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The map label for this gene is kgtP [H]

Identifier: 66047226

GI number: 66047226

Start: 4763337

End: 4764662

Strand: Direct

Name: kgtP [H]

Synonym: Psyr_3999

Alternate gene names: 66047226

Gene position: 4763337-4764662 (Clockwise)

Preceding gene: 66047225

Following gene: 66047228

Centisome position: 78.17

GC content: 58.45

Gene sequence:

>1326_bases
ATGGAAACTTCCAATCCCGCCTCCCATGGGTCGGCTGCTACTGCCGCTGGCCAGAAAACCACCTCCAGCCGTCTCAAATC
GATTTTCAGTGGCTCGGTCGGCAACATGGTCGAGTGGTACGACTGGTACGTCTACGCCGCCTTCTCGCTGTACTTCGCCA
AAGCCTTCTTTCCCAAGGGCGACACCACCGCCCAGTTGCTCAACACCGCTGCGATCTTTGCCGTCGGCTTTCTGATGCGG
CCTATCGGTGGCTGGCTGATGGGGCTTTACGCTGACTACAAAGGCCGCAAGGCTGCACTGATGGCCTCGGTGCTGCTGAT
GTGCTTCGGCTCGCTGATCATTGCCCTGACGCCAGGCTATGAAAGCATCGGCGTCGGTGCTCCGATCCTGCTGGTGTTTG
CCCGCTTGCTGCAGGGCCTGTCTGTCGGCGGTGAATACGGCACGTCCGCCACCTACCTCAGCGAAATGGCCACCAAGGAG
CGTCGCGGCTTCTTCTCCAGCTTTCAGTACGTCACGCTGATTTCCGGCCAGCTCATCGCGCTGGGCGTGCTGATCGTTCT
GCAACAGACGCTGACCACCGAGCAGCTCTATGCCTGGGGCTGGCGTATCCCGTTCGTCATCGGTGCCCTGTGCGCAATCG
TCGCGCTGTTCCTGCGTCGCGGCATGGAAGAAACCGAGTCGTTCACGCGCAAGAAGAAGGAAAAGCCCAAGGAAAGCCTG
ATGCGCACGCTGATGCGTCATCCCAAGGAACTGATGACCGTCGTGGGTCTGACCATGGGCGGGACGCTGGCTTTCTACAC
TTACACCACTTATATGCAGAAGTATCTGGTCAACACCGTCGGCATGAGCATCACCGACTCGACGTCGATATCAGCGGCGA
CACTGTTTCTGTTCATGCTGTTGCAGCCGGTCGTTGGTGCGCTGTCCGACAAGATCGGGCGTCGTCCGATCCTGATTGCG
TTCGGCGTACTGGGAACGCTGTGTACCGTACCGATCCTGACCACGCTGCATACCATTCAGACATGGTGGGGTGCGTTCTT
CCTGATCATGGCGGCATTGATCATTGTCAGCGGCTATACCTCGATCAACGCAGTGGTGAAGGCCGAGCTGTTTCCGACCG
AGATCCGTGCGCTGGGCGTCGGTCTGCCTTACGCCCTGACGGTATCGATCTTCGGCGGCACTGCGGAATACATCGCGCTG
TGGTTCAAGAGCATCGGGATGGAAACCGGTTACTACTGGTACGTCACTGCCTGTATTGCCTGCTCGCTGCTGGTGTATGT
GTTCATGAAAGACACCCGCAAACACTCGCGTATCGAAACTGACTGA

Upstream 100 bases:

>100_bases
CCGCTCTAGAACAAGCCTTCATGGTCTGGCACAGCTCCTGCTATGTAACGGGCAGGGCATCGAATGCCTCCTTCCAAAAA
TAATGAAAACAAGGAACACC

Downstream 100 bases:

>100_bases
TCGGATTGCGACGATTCTCGTGCCCAGGCTCCGCTCTCATCGTTATATACAGATCTCGTGGGAGCGAGCTTGCTCGCGAA
GAGGCCGGTACAGCCTCCAG

Product: major facilitator transporter

Products: Proton [Cytoplasm]; 2-oxoglutarate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
METSNPASHGSAATAAGQKTTSSRLKSIFSGSVGNMVEWYDWYVYAAFSLYFAKAFFPKGDTTAQLLNTAAIFAVGFLMR
PIGGWLMGLYADYKGRKAALMASVLLMCFGSLIIALTPGYESIGVGAPILLVFARLLQGLSVGGEYGTSATYLSEMATKE
RRGFFSSFQYVTLISGQLIALGVLIVLQQTLTTEQLYAWGWRIPFVIGALCAIVALFLRRGMEETESFTRKKKEKPKESL
MRTLMRHPKELMTVVGLTMGGTLAFYTYTTYMQKYLVNTVGMSITDSTSISAATLFLFMLLQPVVGALSDKIGRRPILIA
FGVLGTLCTVPILTTLHTIQTWWGAFFLIMAALIIVSGYTSINAVVKAELFPTEIRALGVGLPYALTVSIFGGTAEYIAL
WFKSIGMETGYYWYVTACIACSLLVYVFMKDTRKHSRIETD

Sequences:

>Translated_441_residues
METSNPASHGSAATAAGQKTTSSRLKSIFSGSVGNMVEWYDWYVYAAFSLYFAKAFFPKGDTTAQLLNTAAIFAVGFLMR
PIGGWLMGLYADYKGRKAALMASVLLMCFGSLIIALTPGYESIGVGAPILLVFARLLQGLSVGGEYGTSATYLSEMATKE
RRGFFSSFQYVTLISGQLIALGVLIVLQQTLTTEQLYAWGWRIPFVIGALCAIVALFLRRGMEETESFTRKKKEKPKESL
MRTLMRHPKELMTVVGLTMGGTLAFYTYTTYMQKYLVNTVGMSITDSTSISAATLFLFMLLQPVVGALSDKIGRRPILIA
FGVLGTLCTVPILTTLHTIQTWWGAFFLIMAALIIVSGYTSINAVVKAELFPTEIRALGVGLPYALTVSIFGGTAEYIAL
WFKSIGMETGYYWYVTACIACSLLVYVFMKDTRKHSRIETD
>Mature_441_residues
METSNPASHGSAATAAGQKTTSSRLKSIFSGSVGNMVEWYDWYVYAAFSLYFAKAFFPKGDTTAQLLNTAAIFAVGFLMR
PIGGWLMGLYADYKGRKAALMASVLLMCFGSLIIALTPGYESIGVGAPILLVFARLLQGLSVGGEYGTSATYLSEMATKE
RRGFFSSFQYVTLISGQLIALGVLIVLQQTLTTEQLYAWGWRIPFVIGALCAIVALFLRRGMEETESFTRKKKEKPKESL
MRTLMRHPKELMTVVGLTMGGTLAFYTYTTYMQKYLVNTVGMSITDSTSISAATLFLFMLLQPVVGALSDKIGRRPILIA
FGVLGTLCTVPILTTLHTIQTWWGAFFLIMAALIIVSGYTSINAVVKAELFPTEIRALGVGLPYALTVSIFGGTAEYIAL
WFKSIGMETGYYWYVTACIACSLLVYVFMKDTRKHSRIETD

Specific function: Uptake of alpha-ketoglutarate across the boundary membrane with the concomitant import of a cation (symport system) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788942, Length=428, Percent_Identity=55.8411214953271, Blast_Score=441, Evalue=1e-125,
Organism=Escherichia coli, GI1790550, Length=422, Percent_Identity=31.2796208530806, Blast_Score=214, Evalue=6e-57,
Organism=Escherichia coli, GI1788292, Length=383, Percent_Identity=32.6370757180157, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI1789941, Length=428, Percent_Identity=31.5420560747664, Blast_Score=168, Evalue=7e-43,
Organism=Escherichia coli, GI87082231, Length=216, Percent_Identity=31.4814814814815, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI87082404, Length=387, Percent_Identity=25.5813953488372, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004736
- InterPro:   IPR020846
- InterPro:   IPR016196
- InterPro:   IPR005828
- InterPro:   IPR005829 [H]

Pfam domain/function: PF00083 Sugar_tr [H]

EC number: NA

Molecular weight: Translated: 48404; Mature: 48404

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METSNPASHGSAATAAGQKTTSSRLKSIFSGSVGNMVEWYDWYVYAAFSLYFAKAFFPKG
CCCCCCCCCCCHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
DTTAQLLNTAAIFAVGFLMRPIGGWLMGLYADYKGRKAALMASVLLMCFGSLIIALTPGY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEECCCC
ESIGVGAPILLVFARLLQGLSVGGEYGTSATYLSEMATKERRGFFSSFQYVTLISGQLIA
CCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGVLIVLQQTLTTEQLYAWGWRIPFVIGALCAIVALFLRRGMEETESFTRKKKEKPKESL
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHH
MRTLMRHPKELMTVVGLTMGGTLAFYTYTTYMQKYLVNTVGMSITDSTSISAATLFLFML
HHHHHHCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
LQPVVGALSDKIGRRPILIAFGVLGTLCTVPILTTLHTIQTWWGAFFLIMAALIIVSGYT
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
SINAVVKAELFPTEIRALGVGLPYALTVSIFGGTAEYIALWFKSIGMETGYYWYVTACIA
HHHHHHHHHHHHHHHHHHHCCCCHHEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
CSLLVYVFMKDTRKHSRIETD
HHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
METSNPASHGSAATAAGQKTTSSRLKSIFSGSVGNMVEWYDWYVYAAFSLYFAKAFFPKG
CCCCCCCCCCCHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
DTTAQLLNTAAIFAVGFLMRPIGGWLMGLYADYKGRKAALMASVLLMCFGSLIIALTPGY
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEECCCC
ESIGVGAPILLVFARLLQGLSVGGEYGTSATYLSEMATKERRGFFSSFQYVTLISGQLIA
CCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGVLIVLQQTLTTEQLYAWGWRIPFVIGALCAIVALFLRRGMEETESFTRKKKEKPKESL
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHH
MRTLMRHPKELMTVVGLTMGGTLAFYTYTTYMQKYLVNTVGMSITDSTSISAATLFLFML
HHHHHHCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
LQPVVGALSDKIGRRPILIAFGVLGTLCTVPILTTLHTIQTWWGAFFLIMAALIIVSGYT
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
SINAVVKAELFPTEIRALGVGLPYALTVSIFGGTAEYIALWFKSIGMETGYYWYVTACIA
HHHHHHHHHHHHHHHHHHHCCCCHHEEEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
CSLLVYVFMKDTRKHSRIETD
HHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 2-oxoglutarate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 2-oxoglutarate [Periplasm] = Proton [Cytoplasm] + 2-oxoglutarate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2118499; 9205837; 9278503; 1709493; 2190187; 2053984; 8419306 [H]