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The map label for this gene is livM [H]

Identifier: 66047074

GI number: 66047074

Start: 4585993

End: 4587258

Strand: Direct

Name: livM [H]

Synonym: Psyr_3847

Alternate gene names: 66047074

Gene position: 4585993-4587258 (Clockwise)

Preceding gene: 66047073

Following gene: 66047075

Centisome position: 75.26

GC content: 60.66

Gene sequence:

>1266_bases
ATGAGCAAGTCTTTCAAACAGGCGCTGTTCAGCGCCGCACTGGTCTGGGCTGTGGCCTACCCGGTGTTTGGCCTGAAACT
GGCCTTTTCCGGCGTCACCCTGCAAGTGCAGAACGCCAGCCCGCTGACCCTGACCATTATTGCCGTGTGTTCGGTCCTGC
TGTTTCTGCGCGTATTGTTTGCCGAGCAGATCAGCGGCCTGCGTCGCGGCTCCGACAAACCGCTGATCCCGCAAAAGACC
AGCGACTTCCTGACCCAGCCGAAAACCCAGCGCTGGGGCCTGGCAGCGCTGATCGTGCTGGCCTTCATCTGGCCATTCTT
CGGGTCGCGCGGTGCGGTGGACATTGCCACGCTGATCCTGATCTACGTGATGCTCGGCCTCGGCCTGAATATCGTGGTCG
GCCTGGCAGGTCTGCTTGACCTGGGCTATGTCGGTTTCTATGCGGTCGGCGCCTACAGCTATGCCCTGCTGTCGCACTAT
TACGGGCTCGGCTTCTGGATCTGCCTGCCGATCGCGGGGCTGATGGCGGCGCTGTTCGGGTTCCTGCTGGGCTTTCCGGT
GTTGCGTCTGCGCGGCGACTATCTGGCCATCGTGACGCTGGGGTTCGGCGAGATCATCCGCATCTTCCTGCGCAACCTGA
CCGATATCACCGGCGGTCCGAACGGCATCAGCAACATCGAAAAGCCGACCTTCTTCGGCCTGACTTTCGAGCGCAAGGCT
GCTGAAGGCATGCAGACCTTCCACGAGTTCTTCGGCCTGCCGTACAACTCGATCAACAAGGTCATCTTCCTCTACCTGAT
CGCCCTGCTGCTGGCACTGGCGGCGTTGTTCGTCATCAATCGCCTGCTGCGCATGCCGATCGGCCGGGCCTGGGAAGCCT
TGCGCGAAGACGAAATCGCCTGTCGCGCACTGGGTCTGAACCCGACCGTGATCAAGCTCTCGGCCTTCACCCTTGGCGCT
GCGTTCGCAGGTTTCGCAGGTAGCTTCTTTGCTGCACGTCAGGGTCTGATCACCCCGGAATCGTTCACCTTCATCGAGTC
GGCAATCATCCTGGCCATCGTGGTGCTGGGTGGCATGGGCTCGCAACTGGGCGTGATTCTCGCGGCCATCGTGATGATCC
TGTTGCCTGAGCTGATGCGTGAGTTCAGCGACTACCGCATGCTGATGTTCGGCGCGCTGATGGTGCTGATGATGATCTGG
CGTCCACAAGGCTTCCTGCCGATGCAGCGCCCCGAAATGAAATTGAAAGCGGAGCTGCCGAAATGA

Upstream 100 bases:

>100_bases
TTGGTGATCAGTACAAGGACGTCGTGGCTTTCGGCCTGCTGGTCCTGGTGCTGCTGTTCCGACCGACCGGCATTCTGGGT
CGTCCGGAGGTTGAGAAAGT

Downstream 100 bases:

>100_bases
GCCGCCCATTACTGCAAGCCACCGGCTTGAGCATGCGTTTTGGCGGCCTGCTGGCGGTCAATGGCGTTGCCCTGACCGTC
AATCAGGGGCAGGTCGTATC

Product: leucine/isoleucine/valine transporter permease subunit

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MSKSFKQALFSAALVWAVAYPVFGLKLAFSGVTLQVQNASPLTLTIIAVCSVLLFLRVLFAEQISGLRRGSDKPLIPQKT
SDFLTQPKTQRWGLAALIVLAFIWPFFGSRGAVDIATLILIYVMLGLGLNIVVGLAGLLDLGYVGFYAVGAYSYALLSHY
YGLGFWICLPIAGLMAALFGFLLGFPVLRLRGDYLAIVTLGFGEIIRIFLRNLTDITGGPNGISNIEKPTFFGLTFERKA
AEGMQTFHEFFGLPYNSINKVIFLYLIALLLALAALFVINRLLRMPIGRAWEALREDEIACRALGLNPTVIKLSAFTLGA
AFAGFAGSFFAARQGLITPESFTFIESAIILAIVVLGGMGSQLGVILAAIVMILLPELMREFSDYRMLMFGALMVLMMIW
RPQGFLPMQRPEMKLKAELPK

Sequences:

>Translated_421_residues
MSKSFKQALFSAALVWAVAYPVFGLKLAFSGVTLQVQNASPLTLTIIAVCSVLLFLRVLFAEQISGLRRGSDKPLIPQKT
SDFLTQPKTQRWGLAALIVLAFIWPFFGSRGAVDIATLILIYVMLGLGLNIVVGLAGLLDLGYVGFYAVGAYSYALLSHY
YGLGFWICLPIAGLMAALFGFLLGFPVLRLRGDYLAIVTLGFGEIIRIFLRNLTDITGGPNGISNIEKPTFFGLTFERKA
AEGMQTFHEFFGLPYNSINKVIFLYLIALLLALAALFVINRLLRMPIGRAWEALREDEIACRALGLNPTVIKLSAFTLGA
AFAGFAGSFFAARQGLITPESFTFIESAIILAIVVLGGMGSQLGVILAAIVMILLPELMREFSDYRMLMFGALMVLMMIW
RPQGFLPMQRPEMKLKAELPK
>Mature_420_residues
SKSFKQALFSAALVWAVAYPVFGLKLAFSGVTLQVQNASPLTLTIIAVCSVLLFLRVLFAEQISGLRRGSDKPLIPQKTS
DFLTQPKTQRWGLAALIVLAFIWPFFGSRGAVDIATLILIYVMLGLGLNIVVGLAGLLDLGYVGFYAVGAYSYALLSHYY
GLGFWICLPIAGLMAALFGFLLGFPVLRLRGDYLAIVTLGFGEIIRIFLRNLTDITGGPNGISNIEKPTFFGLTFERKAA
EGMQTFHEFFGLPYNSINKVIFLYLIALLLALAALFVINRLLRMPIGRAWEALREDEIACRALGLNPTVIKLSAFTLGAA
FAGFAGSFFAARQGLITPESFTFIESAIILAIVVLGGMGSQLGVILAAIVMILLPELMREFSDYRMLMFGALMVLMMIWR
PQGFLPMQRPEMKLKAELPK

Specific function: Component of the high affinity leucine, isoleucine, valine, transport system (LIV-I), which is operative without Na(+) and is specific for alanine and threonine, in addition to branched-chain amino acids [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=411, Percent_Identity=63.5036496350365, Blast_Score=458, Evalue=1e-130,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 46155; Mature: 46024

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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C
>Mature Secondary Structure 
SKSFKQALFSAALVWAVAYPVFGLKLAFSGVTLQVQNASPLTLTIIAVCSVLLFLRVLF
CHHHHHHHHHHHHHHHHHHHHHHHHHEECCEEEEECCCCCHHHHHHHHHHHHHHHHHHH
AEQISGLRRGSDKPLIPQKTSDFLTQPKTQRWGLAALIVLAFIWPFFGSRGAVDIATLIL
HHHHHHHHCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
IYVMLGLGLNIVVGLAGLLDLGYVGFYAVGAYSYALLSHYYGLGFWICLPIAGLMAALFG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLLGFPVLRLRGDYLAIVTLGFGEIIRIFLRNLTDITGGPNGISNIEKPTFFGLTFERKA
HHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECEEHHHHH
AEGMQTFHEFFGLPYNSINKVIFLYLIALLLALAALFVINRLLRMPIGRAWEALREDEIA
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
CRALGLNPTVIKLSAFTLGAAFAGFAGSFFAARQGLITPESFTFIESAIILAIVVLGGMG
HHEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCC
SQLGVILAAIVMILLPELMREFSDYRMLMFGALMVLMMIWRPQGFLPMQRPEMKLKAELP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2120183; 10984043 [H]