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The map label for this gene is murC [H]

Identifier: 66047328

GI number: 66047328

Start: 4889477

End: 4890937

Strand: Reverse

Name: murC [H]

Synonym: Psyr_4101

Alternate gene names: 66047328

Gene position: 4890937-4889477 (Counterclockwise)

Preceding gene: 66047329

Following gene: 66047327

Centisome position: 80.26

GC content: 62.15

Gene sequence:

>1461_bases
ATGGTTGAGAATCAACGCGCCATGCCACAACCTGAAATGCGCCGTATCCGTCGTATCCACTTCGTCGGTATCGGCGGCGT
AGGCATGTGCGGGATCGCCGAGGTGTTGTTGAACCTGGGCTACGAAGTCTCGGGCTCCGACCTGAAGGGCTCGGCCGTGA
CCGAACGCCTGGAATCGTTCGGCGCACAGATTTTCATCGGCCATCGTGCCGAGAACACCATCGGTGCCGACGTGCTGGTA
GTGTCCAGTGCCGTCAACACCTCCAACCCGGAAGTGGCCACTGCCCTGGAGCGCCGCATTCCGGTCGTACCGCGTGCCGA
GATGCTCGCCGAGCTGATGCGTTATCGCCACGGCATCGCCGTTGCCGGTACGCATGGCAAGACCACCACCACCAGCCTGA
TCGCTTCGGTATTCGCTGCCGGCGGCCTGGACCCGACCTTCGTGATTGGCGGCCGTCTCAATGCGGCAGGCACCAATGCG
CAGTTGGGCACCAGCCGCTACCTGATCGCCGAAGCCGATGAAAGCGACGCCAGCTTCCTGCACCTGCAGCCTCTGGTCGC
AGTGGTCACCAATATCGACGCCGATCACATGGCGACCTACGAAGGCGACTTCAACAAACTGAAGAAGACCTTCGTCGAGT
TCCTGCACAACCTGCCGTTCTACGGGCTGGCAGTCATGTGCATCGACGACCCGGTGGTGCGTGAGATTCTGCCGCTGGTC
AAGCGTCCGACGCTGACCTACGGCTTCAGCGAGTCTGCCGATATACGCGCAATCAATGTGCGTCAGGACGGCATGCTGAC
CTTCTTCACCGTACTGCGCCGCGACCGCGAGCCGCTGGATGTGTCGGTGAACATGCCCGGCAATCACAACGTACTCAACT
CGCTGGCGACCATTGCCATCGCCACTGATGAGGGTGTCAGCGACGAGGCCATCGTTCAGGGCCTTTCCGGGTTCCAGGGC
GTCGGTCGGCGCTTCCAGGTTTACGGCGAGCTGCCGGTCGACGGTGGTCACGTGATGCTGGTCGATGACTACGGTCACCA
CCCGCGCGAAGTCGCAGCCGTGATTAACGCTGTGCGTGGCGGCTGGCCTGATCGTCGTCTGGTAATGGTTTACCAGCCAC
ACCGTTTCAGCCGCACCCGTGACCTGTACGACGATTTCGTCCAGGTCCTGGCGGACGCCAATGTGCTGCTGCTGATGGAA
GTCTACCCGGCCGGTGAAGAACCGATTCCCGGTGCGGACAGCCGTAACCTGTGCCATAGCATTCGTCAGAGTGGCCAACT
GGACCCGATCTACATCGAGCGTGGCGTCGAGCTGGCGCCGTTGGTCAAGCCGCTGCTGCGCGCCGGCGACATCCTGCTGT
GCCAGGGCGCTGGCGACATCGGTGGTCTCGCACCGCAGTTACTCAAGAGCCCGCTGTTCGCCGGTGCCAAAGTGGCCTCC
ACCGAAGGGAAGCTGAAATGA

Upstream 100 bases:

>100_bases
ATGCAACCCGAACAATTGAACAGCATGGCCCGCACTGCACGCAGCCTGGCCAAGCCTGATGCAACCCGCACCGTCGTCAA
CGTCTGCGTGGAGGTGGCCC

Downstream 100 bases:

>100_bases
CAGCCGTTGCCCAGTCGTCCCTGCGCTCGACTCTCGAGCCGAAAAGCTTCGGCCGTGTCGCCGTGCTCTTCGGTGGCAAG
AGTGCCGAGCGTGCGGTCTC

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MVENQRAMPQPEMRRIRRIHFVGIGGVGMCGIAEVLLNLGYEVSGSDLKGSAVTERLESFGAQIFIGHRAENTIGADVLV
VSSAVNTSNPEVATALERRIPVVPRAEMLAELMRYRHGIAVAGTHGKTTTTSLIASVFAAGGLDPTFVIGGRLNAAGTNA
QLGTSRYLIAEADESDASFLHLQPLVAVVTNIDADHMATYEGDFNKLKKTFVEFLHNLPFYGLAVMCIDDPVVREILPLV
KRPTLTYGFSESADIRAINVRQDGMLTFFTVLRRDREPLDVSVNMPGNHNVLNSLATIAIATDEGVSDEAIVQGLSGFQG
VGRRFQVYGELPVDGGHVMLVDDYGHHPREVAAVINAVRGGWPDRRLVMVYQPHRFSRTRDLYDDFVQVLADANVLLLME
VYPAGEEPIPGADSRNLCHSIRQSGQLDPIYIERGVELAPLVKPLLRAGDILLCQGAGDIGGLAPQLLKSPLFAGAKVAS
TEGKLK

Sequences:

>Translated_486_residues
MVENQRAMPQPEMRRIRRIHFVGIGGVGMCGIAEVLLNLGYEVSGSDLKGSAVTERLESFGAQIFIGHRAENTIGADVLV
VSSAVNTSNPEVATALERRIPVVPRAEMLAELMRYRHGIAVAGTHGKTTTTSLIASVFAAGGLDPTFVIGGRLNAAGTNA
QLGTSRYLIAEADESDASFLHLQPLVAVVTNIDADHMATYEGDFNKLKKTFVEFLHNLPFYGLAVMCIDDPVVREILPLV
KRPTLTYGFSESADIRAINVRQDGMLTFFTVLRRDREPLDVSVNMPGNHNVLNSLATIAIATDEGVSDEAIVQGLSGFQG
VGRRFQVYGELPVDGGHVMLVDDYGHHPREVAAVINAVRGGWPDRRLVMVYQPHRFSRTRDLYDDFVQVLADANVLLLME
VYPAGEEPIPGADSRNLCHSIRQSGQLDPIYIERGVELAPLVKPLLRAGDILLCQGAGDIGGLAPQLLKSPLFAGAKVAS
TEGKLK
>Mature_486_residues
MVENQRAMPQPEMRRIRRIHFVGIGGVGMCGIAEVLLNLGYEVSGSDLKGSAVTERLESFGAQIFIGHRAENTIGADVLV
VSSAVNTSNPEVATALERRIPVVPRAEMLAELMRYRHGIAVAGTHGKTTTTSLIASVFAAGGLDPTFVIGGRLNAAGTNA
QLGTSRYLIAEADESDASFLHLQPLVAVVTNIDADHMATYEGDFNKLKKTFVEFLHNLPFYGLAVMCIDDPVVREILPLV
KRPTLTYGFSESADIRAINVRQDGMLTFFTVLRRDREPLDVSVNMPGNHNVLNSLATIAIATDEGVSDEAIVQGLSGFQG
VGRRFQVYGELPVDGGHVMLVDDYGHHPREVAAVINAVRGGWPDRRLVMVYQPHRFSRTRDLYDDFVQVLADANVLLLME
VYPAGEEPIPGADSRNLCHSIRQSGQLDPIYIERGVELAPLVKPLLRAGDILLCQGAGDIGGLAPQLLKSPLFAGAKVAS
TEGKLK

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=467, Percent_Identity=61.2419700214133, Blast_Score=550, Evalue=1e-158,
Organism=Escherichia coli, GI1790680, Length=464, Percent_Identity=28.2327586206897, Blast_Score=149, Evalue=4e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 52626; Mature: 52626

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVENQRAMPQPEMRRIRRIHFVGIGGVGMCGIAEVLLNLGYEVSGSDLKGSAVTERLESF
CCCCCCCCCCHHHHHHHEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHC
GAQIFIGHRAENTIGADVLVVSSAVNTSNPEVATALERRIPVVPRAEMLAELMRYRHGIA
CCEEEEEECCCCCCCCEEEEEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCEE
VAGTHGKTTTTSLIASVFAAGGLDPTFVIGGRLNAAGTNAQLGTSRYLIAEADESDASFL
EEECCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCEE
HLQPLVAVVTNIDADHMATYEGDFNKLKKTFVEFLHNLPFYGLAVMCIDDPVVREILPLV
EHHHHHHHHHCCCHHHEEECCCCHHHHHHHHHHHHHCCCHHHEEEEEECCHHHHHHHHHH
KRPTLTYGFSESADIRAINVRQDGMLTFFTVLRRDREPLDVSVNMPGNHNVLNSLATIAI
CCCCEEECCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHEEEEE
ATDEGVSDEAIVQGLSGFQGVGRRFQVYGELPVDGGHVMLVDDYGHHPREVAAVINAVRG
ECCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHC
GWPDRRLVMVYQPHRFSRTRDLYDDFVQVLADANVLLLMEVYPAGEEPIPGADSRNLCHS
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCHHHHHH
IRQSGQLDPIYIERGVELAPLVKPLLRAGDILLCQGAGDIGGLAPQLLKSPLFAGAKVAS
HHHCCCCCCEEEECCCCHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHCHHHCCCEEEC
TEGKLK
CCCCCC
>Mature Secondary Structure
MVENQRAMPQPEMRRIRRIHFVGIGGVGMCGIAEVLLNLGYEVSGSDLKGSAVTERLESF
CCCCCCCCCCHHHHHHHEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHC
GAQIFIGHRAENTIGADVLVVSSAVNTSNPEVATALERRIPVVPRAEMLAELMRYRHGIA
CCEEEEEECCCCCCCCEEEEEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCEE
VAGTHGKTTTTSLIASVFAAGGLDPTFVIGGRLNAAGTNAQLGTSRYLIAEADESDASFL
EEECCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCEEEEEECCCCCCCEE
HLQPLVAVVTNIDADHMATYEGDFNKLKKTFVEFLHNLPFYGLAVMCIDDPVVREILPLV
EHHHHHHHHHCCCHHHEEECCCCHHHHHHHHHHHHHCCCHHHEEEEEECCHHHHHHHHHH
KRPTLTYGFSESADIRAINVRQDGMLTFFTVLRRDREPLDVSVNMPGNHNVLNSLATIAI
CCCCEEECCCCCCCEEEEEECCCCHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHEEEEE
ATDEGVSDEAIVQGLSGFQGVGRRFQVYGELPVDGGHVMLVDDYGHHPREVAAVINAVRG
ECCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHC
GWPDRRLVMVYQPHRFSRTRDLYDDFVQVLADANVLLLMEVYPAGEEPIPGADSRNLCHS
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCHHHHHH
IRQSGQLDPIYIERGVELAPLVKPLLRAGDILLCQGAGDIGGLAPQLLKSPLFAGAKVAS
HHHCCCCCCEEEECCCCHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHHCHHHCCCEEEC
TEGKLK
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA