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The map label for this gene is pyrC [H]

Identifier: 66047121

GI number: 66047121

Start: 4635863

End: 4636906

Strand: Direct

Name: pyrC [H]

Synonym: Psyr_3894

Alternate gene names: 66047121

Gene position: 4635863-4636906 (Clockwise)

Preceding gene: 66047118

Following gene: 66047122

Centisome position: 76.08

GC content: 62.07

Gene sequence:

>1044_bases
ATGTCTGACCGCCTGACCCTCCTGCGTCCCGACGACTGGCATATTCACCTCCGTGACGGAGCTGTCTTGCCTCATACCGT
TGCTGACGTAGCGCGAACTTTTGGCCGCGCAATCATCATGCCCAACCTCGTGCCTCCGGTACGCAACGCGCAGCAAGCCG
ATGCCTATCGCCAGCGCATTCTGGCGGCACGTCCGGCCACCAGCCGCTTCGAGCCATTGATGGTGCTGTACCTCACCGAC
CAGACCACGCCCGACGACATCCGCACCGCCAAGGCCAGTGGCTTCGTGTATGCGGCCAAGCTGTATCCGGCCGGCGCGAC
CACCAACTCCGATTCCGGTGTCACCAGCATCGACAAGATCTTCCCTGCCCTCGAAGCCATGGCCGACGTCGGCATGCTGC
TGCTGGTGCACGGGGAAGTAACACGTGGCGAAATCGACGTGTTCGATCGCGAGAAGGTCTTCATCGATGAGCACCTGCGC
CGTGTAGTCGAGCGCTTCCCGAGCCTGAAAGTGGTGTTCGAACACATCACCACCGGTGAAGCGGTGCAGTTCGTCAATGA
AGCTTCAGCCAATGTCGCGGCGACCATCACCGCGCACCACCTGCTGTACAACCGTAACCACATGCTGGTCGGCGGGATTC
GTCCGCACTTCTATTGCCTGCCGATCCTCAAGCGCAATACTCATCAGACAGCCCTGCTCGACGCGGCCACCAGCGGCAGC
GGCAAGTTCTTCCTGGGCACCGACTCGGCGCCGCATGCCCAGCATGCCAAGGAAAACGCTTGCGGTTGCGCCGGGTGCTA
CACCGCCTACGCAGCCATCGAACTGTATGCAGAAGCTTTCGAGCAACGTAACGCCCTGGACAAGCTGGAAGGCTTCGCCA
GCCTTCACGGTCCGGCGTTCTACGGCTTGCCCGCCAATCAGGACACCATCACGCTGGTGCGTGACGAGTGGACCGCCCCT
GCCAGCCTGCCGTTTGGCGAGTTGACCGTTATCCCGCTGCGCGCAGGTGAAACACTGCGCTGGCGTCTGGAGGAACACGC
GTGA

Upstream 100 bases:

>100_bases
AGGGAGCTATCGGTAACTTCATGCAAAACTTGATAGCGGATGCCTGAGAGAGTCTTTTCCGGTAGCATTCCCAGCGAGTT
TGACCCGCCTGGAATCCCCA

Downstream 100 bases:

>100_bases
GTGAAGATCATTTTGACGACGAACACGAAGGCCACGGCGGTGGCGGCGGTTCCCGTCACCCGATGGCGGCGCGCTTTCGC
GGCTACCTGCCAGTGGTCGT

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MSDRLTLLRPDDWHIHLRDGAVLPHTVADVARTFGRAIIMPNLVPPVRNAQQADAYRQRILAARPATSRFEPLMVLYLTD
QTTPDDIRTAKASGFVYAAKLYPAGATTNSDSGVTSIDKIFPALEAMADVGMLLLVHGEVTRGEIDVFDREKVFIDEHLR
RVVERFPSLKVVFEHITTGEAVQFVNEASANVAATITAHHLLYNRNHMLVGGIRPHFYCLPILKRNTHQTALLDAATSGS
GKFFLGTDSAPHAQHAKENACGCAGCYTAYAAIELYAEAFEQRNALDKLEGFASLHGPAFYGLPANQDTITLVRDEWTAP
ASLPFGELTVIPLRAGETLRWRLEEHA

Sequences:

>Translated_347_residues
MSDRLTLLRPDDWHIHLRDGAVLPHTVADVARTFGRAIIMPNLVPPVRNAQQADAYRQRILAARPATSRFEPLMVLYLTD
QTTPDDIRTAKASGFVYAAKLYPAGATTNSDSGVTSIDKIFPALEAMADVGMLLLVHGEVTRGEIDVFDREKVFIDEHLR
RVVERFPSLKVVFEHITTGEAVQFVNEASANVAATITAHHLLYNRNHMLVGGIRPHFYCLPILKRNTHQTALLDAATSGS
GKFFLGTDSAPHAQHAKENACGCAGCYTAYAAIELYAEAFEQRNALDKLEGFASLHGPAFYGLPANQDTITLVRDEWTAP
ASLPFGELTVIPLRAGETLRWRLEEHA
>Mature_346_residues
SDRLTLLRPDDWHIHLRDGAVLPHTVADVARTFGRAIIMPNLVPPVRNAQQADAYRQRILAARPATSRFEPLMVLYLTDQ
TTPDDIRTAKASGFVYAAKLYPAGATTNSDSGVTSIDKIFPALEAMADVGMLLLVHGEVTRGEIDVFDREKVFIDEHLRR
VVERFPSLKVVFEHITTGEAVQFVNEASANVAATITAHHLLYNRNHMLVGGIRPHFYCLPILKRNTHQTALLDAATSGSG
KFFLGTDSAPHAQHAKENACGCAGCYTAYAAIELYAEAFEQRNALDKLEGFASLHGPAFYGLPANQDTITLVRDEWTAPA
SLPFGELTVIPLRAGETLRWRLEEHA

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787301, Length=344, Percent_Identity=54.6511627906977, Blast_Score=392, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6323452, Length=356, Percent_Identity=35.1123595505618, Blast_Score=188, Evalue=1e-48,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004721
- InterPro:   IPR002195 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 38253; Mature: 38122

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDRLTLLRPDDWHIHLRDGAVLPHTVADVARTFGRAIIMPNLVPPVRNAQQADAYRQRI
CCCCEEEECCCCCEEEEECCCCCCHHHHHHHHHHCCEEECCCCCCCCCCCHHHHHHHHHH
LAARPATSRFEPLMVLYLTDQTTPDDIRTAKASGFVYAAKLYPAGATTNSDSGVTSIDKI
HHCCCCCCCCCCEEEEEEECCCCCHHHHHHHCCCEEEEEEEECCCCCCCCCCCCHHHHHH
FPALEAMADVGMLLLVHGEVTRGEIDVFDREKVFIDEHLRRVVERFPSLKVVFEHITTGE
HHHHHHHHCCCEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEHHHHHCCCH
AVQFVNEASANVAATITAHHLLYNRNHMLVGGIRPHFYCLPILKRNTHQTALLDAATSGS
HHHHHHHCCCCEEEEEEEEHHEECCCEEEEECCCCCEEEEEEHHCCCCCEEEEEECCCCC
GKFFLGTDSAPHAQHAKENACGCAGCYTAYAAIELYAEAFEQRNALDKLEGFASLHGPAF
CEEEEECCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
YGLPANQDTITLVRDEWTAPASLPFGELTVIPLRAGETLRWRLEEHA
ECCCCCCCEEEEEECCCCCCCCCCCCCEEEEEECCCCEEEEEEECCC
>Mature Secondary Structure 
SDRLTLLRPDDWHIHLRDGAVLPHTVADVARTFGRAIIMPNLVPPVRNAQQADAYRQRI
CCCEEEECCCCCEEEEECCCCCCHHHHHHHHHHCCEEECCCCCCCCCCCHHHHHHHHHH
LAARPATSRFEPLMVLYLTDQTTPDDIRTAKASGFVYAAKLYPAGATTNSDSGVTSIDKI
HHCCCCCCCCCCEEEEEEECCCCCHHHHHHHCCCEEEEEEEECCCCCCCCCCCCHHHHHH
FPALEAMADVGMLLLVHGEVTRGEIDVFDREKVFIDEHLRRVVERFPSLKVVFEHITTGE
HHHHHHHHCCCEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEHHHHHCCCH
AVQFVNEASANVAATITAHHLLYNRNHMLVGGIRPHFYCLPILKRNTHQTALLDAATSGS
HHHHHHHCCCCEEEEEEEEHHEECCCEEEEECCCCCEEEEEEHHCCCCCEEEEEECCCCC
GKFFLGTDSAPHAQHAKENACGCAGCYTAYAAIELYAEAFEQRNALDKLEGFASLHGPAF
CEEEEECCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
YGLPANQDTITLVRDEWTAPASLPFGELTVIPLRAGETLRWRLEEHA
ECCCCCCCEEEEEECCCCCCCCCCCCCEEEEEECCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA