCAGCCTGGCGCTGGTCGATGTGCAAACCCCATACTGGGTGTTGCTGGTGCATCTGGGGCTGCTCGGCGCGGTCA
ACTCCTTGCAGTTCACGGCGATGAATACGGTCACCCTGATCGATCTGGACGATGCCAGTGCAGCGAGTGGCAACAGCCTG
CTCTCGGTCGTGGCACAGCTGTCCCTGAGTCTTGGCGTGGCAAGCGCAGCAGCCTTGCTGGGTGGTTTCAGCGAAGAAGT
AGCCACCGGCGAGGTCAGCAGCATGCTGGGGGCGTTCCAGATGACCTTCCTGAGTGTCGGGGTGCTGGCCATGTTTGCAG
CAGGTATTTTCCTGCAATTGCCCGCGAAGGAGCCCAGGATGGCCAAAGCCTGA

Upstream 100 bases:

>100_bases
GATTCTCCAATCGAGTACCTACAGTCAGCGCCAGACCGGTTCAATACAGTTGCCTGGCGCATTGATCAGCCGACTCACCC
TCACGCTATAGCAGGAGCCT

Downstream 100 bases:

>100_bases
TTGACAACGGCTCGTGACTGGAGCACATCTGCAAAGCGAATTCCCCTGGAAAACGGGGGTTTCGCCCGAAAAATCAACGA
ATTTGAGTATCCGACCAGAT

Product: major facilitator transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MQNSAAPIMDEKTLRWMPWVIAIAFFMQSLDGTILNTALPSMARSLAEDPLRMQSVVIAYMLTIALLIPASGWIADRFGI
KRIFFSAILLFSFGSLLCALSWSLNVLVAARVIQGLGGALMLPIGRLIVLRAYPRSELVRIMGFITVPGLLGPLLGPTLG
GWMVEYLSWHWIFLINIPVGILGCYAVKHFIPDLPGGGRTRFDGVGFILFGAAMILITIALEGLGELHLPHMRVVLLLFA
GMGCLAAYWLRAGHIESPLFAPSLFRTRTFAVGIMGNLFARLGSGALPFLVPLLLQVALGYSPSQAGMSMLPLAAAGMFA
KTVARWLIERLGYRVILTGNTLLLGILLASLALVDVQTPYWVLLVHLGLLGAVNSLQFTAMNTVTLIDLDDASAASGNSL
LSVVAQLSLSLGVASAAALLGGFSEEVATGEVSSMLGAFQMTFLSVGVLAMFAAGIFLQLPAKEPRMAKA

Sequences:

>Translated_470_residues
MQNSAAPIMDEKTLRWMPWVIAIAFFMQSLDGTILNTALPSMARSLAEDPLRMQSVVIAYMLTIALLIPASGWIADRFGI
KRIFFSAILLFSFGSLLCALSWSLNVLVAARVIQGLGGALMLPIGRLIVLRAYPRSELVRIMGFITVPGLLGPLLGPTLG
GWMVEYLSWHWIFLINIPVGILGCYAVKHFIPDLPGGGRTRFDGVGFILFGAAMILITIALEGLGELHLPHMRVVLLLFA
GMGCLAAYWLRAGHIESPLFAPSLFRTRTFAVGIMGNLFARLGSGALPFLVPLLLQVALGYSPSQAGMSMLPLAAAGMFA
KTVARWLIERLGYRVILTGNTLLLGILLASLALVDVQTPYWVLLVHLGLLGAVNSLQFTAMNTVTLIDLDDASAASGNSL
LSVVAQLSLSLGVASAAALLGGFSEEVATGEVSSMLGAFQMTFLSVGVLAMFAAGIFLQLPAKEPRMAKA
>Mature_470_residues
MQNSAAPIMDEKTLRWMPWVIAIAFFMQSLDGTILNTALPSMARSLAEDPLRMQSVVIAYMLTIALLIPASGWIADRFGI
KRIFFSAILLFSFGSLLCALSWSLNVLVAARVIQGLGGALMLPIGRLIVLRAYPRSELVRIMGFITVPGLLGPLLGPTLG
GWMVEYLSWHWIFLINIPVGILGCYAVKHFIPDLPGGGRTRFDGVGFILFGAAMILITIALEGLGELHLPHMRVVLLLFA
GMGCLAAYWLRAGHIESPLFAPSLFRTRTFAVGIMGNLFARLGSGALPFLVPLLLQVALGYSPSQAGMSMLPLAAAGMFA
KTVARWLIERLGYRVILTGNTLLLGILLASLALVDVQTPYWVLLVHLGLLGAVNSLQFTAMNTVTLIDLDDASAASGNSL
LSVVAQLSLSLGVASAAALLGGFSEEVATGEVSSMLGAFQMTFLSVGVLAMFAAGIFLQLPAKEPRMAKA

Specific function: Unknown

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=460, Percent_Identity=48.0434782608696, Blast_Score=411, Evalue=1e-116,
Organism=Escherichia coli, GI1788392, Length=458, Percent_Identity=46.2882096069869, Blast_Score=363, Evalue=1e-101,
Organism=Escherichia coli, GI87081983, Length=317, Percent_Identity=31.5457413249211, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1789042, Length=404, Percent_Identity=26.2376237623762, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1788710, Length=438, Percent_Identity=26.4840182648402, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1788509, Length=136, Percent_Identity=30.8823529411765, Blast_Score=63, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6325455, Length=129, Percent_Identity=32.5581395348837, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001411 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 50218; Mature: 50218

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNSAAPIMDEKTLRWMPWVIAIAFFMQSLDGTILNTALPSMARSLAEDPLRMQSVVIAY
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCHHHHHHHHHHH
MLTIALLIPASGWIADRFGIKRIFFSAILLFSFGSLLCALSWSLNVLVAARVIQGLGGAL
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
MLPIGRLIVLRAYPRSELVRIMGFITVPGLLGPLLGPTLGGWMVEYLSWHWIFLINIPVG
HHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEEEEECHHH
ILGCYAVKHFIPDLPGGGRTRFDGVGFILFGAAMILITIALEGLGELHLPHMRVVLLLFA
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
GMGCLAAYWLRAGHIESPLFAPSLFRTRTFAVGIMGNLFARLGSGALPFLVPLLLQVALG
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
YSPSQAGMSMLPLAAAGMFAKTVARWLIERLGYRVILTGNTLLLGILLASLALVDVQTPY
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHCCCHH
WVLLVHLGLLGAVNSLQFTAMNTVTLIDLDDASAASGNSLLSVVAQLSLSLGVASAAALL
HHHHHHHHHHHHHCCCEEEEECEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GGFSEEVATGEVSSMLGAFQMTFLSVGVLAMFAAGIFLQLPAKEPRMAKA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCC
>Mature Secondary Structure
MQNSAAPIMDEKTLRWMPWVIAIAFFMQSLDGTILNTALPSMARSLAEDPLRMQSVVIAY
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCHHHHHHHHHHH
MLTIALLIPASGWIADRFGIKRIFFSAILLFSFGSLLCALSWSLNVLVAARVIQGLGGAL
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
MLPIGRLIVLRAYPRSELVRIMGFITVPGLLGPLLGPTLGGWMVEYLSWHWIFLINIPVG
HHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEEEEECHHH
ILGCYAVKHFIPDLPGGGRTRFDGVGFILFGAAMILITIALEGLGELHLPHMRVVLLLFA
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
GMGCLAAYWLRAGHIESPLFAPSLFRTRTFAVGIMGNLFARLGSGALPFLVPLLLQVALG
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
YSPSQAGMSMLPLAAAGMFAKTVARWLIERLGYRVILTGNTLLLGILLASLALVDVQTPY
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHCCCHH
WVLLVHLGLLGAVNSLQFTAMNTVTLIDLDDASAASGNSLLSVVAQLSLSLGVASAAALL
HHHHHHHHHHHHHCCCEEEEECEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
GGFSEEVATGEVSSMLGAFQMTFLSVGVLAMFAAGIFLQLPAKEPRMAKA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA