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The map label for this gene is galE [C]

Identifier: 66047702

GI number: 66047702

Start: 5335505

End: 5336434

Strand: Reverse

Name: galE [C]

Synonym: Psyr_4475

Alternate gene names: 66047702

Gene position: 5336434-5335505 (Counterclockwise)

Preceding gene: 66047703

Following gene: 66047701

Centisome position: 87.57

GC content: 62.58

Gene sequence:

>930_bases
ATGTCTGACGCTCCTGTTCTGATCACTGGAGGTGCGGGTTTCATCGGCTCGCACCTGACCGACGCATTGCTTGCCAGCGG
GCAGGCCGTGCGTATCCTCGACAACCTCTCGGCAGGCAAGCGCAGCAATTTGCCGCTCGACAATCCGCGGGTCGAGCTGA
TCGAAGGAGACGTGGCCGATGCCGACCTGGTCAAGCGCGCGGCGCAGGGCTGTAAAGCCGTCGTGCACCTGGCGGCAGTG
GCTTCGGTGCAGGCGTCGGTAGACGACCCGGTGCGCACCCACCAGAGCAACTTCATCGGTACGTTGAATGTCTGCGAGGC
CATGCGCGAAGCGGGCATCAAGCGCGTGATCTTCGCATCAAGCGCGGCGGTGTACGGCAACAACGGTGAGGGCGAAGCGA
TCACCGAGGACACCACCAAGGCACCGCTGACCCCTTACGCTTCGGACAAGCTGGCCAGCGAGTATTACCTGGATTTCTAC
CGTCGCCAGCATGGCCTGGAACCGGTGATCTTTCGCTTCTTCAACATTTTCGGGCCACGCCAGGACCCATCGTCGCCGTA
CTCCGGCGTGATCAGCATCTTTGCCGAGCGTATCCGCAAAGGCCTGCCGATCAGCGTGTTTGGCGACGGCGAGCAGACGC
GGGATTTCTACTATGTCGGGGATCTGCTCAAGCTGCTGCTGCAGGCCTTGTCACGGGAAAGCGCCATCGAAGGCGCGATC
AACGTCGGCCTGAACAAGACCACGTCGCTCAACGAACTGCTGGCTGCGCTTGCGCAGGTGGTCGGCAAGCAGCCGGAAGT
CACCTACCAGGCGCCGCGCTCGGGCGATATCAAACATTCCCGCGCCAGCAACCAGCGCCTGCTGGAACACTTCACCCTCG
ACGAGCCAACGCCGCTGGTGCGTGGGCTGGAGTTGCTGATGGGGCAGTGA

Upstream 100 bases:

>100_bases
CACGCGGTATTGGCCTGCAAGAAAATTCTCCACACCTTCGGCATCAAGCCTCGCGCCTGGCGGGCCGGTCTGCCAAACCT
GCTGGATCGGTATTATCGAC

Downstream 100 bases:

>100_bases
GTCCTACATCGAATGTAACTGCCCATTCGCGAACAAGTTCGCTCCTACAAAAGCCTGTGAGCACCTGTAGGAGCGAACTT
GTTCGCGAAGACGCTATTGC

Product: NAD-dependent epimerase/dehydratase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MSDAPVLITGGAGFIGSHLTDALLASGQAVRILDNLSAGKRSNLPLDNPRVELIEGDVADADLVKRAAQGCKAVVHLAAV
ASVQASVDDPVRTHQSNFIGTLNVCEAMREAGIKRVIFASSAAVYGNNGEGEAITEDTTKAPLTPYASDKLASEYYLDFY
RRQHGLEPVIFRFFNIFGPRQDPSSPYSGVISIFAERIRKGLPISVFGDGEQTRDFYYVGDLLKLLLQALSRESAIEGAI
NVGLNKTTSLNELLAALAQVVGKQPEVTYQAPRSGDIKHSRASNQRLLEHFTLDEPTPLVRGLELLMGQ

Sequences:

>Translated_309_residues
MSDAPVLITGGAGFIGSHLTDALLASGQAVRILDNLSAGKRSNLPLDNPRVELIEGDVADADLVKRAAQGCKAVVHLAAV
ASVQASVDDPVRTHQSNFIGTLNVCEAMREAGIKRVIFASSAAVYGNNGEGEAITEDTTKAPLTPYASDKLASEYYLDFY
RRQHGLEPVIFRFFNIFGPRQDPSSPYSGVISIFAERIRKGLPISVFGDGEQTRDFYYVGDLLKLLLQALSRESAIEGAI
NVGLNKTTSLNELLAALAQVVGKQPEVTYQAPRSGDIKHSRASNQRLLEHFTLDEPTPLVRGLELLMGQ
>Mature_308_residues
SDAPVLITGGAGFIGSHLTDALLASGQAVRILDNLSAGKRSNLPLDNPRVELIEGDVADADLVKRAAQGCKAVVHLAAVA
SVQASVDDPVRTHQSNFIGTLNVCEAMREAGIKRVIFASSAAVYGNNGEGEAITEDTTKAPLTPYASDKLASEYYLDFYR
RQHGLEPVIFRFFNIFGPRQDPSSPYSGVISIFAERIRKGLPISVFGDGEQTRDFYYVGDLLKLLLQALSRESAIEGAIN
VGLNKTTSLNELLAALAQVVGKQPEVTYQAPRSGDIKHSRASNQRLLEHFTLDEPTPLVRGLELLMGQ

Specific function: Galactose metabolism; third step. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=305, Percent_Identity=30.8196721311475, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI7657641, Length=263, Percent_Identity=31.1787072243346, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI56237023, Length=306, Percent_Identity=28.7581699346405, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI56118217, Length=306, Percent_Identity=28.7581699346405, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI189083684, Length=306, Percent_Identity=28.7581699346405, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI193211614, Length=247, Percent_Identity=31.1740890688259, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI8393516, Length=247, Percent_Identity=31.1740890688259, Blast_Score=92, Evalue=5e-19,
Organism=Escherichia coli, GI1786974, Length=320, Percent_Identity=30.625, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1788353, Length=301, Percent_Identity=28.9036544850498, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI48994969, Length=304, Percent_Identity=28.6184210526316, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1788589, Length=288, Percent_Identity=26.7361111111111, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790049, Length=299, Percent_Identity=26.7558528428094, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788366, Length=253, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17539532, Length=295, Percent_Identity=28.8135593220339, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17568069, Length=300, Percent_Identity=27.6666666666667, Blast_Score=100, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI71982038, Length=307, Percent_Identity=28.9902280130293, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71982035, Length=306, Percent_Identity=29.0849673202614, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI115532424, Length=297, Percent_Identity=24.9158249158249, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17570557, Length=205, Percent_Identity=29.2682926829268, Blast_Score=71, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6319493, Length=311, Percent_Identity=26.6881028938907, Blast_Score=97, Evalue=3e-21,
Organism=Drosophila melanogaster, GI21356223, Length=309, Percent_Identity=30.42071197411, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI19923002, Length=307, Percent_Identity=29.9674267100977, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24158427, Length=282, Percent_Identity=25.177304964539, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 33352; Mature: 33221

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDAPVLITGGAGFIGSHLTDALLASGQAVRILDNLSAGKRSNLPLDNPRVELIEGDVAD
CCCCCEEEECCCCHHHHHHHHHHHHCCCEEEEHHHCCCCCCCCCCCCCCCEEEEECCCCC
ADLVKRAAQGCKAVVHLAAVASVQASVDDPVRTHQSNFIGTLNVCEAMREAGIKRVIFAS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEC
SAAVYGNNGEGEAITEDTTKAPLTPYASDKLASEYYLDFYRRQHGLEPVIFRFFNIFGPR
CCEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
QDPSSPYSGVISIFAERIRKGLPISVFGDGEQTRDFYYVGDLLKLLLQALSRESAIEGAI
CCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
NVGLNKTTSLNELLAALAQVVGKQPEVTYQAPRSGDIKHSRASNQRLLEHFTLDEPTPLV
HCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCHHH
RGLELLMGQ
HHHHHHHCC
>Mature Secondary Structure 
SDAPVLITGGAGFIGSHLTDALLASGQAVRILDNLSAGKRSNLPLDNPRVELIEGDVAD
CCCCEEEECCCCHHHHHHHHHHHHCCCEEEEHHHCCCCCCCCCCCCCCCEEEEECCCCC
ADLVKRAAQGCKAVVHLAAVASVQASVDDPVRTHQSNFIGTLNVCEAMREAGIKRVIFAS
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHCCCCEEEEEC
SAAVYGNNGEGEAITEDTTKAPLTPYASDKLASEYYLDFYRRQHGLEPVIFRFFNIFGPR
CCEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
QDPSSPYSGVISIFAERIRKGLPISVFGDGEQTRDFYYVGDLLKLLLQALSRESAIEGAI
CCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
NVGLNKTTSLNELLAALAQVVGKQPEVTYQAPRSGDIKHSRASNQRLLEHFTLDEPTPLV
HCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCHHH
RGLELLMGQ
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]