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The map label for this gene is glyA1 [H]

Identifier: 66047936

GI number: 66047936

Start: 5583431

End: 5584684

Strand: Direct

Name: glyA1 [H]

Synonym: Psyr_4712

Alternate gene names: 66047936

Gene position: 5583431-5584684 (Clockwise)

Preceding gene: 66047935

Following gene: 66047937

Centisome position: 91.63

GC content: 62.52

Gene sequence:

>1254_bases
ATGTTCAGCAAGCAAGACCAGATCCAGGGTTATGACGATGCACTGTTGTCGGCGATGAACGCCGAGGAGCAGCGTCAGGA
AGACCATATCGAGCTGATCGCCTCGGAGAACTACACCAGCAAACGCGTGATGCAGGCGCAGGGCAGCGGCCTGACCAACA
AGTACGCAGAGGGCTATCCCGGCAAGCGTTACTACGGCGGTTGCGAGCACGTCGACAAGGTCGAGCAACTGGCCATCGAA
CGCGCCAGACAGCTGTTTGGTGCCGACTATGCCAACGTTCAGCCGCATTCCGGAAGTCAGGCCAACGCAGCGGTCTATCT
GGCGCTGCTTCAGGCCGGCGATACCGTGTTGGGCATGAGCCTGGCGCACGGCGGTCATCTGACTCACGGTGCCAAGGTCA
GCTTCTCGGGCAAACTCTATAACGCCGTTCAGTACGGCATCGACACCGCGACCGGGCTGATCGATTACGACGAAGTCGAG
CGCATTGCCGTCGAATGCCAGCCGAAAATGATCATCGCCGGGTTTTCAGCCTACTCCAAGACCCTCGACTTCCCGCGCTT
CCGCGCAATCGCCGACAAGGTGGGCGCCTACCTGTTCGTCGACATGGCGCACGTCGCCGGTCTGGTTGCAGCCGGTCTTT
ACCCGAATCCGCTGCCCTACGCAGACGTAGTCACCACCACGACCCACAAGACCCTGCGCGGCCCACGCGGCGGCCTGATT
CTGGCCAGGGCCAACGAAGAGCTGGAAAAGAAATTCAATTCCGCCGTCTTCCCCGGTGGTCAGGGCGGCCCGCTGATGCA
CGTGATCGCCGCCAAGGCCGTGTGTTTCAAGGAAGCCATGGAGCCCGGCTTCAAGGCCTATCAACAGCAGGTCATCGACA
ACGCGCAAGCGATGGCGCAGGTGTTCATCGACCGAGGCTTCGACGTGGTCTCCGGCGGCACCGACAACCATCTGTTTCTG
GTCAGCCTGATCCGTCAGGGCCTGACCGGCAAGGACGCCGACGCCGCGCTGGGGCGTGCGCACATCACCGTCAACAAGAA
CTCGGTGCCCAACGACCCGCAGTCGCCGTTCGTGACGTCCGGCCTGCGCATCGGCACACCGGCCGTTACCACCCGCGGCT
TCAAGGTGACCCAGTGCGTCGAGCTGGCCGGCTGGATCTGCGACATCCTCGACAACCTCGGTGATGCCGATGTCGAGGCC
GACGTCGCCAGCCAGGTCGCCGCCCTGTGCGCCGATTTTCCGGTTTATCGCTGA

Upstream 100 bases:

>100_bases
GGCATTTGGCGTCTTCGGTGCGGCCCTACCATCGCTCTCAGAGGGCTCTGTTCAGCCCGAACGACAAGTCAGGCGCCGCG
CCGCCGCTGGGAGATCCGCG

Downstream 100 bases:

>100_bases
GTCAGGAGTAGCCTCACATGCAGCATTACTCAGGCTTCGGCCTTCTCAAGCATTCCCTCAGCCACCATGAAAACTGGCAG
CGCATGTGGCGCACGCCGAC

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT 1; Serine methylase 1 [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MFSKQDQIQGYDDALLSAMNAEEQRQEDHIELIASENYTSKRVMQAQGSGLTNKYAEGYPGKRYYGGCEHVDKVEQLAIE
RARQLFGADYANVQPHSGSQANAAVYLALLQAGDTVLGMSLAHGGHLTHGAKVSFSGKLYNAVQYGIDTATGLIDYDEVE
RIAVECQPKMIIAGFSAYSKTLDFPRFRAIADKVGAYLFVDMAHVAGLVAAGLYPNPLPYADVVTTTTHKTLRGPRGGLI
LARANEELEKKFNSAVFPGGQGGPLMHVIAAKAVCFKEAMEPGFKAYQQQVIDNAQAMAQVFIDRGFDVVSGGTDNHLFL
VSLIRQGLTGKDADAALGRAHITVNKNSVPNDPQSPFVTSGLRIGTPAVTTRGFKVTQCVELAGWICDILDNLGDADVEA
DVASQVAALCADFPVYR

Sequences:

>Translated_417_residues
MFSKQDQIQGYDDALLSAMNAEEQRQEDHIELIASENYTSKRVMQAQGSGLTNKYAEGYPGKRYYGGCEHVDKVEQLAIE
RARQLFGADYANVQPHSGSQANAAVYLALLQAGDTVLGMSLAHGGHLTHGAKVSFSGKLYNAVQYGIDTATGLIDYDEVE
RIAVECQPKMIIAGFSAYSKTLDFPRFRAIADKVGAYLFVDMAHVAGLVAAGLYPNPLPYADVVTTTTHKTLRGPRGGLI
LARANEELEKKFNSAVFPGGQGGPLMHVIAAKAVCFKEAMEPGFKAYQQQVIDNAQAMAQVFIDRGFDVVSGGTDNHLFL
VSLIRQGLTGKDADAALGRAHITVNKNSVPNDPQSPFVTSGLRIGTPAVTTRGFKVTQCVELAGWICDILDNLGDADVEA
DVASQVAALCADFPVYR
>Mature_417_residues
MFSKQDQIQGYDDALLSAMNAEEQRQEDHIELIASENYTSKRVMQAQGSGLTNKYAEGYPGKRYYGGCEHVDKVEQLAIE
RARQLFGADYANVQPHSGSQANAAVYLALLQAGDTVLGMSLAHGGHLTHGAKVSFSGKLYNAVQYGIDTATGLIDYDEVE
RIAVECQPKMIIAGFSAYSKTLDFPRFRAIADKVGAYLFVDMAHVAGLVAAGLYPNPLPYADVVTTTTHKTLRGPRGGLI
LARANEELEKKFNSAVFPGGQGGPLMHVIAAKAVCFKEAMEPGFKAYQQQVIDNAQAMAQVFIDRGFDVVSGGTDNHLFL
VSLIRQGLTGKDADAALGRAHITVNKNSVPNDPQSPFVTSGLRIGTPAVTTRGFKVTQCVELAGWICDILDNLGDADVEA
DVASQVAALCADFPVYR

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=396, Percent_Identity=46.4646464646465, Blast_Score=350, Evalue=2e-96,
Organism=Homo sapiens, GI261862352, Length=396, Percent_Identity=46.4646464646465, Blast_Score=349, Evalue=2e-96,
Organism=Homo sapiens, GI261862350, Length=396, Percent_Identity=46.4646464646465, Blast_Score=349, Evalue=2e-96,
Organism=Homo sapiens, GI261862348, Length=396, Percent_Identity=46.4646464646465, Blast_Score=349, Evalue=2e-96,
Organism=Homo sapiens, GI261862346, Length=396, Percent_Identity=45.2020202020202, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI22547186, Length=401, Percent_Identity=45.3865336658354, Blast_Score=317, Evalue=9e-87,
Organism=Homo sapiens, GI22547189, Length=388, Percent_Identity=42.7835051546392, Blast_Score=284, Evalue=9e-77,
Organism=Escherichia coli, GI1788902, Length=417, Percent_Identity=72.1822541966427, Blast_Score=602, Evalue=1e-173,
Organism=Caenorhabditis elegans, GI25144732, Length=391, Percent_Identity=49.1048593350384, Blast_Score=364, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI25144729, Length=391, Percent_Identity=49.1048593350384, Blast_Score=363, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6319739, Length=397, Percent_Identity=47.103274559194, Blast_Score=363, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6323087, Length=385, Percent_Identity=46.2337662337662, Blast_Score=340, Evalue=3e-94,
Organism=Drosophila melanogaster, GI24640005, Length=396, Percent_Identity=48.4848484848485, Blast_Score=369, Evalue=1e-102,
Organism=Drosophila melanogaster, GI221329721, Length=396, Percent_Identity=48.4848484848485, Blast_Score=368, Evalue=1e-102,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 44874; Mature: 44874

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSKQDQIQGYDDALLSAMNAEEQRQEDHIELIASENYTSKRVMQAQGSGLTNKYAEGYP
CCCCCCCCCCHHHHHHHHHCHHHHHHHHHEEEEECCCCCHHHHHHHCCCCCCCHHHCCCC
GKRYYGGCEHVDKVEQLAIERARQLFGADYANVQPHSGSQANAAVYLALLQAGDTVLGMS
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEH
LAHGGHLTHGAKVSFSGKLYNAVQYGIDTATGLIDYDEVERIAVECQPKMIIAGFSAYSK
HHCCCCCCCCCEEEECCHHHHHHHHCCHHHHCCCCHHHHHHHHHHCCCCEEEEECHHHHH
TLDFPRFRAIADKVGAYLFVDMAHVAGLVAAGLYPNPLPYADVVTTTTHKTLRGPRGGLI
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEECCCHHHHCCCCCCEE
LARANEELEKKFNSAVFPGGQGGPLMHVIAAKAVCFKEAMEPGFKAYQQQVIDNAQAMAQ
EEECCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
VFIDRGFDVVSGGTDNHLFLVSLIRQGLTGKDADAALGRAHITVNKNSVPNDPQSPFVTS
HHHHCCCEEECCCCCCHHHHHHHHHCCCCCCCCHHHCCEEEEEECCCCCCCCCCCCCHHC
GLRIGTPAVTTRGFKVTQCVELAGWICDILDNLGDADVEADVASQVAALCADFPVYR
CEEECCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MFSKQDQIQGYDDALLSAMNAEEQRQEDHIELIASENYTSKRVMQAQGSGLTNKYAEGYP
CCCCCCCCCCHHHHHHHHHCHHHHHHHHHEEEEECCCCCHHHHHHHCCCCCCCHHHCCCC
GKRYYGGCEHVDKVEQLAIERARQLFGADYANVQPHSGSQANAAVYLALLQAGDTVLGMS
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEH
LAHGGHLTHGAKVSFSGKLYNAVQYGIDTATGLIDYDEVERIAVECQPKMIIAGFSAYSK
HHCCCCCCCCCEEEECCHHHHHHHHCCHHHHCCCCHHHHHHHHHHCCCCEEEEECHHHHH
TLDFPRFRAIADKVGAYLFVDMAHVAGLVAAGLYPNPLPYADVVTTTTHKTLRGPRGGLI
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEECCCHHHHCCCCCCEE
LARANEELEKKFNSAVFPGGQGGPLMHVIAAKAVCFKEAMEPGFKAYQQQVIDNAQAMAQ
EEECCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
VFIDRGFDVVSGGTDNHLFLVSLIRQGLTGKDADAALGRAHITVNKNSVPNDPQSPFVTS
HHHHCCCEEECCCCCCHHHHHHHHHCCCCCCCCHHHCCEEEEEECCCCCCCCCCCCCHHC
GLRIGTPAVTTRGFKVTQCVELAGWICDILDNLGDADVEADVASQVAALCADFPVYR
CEEECCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12534463 [H]