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The map label for this gene is proA [H]

Identifier: 66047596

GI number: 66047596

Start: 5222085

End: 5223350

Strand: Reverse

Name: proA [H]

Synonym: Psyr_4369

Alternate gene names: 66047596

Gene position: 5223350-5222085 (Counterclockwise)

Preceding gene: 66047600

Following gene: 66047595

Centisome position: 85.72

GC content: 63.11

Gene sequence:

>1266_bases
ATGACTGAGTCCGTTCTTGACTACATGACCCGCCTGGGTCGCGCCGCCCGCGAAGCTTCGCGAGTGATCGGTCGTGCCAG
CACTGCGCAGAAGAACCGCGCCCTGCAGGCCACTGCCGCCGCTCTGGACGAAGCCCGCGCCGAGCTGTCTGCCGCCAATG
CGCTGGACCTGGCCAATGGTCAGGCGAACGGGCTTGAGCCGGCCATGCTCGAGCGTCTGGCCCTGACCCCCGCACGGATC
GACGGCATGATCGTCGGGTTGCGTCAGGTTGCAGCGCTGGCAGACCCGGTCGGTGCGATCCGCGACATGAGCTATCGGCC
GTCGGGTATTCAGGTCGGCAAGATGCGCGTGCCGCTGGGGGTTGTCGGAATCATCTACGAGTCACGTCCGAACGTGACCA
TCGATGCGGCCAGTCTGTGTCTGAAGTCCGGAAACGCAACCATCCTGCGCGGTGGTTCCGAAGCCATTCATTCCAATCGC
GCCATCGCGGCCTGCATTGAACGCGGTCTGGCCGAGGCCGGGCTGCCCGCTGCTGTCGTGCAAGTGGTTGAAACCACCGA
CCGTGCAGCGGTTGGCGCGCTGATCAGCATGCCCGAGTACGTGGACGTCATCGTTCCGCGTGGCGGCAAGGGCCTGATCG
AGCGCGTCAGCCGCGATGCGCGGGTGCCGGTCATCAAGCATCTGGACGGCATCTGTCATGTGTATGTCAGTGCCCACGCC
GATCTGCCCAAGGCGCAGAAGATCGCCTTCAACGCCAAGACCTACCGTTACGGGATCTGCGGCGCGATGGAAACCCTGCT
GGTCGATCAGACCATTGCCGCCGACTTTTTGCCGTCGATGGCCGCACAGTTTCGCGAGAAGGGTGTCGAGTTGCGCGGTT
GCGAGCGTACCCGTGAGCTGATCGACGTGATCCCGGCCACCGAGGACGACTGGCATACCGAGTACCTGGACGCGATTCTG
TCTATTCGCGTCGTGTCCGGGCTGGATGAAGCCATCGAGCACATCAACCATTACGGCTCGCATCACAGCGATGCCATCGT
TTCGGACCACCAGAGTCAGGTGCGCCGGTTCATGGCCGAGGTCGATTCCAGTTCGGTCATGGTCAACGCGCCGACCTGCT
TCGCTGACGGGTTCGAATACGGCCTGGGTGCCGAGATCGGCATTTCTACTGATAAGCTGCACGCCCGCGGTCCTGTCGGT
CTTGAAGGGCTGACCTGCGAGAAGTACATCGTGATCGGTGACGGCCAATTGCGCGGACAAGCCTGA

Upstream 100 bases:

>100_bases
CTGCGCACTGATATCGACCATCCGCCTGTCTGCGCTGTCGTTCGGGCGGCACGACAGCTATAATCAGCCGCTTTCCTCTT
TGCCAAGACCTCTGAGACCA

Downstream 100 bases:

>100_bases
CTTGAATAGCCCCATGACCGCGCTGCCCAGACGTATCGGCATGCTTGGGGGCACGTTCGACCCGGTTCATATCGGTCATT
TGCGCGGTGCGCTCGAAGTG

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MTESVLDYMTRLGRAAREASRVIGRASTAQKNRALQATAAALDEARAELSAANALDLANGQANGLEPAMLERLALTPARI
DGMIVGLRQVAALADPVGAIRDMSYRPSGIQVGKMRVPLGVVGIIYESRPNVTIDAASLCLKSGNATILRGGSEAIHSNR
AIAACIERGLAEAGLPAAVVQVVETTDRAAVGALISMPEYVDVIVPRGGKGLIERVSRDARVPVIKHLDGICHVYVSAHA
DLPKAQKIAFNAKTYRYGICGAMETLLVDQTIAADFLPSMAAQFREKGVELRGCERTRELIDVIPATEDDWHTEYLDAIL
SIRVVSGLDEAIEHINHYGSHHSDAIVSDHQSQVRRFMAEVDSSSVMVNAPTCFADGFEYGLGAEIGISTDKLHARGPVG
LEGLTCEKYIVIGDGQLRGQA

Sequences:

>Translated_421_residues
MTESVLDYMTRLGRAAREASRVIGRASTAQKNRALQATAAALDEARAELSAANALDLANGQANGLEPAMLERLALTPARI
DGMIVGLRQVAALADPVGAIRDMSYRPSGIQVGKMRVPLGVVGIIYESRPNVTIDAASLCLKSGNATILRGGSEAIHSNR
AIAACIERGLAEAGLPAAVVQVVETTDRAAVGALISMPEYVDVIVPRGGKGLIERVSRDARVPVIKHLDGICHVYVSAHA
DLPKAQKIAFNAKTYRYGICGAMETLLVDQTIAADFLPSMAAQFREKGVELRGCERTRELIDVIPATEDDWHTEYLDAIL
SIRVVSGLDEAIEHINHYGSHHSDAIVSDHQSQVRRFMAEVDSSSVMVNAPTCFADGFEYGLGAEIGISTDKLHARGPVG
LEGLTCEKYIVIGDGQLRGQA
>Mature_420_residues
TESVLDYMTRLGRAAREASRVIGRASTAQKNRALQATAAALDEARAELSAANALDLANGQANGLEPAMLERLALTPARID
GMIVGLRQVAALADPVGAIRDMSYRPSGIQVGKMRVPLGVVGIIYESRPNVTIDAASLCLKSGNATILRGGSEAIHSNRA
IAACIERGLAEAGLPAAVVQVVETTDRAAVGALISMPEYVDVIVPRGGKGLIERVSRDARVPVIKHLDGICHVYVSAHAD
LPKAQKIAFNAKTYRYGICGAMETLLVDQTIAADFLPSMAAQFREKGVELRGCERTRELIDVIPATEDDWHTEYLDAILS
IRVVSGLDEAIEHINHYGSHHSDAIVSDHQSQVRRFMAEVDSSSVMVNAPTCFADGFEYGLGAEIGISTDKLHARGPVGL
EGLTCEKYIVIGDGQLRGQA

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI62912457, Length=404, Percent_Identity=34.6534653465347, Blast_Score=248, Evalue=1e-65,
Organism=Homo sapiens, GI21361368, Length=404, Percent_Identity=34.6534653465347, Blast_Score=247, Evalue=1e-65,
Organism=Escherichia coli, GI1786438, Length=415, Percent_Identity=45.7831325301205, Blast_Score=369, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17569967, Length=405, Percent_Identity=34.5679012345679, Blast_Score=250, Evalue=9e-67,
Organism=Caenorhabditis elegans, GI17569969, Length=405, Percent_Identity=34.5679012345679, Blast_Score=250, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6324899, Length=435, Percent_Identity=36.551724137931, Blast_Score=282, Evalue=8e-77,
Organism=Drosophila melanogaster, GI21357643, Length=405, Percent_Identity=37.2839506172839, Blast_Score=266, Evalue=3e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 44944; Mature: 44813

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTESVLDYMTRLGRAAREASRVIGRASTAQKNRALQATAAALDEARAELSAANALDLANG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCC
QANGLEPAMLERLALTPARIDGMIVGLRQVAALADPVGAIRDMSYRPSGIQVGKMRVPLG
CCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCEE
VVGIIYESRPNVTIDAASLCLKSGNATILRGGSEAIHSNRAIAACIERGLAEAGLPAAVV
EEEEEEECCCCEEEEHHHHHHHCCCEEEEECCHHHHHCCCHHHHHHHHHHHHCCCHHHHH
QVVETTDRAAVGALISMPEYVDVIVPRGGKGLIERVSRDARVPVIKHLDGICHVYVSAHA
HHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHCCCCCCCHHHHCCCCEEEEEECCC
DLPKAQKIAFNAKTYRYGICGAMETLLVDQTIAADFLPSMAAQFREKGVELRGCERTREL
CCCCHHHEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECHHHHHHH
IDVIPATEDDWHTEYLDAILSIRVVSGLDEAIEHINHYGSHHSDAIVSDHQSQVRRFMAE
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
VDSSSVMVNAPTCFADGFEYGLGAEIGISTDKLHARGPVGLEGLTCEKYIVIGDGQLRGQ
CCCCCEEEECCCHHHCCCCCCCCCEECCCCCCCCCCCCCCCCCCEECEEEEEECCCCCCC
A
C
>Mature Secondary Structure 
TESVLDYMTRLGRAAREASRVIGRASTAQKNRALQATAAALDEARAELSAANALDLANG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCC
QANGLEPAMLERLALTPARIDGMIVGLRQVAALADPVGAIRDMSYRPSGIQVGKMRVPLG
CCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCEE
VVGIIYESRPNVTIDAASLCLKSGNATILRGGSEAIHSNRAIAACIERGLAEAGLPAAVV
EEEEEEECCCCEEEEHHHHHHHCCCEEEEECCHHHHHCCCHHHHHHHHHHHHCCCHHHHH
QVVETTDRAAVGALISMPEYVDVIVPRGGKGLIERVSRDARVPVIKHLDGICHVYVSAHA
HHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHCCCCCCCHHHHCCCCEEEEEECCC
DLPKAQKIAFNAKTYRYGICGAMETLLVDQTIAADFLPSMAAQFREKGVELRGCERTREL
CCCCHHHEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECHHHHHHH
IDVIPATEDDWHTEYLDAILSIRVVSGLDEAIEHINHYGSHHSDAIVSDHQSQVRRFMAE
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
VDSSSVMVNAPTCFADGFEYGLGAEIGISTDKLHARGPVGLEGLTCEKYIVIGDGQLRGQ
CCCCCEEEECCCHHHCCCCCCCCCEECCCCCCCCCCCCCCCCCCEECEEEEEECCCCCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA