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The map label for this gene is ksgA [H]

Identifier: 66047854

GI number: 66047854

Start: 5487636

End: 5488442

Strand: Direct

Name: ksgA [H]

Synonym: Psyr_4627

Alternate gene names: 66047854

Gene position: 5487636-5488442 (Clockwise)

Preceding gene: 66047853

Following gene: 66047855

Centisome position: 90.05

GC content: 61.71

Gene sequence:

>807_bases
ATGACCGAGCAATACCAACACCGGGCGCGCAAGCGCTTCGGGCAGAACTTCCTGCACGACGCAGGCGTTATCGACAAGAT
CCTGCGTGCCATCCGTGCCAGACCTGAAGACCGGCTGCTGGAAATCGGGCCGGGCCAGGGCGCACTGACCGAGGGCCTGC
TCGACAGCGGCGCTCAGCTGGACGTGGTCGAGCTGGACAAGGACCTGATCCCGATCCTGAACGGTCAGTTCGCCAGCAAG
CCGAACTTCAACCTGCATCAGGGCGATGCACTGAAGTTCGACTTCAACACCCTCGGCGCAGACCCGCGCAGCCTGCGGGT
GGTGGGCAACCTGCCGTACAACATCTCGACACCGCTGATTTTTCACCTGCTGCAGAACGCCAGCCTGATCCGCGACATGC
ACTTCATGCTGCAAAAGGAAGTGGTCGAGCGCATGGCTGCCGGACCCGGCGGCGGTGACTGGGGTCGTCTGTCGATCATG
GTCCAGTACCATTGCCGCGTGGAACACCTGTTCAACGTCGGACCGGGTGCGTTCAACCCGCCGCCGAAAGTGGACTCGGC
CATTGTGCGCCTCGTCCCATACGAAACACTGCCGCACCCTGCCAAGGATCACCGTGTGCTGGAGCGCATCGTGCGTGAAG
CGTTCAACCAGCGTCGCAAGACCTTGCGCAACACGCTCAAGCTGCTGTTGACCAGCGATGAGATCACCGCTTCCGGAGTA
GACGGCAGCTTGCGCCCCGAGCAGCTCGATCTGGCTGCATTCGTTCGTCTGGCGGACACTCTCAGCGAAAAAGTTGTGAC
AGAGTGA

Upstream 100 bases:

>100_bases
ATCACGGCACGGCGCTGGACCTGGCTGGCACCGCGAACATCGACACCGGCAGCCTGCACGTCGCACTGCAAACCGCCTAC
CAGATGGCCGAGACCCATTC

Downstream 100 bases:

>100_bases
ACCCTGGGGACAAGTAAACGGCAGGCTCAGTCGTCATTTTCCGCTTACTTGTCCTAGACTGATCTACCTGCCGCACACGC
CCTTTTTTCGCAGCTATGGA

Product: dimethyladenosine transferase

Products: NA

Alternate protein names: 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase; 16S rRNA dimethyladenosine transferase; 16S rRNA dimethylase; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase [H]

Number of amino acids: Translated: 268; Mature: 267

Protein sequence:

>268_residues
MTEQYQHRARKRFGQNFLHDAGVIDKILRAIRARPEDRLLEIGPGQGALTEGLLDSGAQLDVVELDKDLIPILNGQFASK
PNFNLHQGDALKFDFNTLGADPRSLRVVGNLPYNISTPLIFHLLQNASLIRDMHFMLQKEVVERMAAGPGGGDWGRLSIM
VQYHCRVEHLFNVGPGAFNPPPKVDSAIVRLVPYETLPHPAKDHRVLERIVREAFNQRRKTLRNTLKLLLTSDEITASGV
DGSLRPEQLDLAAFVRLADTLSEKVVTE

Sequences:

>Translated_268_residues
MTEQYQHRARKRFGQNFLHDAGVIDKILRAIRARPEDRLLEIGPGQGALTEGLLDSGAQLDVVELDKDLIPILNGQFASK
PNFNLHQGDALKFDFNTLGADPRSLRVVGNLPYNISTPLIFHLLQNASLIRDMHFMLQKEVVERMAAGPGGGDWGRLSIM
VQYHCRVEHLFNVGPGAFNPPPKVDSAIVRLVPYETLPHPAKDHRVLERIVREAFNQRRKTLRNTLKLLLTSDEITASGV
DGSLRPEQLDLAAFVRLADTLSEKVVTE
>Mature_267_residues
TEQYQHRARKRFGQNFLHDAGVIDKILRAIRARPEDRLLEIGPGQGALTEGLLDSGAQLDVVELDKDLIPILNGQFASKP
NFNLHQGDALKFDFNTLGADPRSLRVVGNLPYNISTPLIFHLLQNASLIRDMHFMLQKEVVERMAAGPGGGDWGRLSIMV
QYHCRVEHLFNVGPGAFNPPPKVDSAIVRLVPYETLPHPAKDHRVLERIVREAFNQRRKTLRNTLKLLLTSDEITASGVD
GSLRPEQLDLAAFVRLADTLSEKVVTE

Specific function: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits [H]

COG id: COG0030

COG function: function code J; Dimethyladenosine transferase (rRNA methylation)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily [H]

Homologues:

Organism=Homo sapiens, GI156415992, Length=281, Percent_Identity=33.8078291814947, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI7657198, Length=247, Percent_Identity=34.0080971659919, Blast_Score=125, Evalue=3e-29,
Organism=Escherichia coli, GI1786236, Length=259, Percent_Identity=52.1235521235521, Blast_Score=270, Evalue=9e-74,
Organism=Caenorhabditis elegans, GI25141369, Length=294, Percent_Identity=30.952380952381, Blast_Score=131, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI25146882, Length=218, Percent_Identity=33.9449541284404, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6324989, Length=218, Percent_Identity=31.1926605504587, Blast_Score=103, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21357273, Length=290, Percent_Identity=32.7586206896552, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI21358017, Length=221, Percent_Identity=36.6515837104072, Blast_Score=124, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023165
- InterPro:   IPR020596
- InterPro:   IPR001737
- InterPro:   IPR020598
- InterPro:   IPR011530 [H]

Pfam domain/function: PF00398 RrnaAD [H]

EC number: =2.1.1.182 [H]

Molecular weight: Translated: 29993; Mature: 29862

Theoretical pI: Translated: 7.86; Mature: 7.86

Prosite motif: PS01131 RRNA_A_DIMETH ; PS00290 IG_MHC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQYQHRARKRFGQNFLHDAGVIDKILRAIRARPEDRLLEIGPGQGALTEGLLDSGAQL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHCCCCCE
DVVELDKDLIPILNGQFASKPNFNLHQGDALKFDFNTLGADPRSLRVVGNLPYNISTPLI
EHHHHCCHHHHHHCCCCCCCCCCCCCCCCEEEEEHHHCCCCCCEEEEEECCCCCCCHHHH
FHLLQNASLIRDMHFMLQKEVVERMAAGPGGGDWGRLSIMVQYHCRVEHLFNVGPGAFNP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEHHHHHHHHCCCCCCCCC
PPKVDSAIVRLVPYETLPHPAKDHRVLERIVREAFNQRRKTLRNTLKLLLTSDEITASGV
CCCHHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCC
DGSLRPEQLDLAAFVRLADTLSEKVVTE
CCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TEQYQHRARKRFGQNFLHDAGVIDKILRAIRARPEDRLLEIGPGQGALTEGLLDSGAQL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHCCCCCE
DVVELDKDLIPILNGQFASKPNFNLHQGDALKFDFNTLGADPRSLRVVGNLPYNISTPLI
EHHHHCCHHHHHHCCCCCCCCCCCCCCCCEEEEEHHHCCCCCCEEEEEECCCCCCCHHHH
FHLLQNASLIRDMHFMLQKEVVERMAAGPGGGDWGRLSIMVQYHCRVEHLFNVGPGAFNP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEHHHHHHHHCCCCCCCCC
PPKVDSAIVRLVPYETLPHPAKDHRVLERIVREAFNQRRKTLRNTLKLLLTSDEITASGV
CCCHHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCC
DGSLRPEQLDLAAFVRLADTLSEKVVTE
CCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA