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The map label for this gene is fklB [H]

Identifier: 66047482

GI number: 66047482

Start: 5072884

End: 5073501

Strand: Reverse

Name: fklB [H]

Synonym: Psyr_4255

Alternate gene names: 66047482

Gene position: 5073501-5072884 (Counterclockwise)

Preceding gene: 66047483

Following gene: 66047479

Centisome position: 83.26

GC content: 62.3

Gene sequence:

>618_bases
ATGTCCGAAGTCAATCTGTCCACCGACGAAACCCGCGTCAGCTACGGCATTGGCCGTCAGTTGGGCGATCAGTTGCGCGA
CAACCCGCCACCGGGCGTCGATCTGGAAGCCATCGTGGCAGGCCTGCGCGATGCGTTTGGCGGTCAGCCAAGCCGTGTCG
GTCAGGAAGAAATGTCCGCCAGCTTCAAGGTCATCCGCGAAATCATGCAGGCTGAAGCAGCCGCCAAGGCTGAACAGGCT
GCGGGCGCCGGCAAGGCCTACCTGGCTGAAAACGCCAAGCGCGAAGGCGTGACCACGCTGGCTTCGGGTCTGCAATTCGA
AGTCGTGACCGCTGGTACTGGCGCCAAGCCAACCCGTGAAGACCAGGTACGCGTTCACTACCACGGCACGTTGATCGACG
GTAACGTCTTCGACAGCTCCTACGATCGTGGCGAGCCGGCCGAATTTCCGGTCAGCGGCGTGATTGCCGGCTGGACCGAG
GCGCTGCAACTGATGAACGCCGGCAGCAAATGGCGTCTGCACGTGCCGAGCGAACTGGCTTACGGCGCTCAGGGCGTAGG
CAGCATCGCACCGCACAGCGTGCTGGTGTTTGACGTGGAACTGCTGGACGTTCTGTAA

Upstream 100 bases:

>100_bases
CTGCTCGGCCTTTTGTCCGGGGTGTATCAGCGAGTGTCGAGGTGATGGCCATCAGGTCTCAACCGCTCACTGACTGTATG
CCCCCATGCGGAGCAGTGTC

Downstream 100 bases:

>100_bases
GCGACGCGGTCGATGCAGATGGTCGCTGAGCGAATCGCGCCGATTCGTTCAGCGACGCAGTTGTGCTGATGCTTCATGCT
CAGTGCAACTCACCCATGGG

Product: FKBP-type peptidyl-prolyl isomerase, N-terminal:peptidylprolyl isomerase, FKBP-type

Products: NA

Alternate protein names: FKBP22; PPIase; Rotamase [H]

Number of amino acids: Translated: 205; Mature: 204

Protein sequence:

>205_residues
MSEVNLSTDETRVSYGIGRQLGDQLRDNPPPGVDLEAIVAGLRDAFGGQPSRVGQEEMSASFKVIREIMQAEAAAKAEQA
AGAGKAYLAENAKREGVTTLASGLQFEVVTAGTGAKPTREDQVRVHYHGTLIDGNVFDSSYDRGEPAEFPVSGVIAGWTE
ALQLMNAGSKWRLHVPSELAYGAQGVGSIAPHSVLVFDVELLDVL

Sequences:

>Translated_205_residues
MSEVNLSTDETRVSYGIGRQLGDQLRDNPPPGVDLEAIVAGLRDAFGGQPSRVGQEEMSASFKVIREIMQAEAAAKAEQA
AGAGKAYLAENAKREGVTTLASGLQFEVVTAGTGAKPTREDQVRVHYHGTLIDGNVFDSSYDRGEPAEFPVSGVIAGWTE
ALQLMNAGSKWRLHVPSELAYGAQGVGSIAPHSVLVFDVELLDVL
>Mature_204_residues
SEVNLSTDETRVSYGIGRQLGDQLRDNPPPGVDLEAIVAGLRDAFGGQPSRVGQEEMSASFKVIREIMQAEAAAKAEQAA
GAGKAYLAENAKREGVTTLASGLQFEVVTAGTGAKPTREDQVRVHYHGTLIDGNVFDSSYDRGEPAEFPVSGVIAGWTEA
LQLMNAGSKWRLHVPSELAYGAQGVGSIAPHSVLVFDVELLDVL

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cytoplasm. Periplasm. Note=According to PubMed:7610040 it is periplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=106, Percent_Identity=44.3396226415094, Blast_Score=81, Evalue=5e-16,
Organism=Homo sapiens, GI4503725, Length=106, Percent_Identity=44.3396226415094, Blast_Score=81, Evalue=5e-16,
Organism=Homo sapiens, GI4758380, Length=106, Percent_Identity=38.6792452830189, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI33469985, Length=85, Percent_Identity=43.5294117647059, Blast_Score=68, Evalue=5e-12,
Organism=Escherichia coli, GI87082390, Length=206, Percent_Identity=51.9417475728155, Blast_Score=196, Evalue=1e-51,
Organism=Escherichia coli, GI1789745, Length=213, Percent_Identity=41.3145539906103, Blast_Score=149, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17540882, Length=92, Percent_Identity=42.3913043478261, Blast_Score=70, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71993519, Length=93, Percent_Identity=40.8602150537634, Blast_Score=67, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6320727, Length=88, Percent_Identity=53.4090909090909, Blast_Score=86, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6324194, Length=105, Percent_Identity=44.7619047619048, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI281363946, Length=110, Percent_Identity=40.9090909090909, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI17352457, Length=110, Percent_Identity=40.9090909090909, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24655568, Length=106, Percent_Identity=42.4528301886792, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI21356629, Length=88, Percent_Identity=44.3181818181818, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 21754; Mature: 21622

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEVNLSTDETRVSYGIGRQLGDQLRDNPPPGVDLEAIVAGLRDAFGGQPSRVGQEEMSA
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHH
SFKVIREIMQAEAAAKAEQAAGAGKAYLAENAKREGVTTLASGLQFEVVTAGTGAKPTRE
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHCCHHHHHCCCEEEEEECCCCCCCCCC
DQVRVHYHGTLIDGNVFDSSYDRGEPAEFPVSGVIAGWTEALQLMNAGSKWRLHVPSELA
CCEEEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCHHHH
YGAQGVGSIAPHSVLVFDVELLDVL
CCCCCCCCCCCCEEEEEEHHHHHCC
>Mature Secondary Structure 
SEVNLSTDETRVSYGIGRQLGDQLRDNPPPGVDLEAIVAGLRDAFGGQPSRVGQEEMSA
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHH
SFKVIREIMQAEAAAKAEQAAGAGKAYLAENAKREGVTTLASGLQFEVVTAGTGAKPTRE
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHCCHHHHHCCCEEEEEECCCCCCCCCC
DQVRVHYHGTLIDGNVFDSSYDRGEPAEFPVSGVIAGWTEALQLMNAGSKWRLHVPSELA
CCEEEEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCHHHH
YGAQGVGSIAPHSVLVFDVELLDVL
CCCCCCCCCCCCEEEEEEHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 8703024; 9298646 [H]