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The map label for this gene is metR [H]

Identifier: 66047144

GI number: 66047144

Start: 4660539

End: 4661456

Strand: Direct

Name: metR [H]

Synonym: Psyr_3917

Alternate gene names: 66047144

Gene position: 4660539-4661456 (Clockwise)

Preceding gene: 66047140

Following gene: 66047148

Centisome position: 76.48

GC content: 62.2

Gene sequence:

>918_bases
GTGCTTGAAATACGCCACCTCAAAACCCTGCATGCCCTGCGCGAGGCCGACAGCCTTGTGGAGGCAGCCGAGCGCCTGCA
TTTGACGCAGTCGGCGCTGTCCCATCAGTTCAAGGAGCTGGAAGAGCGCATGGGCATGCCGCTGTTTGTACGCAAGACCA
AACCGGTGCGCTTTACCAGCGCCGGTTTGCGCCTGCTGCAACTGGCCGACTCCATCCTGCCGCAACTGCGCAGTGCCGAG
CGCGACATCGCCCGACTGGCCGGTGGTACGGCGGGACGCCTGCACATGGCAATCGAGTGCCACAGCTGTTTTCAGTGGCT
GATGCCGACCATCGACCAGTTCCGCGATGCCTGGCCCGAGGTCGAACTGGACCTGTCTTCCGGTTTCTCGTTCGCGCCCT
TGCCTGCCCTGGCGCGTGGCGATCTGGACCTGGTGGTGACCTCGGACCCGCTGGAATTGCCCGGCATCACCTACGTGCCG
CTGTTTACCTATGAAGCGATGCTGGCGGTGGCCAATCAACATGCGCTGGCAACCAGGCCCTACATCGTCCCGGAAGACTT
GCTGAGTGAAACGCTGATCACTTACCCGGTGGAACGCGACCGGCTGGACATCTTCACGCGCTTTCTGGAGCCCGCCGACA
TCGAACCGGCACAGGTACGAACATCAGAGTTGACGGTGATGATGATGCAACTGGTCGCCAGCGGGCGCGGGGTCTGCGGC
ATGCCGCACTGGGCGCTGCATGAATACAGCTCACGCGGCTATGTGAAGGCCAAGCGGTTGGGCGAGAAAGGACTGTTTGC
GACGCTCTATGCCGGTATCCGCGCCGACATGCTCGACGCACCGTACATGCGCGATTTCCTGCTGACCGCCAAGGACACCT
CGTTTTCGACGCTCGACGGGGTAAGTGTGGTTCGCTGA

Upstream 100 bases:

>100_bases
TCCTCCATAAAAGATGGGGCTATTGTCGACAGCTGACACAACATGAGACAAACTCATTTTTTTCGTGTTGATCACAAATA
CTGCTCATGGAGCACTGACC

Downstream 100 bases:

>100_bases
CAGTGCCGTCCTGCACCACGATGCAGGACGACTGCGCCGTTCAGCTACGTGCTGCCTGCCGCTTCAGATACAGCGGCAGG
ATCAGATCGCGGGTCAACGG

Product: regulatory protein, LysR:LysR, substrate-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MLEIRHLKTLHALREADSLVEAAERLHLTQSALSHQFKELEERMGMPLFVRKTKPVRFTSAGLRLLQLADSILPQLRSAE
RDIARLAGGTAGRLHMAIECHSCFQWLMPTIDQFRDAWPEVELDLSSGFSFAPLPALARGDLDLVVTSDPLELPGITYVP
LFTYEAMLAVANQHALATRPYIVPEDLLSETLITYPVERDRLDIFTRFLEPADIEPAQVRTSELTVMMMQLVASGRGVCG
MPHWALHEYSSRGYVKAKRLGEKGLFATLYAGIRADMLDAPYMRDFLLTAKDTSFSTLDGVSVVR

Sequences:

>Translated_305_residues
MLEIRHLKTLHALREADSLVEAAERLHLTQSALSHQFKELEERMGMPLFVRKTKPVRFTSAGLRLLQLADSILPQLRSAE
RDIARLAGGTAGRLHMAIECHSCFQWLMPTIDQFRDAWPEVELDLSSGFSFAPLPALARGDLDLVVTSDPLELPGITYVP
LFTYEAMLAVANQHALATRPYIVPEDLLSETLITYPVERDRLDIFTRFLEPADIEPAQVRTSELTVMMMQLVASGRGVCG
MPHWALHEYSSRGYVKAKRLGEKGLFATLYAGIRADMLDAPYMRDFLLTAKDTSFSTLDGVSVVR
>Mature_305_residues
MLEIRHLKTLHALREADSLVEAAERLHLTQSALSHQFKELEERMGMPLFVRKTKPVRFTSAGLRLLQLADSILPQLRSAE
RDIARLAGGTAGRLHMAIECHSCFQWLMPTIDQFRDAWPEVELDLSSGFSFAPLPALARGDLDLVVTSDPLELPGITYVP
LFTYEAMLAVANQHALATRPYIVPEDLLSETLITYPVERDRLDIFTRFLEPADIEPAQVRTSELTVMMMQLVASGRGVCG
MPHWALHEYSSRGYVKAKRLGEKGLFATLYAGIRADMLDAPYMRDFLLTAKDTSFSTLDGVSVVR

Specific function: Control of the last step in methionine biosynthesis; metR is a positive activator of the metA, metE and metH genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790262, Length=292, Percent_Identity=47.2602739726027, Blast_Score=280, Evalue=1e-76,
Organism=Escherichia coli, GI157672245, Length=228, Percent_Identity=28.9473684210526, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788887, Length=293, Percent_Identity=27.6450511945392, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1790208, Length=170, Percent_Identity=30.5882352941176, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1790399, Length=249, Percent_Identity=28.5140562248996, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1789173, Length=242, Percent_Identity=28.5123966942149, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787601, Length=180, Percent_Identity=30.5555555555556, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788296, Length=296, Percent_Identity=28.0405405405405, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787806, Length=270, Percent_Identity=22.2222222222222, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI2367136, Length=238, Percent_Identity=23.9495798319328, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1787879, Length=253, Percent_Identity=26.0869565217391, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786401, Length=252, Percent_Identity=25.3968253968254, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI145693105, Length=191, Percent_Identity=24.0837696335079, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1787530, Length=279, Percent_Identity=24.3727598566308, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1789506, Length=169, Percent_Identity=25.4437869822485, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788748, Length=243, Percent_Identity=23.8683127572016, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI87081904, Length=177, Percent_Identity=29.3785310734463, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1787589, Length=129, Percent_Identity=30.2325581395349, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34202; Mature: 34202

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEIRHLKTLHALREADSLVEAAERLHLTQSALSHQFKELEERMGMPLFVRKTKPVRFTS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEHH
AGLRLLQLADSILPQLRSAERDIARLAGGTAGRLHMAIECHSCFQWLMPTIDQFRDAWPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHHCCCC
VELDLSSGFSFAPLPALARGDLDLVVTSDPLELPGITYVPLFTYEAMLAVANQHALATRP
EEEECCCCCCCCCCCHHHCCCEEEEEECCCCCCCCCEEEHHHHHHHHHHHHHCHHHCCCC
YIVPEDLLSETLITYPVERDRLDIFTRFLEPADIEPAQVRTSELTVMMMQLVASGRGVCG
CCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
MPHWALHEYSSRGYVKAKRLGEKGLFATLYAGIRADMLDAPYMRDFLLTAKDTSFSTLDG
CCHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHEEECCCCCCCCCC
VSVVR
CHHCC
>Mature Secondary Structure
MLEIRHLKTLHALREADSLVEAAERLHLTQSALSHQFKELEERMGMPLFVRKTKPVRFTS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCEEHH
AGLRLLQLADSILPQLRSAERDIARLAGGTAGRLHMAIECHSCFQWLMPTIDQFRDAWPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHHCCCC
VELDLSSGFSFAPLPALARGDLDLVVTSDPLELPGITYVPLFTYEAMLAVANQHALATRP
EEEECCCCCCCCCCCHHHCCCEEEEEECCCCCCCCCEEEHHHHHHHHHHHHHCHHHCCCC
YIVPEDLLSETLITYPVERDRLDIFTRFLEPADIEPAQVRTSELTVMMMQLVASGRGVCG
CCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
MPHWALHEYSSRGYVKAKRLGEKGLFATLYAGIRADMLDAPYMRDFLLTAKDTSFSTLDG
CCHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHEEECCCCCCCCCC
VSVVR
CHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]