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The map label for this gene is cobB [H]

Identifier: 66047546

GI number: 66047546

Start: 5170451

End: 5170846

Strand: Reverse

Name: cobB [H]

Synonym: Psyr_4319

Alternate gene names: 66047546

Gene position: 5170846-5170451 (Counterclockwise)

Preceding gene: 66047547

Following gene: 66047544

Centisome position: 84.86

GC content: 54.8

Gene sequence:

>396_bases
GTGCCTGAATTTGGAAGCGCCGCGAAGGCCCTGTCCCAAGCCCCCGAGATCGTCATTTTCACGGGTGCGGGAATCTCAGC
TGAAAGTGGCATCCCCACGTACAACGATCCATTGACCGGTACTTGGGCTTCATACGATCCGCGCAATATGGAAACAGCCA
AGGCCTTTCGTGAAAATCCTCCGTTGGTATGGGGATGGTACCTGTGGCGGCGCCAACAGGTCTCTAAAGCAGCTCCCAAT
GATGCACACCTCGCGGTGAGCCGACTGGCCAAATCAGGGTATAACGTCTCCGTTATCACTCAAAACATTGATGACTTGCA
TGAACGAGCGGGATCTGTGGATGTACTGCATCTCCATGGGAGTTTGCACCGGCCGGCGGCATGGCTAACGGAATAA

Upstream 100 bases:

>100_bases
TGGCCGGATGATCCATTGGTGGCGGAGGCTACGGCGCGGGTGAAGCCGAGGGGGACTTAGAGGGCAAAATACTGGTTAAA
CCTTATGGACTGGATGTTCT

Downstream 100 bases:

>100_bases
ATGCAGGTGGGAGCGCCGGGCTTTTCTGCGCTTGCAGCCGAATCCATTTGTGGACGAGGTTTGCGTTGAGACTATGGCTG
AGTGCGACGCTGGCAATCGA

Product: silent information regulator protein Sir2

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 131; Mature: 130

Protein sequence:

>131_residues
MPEFGSAAKALSQAPEIVIFTGAGISAESGIPTYNDPLTGTWASYDPRNMETAKAFRENPPLVWGWYLWRRQQVSKAAPN
DAHLAVSRLAKSGYNVSVITQNIDDLHERAGSVDVLHLHGSLHRPAAWLTE

Sequences:

>Translated_131_residues
MPEFGSAAKALSQAPEIVIFTGAGISAESGIPTYNDPLTGTWASYDPRNMETAKAFRENPPLVWGWYLWRRQQVSKAAPN
DAHLAVSRLAKSGYNVSVITQNIDDLHERAGSVDVLHLHGSLHRPAAWLTE
>Mature_130_residues
PEFGSAAKALSQAPEIVIFTGAGISAESGIPTYNDPLTGTWASYDPRNMETAKAFRENPPLVWGWYLWRRQQVSKAAPND
AHLAVSRLAKSGYNVSVITQNIDDLHERAGSVDVLHLHGSLHRPAAWLTE

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI300795542, Length=120, Percent_Identity=43.3333333333333, Blast_Score=103, Evalue=3e-23,
Organism=Homo sapiens, GI6912664, Length=120, Percent_Identity=43.3333333333333, Blast_Score=103, Evalue=4e-23,
Organism=Homo sapiens, GI13787215, Length=120, Percent_Identity=43.3333333333333, Blast_Score=103, Evalue=4e-23,
Organism=Homo sapiens, GI6912662, Length=118, Percent_Identity=35.5932203389831, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI308199517, Length=113, Percent_Identity=42.4778761061947, Blast_Score=94, Evalue=3e-21,
Organism=Drosophila melanogaster, GI28571445, Length=116, Percent_Identity=37.0689655172414, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 14367; Mature: 14236

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEFGSAAKALSQAPEIVIFTGAGISAESGIPTYNDPLTGTWASYDPRNMETAKAFRENP
CCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCC
PLVWGWYLWRRQQVSKAAPNDAHLAVSRLAKSGYNVSVITQNIDDLHERAGSVDVLHLHG
CEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEECCHHHHHHHHCCEEEEEECC
SLHRPAAWLTE
CCCCCCCCCCC
>Mature Secondary Structure 
PEFGSAAKALSQAPEIVIFTGAGISAESGIPTYNDPLTGTWASYDPRNMETAKAFRENP
CCCCHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCC
PLVWGWYLWRRQQVSKAAPNDAHLAVSRLAKSGYNVSVITQNIDDLHERAGSVDVLHLHG
CEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEECCHHHHHHHHCCEEEEEECC
SLHRPAAWLTE
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12534463 [H]