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The map label for this gene is accC [H]

Identifier: 66047628

GI number: 66047628

Start: 5262284

End: 5263627

Strand: Direct

Name: accC [H]

Synonym: Psyr_4401

Alternate gene names: 66047628

Gene position: 5262284-5263627 (Clockwise)

Preceding gene: 66047627

Following gene: 66047629

Centisome position: 86.36

GC content: 59.45

Gene sequence:

>1344_bases
ATGTTGGAAAAAGTTCTGATCGCCAACCGCGGCGAAATTGCCTTGCGCATCTTGCGTGCCTGTAAAGAACTGGGCATCAA
GACCGTCGCTGTACACTCCACCGCAGATCGCGAGCTGATGCACCTGGGCCTGGCAGACGAAACCGTCTGCATCGGTCCGG
CACCGGCCAATCTGTCCTACCTGAACATTCCGGCGATCATTTCGGCTGCCGAAGTGACCGGCGCCACCGCGATCCACCCG
GGTTACGGGTTTCTCGCCGAGAACGCCGACTTCGCCGAACAGGTCGAAAAATCCGGCTTTGCCTTCATCGGTCCAAAAGC
AGACACCATTCGCCTGATGGGTGACAAGGTTTCCGCCAAGGACGCCATGAAGCTGGCCAACGTGCCGACCGTTCCCGGTT
CCGACGGCCCGCTGCCGGAAGACGAAGCCACCGCTCTGCGCATTGGTCGTGAAGTCGGTTACCCGGTGATCATCAAGGCC
GCCGGTGGCGGTGGTGGTCGCGGCATGCGTGTGGTTCATCGCGAAGAAGACCTGATCGAAGCCGCTTCCCAGACCCGCGC
CGAAGCAGCCGCCTGGTTCAGCAACCCGATGGTCTACCTGGAAAAATACCTGACCAACCCACGTCACGTGGAAGTTCAGG
TGATTTCCGACGGTCAGGGCCAGGCCATCCACCTGGGCGATCGTGACTGCTCGCTGCAGCGCCGCCATCAGAAGGTTCTG
GAAGAAGCGCCGGCACCGTTCATCGATGAAAAGGCGCGCGAGGATGTTCTGGCTGCCTGCGTCAAGGCGTGTATCGATAT
CGGCTATCGCGGTGCGGGTACGTTCGAGTTCCTGTACGAGAACGGTCGTTTCTACTTCATCGAAATGAACACCCGTGTTC
AGGTGGAGCATCCGGTTTCGGAAATGGTCACCGGCATCGACATCGTCAAGGAGATGCTCAGCATCGCCGCCGGCAACAAA
CTGTCGTATACCCAGGATGACGTGGTCATCAAGGGCCATGCGCTGGAATGCCGGATCAACGCCGAAGACCCGAAGACCTT
CGTGCCAAGCCCAGGTCTGGTCAAGCATTTCCACGCACCGGGCGGCAACGGTGTACGGGTCGATTCGCACCTGTACAGCG
GCTACAAGGTACCGTCCAACTATGACTCGCTGATCGGTAAAGTGATCACCTGGGGCGCGACCCGCGAAGAAGCCATGGCA
CGCATGCGCAATGCCCTGGACGAAATCGTGGTCGACGGGATCAAGACCAACATCCCGCTGCACCGCGACCTGACCCGCGA
TGAAGGCTTCTGCGAAGGCGGAGTCAACATCCACTACCTGGAGCACAAACTGGCCAATCAATAA

Upstream 100 bases:

>100_bases
AAACCAGCGGTGTGATCGAATCCATCCTGGTAGAAAACGGTCAGCCGGTTGAGTTTGACCAGCCGCTGTTCACAATCGTT
TGACCCGGGGAGAGCCTGCG

Downstream 100 bases:

>100_bases
GCCAGTCTGCTTCACAACGACAAAGCCGCAGTGATGCGGCTTTGTTGTTTGCAGCGCATAGCAGTAAACTTGCCCGCTTC
CTGCGGCCGCACTGGCCTTA

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MLEKVLIANRGEIALRILRACKELGIKTVAVHSTADRELMHLGLADETVCIGPAPANLSYLNIPAIISAAEVTGATAIHP
GYGFLAENADFAEQVEKSGFAFIGPKADTIRLMGDKVSAKDAMKLANVPTVPGSDGPLPEDEATALRIGREVGYPVIIKA
AGGGGGRGMRVVHREEDLIEAASQTRAEAAAWFSNPMVYLEKYLTNPRHVEVQVISDGQGQAIHLGDRDCSLQRRHQKVL
EEAPAPFIDEKAREDVLAACVKACIDIGYRGAGTFEFLYENGRFYFIEMNTRVQVEHPVSEMVTGIDIVKEMLSIAAGNK
LSYTQDDVVIKGHALECRINAEDPKTFVPSPGLVKHFHAPGGNGVRVDSHLYSGYKVPSNYDSLIGKVITWGATREEAMA
RMRNALDEIVVDGIKTNIPLHRDLTRDEGFCEGGVNIHYLEHKLANQ

Sequences:

>Translated_447_residues
MLEKVLIANRGEIALRILRACKELGIKTVAVHSTADRELMHLGLADETVCIGPAPANLSYLNIPAIISAAEVTGATAIHP
GYGFLAENADFAEQVEKSGFAFIGPKADTIRLMGDKVSAKDAMKLANVPTVPGSDGPLPEDEATALRIGREVGYPVIIKA
AGGGGGRGMRVVHREEDLIEAASQTRAEAAAWFSNPMVYLEKYLTNPRHVEVQVISDGQGQAIHLGDRDCSLQRRHQKVL
EEAPAPFIDEKAREDVLAACVKACIDIGYRGAGTFEFLYENGRFYFIEMNTRVQVEHPVSEMVTGIDIVKEMLSIAAGNK
LSYTQDDVVIKGHALECRINAEDPKTFVPSPGLVKHFHAPGGNGVRVDSHLYSGYKVPSNYDSLIGKVITWGATREEAMA
RMRNALDEIVVDGIKTNIPLHRDLTRDEGFCEGGVNIHYLEHKLANQ
>Mature_447_residues
MLEKVLIANRGEIALRILRACKELGIKTVAVHSTADRELMHLGLADETVCIGPAPANLSYLNIPAIISAAEVTGATAIHP
GYGFLAENADFAEQVEKSGFAFIGPKADTIRLMGDKVSAKDAMKLANVPTVPGSDGPLPEDEATALRIGREVGYPVIIKA
AGGGGGRGMRVVHREEDLIEAASQTRAEAAAWFSNPMVYLEKYLTNPRHVEVQVISDGQGQAIHLGDRDCSLQRRHQKVL
EEAPAPFIDEKAREDVLAACVKACIDIGYRGAGTFEFLYENGRFYFIEMNTRVQVEHPVSEMVTGIDIVKEMLSIAAGNK
LSYTQDDVVIKGHALECRINAEDPKTFVPSPGLVKHFHAPGGNGVRVDSHLYSGYKVPSNYDSLIGKVITWGATREEAMA
RMRNALDEIVVDGIKTNIPLHRDLTRDEGFCEGGVNIHYLEHKLANQ

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI65506442, Length=443, Percent_Identity=46.5011286681716, Blast_Score=400, Evalue=1e-111,
Organism=Homo sapiens, GI295821183, Length=443, Percent_Identity=46.5011286681716, Blast_Score=400, Evalue=1e-111,
Organism=Homo sapiens, GI189095269, Length=443, Percent_Identity=46.5011286681716, Blast_Score=400, Evalue=1e-111,
Organism=Homo sapiens, GI116805327, Length=442, Percent_Identity=45.0226244343891, Blast_Score=393, Evalue=1e-109,
Organism=Homo sapiens, GI106049528, Length=447, Percent_Identity=43.4004474272931, Blast_Score=353, Evalue=1e-97,
Organism=Homo sapiens, GI106049295, Length=447, Percent_Identity=43.4004474272931, Blast_Score=353, Evalue=1e-97,
Organism=Homo sapiens, GI106049292, Length=447, Percent_Identity=43.4004474272931, Blast_Score=353, Evalue=1e-97,
Organism=Homo sapiens, GI38679960, Length=508, Percent_Identity=30.9055118110236, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI38679971, Length=508, Percent_Identity=30.9055118110236, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI38679974, Length=508, Percent_Identity=30.9055118110236, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI38679977, Length=508, Percent_Identity=30.9055118110236, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI38679967, Length=508, Percent_Identity=30.9055118110236, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI134142062, Length=515, Percent_Identity=29.3203883495146, Blast_Score=221, Evalue=1e-57,
Organism=Escherichia coli, GI1789654, Length=447, Percent_Identity=69.5749440715884, Blast_Score=627, Evalue=0.0,
Organism=Escherichia coli, GI1786216, Length=245, Percent_Identity=24.0816326530612, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17567343, Length=443, Percent_Identity=46.27539503386, Blast_Score=394, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI71987519, Length=442, Percent_Identity=44.5701357466063, Blast_Score=361, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17562816, Length=447, Percent_Identity=41.834451901566, Blast_Score=336, Evalue=1e-92,
Organism=Caenorhabditis elegans, GI71997168, Length=509, Percent_Identity=28.2907662082515, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI71997163, Length=509, Percent_Identity=28.2907662082515, Blast_Score=192, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI133931226, Length=496, Percent_Identity=28.4274193548387, Blast_Score=187, Evalue=9e-48,
Organism=Saccharomyces cerevisiae, GI6319695, Length=440, Percent_Identity=45.9090909090909, Blast_Score=345, Evalue=7e-96,
Organism=Saccharomyces cerevisiae, GI6319685, Length=443, Percent_Identity=41.9864559819413, Blast_Score=345, Evalue=8e-96,
Organism=Saccharomyces cerevisiae, GI6321376, Length=440, Percent_Identity=46.5909090909091, Blast_Score=339, Evalue=5e-94,
Organism=Saccharomyces cerevisiae, GI6324343, Length=527, Percent_Identity=30.1707779886148, Blast_Score=217, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6323863, Length=460, Percent_Identity=30.8695652173913, Blast_Score=206, Evalue=8e-54,
Organism=Drosophila melanogaster, GI24651757, Length=447, Percent_Identity=42.5055928411633, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24652212, Length=447, Percent_Identity=45.1901565995526, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652210, Length=447, Percent_Identity=45.1901565995526, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652214, Length=447, Percent_Identity=45.1901565995526, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI19921944, Length=447, Percent_Identity=45.1901565995526, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652216, Length=447, Percent_Identity=45.1901565995526, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI281363050, Length=447, Percent_Identity=45.1901565995526, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652224, Length=447, Percent_Identity=45.1901565995526, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652222, Length=447, Percent_Identity=45.1901565995526, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652220, Length=447, Percent_Identity=45.1901565995526, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24652218, Length=447, Percent_Identity=45.1901565995526, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24651759, Length=409, Percent_Identity=41.8092909535452, Blast_Score=332, Evalue=4e-91,
Organism=Drosophila melanogaster, GI161076407, Length=509, Percent_Identity=29.2730844793713, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24586460, Length=509, Percent_Identity=29.2730844793713, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI161076409, Length=509, Percent_Identity=29.2730844793713, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24586458, Length=509, Percent_Identity=29.2730844793713, Blast_Score=213, Evalue=2e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 48662; Mature: 48662

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEKVLIANRGEIALRILRACKELGIKTVAVHSTADRELMHLGLADETVCIGPAPANLSY
CCCCEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHEECCCCCEEEECCCCCCCEE
LNIPAIISAAEVTGATAIHPGYGFLAENADFAEQVEKSGFAFIGPKADTIRLMGDKVSAK
EECCHHHHHHHHCCCEEECCCCCEEECCCHHHHHHHHCCCEEECCCCCEEEEECCCCCHH
DAMKLANVPTVPGSDGPLPEDEATALRIGREVGYPVIIKAAGGGGGRGMRVVHREEDLIE
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCEEEECHHHHHH
AASQTRAEAAAWFSNPMVYLEKYLTNPRHVEVQVISDGQGQAIHLGDRDCSLQRRHQKVL
HHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHH
EEAPAPFIDEKAREDVLAACVKACIDIGYRGAGTFEFLYENGRFYFIEMNTRVQVEHPVS
HHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCEEEEEEECCEEEECCCHH
EMVTGIDIVKEMLSIAAGNKLSYTQDDVVIKGHALECRINAEDPKTFVPSPGLVKHFHAP
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEEECCCCCCCCCCCCCHHHEEECC
GGNGVRVDSHLYSGYKVPSNYDSLIGKVITWGATREEAMARMRNALDEIVVDGIKTNIPL
CCCCEEECCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHCCCCC
HRDLTRDEGFCEGGVNIHYLEHKLANQ
CCCCCCCCCCCCCCCEEEEECHHHCCC
>Mature Secondary Structure
MLEKVLIANRGEIALRILRACKELGIKTVAVHSTADRELMHLGLADETVCIGPAPANLSY
CCCCEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHEECCCCCEEEECCCCCCCEE
LNIPAIISAAEVTGATAIHPGYGFLAENADFAEQVEKSGFAFIGPKADTIRLMGDKVSAK
EECCHHHHHHHHCCCEEECCCCCEEECCCHHHHHHHHCCCEEECCCCCEEEEECCCCCHH
DAMKLANVPTVPGSDGPLPEDEATALRIGREVGYPVIIKAAGGGGGRGMRVVHREEDLIE
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCEEEECHHHHHH
AASQTRAEAAAWFSNPMVYLEKYLTNPRHVEVQVISDGQGQAIHLGDRDCSLQRRHQKVL
HHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCCHHHHHHHHHH
EEAPAPFIDEKAREDVLAACVKACIDIGYRGAGTFEFLYENGRFYFIEMNTRVQVEHPVS
HHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCEEEEEEECCEEEECCCHH
EMVTGIDIVKEMLSIAAGNKLSYTQDDVVIKGHALECRINAEDPKTFVPSPGLVKHFHAP
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEEECCCCCCCCCCCCCHHHEEECC
GGNGVRVDSHLYSGYKVPSNYDSLIGKVITWGATREEAMARMRNALDEIVVDGIKTNIPL
CCCCEEECCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCHHCCCCC
HRDLTRDEGFCEGGVNIHYLEHKLANQ
CCCCCCCCCCCCCCCEEEEECHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7693652; 10984043 [H]