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The map label for this gene is ftsI [H]

Identifier: 66047335

GI number: 66047335

Start: 4898461

End: 4900191

Strand: Reverse

Name: ftsI [H]

Synonym: Psyr_4108

Alternate gene names: 66047335

Gene position: 4900191-4898461 (Counterclockwise)

Preceding gene: 66047336

Following gene: 66047334

Centisome position: 80.41

GC content: 61.12

Gene sequence:

>1731_bases
ATGATGAAACTTGATGGCGCTCTTTATCCGTGGCGTTTTCGCGTAGTCGTGGGGCTGCTGGTGTCCCTCGTGCTCGCCAT
TTGCTGGCGCATTGTCGACCTGCAGGTCATCGACCATACCTTTCTCAAGGAACAGGGCGATGCACGCAGCCTTCGGCATA
TCCCTATTCCGGCGCACCGTGGCCTGATCACCGACCGTAACGGCGAGCCGCTGGCGGTCAGTACTCCGGTGACGACGCTG
TGGGCCAACCCGCGTGAAATGCAGCAGGACAAGTCCAAGTGGCCGATGCTGGCCGCCGCGCTGGGCCAGGATCTCAAGGC
ATTGACCGAGCGTCTGGACTCGCAGGCGAACAAGGAATTCATCTACCTGGTCCGTGGCCTGACGCCAGAACAGGGCCAGT
CGGTCATCGATCTGAAAGTGCCCGGCGTTTACGGCATCGAAGAGTTCCGCCGCTTTTATCCGGCCGGCGATGTCACCGCA
CACATGGTCGGCTTTACCGACCTTGACGACCATGGCCGGGAAGGCGTCGAGCTGGCCTATGACGACTGGCTCGCCGGTGT
GCCCGGCAAGCGTCAGGTCATCAAGGACCGGCGCGGCCGACTGATCAAGGATGTTCAGGTCACCAAGAATGCCAAGGCCG
GAAAGACCTTGGCTTTGTCTATTGACCTGCGCCTGCAGTACCTGGCGACCCGTGAACTGCGCAATGCCATCGTCGAGAAC
GAGGCCAAGGCCGGCAGCATGGTGATCATGGACGTCAAGACCGGTGAGGTTCTGGCGATGGTCAACCAGCCGACCTATAA
CCCGAACAACCGTCGCACCATGGTGCCTGCCGCCATGCGCAACCGGGCCATCATCGACGTGTTCGAACCCGGTTCGACCA
TGAAGCCGATCTCCATGACCGCAGCGCTGGACAGTGGCCGCTGGAAGCCGACCGACAAGGTCGAGGTTTATCCGGGCACC
CTGCAGATCGGCAAGTACACGATTCGTGACGTGACCAAGACCGAAGGCCCGATCCTCGATCTGACCGGCATTCTGATCAA
CTCCAGTAACGTCGGCATGAGCAAGGTTGCGTTTGATGTGGGCGGTGAGGCGATCTTCCGTGCCATGCAGCGCGTCGGTT
TCGGTCAGTACACCGGTCTCGGCTTCCCTGGCGAGCGCGTCGGCAACCTGCCCAACTACCGTGAATGGCGCAAGGCCGAA
ACCGCCACGCTGTCCTATGGCTACGGTCTGTCGGTCACGGCCTTGCAGCTGGTGCATGCCTACGGCGCGCTGGCCAACAA
TGGCCGCATCGTGCCGTTGACCATCCTGAAAACAGATAAAGAGCCGGAGTCGACCCAGGCCATTCCGGAGAAAACCGCGA
AGACCCTGCAAGGCATGTTGCAGCAGGTTATCGAGGACCCACGCGGCGTCTATCGCGCCCGTGTGCCGTCCTACCACGTC
GGCGGCAAGAGTGGTACGGCGCGCAAGACGTCCATTGGCACCAAGGGCTATGCGGAAAATTCCTATCGCTCGCTGTTCGC
CGGTTTCGGCCCGATGAGTAACCCGCGTTACGCCATCGTGGTGGTCATCGACGAGCCGAGCAAGGGTGGTTACTACGGTG
GTCTGGTTTCGGCCCCGGTATTCAGCAAGGTCATGTCCGGCACGTTGCGTCTGATGAACGTGACGCCGGACAACCTTGCG
CCACCTGAACAAGTCAACGCCGCACCGGCAGCCAAAGGAGGGCGTGGTTGA

Upstream 100 bases:

>100_bases
AGCAGAGCACCTGGACTGCGCATAGCCGTATCGAAACTCTGGCCACCGAACAGCTGAAGATGCGCATCCCGAGCGCTGCC
GAAGTGCGGATGGTGGCGCC

Downstream 100 bases:

>100_bases
TGGCCTTTAATCTGAGCAAGATTTTCGCTCACACCGACCGCGATGCGCTGATTCGCGAGTTGACCCTCGACAGCCGCAAT
GTGCGCCCGGGCGACCTGTT

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: Penicillin-binding protein 3; PBP-3; Peptidoglycan glycosyltransferase 3 [H]

Number of amino acids: Translated: 576; Mature: 576

Protein sequence:

>576_residues
MMKLDGALYPWRFRVVVGLLVSLVLAICWRIVDLQVIDHTFLKEQGDARSLRHIPIPAHRGLITDRNGEPLAVSTPVTTL
WANPREMQQDKSKWPMLAAALGQDLKALTERLDSQANKEFIYLVRGLTPEQGQSVIDLKVPGVYGIEEFRRFYPAGDVTA
HMVGFTDLDDHGREGVELAYDDWLAGVPGKRQVIKDRRGRLIKDVQVTKNAKAGKTLALSIDLRLQYLATRELRNAIVEN
EAKAGSMVIMDVKTGEVLAMVNQPTYNPNNRRTMVPAAMRNRAIIDVFEPGSTMKPISMTAALDSGRWKPTDKVEVYPGT
LQIGKYTIRDVTKTEGPILDLTGILINSSNVGMSKVAFDVGGEAIFRAMQRVGFGQYTGLGFPGERVGNLPNYREWRKAE
TATLSYGYGLSVTALQLVHAYGALANNGRIVPLTILKTDKEPESTQAIPEKTAKTLQGMLQQVIEDPRGVYRARVPSYHV
GGKSGTARKTSIGTKGYAENSYRSLFAGFGPMSNPRYAIVVVIDEPSKGGYYGGLVSAPVFSKVMSGTLRLMNVTPDNLA
PPEQVNAAPAAKGGRG

Sequences:

>Translated_576_residues
MMKLDGALYPWRFRVVVGLLVSLVLAICWRIVDLQVIDHTFLKEQGDARSLRHIPIPAHRGLITDRNGEPLAVSTPVTTL
WANPREMQQDKSKWPMLAAALGQDLKALTERLDSQANKEFIYLVRGLTPEQGQSVIDLKVPGVYGIEEFRRFYPAGDVTA
HMVGFTDLDDHGREGVELAYDDWLAGVPGKRQVIKDRRGRLIKDVQVTKNAKAGKTLALSIDLRLQYLATRELRNAIVEN
EAKAGSMVIMDVKTGEVLAMVNQPTYNPNNRRTMVPAAMRNRAIIDVFEPGSTMKPISMTAALDSGRWKPTDKVEVYPGT
LQIGKYTIRDVTKTEGPILDLTGILINSSNVGMSKVAFDVGGEAIFRAMQRVGFGQYTGLGFPGERVGNLPNYREWRKAE
TATLSYGYGLSVTALQLVHAYGALANNGRIVPLTILKTDKEPESTQAIPEKTAKTLQGMLQQVIEDPRGVYRARVPSYHV
GGKSGTARKTSIGTKGYAENSYRSLFAGFGPMSNPRYAIVVVIDEPSKGGYYGGLVSAPVFSKVMSGTLRLMNVTPDNLA
PPEQVNAAPAAKGGRG
>Mature_576_residues
MMKLDGALYPWRFRVVVGLLVSLVLAICWRIVDLQVIDHTFLKEQGDARSLRHIPIPAHRGLITDRNGEPLAVSTPVTTL
WANPREMQQDKSKWPMLAAALGQDLKALTERLDSQANKEFIYLVRGLTPEQGQSVIDLKVPGVYGIEEFRRFYPAGDVTA
HMVGFTDLDDHGREGVELAYDDWLAGVPGKRQVIKDRRGRLIKDVQVTKNAKAGKTLALSIDLRLQYLATRELRNAIVEN
EAKAGSMVIMDVKTGEVLAMVNQPTYNPNNRRTMVPAAMRNRAIIDVFEPGSTMKPISMTAALDSGRWKPTDKVEVYPGT
LQIGKYTIRDVTKTEGPILDLTGILINSSNVGMSKVAFDVGGEAIFRAMQRVGFGQYTGLGFPGERVGNLPNYREWRKAE
TATLSYGYGLSVTALQLVHAYGALANNGRIVPLTILKTDKEPESTQAIPEKTAKTLQGMLQQVIEDPRGVYRARVPSYHV
GGKSGTARKTSIGTKGYAENSYRSLFAGFGPMSNPRYAIVVVIDEPSKGGYYGGLVSAPVFSKVMSGTLRLMNVTPDNLA
PPEQVNAAPAAKGGRG

Specific function: Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein; Periplasmic side. Note=The bulk of the molecule, except for the N-terminal membrane anchor region, protrudes into the periplasmic space, where it acts on murein (By similarity) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=554, Percent_Identity=44.043321299639, Blast_Score=449, Evalue=1e-127,
Organism=Escherichia coli, GI1786854, Length=612, Percent_Identity=25.4901960784314, Blast_Score=140, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: =2.4.1.129 [H]

Molecular weight: Translated: 63116; Mature: 63116

Theoretical pI: Translated: 9.96; Mature: 9.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKLDGALYPWRFRVVVGLLVSLVLAICWRIVDLQVIDHTFLKEQGDARSLRHIPIPAHR
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCC
GLITDRNGEPLAVSTPVTTLWANPREMQQDKSKWPMLAAALGQDLKALTERLDSQANKEF
CEEECCCCCCEEEECCCCEEECCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEE
IYLVRGLTPEQGQSVIDLKVPGVYGIEEFRRFYPAGDVTAHMVGFTDLDDHGREGVELAY
EEEEECCCCCCCCEEEEEECCCCCCHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCEEEE
DDWLAGVPGKRQVIKDRRGRLIKDVQVTKNAKAGKTLALSIDLRLQYLATRELRNAIVEN
HHHHCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCEEEEEEEEEEHHHHHHHHHHHHHHC
EAKAGSMVIMDVKTGEVLAMVNQPTYNPNNRRTMVPAAMRNRAIIDVFEPGSTMKPISMT
CCCCCCEEEEEECCCCEEEEECCCCCCCCCCEEECCHHHCCCEEEEEECCCCCCCCEEEE
AALDSGRWKPTDKVEVYPGTLQIGKYTIRDVTKTEGPILDLTGILINSSNVGMSKVAFDV
EEECCCCCCCCCCEEEECCEEEECCEEEEECCCCCCCEEEEEEEEEECCCCCHHHEEECC
GGEAIFRAMQRVGFGQYTGLGFPGERVGNLPNYREWRKAETATLSYGYGLSVTALQLVHA
CHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCHHHHHHHCCEEEECCCCCHHHHHHHHHH
YGALANNGRIVPLTILKTDKEPESTQAIPEKTAKTLQGMLQQVIEDPRGVYRARVPSYHV
HHHHCCCCEEEEEEEEECCCCCCHHHCCHHHHHHHHHHHHHHHHHCCHHHHECCCCCEEC
GGKSGTARKTSIGTKGYAENSYRSLFAGFGPMSNPRYAIVVVIDEPSKGGYYGGLVSAPV
CCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHH
FSKVMSGTLRLMNVTPDNLAPPEQVNAAPAAKGGRG
HHHHHHCCEEEEEECCCCCCCHHHCCCCCCCCCCCC
>Mature Secondary Structure
MMKLDGALYPWRFRVVVGLLVSLVLAICWRIVDLQVIDHTFLKEQGDARSLRHIPIPAHR
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCC
GLITDRNGEPLAVSTPVTTLWANPREMQQDKSKWPMLAAALGQDLKALTERLDSQANKEF
CEEECCCCCCEEEECCCCEEECCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEE
IYLVRGLTPEQGQSVIDLKVPGVYGIEEFRRFYPAGDVTAHMVGFTDLDDHGREGVELAY
EEEEECCCCCCCCEEEEEECCCCCCHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCEEEE
DDWLAGVPGKRQVIKDRRGRLIKDVQVTKNAKAGKTLALSIDLRLQYLATRELRNAIVEN
HHHHCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCEEEEEEEEEEHHHHHHHHHHHHHHC
EAKAGSMVIMDVKTGEVLAMVNQPTYNPNNRRTMVPAAMRNRAIIDVFEPGSTMKPISMT
CCCCCCEEEEEECCCCEEEEECCCCCCCCCCEEECCHHHCCCEEEEEECCCCCCCCEEEE
AALDSGRWKPTDKVEVYPGTLQIGKYTIRDVTKTEGPILDLTGILINSSNVGMSKVAFDV
EEECCCCCCCCCCEEEECCEEEECCEEEEECCCCCCCEEEEEEEEEECCCCCHHHEEECC
GGEAIFRAMQRVGFGQYTGLGFPGERVGNLPNYREWRKAETATLSYGYGLSVTALQLVHA
CHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCHHHHHHHCCEEEECCCCCHHHHHHHHHH
YGALANNGRIVPLTILKTDKEPESTQAIPEKTAKTLQGMLQQVIEDPRGVYRARVPSYHV
HHHHCCCCEEEEEEEEECCCCCCHHHCCHHHHHHHHHHHHHHHHHCCHHHHECCCCCEEC
GGKSGTARKTSIGTKGYAENSYRSLFAGFGPMSNPRYAIVVVIDEPSKGGYYGGLVSAPV
CCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHH
FSKVMSGTLRLMNVTPDNLAPPEQVNAAPAAKGGRG
HHHHHHCCEEEEEECCCCCCCHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]